Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 13, 2023
Abstract
Porcine
reproductive
and
respiratory
syndrome
is
endemic
worldwide,
seriously
affecting
development
of
the
pig
industry,
but
vaccine
strategies
have
limited
protective
effects
against
PRRSV
transmission.
The
aim
this
study
was
to
identify
potential
anti-PRRSV
drugs.
We
examined
cytotoxicity
seven
compounds
formulated
by
mass
ratio
between
glycyrrhizic
acid
matrine
their
inhibition
rate
in
vitro
.
results
showed
that
all
had
direct
killing
therapeutic
on
PRRSV,
inhibited
replication
a
time-
dose-dependent
manner.
Then,
compound
with
best
effect
selected
for
subsequent
vivo
experiments.
Pigs
were
divided
into
control
group
medication
conduct
evaluation.
pigs
treated
4:1
100%
morbidity
after
challenge,
mortality
reached
75%
8th
day
challenge.
These
suggest
has
no
practical
can
instead
accelerate
death
infected
pigs.
Next,
we
further
analyzed
semiprotective
obtained
from
through
determine
whether
synergize
indicated
higher
more
severe
clinical
reactions
infection
(
p
<
0.05).
levels
proinflammatory
cytokines
(IL-6,
IL-8,
IL-1β,
IFN-γ,
TNF-α)
significantly
upregulated
compound-treated
compared
positive
0.05),
there
synergistic
enhancement
live
attenuated
enhanced
inflammatory
response,
prompted
body
produce
excessive
caused
damage,
preventing
being
produced.
In
conclusion,
present
revealed
effectiveness
does
not
mean
it
effective
developing
Our
finding
that,
order
find
drugs,
comprehensive
drug
screening
required,
at
least
solid
anti-inflammatory
ability
may
help
new
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 2485 - 2529
Published: June 1, 2024
Abstract:
Ferroptosis,
a
unique
form
of
programmed
cell
death,
is
initiated
by
an
excess
iron
accumulation
and
lipid
peroxidation-induced
damage.
There
growing
body
evidence
indicating
that
ferroptosis
plays
critical
role
in
the
advancement
tumors.
The
increased
metabolic
activity
higher
levels
tumor
cells
make
them
particularly
vulnerable
to
ferroptosis.
As
result,
targeted
induction
becoming
increasingly
promising
approach
for
cancer
treatment.
This
review
offers
overview
regulatory
mechanisms
ferroptosis,
delves
into
mechanism
action
traditional
small
molecule
inducers
their
effects
on
various
In
addition,
latest
progress
inducing
using
new
means
such
as
proteolysis-targeting
chimeras
(PROTACs),
photodynamic
therapy
(PDT),
sonodynamic
(SDT)
nanomaterials
summarized.
Finally,
this
discusses
challenges
opportunities
development
ferroptosis-inducing
agents,
focusing
discovering
targets,
improving
selectivity,
reducing
toxic
side
effects.
Keywords:
inducers,
molecules,
PROTACs,
PDT,
SDT,
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6613 - 6613
Published: June 16, 2024
Matrine
(MT)
possesses
anti-inflammatory,
anti-allergic
and
antioxidative
properties.
However,
the
impact
underlying
mechanisms
of
matrine
on
colitis
are
unclear.
The
purpose
this
research
was
to
examine
protective
regulatory
mechanism
dextran
sulfate
sodium
(DSS)-induced
ulcerative
(UC)
in
mice.
MT
alleviated
DSS-induced
UC
by
inhibiting
weight
loss,
relieving
colon
shortening
reducing
disease
activity
index
(DAI).
Moreover,
intestinal
injury
number
goblet
cells
were
reversed
MT,
as
alterations
expression
zonula
occludens-1
(ZO-1)
occludin
colon.
Simultaneously,
not
only
effectively
restored
oxidative
stress
colonic
tissues
but
also
reduced
production
inflammatory
cytokines.
Furthermore,
could
treat
mice
regulating
T
cell
(Treg)/T
helper
17
(Th17)
imbalance.
We
observed
further
evidence
that
decrease
flora
diversity,
proportion
Firmicutes
Bacteroidetes,
decreased
Proteobacteria
increased
relative
abundance
Lactobacillus
Akkermansia
In
conclusion,
these
results
suggest
may
mitigate
enhancing
barrier
integrity,
Treg/Th17
imbalance,
inflammation,
modulating
gut
microbiota.
These
findings
provide
strong
for
development
application
a
dietary
treatment
UC.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(6), P. 2962 - 2992
Published: April 10, 2024
Abstract
Neuropathic
pain
(NP)
is
a
common
chronic
with
heterogeneous
clinical
features,
and
consequent
lowering
of
quality
life.
Currently,
although
conventional
chemical
drugs
can
effectively
manage
NP
symptoms
in
the
short
term,
their
long‐term
efficacy
limited,
they
come
significant
side
effects.
In
this
regard,
traditional
Chinese
medicine
(TCM)
provides
promising
avenue
for
treating
NP.
Numerous
pharmacological
studies
have
substantiated
effectiveness
TCM
multiple
targets
mechanisms.
We
aimed
to
outline
characteristics
TCM,
including
compound
prescriptions,
single
herbs,
active
ingredients,
physical
therapy,
treatment
discussed
by
analyzing
pathogenesis
Various
databases,
such
as
PubMed,
Web
Science,
China
National
Knowledge
Infrastructure,
Wanfang
database,
were
searched.
focused
on
recent
research
progress
TCM.
Finally,
we
proposed
future
challenges
emerging
trends
demonstrates
treatment,
employing
multi‐mechanisms.
Drawing
from
theory
syndrome
differentiation,
four
types
dialectical
treatments
prescriptions
introduced:
promoting
blood
circulation
removing
stasis;
promote
Qi
flow;
warming
Yang
benefiting
Qi;
soothing
liver
regulating
Qi.
Meanwhile,
33
herbs
25
ingredients
included.
addition,
therapy
(e.g.,
acupuncture,
massage,
acupoint
injection,
fumigation)
also
showed
good
treatment.
particularly
through
use
holds
bright
prospects
owing
its
diverse
holistic
Nonetheless,
multi‐targets
may
result
possible
disadvantages
mechanisms
need
further
evaluation.
Here,
provide
an
overview
via
based
potential
therapeutic
mechanisms,
thus
providing
reference
studies.
