Antimicrobial Actions and Applications of Chitosan

Polymers, Journal Year: 2021, Volume and Issue: 13(6), P. 904 - 904

Published: March 15, 2021

Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the varies, because associated with physicochemical characteristics depends on type microorganism. In review article, fundamental properties, modes action, effects-related factors are discussed. We further summarize how microorganisms genetically respond chitosan. Finally, applications chitosan-based biomaterials, such as nanoparticles films, combination current clinical antibiotics or antifungal drugs, also addressed.

Language: Английский

---

Drug release study of the chitosan-based nanoparticles

Heliyon, Journal Year: 2021, Volume and Issue: 8(1), P. e08674 - e08674

Published: Dec. 24, 2021

Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted delivery, and controlled release. Chitosan-based nanoparticles (CSNPs) are employed as imaging delivering the particular sites in regulated manner. Drug release is an important factor ensuring high reproducibility, stability, quality control of CSNPs, scientific-based for developing CSNPs. Several factors influence from composition, composition ratio, ingredient interactions, preparation methods. Early, CSNPs were used improving solubility, pharmacokinetics, pharmacotherapeutics properties. Chitosan has developed toward system by exploring positively charged properties modifiable functional groups. Various modifications polymer backbone, charge, or groups will undoubtedly affect The significant on its therapeutic actions. Our review's objective was summarize discuss relationship between modification kinetics model. Kinetic models help describe rate, leading increased efficiency, accuracy, safety dose, optimizing device's design, evaluating improvement patient compatibility. In conclusion, almost all showed bi-phasic release, initial burst time followed manner achieving expected stimuli external can be applied. promising technique systems.

Language: Английский

---

Emerging Applications of Nanotechnology in Healthcare and Medicine

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6624 - 6624

Published: Sept. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Language: Английский

---

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Feb. 3, 2022

Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to but also subcellular organelles. Variety natural sources, availability different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, biodegradability presented polymers one the most desired materials for nanocarrier design. Recent innovative concepts advances PNC-associated nanotechnology providing unprecedented opportunities engineer their functions. The efficiency therapeutic loading has got considerably increased. Structural design-based varieties PNCs widely employed delivery small molecules genes, proteins. gained ever-increasing attention certainly paves way develop advanced nanomedicines. This article presents a comprehensive investigation structural influences properties on drug profiles with perspectives highlighting inevitability incorporating both multi-stimuli-responsive multi-drug single carrier design intelligent new emerging research directions this rapidly developing area.

Language: Английский

---

Extraction and application of keratin from natural resources: a review

3 Biotech, Journal Year: 2021, Volume and Issue: 11(5)

Published: April 16, 2021

Language: Английский

---

Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications

Materials, Journal Year: 2022, Volume and Issue: 15(19), P. 6521 - 6521

Published: Sept. 20, 2022

Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food Drug Administration approved chitosan for wound treatment nutritional use. Furthermore, paved the way advancements different biomedical applications including as nanocarrier tissue-engineering scaffold. Its antibacterial, antioxidant, haemostatic properties make it an excellent option dressings. Because of its hydrophilic nature, ideal starting material hydrogels. To suit specific application demands, can be combined with fillers, such hydroxyapatite, to modify mechanical characteristics pH-sensitive cationic have made popular choice gene delivery cancer therapy. Thus, use nanoparticles developing novel drug systems received special attention. This review aims provide overview chitosan-based nanoparticles, focusing on their versatile sciences engineering.

Language: Английский

---

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(2), P. 186 - 186

Published: Jan. 6, 2022

Chitosan and alginate are two of the most studied natural polymers that have attracted interest for multiple uses in their nano form. The biomedical field is one domains benefiting from development nanotechnology, as increasing research has been oriented to developing chitosan-alginate biocompatible delivery vehicles, antimicrobial agents, vaccine adjuvants. Moreover, these nanomaterials origin also become appealing environmental protection (e.g., water treatment, environmental-friendly fertilizers, herbicides, pesticides) food industry. In this respect, present paper aims discuss some newest applications chitosan-alginate-based serve an inception point further field.

Language: Английский

---

Agriculture and environmental management through nanotechnology: Eco-friendly nanomaterial synthesis for soil-plant systems, food safety, and sustainability

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171862 - 171862

Published: March 23, 2024

Language: Английский

---

Surface modification of polycaprolactone nanofibers through hydrolysis and aminolysis: a comparative study on structural characteristics, mechanical properties, and cellular performance

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 9, 2023

Hydrolysis and aminolysis are two main commonly used chemical methods for surface modification of hydrophobic tissue engineering scaffolds. The type reagents along with the concentration treatment time factors that determine effects these on biomaterials. In present study, electrospun poly (ℇ-caprolactone) (PCL) nanofibers were modified through hydrolysis aminolysis. applied solutions NaOH (0.5-2 M) hexamethylenediamine/isopropanol (HMD/IPA, 0.5-2 correspondingly. Three distinct incubation points predetermined treatments. According to scanning electron microscopy results, morphological changes emerged only in higher concentrations solution (1 M 2 prolonged duration (6 12 h). contrast, treatments induced slight features PCL nanofibers. Even though hydrophilicity was noticeably improved both methods, resultant influence comparatively more considerable. As a general trend, resulted moderate decline mechanical performance samples. Energy dispersive spectroscopy analysis indicated elemental after However, X-ray diffraction, thermogravimetric analysis, infrared results did not show noticeable alterations subsequent fibroblast cells well spread exhibited spindle-like shape treated groups. Furthermore, according 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, procedures ameliorated proliferative properties These findings represented nanofibrous samples by can be considered as potentially favorable candidates applications.

Language: Английский

---

Nanoparticle drug delivery systems for synergistic delivery of tumor therapy

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 16, 2023

Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not widely used in tumor therapy due to insufficient ability target specific sites, multidrug resistance drugs, and the high toxicity of drugs. With development RNAi technology, nucleic acids been delivered sites replace or correct defective genes knock down genes. Also, synergistic therapeutic effects can be achieved for combined delivery, which is more effective overcoming cancer cells. These combination therapies achieve better than delivering chemotherapeutic drugs alone, so scope has also expanded three aspects: drug-drug, drug-gene, gene-gene. This review summarizes recent advances nanocarriers co-delivery agents, including i) characterization preparation nanocarriers, such as lipid-based polymer inorganic carriers; ii) advantages disadvantages approaches; iii) effectual cases that applied systems; iv) future perspectives design nanoparticle co-deliver agents.

Language: Английский

---