Biocatalysis and Agricultural Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 103604 - 103604
Published: May 1, 2025
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215367 - 215367
Published: Aug. 25, 2023
Language: Английский
Citations
81
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 216 - 216
Published: Jan. 8, 2023
Nanotechnology takes the lead in providing new therapeutic options for cancer patients. In last decades, lipid-based nanoparticles-solid lipid nanoparticles (SLNs), nanostructured carriers (NLCs), liposomes, and lipid-polymer hybrid nanoparticles-have received particular interest anticancer drug delivery to solid tumors. To improve selectivity target cells and, thus, efficacy, have been functionalized with antibodies that bind receptors overexpressed angiogenic endothelial or cells. Most papers dealing preclinical results of antibody-conjugated claim low systemic toxicity effective tumor inhibition, which not successfully translated into clinical use yet. This review aims summarize current "state-of-the-art" using antibody-functionalized nanoparticles. It includes an update on promising candidates entered trials some explanations translation success.
Language: Английский
Citations
49
International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 4861 - 4877
Published: Oct. 1, 2022
Abstract: Bioavailability is an eternal topic that cannot be circumvented by peroral drug delivery. Adequate blood exposure after oral administration a prerequisite for effective treatment. Nanovesicles as pleiotropic vehicles can solubilize, encapsulate, stabilize active ingredient and promote the payload absorption via various mechanisms. Vesicular systems with nanoscale size, such liposomes, niosomes polymersomes, provide versatile platform delivery of drugs distinct nature. The amphiphilicity vesicles in structure allows hydrophilic lipophilic molecule(s) either or both to loaded, being encapsulated aqueous cavity inner core, respectively. Depending on high transport efficiency based their structural flexibility, gastrointestinal stability, biocompatibility, and/or intestinal epithelial affinity, nanovesicles markedly augment bioavailability poorly absorbed drugs. (VDDSs) demonstrate lot preferences are becoming more prominent late years biomedical applications. Equally, these potentiate drug's therapeutic index ameliorating absorption. This review devotes comment VDDSs special emphasis classification nanovesicles, preparative processes, mechanisms, vivo fate, design rationale were expounded. Knowledge vesicles-mediated enhancement has been properly provided. It concluded many merits will step into energetic arena Keywords: vesicles, delivery, bioavailability, niosomes, exosomes
Language: Английский
Citations
43
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(4)
Published: April 1, 2024
Abstract Recent research in drug delivery has significantly advanced our knowledge of liposome and niosome‐based gels, contributing to the dynamic landscape pharmaceutical advancements. The incorporation these vesicular carriers into gel formulations enhanced stability, while prolonging shelf‐life improving bioavailability encapsulated molecules. synergy between liposomes/niosomes matrices, facilitated by a robust structure, provided protective environment, ensuring sustained release prolonged stability. Liposome‐based gels proved be versatile for various therapeutic applications, demonstrating efficiency solubilizing poorly soluble drugs acting as potent penetration enhancers optimal skin delivery. Today, liposomes serves local depots, thus being fundamental condition controlled optimize patient's outcomes. Insights reveal their potential overcoming conventional challenges, positioning them promising platforms targeted due investigations highlight adaptability niosomal encapsulating both hydrophobic hydrophilic drugs, superior stability release. tunable properties also contributed bioadhesion permeation across biological membranes. primary objective this work is present cutting‐edge findings research, highlighting path modern These innovative solutions offer more efficient interventions, addressing ever‐evolving medicine.
Language: Английский
Citations
9
Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100779 - 100779
Published: March 1, 2025
Language: Английский
Citations
1
Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10
Published: March 14, 2022
Extracellular vesicles (EVs) play a crucial role as potent signal transducers among cells, with the potential to operate cross-species and cross-kingdom communication. Nanoalgosomes are subtype of EVs recently identified isolated from microalgae. Microalgae represent natural bioresource capacity produce several secondary metabolites broad range biological activities commercial applications. The present study highlights upstream downstream processes required for scalable production nanoalgosomes cultures marine microalgae Tetraselmis chuii. Different technical parameters, protocols, conditions were assessed improve isolation by tangential flow filtration (TFF), aiming enhance sample purity yield. optimization overall bioprocess was enhanced quality control checks operated through robust biophysical biochemical characterizations. Further, we showed possibility recycling TFF cells post-EVs multiple EV cycles. results highlight nanoalgosome scalable, cost-effective suitable diverse scientific industrial exploitations.
Language: Английский
Citations
37
Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)
Published: March 24, 2022
We aim to assess the antibacterial and anti-biofilm properties of Niosome-encapsulated Imipenem. After isolating Staphylococcus epidermidis isolates determining their microbial sensitivity, ability form biofilms was examined using plate microtiter assay. Various formulations Imipenem were prepared thin-film hydration method, Minimum Biofilm Inhibitory Concentration (MBIC) (MIC) determined, biofilm genes expression examined. Drug formulations' toxicity effect on HDF cells determined MTT Out 162 separated S. epidermidis, 106 resistant methicillin. 87 MRSE vancomycin-resistant, all which could biofilms. The F1 formulation niosomal with a size 192.3 ± 5.84 an encapsulation index 79.36 1.14 detected, prevented growth BGI 69% reduced icaD, FnbA, EbpS biofilms' P ≤ 0.001 in addition reducing MBIC MIC by 4-6 times. Interestingly, indicated cell viability over 90% at tested concentrations. results present study indicate that reduces resistance antibiotics increasing its antibiotic activity, prove useful as new strategy for drug delivery.
Language: Английский
Citations
29
Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(15), P. 3834 - 3856
Published: Jan. 1, 2023
Gene therapy is a promising approach for the treatment of many diseases. However, effective delivery cargo without degradation
Language: Английский
Citations
19
Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 89, P. 105087 - 105087
Published: Oct. 19, 2023
Skin plays an essential role in our personal image and aesthetics as it is where the first signs of aging are visible. As a way to prevent mitigate this natural physiological process achieve more youthful appearance, consumers constantly looking for innovative options anti-aging skincare products, including effective safer ingredients. Particularly, peptides cosmetic ingredients present formulations attending their efficacy reducing wrinkles hyperpigmentation, and/or stimulating collagen production. Moreover, less irritating alternatives regarding conventional against skin aging. However, despite these advantages, have considerable difficulty penetrate stratum corneum, which hinders bioactivity. This occurs high molecular weight, hydrophilic character, susceptibility enzymatic degradation, requiring application formulation technologies improve stability release pattern through skin. A detailed exposition focused on smart multifunctional nanodelivery systems that been used encapsulate provided, within scope research development products. Briefly, demonstrated biomolecules reliable outstanding alternative considering retinoids sunscreens
Language: Английский
Citations
19
Advanced Science, Journal Year: 2023, Volume and Issue: 11(7)
Published: Dec. 10, 2023
Early clinical diagnosis, effective intraoperative guidance, and an accurate prognosis can lead to timely medical treatment. The current conventional methods have several limitations. Therefore, there is a need develop faster more reliable detection, treatment, monitoring enhance their applications. Raman spectroscopy noninvasive provides highly specific information about the molecular structure biochemical composition of analytes in rapid manner. It has wide range applications biomedicine, materials, settings. This review primarily focuses on application medicine. advantages limitations over traditional are discussed. In addition, combining with machine learning, nanoparticles, probes demonstrated, thereby extending its applicability different phases. Examples last 3 years also integrated. Finally, various prospective approaches based studies surveyed, challenges
Language: Английский
Citations
19