Metabolic Dysfunction-Associated Steatotic Liver Disease in Chronic Hepatitis C Virus Infection: From Basics to Clinical and Nutritional Management DOI Creative Commons
Karina González-Aldaco, Luis A. Torres-Reyes, Claudia Ojeda‐Granados

et al.

Clinics and Practice, Journal Year: 2024, Volume and Issue: 14(6), P. 2542 - 2558

Published: Nov. 24, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with obesity and other cardiometabolic risk factors. MASLD has rapidly become the most common cause of worldwide, currently affecting 38% global population. Excess weight causes chronic inflammation activation different pathways involved in damage. can progress from simple steatosis to steatohepatitis, giving way its inflammatory component, metabolic steatohepatitis (MASH), previously recognized as non-alcoholic hepatitis (NASH). Chronic C virus (HCV) infection remains a significant challenge health it triggers hepatic inflammation, disruption, steatosis. The convergence HCV significantly alter course accelerate progression severe Currently, treatment high cure rate. However, patients who achieve sustained virological response after direct-acting antivirals, gain, excessive calorie intake may contribute increased higher progression. Therefore, effective clinical nutritional management patients, both before viral eradication, crucial reducing death hepatocellular carcinoma. Understanding complex interactions between for managing these appropriately. Herein, host mechanisms inducing damage during coexistence are described, their therapeutic dietary discussed.

Language: Английский

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols DOI Creative Commons

Raissa Bulaty Tauil,

Paula Takano Golono,

Enzo Pereira de Lima

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

Citations

13
Different Short-Chain Fatty Acids Unequally Modulate Intestinal Homeostasis and Reverse Obesity-Related Symptoms in Lead-Exposed High-Fat Diet Mice DOI

Nana Wang,

Yilimilai Dilixiati,

Xiao Liang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(34), P. 18971 - 18985

Published: Aug. 15, 2024

Our previous study showed that heavy metal lead (Pb) exposure exacerbates high-fat-diet (HFD)-induced metabolic damage and significantly depletes the gut microbiota-derived metabolite short-chain fatty acid (SCFA) levels. However, it remains unclear whether SCFA is a key involved in accelerating adverse consequences after Pb exposure. In this study, we explored effects of exogenous supplementation acetate, propionate, butyrate on disorder model Pb-exposed HFD mice. We found three interventions attenuated glycolipid metabolism disorders liver damage, with performing best improving obesity-related symptoms. All promoted abundance

Language: Английский

Citations

6
Sangyod Rice Extract Mitigates Insulin Resistance in HepG2 cells and Hepatic Steatosis in Diabetic Rats via AMPK/mTOR/MAPK Signaling Pathways DOI
Wanthanee Hanchang,

Wanwipha Woonnoi,

Jirawat Saetan

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104662 - 104662

Published: June 28, 2024

Language: Английский

Citations

4
Chlorogenic acid promotes fatty acid beta-oxidation to increase hESCs proliferation and lipid synthesis DOI Creative Commons
Ming Zong,

Jingzhang Ji,

Qinglai Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 27, 2025

Cell metabolism plays a crucial role in regulating the pluripotency of human embryonic stem cells (hESCs). Chlorogenic acid (CGA), an essential dietary polyphenol, exhibits diverse pharmacological effects on regulation. This study examines CGA cell hESCs using H9 model. At concentration 100 µg/ml, showed low toxicity and had no impact viability cells. Furthermore, it promotes NANOG expression. Importantly, enhances Fatty β-oxidation (FAO), thus promoting proliferation lipid synthesis Mechanistically, CGA-induced FAO generates acetyl-CoA, which de novo hyperacetylates H3K27 at promoter regions associated genes, thereby enhancing their highlights potential beneficial provides opportunities for optimizing vitro culture hESCs.

Language: Английский

Citations

0
A Network of Processes for Biorefining Burdock Seeds and Roots DOI Creative Commons
Luigi di Bitonto,

Enrico Scelsi,

Massimiliano Errico

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 937 - 937

Published: Feb. 21, 2024

In this work, a novel sustainable approach was proposed for the integral valorisation of Arctium lappa (burdock) seeds and roots. Firstly, preliminary recovery bioactive compounds, including unsaturated fatty acids, performed. Then, simple sugars (i.e., fructose sucrose) phenolic compounds were extracted by using compressed fluids (supercritical CO2 propane). Consequently, complete characterisation raw biomass extraction residues carried out to determine starting chemical composition in terms residual lipids, proteins, hemicellulose, cellulose, lignin, ash content. Subsequently, three alternative ways utilise successfully tested: (i) enzymatic hydrolysis operated Cellulases (Thricoderma resei) glucose, (ii) direct ethanolysis produce ethyl levulinate; (iii) pyrolysis obtain biochar be used as supports synthesis sulfonated magnetic iron-carbon catalysts (Fe-SMCC) applied dehydration 5-hydroxymethylfurfural (5-HMF). The development these advanced approaches enabled full utilisation resource through production fine chemicals value-added line with principles circular economy.

Language: Английский

Citations

2
Quality Evaluation of Lonicerae Flos Produced in Southwest China Based on HPLC Analysis and Antioxidant Activity DOI Creative Commons
Qundong Liu, Huanhuan Yu, Yuzhuo Dong

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2560 - 2560

Published: May 29, 2024

, the main source of traditional Chinese medicine Lonicerae Flos, is extensively cultivated in Southwest China. However, quality

Language: Английский

Citations

1
Impact of Coffee Intake on Human Aging: Epidemiology and Cellular Mechanisms DOI Creative Commons
Cátia R. Lopes, Rodrigo A. Cunha

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102581 - 102581

Published: Nov. 16, 2024

Language: Английский

Citations

1
Therapeutic Synergies in Traditional Chinese Herbal Teas: An Integrative Review of Lonicerae Japonicae Flos and Complementary Constituents DOI Creative Commons

Yaoxu Zhou,

Jiating Liang,

Chengyong Wang

et al.

International Journal of Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 6(4)

Published: Jan. 1, 2024

This review explores the synergistic blend of traditional Chinese herbal tea components, including Lonicerae Japonicae Flos, jasmine, Siraitia grosvenorii, burdock roots, and wolfberry. Each component is selected for its unique therapeutic properties contribution to overall health benefits. With a resurgence interest in natural remedies holistic health, these teas have garnered attention their potential restore bodily balance harmony as per Traditional Medicine principles. comprehensive overview delves into ethnopharmacological background, cultural significance, scientific evidence supporting health-promoting effects ingredients. Through an examination antipyretic, anti-inflammatory, antimicrobial, antiviral, hepatoprotective properties, this highlights tea's contemporary wellness practices, underscoring blend's role preventive care efficacy against range conditions.

Language: Английский

Citations

0
Metabolic Dysfunction-Associated Steatotic Liver Disease in Chronic Hepatitis C Virus Infection: From Basics to Clinical and Nutritional Management DOI Creative Commons
Karina González-Aldaco, Luis A. Torres-Reyes, Claudia Ojeda‐Granados

et al.

Clinics and Practice, Journal Year: 2024, Volume and Issue: 14(6), P. 2542 - 2558

Published: Nov. 24, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with obesity and other cardiometabolic risk factors. MASLD has rapidly become the most common cause of worldwide, currently affecting 38% global population. Excess weight causes chronic inflammation activation different pathways involved in damage. can progress from simple steatosis to steatohepatitis, giving way its inflammatory component, metabolic steatohepatitis (MASH), previously recognized as non-alcoholic hepatitis (NASH). Chronic C virus (HCV) infection remains a significant challenge health it triggers hepatic inflammation, disruption, steatosis. The convergence HCV significantly alter course accelerate progression severe Currently, treatment high cure rate. However, patients who achieve sustained virological response after direct-acting antivirals, gain, excessive calorie intake may contribute increased higher progression. Therefore, effective clinical nutritional management patients, both before viral eradication, crucial reducing death hepatocellular carcinoma. Understanding complex interactions between for managing these appropriately. Herein, host mechanisms inducing damage during coexistence are described, their therapeutic dietary discussed.

Language: Английский

Citations

0