Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(13), P. 1147 - 1147
Published: July 4, 2024
In
this
work,
AgNPs
were
synthesized
using
an
anthocyanin
extract
from
Peruvian
purple
potato
INIA
328—Kulli
papa.
The
was
obtained
through
a
conventional
extraction
with
acidified
ethanolic
aqueous
solvent.
This
acted
as
both
reducing
and
stabilizing
agent
for
the
reduction
of
silver
ions.
Optimization
synthesis
parameters,
including
pH,
reaction
time,
nitrate
(AgNO3)
concentration,
led
to
optimal
formation
at
pH
10,
time
30
min
AgNO3
concentration
5
mM.
Characterization
techniques
such
X-ray
diffraction
(XRD)
dynamic
light
scattering
(DLS)
revealed
that
had
crystallite
size
9.42
nm
hydrodynamic
diameter
21.6
nm,
zeta
potential
−42.03
mV,
indicating
favorable
colloidal
stability.
Fourier
Transform
Infrared
(FTIR)
analysis
confirmed
presence
functional
groups
on
surface
AgNPs,
contributing
their
Furthermore,
bacterial
activity
evaluated
by
determining
minimum
inhibitory
(MIC)
bactericidal
(MBC).
For
E.
coli,
MIC
0.5
mM
(0.05
mg/mL)
MBC
4.5
(0.49
mg/mL).
Similarly,
S.
aureus,
4.0
(0.43
These
results
highlight
benefits
extract,
in
biomedical
environmental
contexts.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(21), P. 6389 - 6389
Published: Oct. 22, 2021
Gold
nanoparticles
(AuNPs)
have
been
widely
explored
and
are
well-known
for
their
medical
applications.
Chemical
physical
synthesis
methods
a
way
to
make
AuNPs.
In
any
case,
the
hunt
other
more
ecologically
friendly
cost-effective
large-scale
technologies,
such
as
environmentally
biological
processes
known
green
synthesis,
has
gaining
interest
by
worldwide
researchers.
The
international
focus
on
nanotechnology
research
resulted
in
various
nanomaterials
being
used
physiologically
acceptable
Several
advantages
over
conventional
chemical
(simple,
one-step
approach
synthesize,
cost-effectiveness,
energy
efficiency,
biocompatibility)
drawn
scientists’
attention
exploring
of
AuNPs
exploiting
plants’
secondary
metabolites.
Biogenic
approaches,
mainly
plant-based
metal
nanoparticles,
chosen
ideal
strategy
due
environmental
vivo
safety,
well
ease
synthesis.
this
review,
we
reviewed
use
synthesized
treatment
cancer
utilizing
phytochemicals
found
plant
extracts.
This
article
reviews
producing
AuNPs,
characterization
discusses
physiochemical
properties.
study
also
recent
breakthroughs
achievements
using
different
mechanisms
action,
reactive
oxygen
species
(ROS),
mediated
mitochondrial
dysfunction
caspase
activation,
leading
apoptosis,
etc.,
anticancer
cytotoxic
effects.
Understanding
underlying
therapeutic
efficacy
will
aid
developing
personalized
medicines
treatments
potential
strategy.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: April 6, 2022
Current
advancements
in
nanotechnology
and
nanoscience
have
resulted
new
nanomaterials,
which
may
pose
health
environmental
risks.
Furthermore,
several
researchers
are
working
to
optimize
ecologically
friendly
procedures
for
creating
metal
oxide
nanoparticles.
The
primary
goal
is
decrease
the
adverse
effects
of
synthetic
processes,
their
accompanying
chemicals,
resulting
complexes.
Utilizing
various
biomaterials
nanoparticle
preparation
a
beneficial
approach
green
nanotechnology.
using
biological
qualities
nature
through
variety
activities
an
excellent
way
achieve
this
goal.
Algae,
plants,
bacteria,
fungus
been
employed
make
energy-efficient,
low-cost,
nontoxic
metallic
nanoparticles
last
few
decades.
Despite
advantages
chemistry-based
synthesis
over
traditional
methods
as
discussed
article,
there
some
unresolved
issues
such
particle
size
shape
consistency,
reproducibility
process,
understanding
mechanisms
involved
producing
via
entities.
Consequently,
need
further
research
analyze
comprehend
real
synthesis-dependent
processes.
This
currently
untapped
hot
topic
that
required
more
investment
properly
leverage
manufacturing
living
review
covers
synthesizing
utilization
scientific
world.
Scientific African,
Journal Year:
2022,
Volume and Issue:
16, P. e01152 - e01152
Published: March 16, 2022
The
synthesis
of
nanoparticles
via
the
green
routes
is
an
established
technology
for
producing
nano
dimensional
materials
that
are
useful
in
different
fields
where
environmental
friendly
a
major
requirement.
present
study
reports
cost
effective,
eco-friendly
and
straightforward
approach
to
synthesize
zinc
oxide
(ZnONPs)
using
plantain
peel
extract.
optical,
structural
morphological
characteristics
ZnONPs
were
studied
techniques.
X-ray
diffraction
analysis
confirmed
hexagonal
wurtzite
structure,
whose
morphology
particle
size,
according
transmission
electron
microscopy
(TEM),
was
spherical
about
20
nm
size.
antimicrobial
potency
evaluated
agar
well
diffusion
broth
dilution
assays
against
pathogenic
strains
Salmonella
enterica,
Klebsiella
pneumoniae,
Bacillus
cereus
MTCC
430
Staphylococcus
aureus
26923,
isolated
from
beef.
biosynthesized
demonstrated
good
activity
with
MIC
value
100
µg/mL
all
test
isolates.
Based
on
results
obtained,
efficacy
selected
bacteria
followed
sequence:
S.
˃
B.
K.
pneumoniae
enterica.
showed
peels,
which
waste
these
fruits,
could
be
helpful
antibacterial
efficacy.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e29766 - e29766
Published: May 1, 2024
Nanoparticles
have
recently
become
considered
as
a
crucial
player
in
contemporary
medicine,
with
therapeutic
uses
ranging
from
contrast
agents
imaging
to
carriers
for
the
transport
of
drugs
and
genes
into
specific
target.
ability
more
precise
molecular
interactions
human
body
order
target
cells
tissues
minimal
adverse
effects
maximal
outcomes.
With
least
number
side
greatest
possible
benefit,
nanoparticles
can
particular
through
body.
The
majority
global
public
health
problems
are
now
treated
green
synthesized
silver
(AgNPs),
which
substantially
affect
fundamental
structure
DNA
proteins
thus
display
their
antimicrobial
action.
AgNPs
inhibit
proliferation
tumor
induce
oxidative
stress.
By
inhibiting
vascular
endothelial
growth
factor
(HIF)-1,
pro-inflammatory
mediators
generated
by
reduced,
mucin
hypersecretion
is
lessened,
gene
activity
subsequently
regulated
prevent
infections.
biogenic
synthesis
(AgNPs)
using
various
plants
applications
antibacterial,
antifungal,
antioxidant,
anticancer,
anti-inflammatory,
antidiabetic
activities
been
extensively
discussed
this
article.
Also,
because
only
natural
substances
utilized
manufacturing
process,
particles
that
created
naturally
coated,
stabilized,
play
vital
role
these
biomedical
actions.
characterization
AgNPs,
possibility
preparing
AgNPSs
different
shapes
biological
method
impact
on
functions
toxicities,
size,
shape
other
properties
toxicity
profiles,
limitations,
future
prospects
green-mediated
also
reported
study.
major
goal
study
provide
readers
comprehensive,
informed,
up-to-date
summary
production
methods
under-investigational
antidiabetic,
antifungal
anti-inflammatory
properties.
This
review
provides
instructions
suggestions
additional
studies
based
AgNPs.
evaluation
pushes
researchers
look
resources
like
plant
parts
create
useful
nanobiotechnology.
Cancer Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 6, 2024
Abstract
In
recent
studies
with
silver
nanoparticles,
it
has
been
reported
that
the
use
of
nanoparticles
in
carrier
drug
systems
increases
tumor
suppression
and
reduces
drug-related
side
effects.
At
same
time,
combination
traditional
medicine
nanotechnology
provides
opportunity
to
develop
new
antimicrobial
agents.
The
aim
this
study
was
determine
anticancer,
activities
pro-apoptotic
effects
(AgNPs),
carboplatin-loaded
(AgNPs-Car).
Characterization
synthesized
were
carried
out
by
DLS,
EDX-STEM,
FTIR
analysis.
antiproliferative
these
molecules
evaluated
using
XTT
Annexin
V,
respectively.
MIC
(Minimum
Inhibitory
Concentration)
test
used
activity.
anticancer
activity
AgNPs-Car
high
MCF-7
(human
breast
adenocarcinoma),
A549
lung
carcinoma),
C6
(brain
glioma)
cells.
cell
group
most
effective
selective
cytotoxic
It
also
shown
AgNPs
induced
DNA
fragmentation
eventually
increasing
apoptosis
on
Gram-positive
Gram-negative
pathogenic
microorganisms
yeast
fungi.
Among
nanomaterials
reached
values
according
reference
sources,
achieved
better
results.
As
a
result,
found
be
very
successful
targeting
glioma
cells
facilitating
entry
drug.
addition,
their
toxicity
low.
Silver
are
preferred
for
creating
system
because
qualitative
properties
Therefore,
is
an
interesting
field
research
cancer
microorganisms.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: April 22, 2022
The
seaweed
industries
generate
considerable
amounts
of
waste
that
must
be
appropriately
managed.
This
biomass
from
marine
is
a
rich
source
high-value
bioactive
compounds.
Thus,
this
can
adequately
utilized
by
recovering
the
compounds
for
therapeutic
purposes.
Histone
deacetylases
(HDACs)
are
key
epigenetic
regulators
established
as
one
most
promising
targets
cancer
chemotherapy.
In
present
study,
our
objective
to
find
HDAC
2
inhibitor.
We
performed
top-down
in
silico
methodologies
identify
potential
inhibitors
screening
edible
waste.
One
hundred
ninety-three
(n
=
193)
seaweeds
were
initially
screened
and
filtered
with
drug-likeness
properties
using
SwissADME.
After
that,
followed
further
evaluate
their
binding
protein
Glide
high
throughput
virtual
(HTVS),
standard
precision
(SP),
extra
(XP),
quantum
polarized
ligand
docking
(QPLD).
compound
higher
negative
energy
was
selected,
validate
mode
stability
complex,
molecular
dynamics
(MD)
simulations
Desmond
performed.
complex-binding
free
calculation
mechanics-generalized
born
surface
area
(MM-GBSA)
calculation.
Post-MD
simulation
analyses
such
PCA,
DCCM,
landscape
also
evaluated.
mechanical
electronic
assessed
density
functional
theory
(DFT)
study.
These
findings
support
use
resources
like
drug
development
its
obtained
results
encourage
vitro
vivo
research.
Our
show
has
affinity
catalytic
site
properties,
against
cancer.
