Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(10)

Published: Jan. 1, 2023

Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.

Language: Английский

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Peptide Gel Electrolytes for Stabilized Zn Metal Anodes

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 164 - 177

Published: Dec. 22, 2023

The rechargeable aqueous Zn ion battery (AZIB) is considered a promising candidate for future energy storage applications due to its intrinsic safety features and low cost. However, dendrites side reactions (e.g., corrosion, hydrogen evolution reaction, inactive product (Zn hydroxide sulfate) formation) at the metal anode have been serious obstacles realizing satisfactory AZIB performance. application of gel electrolytes common strategy suppressing these problems, but normally used highly cross-linked polymer matrix polyacrylamide (PAM)) brings additional difficulties assembly recycling. Herein, we developed electrolyte stabilization, where peptide matrix, biocompatible material, construction. Various experiments simulations elucidate sulfate anion-assisted self-assembly formation effect in stabilizing anodes. Unlike electrolytes, can reversibly transform between liquid states, thus facilitating gel-involved Furthermore, provides fast diffusion (comparable conventional electrolyte) while dendrite growth, achieving stable anodes as validated various cell configurations. We believe that our concept design will inspire more directions protection based on design.

Language: Английский

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Peptide Stereochemistry Effects from pK_a-Shift to Gold Nanoparticle Templating in a Supramolecular Hydrogel

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3011 - 3022

Published: Jan. 18, 2024

The divergent supramolecular behavior of a series tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic, and computational techniques. Only two epimers were able to effectively self-organize into amphipathic structures, leading hydrogels or crystals, respectively. Despite the similarity between peptides' turn conformations, stereoconfiguration led different abilities engage in intramolecular hydrogen bonding. Self-assembly further shifted pKa value C-terminal side chain. As result, across pH range 4–6, only one epimer predominated sufficiently as zwitterion reach critical molar fraction, allowing gelation. By contrast, differing values higher dipole moment other favored crystallization. four tested for gold nanoparticle (AuNP) formation, with hydrogel being key control stabilize AuNPs, yielding nanocomposite that catalyzed photodegradation dye. Importantly, AuNP formation occurred without use reductants than peptide, redox chemistry investigated by LC–MS, NMR, infrared scattering-type near field optical microscopy (IR s-SNOM). This study provides important insights rational design simple peptides minimalistic green building blocks functional nanocomposites.

Language: Английский

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Differently N‐Capped Analogues of Fmoc‐FF

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(28)

Published: March 6, 2023

Short and ultra-short peptides have been recently envisioned as excellent building blocks for the formulation of hydrogels with appealing properties. Due to its simplicity capability gel under physiological conditions, Fmoc-FF (Nα -fluorenylmethoxycarbonyl-diphenylalanine), remains one most studied low molecular-weight hydrogelators. Since first identification in 2006, a plethora analogues were synthetized investigated fabrication novel supramolecular materials. Here we report description which aromatic Fmoc group is replaced other substituents. These are distinguished into five different classes including derivatives: i) customized solid phase peptide synthesis protecting groups; ii) containing non-aromatic groups, iii) iv) derivatized metal complexes v) stimuli-responsive groups. The morphological, mechanical, functional effects caused by this modification on resulting material also pointed out.

Language: Английский

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Supramolecular self-assembled peptide-engineered nanofibers: A propitious proposition for cancer therapy

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 256, P. 128452 - 128452

Published: Dec. 1, 2023

Language: Английский

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Peptide-Based Materials That Exploit Metal Coordination

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 456 - 456

Published: Dec. 27, 2022

Metal–ion coordination has been widely exploited to control the supramolecular behavior of a variety building blocks into functional materials. In particular, peptides offer great chemical diversity for metal-binding modes, combined with inherent biocompatibility and biodegradability that make them attractive especially medicine, sensing, environmental remediation. The focus this review is last 5 years’ progress in exciting field conclude an overview future directions research area currently undertaking.

Language: Английский

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Self-Assembled Peptide Hydrogels in Regenerative Medicine

Gels, Journal Year: 2023, Volume and Issue: 9(8), P. 653 - 653

Published: Aug. 14, 2023

Regenerative medicine is a complex discipline that becoming hot research topic. Skin, bone, and nerve regeneration dominate current treatments in regenerative medicine. A new type of drug urgently needed for their treatment due to high vulnerability damage weak self-repairing ability. self-assembled peptide hydrogel good scaffolding material because it similar the cytoplasmic matrix environment; promotes cell adhesion, migration, proliferation, division; its degradation products are natural harmless proteins. However, fewer studies have examined specific mechanisms hydrogels promoting tissue regeneration. This review summarizes applications short skin, neural healing improve

Language: Английский

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Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy

Nano TransMed, Journal Year: 2023, Volume and Issue: 2(4), P. 100020 - 100020

Published: Dec. 1, 2023

The gastrointestinal system, often regarded as the 'second brain of humanity,' maintains a profound connection with cerebral realm. Unlocking intricate metabolic pathways gut microorganisms is paramount in treatment ailments. This review primarily focuses on biomimetic precision nanocarriers, harnessing metabolites derived from microbiota, to target disorders. Elaborating constituents, it illuminates unique interplay between originating microbiota and domain. Moreover, underscores symbiotic relationship nanocarriers fashioned microbiota-derived augmentation well-being. Offering comprehensive outlook, this sheds light recent applications, challenges, future prospects rooted across spectrum disease treatments. It presents an expansive perspective attributes engineered metabolites, facilitating deeper understanding nexus these

Language: Английский

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Innovative Micro- and Nano-Architectures in Biomedical Engineering for Therapeutic and Diagnostic Applications

Micromachines, Journal Year: 2025, Volume and Issue: 16(4), P. 419 - 419

Published: March 31, 2025

The rapid evolution of micro- and nano-architectures is revolutionizing biomedical engineering, particularly in the fields therapeutic diagnostic micromechanics. This review explores recent innovations nanostructured materials their transformative impact on healthcare applications, ranging from drug delivery tissue engineering to biosensing diagnostics. Key advances fabrication techniques, such as lithography, 3D printing, self-assembly, have enabled unprecedented control over material properties functionalities at microscopic scales. These engineered architectures offer enhanced precision targeting controlled release delivery, foster cellular interactions improve sensitivity specificity devices. We examine critical design parameters, including biocompatibility, mechanical resilience, scalability, which influence clinical efficacy long-term stability. also highlights translational potential current limitations bringing these laboratory research practical applications. By providing a comprehensive overview trends, challenges, future perspectives, this article aims inform inspire further development that hold promise for advancing personalized medicine.

Language: Английский

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Harnessing Peptide-Based Hydrogels for Enhanced Cartilage Tissue Engineering

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 5885 - 5905

Published: Aug. 19, 2024

Cartilage tissue engineering remains a formidable challenge due to its complex, avascular structure and limited regenerative capacity. Traditional approaches, such as microfracture, autografts, stem cell delivery, often fail restore functional adequately. Recently, there has been surge in the exploration of new materials that mimic extracellular microenvironment necessary guide regeneration. This review investigates potential peptide-based hydrogels an innovative solution for cartilage These hydrogels, formed via supramolecular self-assembly, exhibit excellent properties, including biocompatibility, ECM mimicry, controlled biodegradation, making them highly suitable engineering. explains principles peptide hydrogels. It also delves into their specific properties relevant Additionally, this presents recent examples comparative analysis various used The addresses translational challenges these materials, highlighting regulatory hurdles complexities clinical application. comprehensive investigation provides valuable insights biomedical researchers, engineers, professionals aiming enhance repair methodologies.

Language: Английский

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