Exploring the Difficulties of Treatment, Rational Analysis of Homeopathy DOI Open Access

Chi Zhao

International Journal of Homeopathy & Natural Medicines, Journal Year: 2024, Volume and Issue: 10(2), P. 27 - 37

Published: Nov. 28, 2024

Homeopathy began in Germany the late 18th century, creation of homeopathy seems to have opened up a new road medicine, because this treatment has brought advantage many patients, but it is controversial, scholars believe that not scientific. Whether or allopathic unscientific，is crux matter. While therapies undeniably played huge role fight against disease, NCDs, including cancer, been effectively controlled, and World Health Organization's 2030 health goals are unlikely be met. Actually, clinical application beneficial diseases, reducing damage biological function human body due taking traditional drugs. Supporters more effective than therapy, there no sufficient theoretical basis confirm issue. In fact, process organism from disease self-repair, strong self-repair ability cannot replaced by any drug. The occurrence NCDs caused bad information brain, drugs remove mentality, similarly, mentality also, reduce function, conducive promotion organism's ability. order understand root problem, needs rationally analyzed solve problem treatment.

Language: Английский

Natural Compounds for Preventing Age-Related Diseases and Cancers DOI Open Access
Mi‐Ran Ki,

Sol Youn,

Dong Hyun Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

Citations

9
Jianpi Qingre Tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway DOI
Qiao Zhou, Jian Liu,

Yajun Qi

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118953 - 118953

Published: Oct. 1, 2024

Language: Английский

Citations

4
MiR-103-3p regulates chondrocyte autophagy, apoptosis, and ECM degradation through the PI3K/Akt/mTOR pathway by targeting CPEB3 DOI Creative Commons
Jun Li,

Farui Sun,

Yuanjin Zhang

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 29, 2025

Chondrocyte apoptosis is associated with the severity of cartilage destruction and matrix degeneration in progression osteoarthritis. Increasing evidence indicates that autophagy has a significant cytoprotective effect against chondrocyte apoptosis. Here, we investigated role microRNA-103-3p (miR-103-3p) regulating function elucidated underlying mechanism. MiR-103-3p expression interleukin-1β (IL-1β)-stimulated chondrocytes was evaluated using RT-qPCR. The targets miR-103-3p predicted by online databases were verified biotin-based pulldown assay luciferase reporter assay. IL-1β stimulated-chondrocytes transfected inhibitor along siRNA targeting cytoplasmic polyadenylation element-binding protein3 (siCPEB3), 3-MA, or PI3K agonist 740 Y-P. proliferation cell counting kit-8. Apoptosis detected flow cytometry. levels apoptosis-, extracellular (ECM)-, autophagy-, PI3K/Akt/mTOR pathway-related proteins immunoblotting immunofluorescence. We found stimulation upregulated downregulated CPEB3 mouse chondrocytes. Inhibiting reduced IL-1β-induced ECM macromolecule degradation while enhancing targeted CPEB3, its downregulation rescued level stimulated-chondrocytes. inhibited pathway upregulating CPEB3. Y-P, knockdown counteracted on apoptosis, degradation, autophagy. Overall, inhibition reduces through CPEB3/PI3K/Akt/mTOR pathway.

Language: Английский

Citations

0
TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway DOI Open Access
Jishang Huang,

Qun Ren,

Linhui Jiao

et al.

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 28(1)

Published: May 15, 2024

Osteoarthritis (OA) is a disease of the joints, characterized by chronic inflammation, cartilage destruction and extracellular matrix (ECM) remodeling. Aberrant chondrocyte hypertrophy promotes OA development. Collagen X, biomarker hypertrophy, upregulated runt‑related transcription factor 2 (Runx2), which mediated bone morphogenetic protein 4 (BMP4)/Smad1 signaling pathway. BMP binding endothelial regulator (BMPER), secreted glycoprotein, acts as an agonist BMP4. 5,7,3',4'‑tetramethoxyflavone (TMF) natural flavonoid derived from Murraya exotica L. Results our previous study demonstrated that TMF exhibits chondroprotective effects against development through activation Forkhead box O3a (FOXO3a) expression. However, whether suppresses FOXO3a expression inhibition BMPER/BMP4/Smad1 remains unknown. present revealed inhibited collagen X Runx2 expression, signaling, activated expression; thus, protecting BMPER overexpression knockdown impacted protective TMF. Thus, in mediating FOXO3a/BMPER

Language: Английский

Citations

2
Exploring the impact of curcumin on osteoarthritis symptomatology: correlations and insights from a Bulgarian cohort DOI Creative Commons
Krasimir Kraev, Petar Uchikov, Bozhidar Hristov

et al.

Folia Medica, Journal Year: 2024, Volume and Issue: 66(4), P. 461 - 465

Published: Aug. 31, 2024

Introduction : Osteoarthritis is a prevalent degenerative joint disorder associated with pain and functional impairment. Curcumin, natural anti-inflammatory compound, has garnered attention for its potential therapeutic benefits in osteoarthritis management. Aim This study aimed to investigate the correlations between curcumin use, patient characteristics, medication changes health outcomes among patients. The primary hypothesis was that use would correlate positive metrics. Materials methods A cohort of 60 patients enrolled this observational divided into 4 groups according type osteoarthritis. Patient selection criteria included diagnosis consent supplementation. outcome variable metrics measured across three visits. Body mass index, nonsteroidal drugs (NSAIDs) paracetamol were also recorded. Correlation analysis paired t -tests employed examine relationships variables Results analyses revealed weak negative correlation BMI ‘Visit 1’ 2’ ( r =−0.09). NSAIDs exhibited during period =0.17), while displayed =−0.05) changes. Statistically significant observed (mean change =−5.93, p <0.05), aligning prior studies indicating curcumin’s symptom relief. Conclusions provides valuable insights intricate exist curcumin, Despite many limitations, including sample size research duration, our indicates may have impact on symptomatology findings highlight need more studies, larger trials, mechanistic completely understand role

Language: Английский

Citations

1
Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

Citations

0
Exploring the Difficulties of Treatment, Rational Analysis of Homeopathy DOI Open Access

Chi Zhao

International Journal of Homeopathy & Natural Medicines, Journal Year: 2024, Volume and Issue: 10(2), P. 27 - 37

Published: Nov. 28, 2024

Homeopathy began in Germany the late 18th century, creation of homeopathy seems to have opened up a new road medicine, because this treatment has brought advantage many patients, but it is controversial, scholars believe that not scientific. Whether or allopathic unscientific，is crux matter. While therapies undeniably played huge role fight against disease, NCDs, including cancer, been effectively controlled, and World Health Organization's 2030 health goals are unlikely be met. Actually, clinical application beneficial diseases, reducing damage biological function human body due taking traditional drugs. Supporters more effective than therapy, there no sufficient theoretical basis confirm issue. In fact, process organism from disease self-repair, strong self-repair ability cannot replaced by any drug. The occurrence NCDs caused bad information brain, drugs remove mentality, similarly, mentality also, reduce function, conducive promotion organism's ability. order understand root problem, needs rationally analyzed solve problem treatment.

Language: Английский

Citations

0