A systematic review of polymer composite in biomedical engineering

European Polymer Journal, Journal Year: 2021, Volume and Issue: 154, P. 110534 - 110534

Published: May 23, 2021

Language: Английский

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Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(7), P. 983 - 983

Published: June 29, 2021

The socioeconomic impact of osteochondral (OC) damage has been increasing steadily over time in the global population, and promise tissue engineering generating biomimetic tissues replicating physiological OC environment architecture falling short its projected potential. most recent advances are summarised this work, with a focus on electrospun 3D printed biomaterials combined stem cells biochemical stimuli, to identify what is causing pitfall between bench patients’ bedside. Even though significant progress achieved electrospinning, 3D-(bio)printing, induced pluripotent cell (iPSC) technologies, it still challenging artificially emulate interface achieve complete regeneration bone cartilage tissues. Their intricate need for tight spatiotemporal control cellular cues hinder attainment long-term functional integration tissue-engineered constructs. Moreover, complexity high variability experimental conditions used different studies undermine scalability reproducibility prospective regenerative medicine solutions. It clear that further development standardised, integrative, economically viable methods regarding scaffold production, selection, additional biomechanical stimulation likely be key accelerate clinical translation fill gap treatment.

Language: Английский

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Advances in Electrospun Nerve Guidance Conduits for Engineering Neural Regeneration

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 219 - 219

Published: Jan. 18, 2022

Injuries to the peripheral nervous system result in devastating consequences with loss of motor and sensory function lifelong impairments. Current treatments have largely relied on surgical procedures, including nerve autografts repair damaged nerves. Despite improvements procedures over years, clinical success is limited by fundamental issues, such as low functionality mismatching between donor While nerves can regenerate some extent, resultant outcomes are often disappointing, particularly for serious injuries, ongoing due poor regeneration a public health problem worldwide. Thus, successful therapeutic modality bring functional recovery urgently needed. With advances three-dimensional cell culturing, guidance conduits (NGCs) emerged promising strategy improving outcomes. Therefore, they offer potential alternative autografts. NGCs tubular biostructures bridge injury sites via orienting axonal growth an organized fashion well supplying supportively appropriate microenvironment. Comprehensive NGC creation requires considerations various aspects, structure design, extracellular matrix components composition. these considerations, production that mimics endogenous enhance neuron–NGC interactions thereby promote restoration target area. The use electrospun fibrous substrates has high replicate native structure. recent electrospinning, it now possible generate numerous different biomimetic features within NGCs. This review explores electrospinning discusses main requirements, challenges developing applying practice injuries.

Language: Английский

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Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 16, 2022

Abstract Nanomaterial-based phototherapy has become an important research direction for cancer therapy, but it still to face some obstacles, such as the toxic side effects and low target specificity. The biomimetic synthesis of nanomaterials using biomolecules is a potential strategy improve photothermal therapy (PTT) photodynamic (PDT) techniques due their endowed biocompatibility, degradability, toxicity, specific targeting. This review presents recent advances in biomolecule-mimetic functional PTT PDT cancers. First, we introduce four methods via case studies discuss advantages each method. Then, DNA, RNA, protein, peptide, polydopamine, others, detail how regulate structure functions obtained nanomaterials. Finally, applications both cancers are demonstrated discussed. We believe that this work valuable readers understand mechanisms nanomaterial-based techniques, will contribute bridging nanotechnology biomedicine realize novel highly effective therapies.

Language: Английский

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Polysaccharide base electrospun nanofibrous scaffolds for cartilage tissue engineering: Challenges and opportunities

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134054 - 134054

Published: July 20, 2024

Language: Английский

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