Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics DOI Creative Commons

Palmira Alessia Cavallaro,

Marzia De Santo,

Emilia Lucia Belsito

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(17), P. 2476 - 2476

Published: Sept. 1, 2023

Breast cancer represents the most common type and one of major leading causes death in female worldwide population. Overexpression HER2, a transmembrane glycoprotein related to epidermal growth factor receptor, results biologically clinically aggressive breast subtype. It is also primary driver for tumor detection progression and, addition being an important prognostic women diagnosed with cancer, HER2 widely known therapeutic target drug development. The aim this review provide updated overview main approaches diagnosis treatment HER2-positive proposed literature over past decade. We focused on different targeting strategies involving antibodies peptides that have been explored their relative outcomes current limitations need be improved. encompasses discussion targeted acting as probes molecular imaging. By using types HER2-targeting strategies, nanotechnology promises overcome some clinical challenges by developing novel HER2-guided nanosystems suitable powerful tools imaging, targeting, therapy.

Language: Английский

Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications DOI Creative Commons
Harish Bhardwaj, Rajendra Jangde

Next Nanotechnology, Journal Year: 2023, Volume and Issue: 2, P. 100013 - 100013

Published: June 1, 2023

Polymers show a vast possibility of chemical modification novel properties and nanomedicine generation in biomedical fields. Polymeric nanoparticle (PNPs) is commonly used as drug carrier, they have good biodegradability, biocompatibility, high drug-loading capacity. PNPs are the broadly nanocarrier including polymeric micelles, liposomes, dendrimers, sponges, colloidal carriers. These NPs also low toxicity, increased therapeutic effectiveness, improved penetration, controlled release enhanced physical stability. widely delivery system subsequently able to load natural synthetic agents including, protein, peptides, growth factors, DNAs, mRNA, drugs. can be applied via several routes administration nasal, oral, intravenous, topical ocular. potentially target specific cells/tissues, promising way increase local concentration, decrease toxicity side effects, prevent nonspecific interaction. The present review focuses on biodegradable polymers, classifications, types, method preparation PNPs, applications targeted their limitations. This presents for respiratory, cancers, liver cirrhosis, ocular, diabetic wounds, Alzheimer's disease.

Language: Английский

Citations

57
Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic DOI Creative Commons
Lorca Alzoubi, Alaa A. A. Aljabali, Murtaza M. Tambuwala

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(8)

Published: Nov. 14, 2023

Abstract This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, medical device production. It also assesses economic, environmental, ethical considerations. In our the literature, we employed comprehensive search strategy, utilizing well-known databases like PubMed Google Scholar. Our chosen keywords encompassed essential topics, including printing, nanotechnology, related areas. We first screened article titles abstracts then conducted detailed examination selected articles without imposing any date limitations. The for inclusion, comprising research studies, clinical investigations, expert opinions, underwent meticulous quality assessment. methodology ensured incorporation high-quality sources, contributing to robust exploration role realm healthcare. highlights printing's potential customized drug delivery systems, patient-specific implants, prosthetics, biofabrication organs. These innovations have significantly improved patient outcomes. Integration nanotechnology has enhanced precision biocompatibility. demonstrates cost-effectiveness sustainability through optimized material usage recycling. healthcare sector witnessed remarkable progress promoting patient-centric approach. From implants radiation shielding offers tailored solutions. Its transformative applications, coupled economic viability sustainability, revolutionize Addressing biocompatibility, standardization, concerns is responsible adoption. Graphical

Language: Английский

Citations

52
Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges DOI Creative Commons

Iman Salahshoori,

Mahdi Golriz,

Marcos A.L. Nobre

et al.

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 395, P. 123888 - 123888

Published: Dec. 27, 2023

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals' targeted and effective administration. However, the intricate interplay between formulations poses challenges their design optimization. Simulations have emerged as indispensable tools for comprehending these interactions enhancing DDS performance to address this complexity. This comprehensive review explores latest advancements simulation techniques provides detailed analysis. The encompasses various methodologies, including molecular dynamics (MD), Monte Carlo (MC), finite element analysis (FEA), computational fluid (CFD), density functional theory (DFT), machine learning (ML), dissipative particle (DPD). These are critically examined context of research. article presents illustrative case studies involving liposomal, polymer-based, nano-particulate, implantable DDSs, demonstrating influential simulations optimizing systems. Furthermore, addresses advantages limitations It also identifies future directions research development, such integrating multiple techniques, refining validating models greater accuracy, overcoming limitations, exploring applications personalized medicine innovative DDSs. employing like MD, MC, FEA, CFD, DFT, ML, DPD offer crucial insights into behaviour, aiding Despite advantages, rapid cost-effective screening, require validation addressing limitations. Future should focus on models, enhance outcomes. paper underscores contribution emphasizing providing valuable facilitating development optimization ultimately patient As we continue explore impact advancing discovery improving DDSs is expected be profound.

Language: Английский

Citations

52
Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications DOI

Ammar Haider,

Shabana I. Khan, Dure Najaf Iqbal

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983

Published: March 26, 2024

Language: Английский

Citations

49
Silver Nanoparticles: Synthesis, Structure, Properties and Applications DOI Creative Commons

Rimsha Abbas,

Jingjing Luo, Xue Qi

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(17), P. 1425 - 1425

Published: Aug. 31, 2024

Silver nanoparticles (Ag NPs) have accumulated significant interest due to their exceptional physicochemical properties and remarkable applications in biomedicine, electronics, catalysis sensing. This comprehensive review provides an in-depth study of synthetic approaches such as biological synthesis, chemical physical synthesis with a detailed overview sub-methodologies, highlighting advantages disadvantages. Additionally, structural affected by methods are discussed detail examining the dimensions surface morphology. The explores distinctive Ag NPs, including optical, electrical, catalytic, antimicrobial properties, which render them beneficial for range applications. Furthermore, this describes diverse several fields, medicine, environmental science, optoelectronics. However, numerous applications, kinds issues still exist. Future attempts need address difficulties regarding techniques, friendliness, affordability. In order ensure secure utilization it is necessary establish sustainability techniques eco-friendly production methods. aims give analysis, multifaceted NPs.

Language: Английский

Citations

22
Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy DOI Creative Commons

Joel Georgeous,

Nour AlSawaftah, Waad H. Abuwatfa

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1332 - 1332

Published: Oct. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Language: Английский

Citations

19
Opportunities and challenges of RiPP-based therapeutics DOI Creative Commons
I. Pfeiffer, M. Schröder, Silja Mordhorst

et al.

Natural Product Reports, Journal Year: 2024, Volume and Issue: 41(7), P. 990 - 1019

Published: Jan. 1, 2024

Covering: up to 2024Ribosomally synthesised and post-translationally modified peptides (RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy bioactivities ranging from antiinfective anticancer analgesic effects. Furthermore, RiPP biosynthetic pathways represent promising production routes for complex drugs, the technology is well-suited engineering produce derivatives with specific functions. Thus, possess features that render them potentially ideal candidates drug discovery development. Nonetheless, only small number RiPP-derived compounds have successfully reached market thus far. This review initially outlines therapeutic opportunities RiPP-based can offer, whilst subsequently discussing limitations require resolution in order fully exploit potential RiPPs towards development innovative drugs.

Language: Английский

Citations

18
Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery DOI

T. Naga Aparna,

Rohit Kumar,

Vimal K. Bhardwaj

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 13, 2025

Language: Английский

Citations

3
Nanoparticle-enhanced drug delivery systems: An up-to-date review DOI
Chenxi Zhang,

Ahmadreza Hemmat,

Nguyen Thi

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126999 - 126999

Published: Jan. 1, 2025

Language: Английский

Citations

3
The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery DOI Creative Commons

D Mitrović,

Dragana Zaklan, Maja Đanić

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1181 - 1181

Published: March 6, 2025

Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.

Language: Английский

Citations

2