Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(3), P. 424 - 424

Published: Jan. 19, 2023

Selenium is an important dietary supplement and essential trace element incorporated into selenoproteins with growth-modulating properties cytotoxic mechanisms of action. However, different compounds selenium usually possess a narrow nutritional or therapeutic window low degree absorption delicate safety margins, depending on the dose chemical form in which they are provided to organism. Hence, nanoparticles (SeNPs) emerging as novel diagnostic platform decreased toxicity capacity enhance biological Se-based compounds. Consistent exciting possibilities offered by nanotechnology diagnosis, treatment, prevention diseases, SeNPs useful tools current biomedical research exceptional benefits potential therapeutics, enhanced bioavailability, improved targeting, effectiveness against oxidative stress inflammation-mediated disorders. In view need for developing eco-friendly, inexpensive, simple, high-throughput agents that can also ally theranostic purposes exhibit negligible side effects, biogenic receiving special attention. The present manuscript aims be reference its kind providing readership thorough comprehensive review emphasizes current, yet expanding, field promise hold among selenium-derived products to, eventually, elicit future developments. First, recalls physiological importance oligo-element introduces unique biological, physicochemical, optoelectronic, catalytic Se nanomaterials. Then, it addresses significance nanosizing pharmacological activity (pharmacokinetics pharmacodynamics) cellular interactions SeNPs. Importantly, discusses detail role biosynthesized innovative personalized nanomedicine-based therapies. Finally, this explores ongoing context SARS-CoV-2 pandemic presents key prospects translational nanomedicine.

Language: Английский

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Nanoparticle-mediated cancer cell therapy: basic science to clinical applications

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 42(3), P. 601 - 627

Published: Feb. 24, 2023

Every sixth person in the world dies due to cancer, making it second leading severe cause of death after cardiovascular diseases. According WHO, cancer claimed nearly 10 million deaths 2020. The most common types cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) stomach. In addition surgery, widely used traditional anti-cancer treatment are radio- chemotherapy. However, these do not distinguish between normal malignant cells. Additional methods evolved over time for early detection targeted therapy cancer. each method has its limitations associated costs quite high with adverse effects on quality life patients. Use individual atoms or a cluster (nanoparticles) can paradigm shift by virtue providing point sight sensing diagnosis Nanoparticles (1-100 nm size) 1000 times smaller size than human cell endowed safer relocation capability attack mechanically chemically at precise location which is one avenue that be destroy cells precisely. This review summarises extant understanding work done this area pave way physicians accelerate use hybrid mode treatments leveraging various nanoparticles.

Language: Английский

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Monte Carlo Simulations in Nanomedicine: Advancing Cancer Imaging and Therapy

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 117 - 117

Published: Jan. 15, 2025

Monte Carlo (MC) simulations have become important in advancing nanoparticle (NP)-based applications for cancer imaging and therapy. This review explores the critical role of MC modeling complex biological interactions, optimizing NP designs, enhancing precision therapeutic diagnostic strategies. Key findings highlight ability to predict bio-distribution, radiation dosimetry, treatment efficacy, providing a robust framework addressing stochastic nature systems. Despite their contributions, face challenges such as complexity, computational demands, scarcity reliable nanoscale data. However, emerging technologies, including hybrid approaches, high-performance computing, quantum simulation, are poised overcome these limitations. Furthermore, novel advancements FLASH radiotherapy, multifunctional NPs, patient-specific data integration expanding capabilities clinical relevance simulations. topical underscores transformative potential bridging fundamental research translation. By facilitating personalized nanomedicine streamlining regulatory trial processes, offer pathway toward more effective, tailored, accessible treatments. The continued evolution simulation techniques, driven by interdisciplinary collaboration technological innovation, ensures that will remain at forefront nanomedicine’s progress.

Language: Английский

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Delving Into Nanoparticle Systems for Enhanced Drug Delivery Technologies

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 4, 2025

Language: Английский

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Application of nanomedicine in radiotherapy sensitization

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 15, 2023

Radiation therapy is an important component of cancer treatment. As research in radiotherapy techniques advances, new methods to enhance tumor response radiation need be on the agenda enable enhanced at low doses. With rapid development nanotechnology and nanomedicine, use nanomaterials as radiosensitizers overcome resistance has attracted great interest. The application emerging biomedical field offers good opportunities improve efficacy radiotherapy, which helps promote will applied clinical practice near future. In this paper, we discuss main types nano-radiosensitizers explore their sensitization mechanisms tissue level, cellular level even molecular biology genetic analyze current status promising provide outlook future applications.

Language: Английский

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Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Coatings, Journal Year: 2023, Volume and Issue: 13(10), P. 1772 - 1772

Published: Oct. 15, 2023

In recent years, significant progress has been made in the surface functionalization of magnetic nanoparticles (MNPs), revolutionizing their utility multimodal imaging, drug delivery, and catalysis. This progression, spanning over last decade, unfolded discernible phases, each marked by distinct advancements paradigm shifts. nascent stage, emphasis was placed on foundational techniques, such as ligand exchange organic coatings, establishing groundwork for subsequent innovations. review navigates through cutting-edge developments tailoring MNP surfaces, illuminating pivotal role advancing these diverse applications. The exploration encompasses an array innovative strategies inorganic encapsulation, engineering, self-assembly, bioconjugation, elucidating how approach impacts or augments performance. Notably, surface-functionalized MNPs exhibit increased efficacy demonstrating improved MRI contrast targeted imaging. current underscores transformative impact modifications delivery systems, enabling controlled release, therapy, enhanced biocompatibility. With a comprehensive analysis characterization techniques future prospects, this surveys dynamic landscape past three years (2021–2023). By dissecting underlying principles applications, provides not only retrospective but also forward-looking perspective potential surface-engineered shaping science, technology, medicine.

Language: Английский

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Dendrimers: Advancements and Potential Applications in Cancer Diagnosis and Treatment—An Overview

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1406 - 1406

Published: May 4, 2023

Cancer is a leading cause of death worldwide, and the main treatment methods for this condition are surgery, chemotherapy, radiotherapy. These invasive can severe adverse reactions among organisms, so nanomaterials increasingly used as structures anticancer therapies. Dendrimers type nanomaterial with unique properties, their production be controlled to obtain compounds desired characteristics. polymeric molecules in cancer diagnosis through targeted distribution some pharmacological substances. have ability fulfill several objectives therapy simultaneously, such targeting tumor cells that healthy tissue not affected, controlling release agents microenvironment, combining strategies based on administration potentiate effect photothermal or photodynamic therapy. The purpose review summarize highlight possible uses dendrimers regarding oncological conditions.

Language: Английский

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Tumor-derived systems as novel biomedical tools—turning the enemy into an ally

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.

Language: Английский

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Nanotechnology-based radiation therapy to cure cancer and the challenges in its clinical applications

Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e17252 - e17252

Published: June 1, 2023

Radiation therapy against cancer frequently fails to attain the desired outcomes because of several restricting aspects. is not a targeted antitumor treatment, and it poses serious threats normal tissues as well. In many cases, some inherent features tumors make them resistant radiation therapy. Several nanoparticles have shown capacity upgrade viability treatment they can directly interact with ionizing increase cellular sensitivity. types nanomaterials been investigated radio-sensitizers, improve efficacy radiotherapy overcome radio-resistance including, metal-based nanoparticles, quantum dots, silica-based polymeric etc. Despite all this research development, certain challenges associated exploitation enhance for are encountered. Potential applications radiosensitizers hindered by difficulties ensuring their production at large scale improved characterizations biological challenges. By overcoming shortcomings like working on pharmacokinetics, physical chemical characterization, be improved. It expected that in future more knowledge will available regarding clinical efficacy, leading successful development nanotechnology-based therapies variety cancers. This review highlights limitations conventional explores potential nanotechnology, specifically use nanomaterials, these discusses concept using effectiveness provides an overview different beneficial properties. The emphasizes need address obstacles application nanotechnology translation.

Language: Английский

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Functionalized Metal Nanoparticles in Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1932 - 1932

Published: July 11, 2023

Currently, there are many studies on the application of nanotechnology in therapy. Metallic nanoparticles promising nanomaterials cancer therapy; however, functionalization these with biomolecules has become relevant as their effect cells is considerably increased by photothermal and photodynamic therapies, drug nanocarriers, specificity antibodies, resulting new therapies that more specific against different types cancer. This review describes functionalized palladium, gold, silver platinum treatment cancer, themselves show an anticancer effect. further enhanced when NPs either DNA, RNA, peptides, proteins, or folic acid other molecules. These can penetrate cell accumulate tumor tissue, a cytotoxic through generation ROS, induction apoptosis, cycle arrest, DNA fragmentation, NP-based therapy strategy be used synergistically chemotherapy radiotherapy to achieve effective reduce side effects.

Language: Английский

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