Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(20)
Published: July 5, 2024
Abstract
Amphiphilic
peptides
have
garnered
significant
attention
due
to
their
highly
designable
and
self‐assembling
behaviors.
Self‐assembled
hold
excellent
potential
in
various
fields
such
as
biosensing,
environmental
monitoring,
drug
delivery,
owing
remarkable
biological,
physical,
chemical
properties.
While
nanomaterials
formed
by
peptide
self‐assembly
found
widespread
use
biomedical
applications,
the
development
of
2D
nanosheets
based
on
amphiphilic
remains
challenging
terms
rational
design
morphology
modulation.
In
this
study,
rationally
designed
molecules
are
self‐assembled
into
(PNS)
under
specific
conditions
encapsulate
gold
nanoparticles
(AuNPs),
resulting
formation
AuNPs/PNS
hybrid
materials
with
high
photothermal
conversion
efficiency.
The
findings
demonstrate
that
PNS
enhances
overall
therapy
effect
nanohybrid
larger
hosting
area
for
AuNPs
higher
biocompatibility.
well‐designed
study
offer
insights
structural
functional
modulation
molecules.
addition,
constructed
biomimetic‐functional
inorganic/organic
applications
engineering.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 5837 - 5858
Published: June 1, 2024
Purpose:
Phototherapy,
known
for
its
high
selectivity,
few
side
effects,
strong
controllability,
and
synergistic
enhancement
of
combined
treatments,
is
widely
used
in
treating
diseases
like
cervical
cancer.
Methods:
In
this
study,
hollow
mesoporous
manganese
dioxide
was
as
a
carrier
to
construct
positively
charged,
poly(allylamine
hydrochloride)–modified
nanoparticles
(NPs).
The
NP
efficiently
loaded
with
the
photosensitizer
indocyanine
green
(ICG)
via
addition
hydrogen
phosphate
ions
produce
counterion
aggregation
effect.
HeLa
cell
membrane
encapsulation
performed
achieve
final
M-HMnO
2
@ICG
NP.
structure,
HMnO
responsively
degrades
release
ICG
tumor
microenvironment,
self-generates
O
sensitization
ICG-mediated
photodynamic
therapy
(PDT),
consumes
GSH
expand
oxidative
stress
therapeutic
effect
[chemodynamic
(CDT)
+
PDT].
accumulated
tissues
exerts
PDT/photothermal
(PTT)
through
single
laser
irradiation,
improving
efficiency
reducing
effects.
increases
nanomedicine
accumulation
confers
an
immune
evasion
ability.
addition,
local
temperatures
induced
by
PTT
can
enhance
CDT.
These
properties
enable
full
achievement
PTT/PDT/CDT
targeted
Results:
Mn
2+
serve
magnetic
resonance
imaging
agent
guide
therapy,
be
photothermal
fluorescence
imaging.
After
intravenous
injection,
effectively
at
mouse
sites;
optimal
timing
in-vivo
treatment
could
verified
near-infrared
fluorescence,
resonance,
NPs
had
best
antitumor
effects
among
groups
under
light
conditions,
showed
good
biocompatibility.
Conclusion:
we
designed
nano-biomimetic
delivery
system
that
improves
hypoxia,
responds
loads
ICG.
It
provides
new
economical
convenient
strategy
phototherapy
CDT
Keywords:
phototherapy,
reactive
oxygen
species,
hypoxia
relief,
collaborative
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(6), P. 531 - 531
Published: March 16, 2024
Biomimetic
scaffolds
imitate
native
tissue
and
can
take
a
multidimensional
form.
They
are
biocompatible
influence
cellular
metabolism,
making
them
attractive
bioengineering
platforms.
The
use
of
biomimetic
adds
complexity
to
traditional
cell
cultivation
methods.
most
commonly
used
technique
involves
cultivating
cells
on
flat
surface
in
two-dimensional
format
due
its
simplicity.
A
three-dimensional
(3D)
provide
microenvironment
for
surrounding
cells.
There
two
main
techniques
obtaining
3D
structures
based
the
presence
scaffolding.
Scaffold-free
consist
spheroid
technologies.
Meanwhile,
scaffold
contain
organoids
all
constructs
that
various
types
scaffolds,
ranging
from
decellularized
extracellular
matrix
(dECM)
through
hydrogels
one
extensively
studied
forms
potential
culture
up
4D
bioprinted
biomaterials.
bioprinting
is
important
create
scaffolds.
versatility
this
allows
many
different
inks,
mainly
hydrogels,
as
well
inorganic
substances.
Increasing
amounts
data
evidence
vast
usage
engineering
personalized
medicine,
with
area
application
being
regeneration
skin
musculoskeletal
systems.
Recent
papers
also
indicate
increasing
vivo
tests
products
which
further
strengthen
importance
branch
emphasize
need
extensive
research
safe
humansbiomimetic
tissues
organs.
In
review
article,
we
recent
advancements
field
preceded
by
an
overview
technologies
led
development
complex
type
culture.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 24, 2023
Abstract
Functional
hydrogels
show
potential
application
in
repairing
spinal
cord
injury
(SCI)
due
to
their
unique
chemical,
physical,
and
biological
properties
functions.
In
this
comprehensive
review,
we
present
recent
advance
the
material
design,
functional
regulation,
SCI
repair
applications
of
bioactive
hydrogels.
Different
from
previously
released
reviews
on
three-dimensional
scaffolds
for
repair,
work
focuses
strategies
design
biologically
regulation
hydrogels,
specifically
aiming
how
these
significant
efforts
can
promoting
performance
SCI.
We
demonstrate
various
methods
techniques
fabrication
with
components
such
as
DNA,
proteins,
peptides,
biomass
polysaccharides,
biopolymers
obtain
including
cell
biocompatibility,
self-healing,
anti-bacterial
activity,
injectability,
bio-adhesion,
bio-degradation,
other
multi-functions
The
drugs/growth
factors,
polymers,
nanoparticles,
one-dimensional
materials,
two-dimensional
materials
highly
effective
treating
are
introduced
discussed
detail.
This
shows
new
viewpoints
ideas
synthesis
state-of-the-art
knowledges
science
nanotechnology,
will
bridge
connection
biomedicine,
further
inspire
clinical
biomedical
fields.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(23), P. 5051 - 5070
Published: Jan. 1, 2023
This
review
summarizes
the
synthesis
of
gold
nanoclusters
using
biomolecules
as
templates
and
their
applications
in
bioimaging,
disease
treatment
drug
delivery.
Critical Reviews in Clinical Laboratory Sciences,
Journal Year:
2024,
Volume and Issue:
61(6), P. 473 - 495
Published: March 7, 2024
Nucleic
acids,
like
DNA
and
RNA,
serve
as
versatile
recognition
elements
in
electrochemical
biosensors,
demonstrating
notable
efficacy
detecting
various
cancer
biomarkers
with
high
sensitivity
selectivity.
These
biosensors
offer
advantages
such
cost-effectiveness,
rapid
response,
ease
of
operation,
minimal
sample
preparation.
This
review
provides
a
comprehensive
overview
recent
developments
nucleic
acid-based
for
diagnosis,
comparing
them
antibody-based
counterparts.
Specific
examples
targeting
key
biomarkers,
including
prostate-specific
antigen,
microRNA-21,
carcinoembryonic
are
highlighted.
The
discussion
delves
into
challenges
limitations,
encompassing
stability,
reproducibility,
interference,
standardization
issues.
suggests
future
research
directions,
exploring
new
acid
elements,
innovative
transducer
materials
designs,
novel
signal
amplification
strategies,
integration
microfluidic
devices
or
portable
instruments.
Evaluating
these
clinical
settings
using
actual
samples
from
patients
healthy
donors
is
emphasized.
sensors
sensitive
specific
at
non-communicable
communicable
disease
biomarkers.
RNA's
self-assembly,
programmability,
catalytic
activity,
dynamic
behavior
enable
adaptable
sensing
platforms.
They
can
increase
biosensor
biocompatibility,
transduction,
nanomaterials.
In
conclusion,
acids-based
hold
significant
potential
to
enhance
detection
treatment
through
early
accurate
diagnosis.
