Heliyon,
Journal Year:
2023,
Volume and Issue:
9(11), P. e21334 - e21334
Published: Oct. 20, 2023
Colorectal
cancer
(CRC)
is
one
of
the
most
common
malignancies
with
a
high
mortality
rate
worldwide.
While
surgery,
chemotherapy,
and
radiotherapy
have
shown
some
effectiveness
in
improving
survival
rates,
they
come
drawbacks
such
as
side
effects
harm
to
healthy
tissues.
The
theranostic
approach,
which
integrates
processes
diagnosis
treatment,
can
minimize
biological
effects.
Photothermal
therapy
(PTT)
an
emerging
treatment
method
that
usages
light-sensitive
agents
generate
heat
at
tumor
site
induce
thermal
erosion.
development
nanotechnology
for
CRC
using
imaging-guided
PTT
has
garnered
significant.
Nanoparticles
suitable
physical
chemical
properties
enhance
efficiency
PTT.
This
approach
enables
monitoring
progress
safeguards
In
this
article,
we
concisely
introduce
application
metal
nanoparticles,
polymeric
carbon
nanoparticles
colorectal
cancer.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 3656 - 3686
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
overview
of
the
latest
nanochemistry
advancements
in
design,
synthesis,
and
utilization
engineered
gold
nanostructures
(GNSs)
for
dental
healthcare
applications.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 444 - 444
Published: March 20, 2025
Nanomaterials
represent
an
innovation
in
cancer
imaging
by
offering
enhanced
contrast,
improved
targeting
capabilities,
and
multifunctional
modalities.
Recent
advancements
material
engineering
have
enabled
the
development
of
nanoparticles
tailored
for
various
techniques,
including
magnetic
resonance
(MRI),
computed
tomography
(CT),
positron
emission
(PET),
ultrasound
(US).
These
nanoscale
agents
improve
sensitivity
specificity,
enabling
early
detection
precise
tumor
characterization.
Monte
Carlo
(MC)
simulations
play
a
pivotal
role
optimizing
nanomaterial-based
modeling
their
interactions
with
biological
tissues,
predicting
contrast
enhancement,
refining
dosimetry
radiation-based
techniques.
computational
methods
provide
valuable
insights
into
nanoparticle
behavior,
aiding
design
more
effective
agents.
Moreover,
artificial
intelligence
(AI)
machine
learning
(ML)
approaches
are
transforming
enhancing
image
reconstruction,
automating
segmentation,
improving
diagnostic
accuracy.
AI-driven
models
can
also
optimize
MC-based
accelerating
data
analysis
through
predictive
modeling.
This
review
explores
latest
imaging,
highlighting
synergy
between
nanotechnology,
MC
simulations,
innovations.
By
integrating
these
interdisciplinary
approaches,
future
technologies
achieve
unprecedented
precision,
paving
way
diagnostics
personalized
treatment
strategies.
Electronics,
Journal Year:
2023,
Volume and Issue:
12(4), P. 972 - 972
Published: Feb. 15, 2023
Cancer
is
one
of
the
leading
causes
death
worldwide.
In
last
few
decades,
cancer
treatment
has
come
a
long
way,
but
multidrug
resistance
(MDR)
in
still
low
survival
rates.
It
means
that
much
research
required
for
an
accurate
diagnosis
and
effective
therapy.
The
new
era
could
include
theranostic
approaches
targeted
delivery
chemotherapeutic
agents
utilizing
nanoparticulate
system.
Recently,
there
been
interest
gained
among
researchers
carbon-based
graphene-based
quantum
dots
due
to
their
higher
biocompatibility
ease
biofunctionalization
compared
conventional
heavy
metal
dots.
Moreover,
these
have
various
interesting
utilities,
including
bioimaging,
biosensing,
dots-mediated
drug
delivery,
role
photodynamic
therapy
(PDT)
photothermal
(PTT).
current
review
highlighted
utility
hybrid
as
system
different
cancers
discussed
bio-molecules
conjugated
investigated
diagnostic/therapeutic
applications
cancer.
influence
conjugation
biomolecules,
such
folic
acid,
PEG,
etc.,
with
on
biopharmaceutical
attributes
(such
aqueous
solubility,
tumor
penetrability,
stability
loaded
therapeutics
microenvironment),
drugs
specifically
tissues,
its
therapeutic
outcome
also
discussed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1052 - 1052
Published: March 24, 2023
Bacterial
membrane
vesicles
(BMVs)
are
known
to
be
critical
communication
tools
in
several
pathophysiological
processes
between
bacteria
and
host
cells.
Given
this
situation,
BMVs
for
transporting
delivering
exogenous
therapeutic
cargoes
have
been
inspiring
as
promising
platforms
developing
smart
drug
delivery
systems
(SDDSs).
In
the
first
section
of
review
paper,
starting
with
an
introduction
pharmaceutical
technology
nanotechnology,
we
delve
into
design
classification
SDDSs.
We
discuss
characteristics
including
their
size,
shape,
charge,
effective
production
purification
techniques,
different
methods
used
cargo
loading
encapsulation.
also
shed
light
on
release
mechanism,
carriers,
recent
remarkable
findings
potential
anticancer
antimicrobial
therapy.
Furthermore,
covers
safety
challenges
that
need
overcome
clinical
use.
Finally,
advancements
prospects
SDDSs
highlight
revolutionizing
fields
nanomedicine
delivery.
conclusion,
paper
aims
provide
a
comprehensive
overview
state-of-the-art
field
SDDSs,
encompassing
design,
composition,
fabrication,
purification,
characterization,
well
various
strategies
targeted
Considering
information,
aim
is
researchers
understanding
current
state
enabling
them
identify
gaps
formulate
new
hypotheses
accelerate
progress
field.
Journal of Nanotheranostics,
Journal Year:
2023,
Volume and Issue:
4(3), P. 299 - 322
Published: July 24, 2023
The
introduction
of
cancer
therapeutics
and
nanotechnology
has
resulted
in
a
paradigm
shift
from
conventional
therapy
to
precision
medicine.
Nanotechnology,
an
interdisciplinary
field
with
focus
on
biomedical
applications,
holds
immense
promise
bringing
about
novel
approaches
for
detection,
diagnosis,
therapy.
past
decade
witnessed
significant
research
material
applications
related
nanoparticles
(NPs).
NPs
differ
small-molecule
drugs
as
they
possess
unique
physicochemical
characteristics,
such
large
surface-to-volume
ratio,
enabling
them
penetrate
live
cells
efficiently.
Traditional
therapies,
chemotherapy,
radiation
therapy,
targeted
immunotherapy,
have
limitations,
cytotoxicity,
lack
specificity,
multiple
drug
resistance,
which
pose
challenges
effective
treatment.
However,
nanomaterials
properties
that
enable
new
therapeutic
modalities
beyond
delivery
the
fight
against
cancer.
Moreover,
(1–100
nm)
numerous
benefits,
biocompatibility,
reduced
toxicity,
excellent
stability,
enhanced
permeability
retention
effect,
precise
targeting,
making
ideal
purpose
this
article
is
provide
consolidated
information
various
bio-inspired
aid
theranostics.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(12), P. 1711 - 1711
Published: Dec. 18, 2024
Nanotechnology
has
revolutionised
biomedical
research,
offering
innovative
healthcare
solutions.
Plant-based
nanotechnology
is
emerging
as
a
sustainable
alternative,
minimising
environmental
impacts
and
enhancing
therapeutic
effectiveness.
This
paper
explores
the
potential
of
plant-derived
nanoparticles
(PNPs)
in
medicine,
highlighting
their
biocompatibility,
multifunctionality,
eco-friendliness.
PNPs,
synthesised
through
green
methods,
have
demonstrated
promising
applications
drug
delivery,
cancer
therapy,
antimicrobial
treatments,
tissue
regeneration.
Their
unique
properties,
such
high
surface
area
bioactive
components,
enable
improved
targeting,
controlled
release,
reducing
side
effects
treatment
efficacy.
Additionally,
compounds’
inherent
antioxidant
retained
within
platinum
(PNPs),
present
opportunities
for
combating
resistance
promoting
wound
healing.
Despite
potential,
challenges
remain
standardising
PNP
synthesis,
ensuring
consistency,
scaling
up
production
industrial
applications.
review
emphasises
need
further
research
on
toxicity,
regulatory
frameworks
to
fully
harness
capabilities
clinical
commercial
represents
promising,
greener
alternative
advancing
solutions,
aligning
with
global
sustainability
goals.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 709 - 725
Published: Jan. 1, 2024
Background:
Radiotherapy
is
a
widely
used
clinical
tool
for
tumor
treatment
but
can
cause
systemic
toxicity
if
excessive
radiation
administered.
Although
numerous
nanoparticles
have
been
developed
as
radiosensitizers
to
reduce
the
required
dose
of
X-ray
irradiation,
they
often
limitations,
such
passive
reliance
on
radiation-induced
apoptosis
in
tumors,
and
little
consider
unique
microenvironment
that
contributes
radiotherapy
resistance.
Methods:
In
this
study,
we
characterized
novel
self-assembled
nanoparticle
containing
dysprosium
ion
manganese
(Dy/Mn-P).
We
systematically
investigated
potential
Dy/Mn-P
(NPs)
reactive
oxygen
species
(ROS)
amplifier
radiosensitizer
enhance
therapy
modulate
at
cellular
level.
Additionally,
evaluated
effect
stimulator
interferon
genes
(STING),
an
innate
immune
signaling
pathway.
Results:
Physicochemical
analysis
demonstrated
prepared
NPs
exhibited
excellent
dispersibility
stability,
degraded
rapidly
lower
pH
values.
Furthermore,
was
internalized
by
cells
selective
towards
compared
normal
cells.
Our
findings
also
revealed
improved
significantly
increased
ROS
generation
under
ionizing
radiation,
resulting
~70%
increase
levels
alone.
This
enhanced
inhibited
~92%
cell
clone
formation
greatly
contributed
cytoplasmic
DNA
exposure.
Subsequently,
activation
STING
pathway
observed,
leading
secretion
pro-inflammatory
factors
maturation
dendritic
(DCs).
Conclusion:
study
demonstrates
potentiate
improving
increasing
endogenous
within
tumor.
amplify
during
radiotherapy,
thereby
triggering
anti-tumor
response.
approach
has
expand
application
treatment.
Keywords:
NPs,
ROS,
microenvironment,
