Within
the
field
of
nanomedicine,
which
is
revolutionizing
cancer
treatment,
solid
lipid
nanoparticles
(SLNs)
have
shown
advantages
over
conventional
chemotherapy
when
tested
on
cells
in
preclinical
studies.
SLNs
proven
to
be
an
innovative
strategy
for
treatment
tri-ple-negative
breast
cells,
providing
greater
efficiency
than
existing
treatments
various
The
encapsulation
antineoplastic
drugs
has
facilitated
a
sustained,
controlled,
and
targeted
release,
enhances
therapeutic
reduces
adverse
effects.
Moreover,
surface
can
modified
increase
efficiency.
For
instance,
coating
these
particles
with
polyethylene
glycol
(PEG)
decreases
their
opsonization,
resulting
longer
life
circulatory
system.
creation
positively
charged
cationic
(cSLNs),
achieved
by
utilization
surfactants
or
ionic
lipids
structural
groups,
increases
affinity
cell
membranes
plasma
proteins.
Hyaluronic
acid
been
added
SLNs,
so
that
distinct
pH
tumor
would
stimulate
release
drug
and/or
genetic
materi-al.
current
revision
summarizes
recent
research
focusing
transport
agents
cytotoxic
effect
triple-negative
cancer.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(18), P. 2585 - 2585
Published: Sept. 18, 2023
Magnetism
plays
a
pivotal
role
in
many
biological
systems.
However,
the
intensity
of
magnetic
forces
exerted
between
bodies
is
usually
low,
which
demands
development
ultra-sensitivity
tools
for
proper
sensing.
In
this
framework,
force
microscopy
(MFM)
offers
excellent
lateral
resolution
and
possibility
conducting
single-molecule
studies
like
other
single-probe
(SPM)
techniques.
This
comprehensive
review
attempts
to
describe
paramount
importance
applications
by
highlighting
MFM's
main
advantages
but
also
intrinsic
limitations.
While
working
principles
are
described
depth,
article
focuses
on
novel
micro-
nanofabrication
procedures
MFM
tips,
enhance
response
signal
tested
biomaterials
compared
commercial
nanoprobes.
work
depicts
some
relevant
examples
where
can
quantitatively
assess
performance
nanomaterials
involved
systems,
including
magnetotactic
bacteria,
cryptochrome
flavoproteins,
nanoparticles
that
interact
with
animal
tissues.
Additionally,
most
promising
perspectives
field
highlighted
make
reader
aware
upcoming
challenges
when
aiming
toward
quantum
technologies.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
32, P. 242 - 259
Published: Oct. 12, 2023
Regulating
macrophage
activation
precisely
is
crucial
in
treating
chronic
inflammation
osteoarthritis
(OA).
However,
the
stable
pro-inflammatory
state
and
deep
distribution
of
macrophages
vivo
pose
a
great
challenge
to
treatment.
In
this
study,
inspired
by
innate
immune,
immune
cell
mobilized
hydrogel
microspheres
were
constructed
microfluidic
methods
load
chemokines,
antibodies
engineered
membrane
vesicles
(sEVs)
via
covalent
non-covalent
junctions.
The
microspheres,
based
on
mixture
streptavidin
grafted
hyaluronic
acid
methacrylate
(HAMA-SA)
Chondroitin
sulfate
(ChSMA)
(HCM),
can
recruit,
capture
reprogram
proinflammatory
joint
cavity
improve
inflammatory
microenvironment.
vitro
experiments
demonstrated
that
had
excellent
recruitment,
capture,
reprogramming
abilities.
Pro-inflammatory
be
transformed
into
anti-inflammatory
with
an
efficiency
88.5
%.
Animal
also
revealed
significant
reduction
synovial
cartilage
matrix
degradation
OA.
Therefore,
may
effective
treatment
OA
for
future.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2529 - 2552
Published: March 1, 2024
Abstract:
The
blood-brain
barrier
(BBB)
and
blood-tumor
(BTB)
pose
substantial
challenges
to
efficacious
drug
delivery
for
glioblastoma
multiforme
(GBM),
a
primary
brain
tumor
with
poor
prognosis.
Nanoparticle-based
combinational
strategies
have
emerged
as
promising
modalities
overcome
these
barriers
enhance
penetration
into
the
parenchyma.
This
review
discusses
various
nanoparticle-based
combinatorial
approaches
that
combine
nanoparticles
cell-based
delivery,
viral
focused
ultrasound,
magnetic
field,
intranasal
permeability
across
BBB
BTB.
Cell-based
involves
using
engineered
cells
carriers
nanoparticles,
taking
advantage
of
their
intrinsic
migratory
homing
capabilities
facilitate
transport
therapeutic
payloads
Viral
uses
vectors
deliver
genes
or
specific
within
GBM
microenvironment.
Focused
coupled
microbubbles
can
temporarily
disrupt
increase
permeability.
Magnetic
field-guided
exploits
targeted
under
an
external
field.
Intranasal
offers
minimally
invasive
avenue
bypass
agents
directly
via
olfactory
trigeminal
pathways.
By
combining
strategies,
synergistic
effects
efficiency,
improve
efficacy,
reduce
off-target
effects.
Future
research
should
focus
on
optimizing
nanoparticle
design,
exploring
new
combination
advancing
preclinical
clinical
investigations
promote
translation
therapies
GBM.
Keywords:
glioblastoma,
barrier,
nanoparticle,
strategy,
ultrasound-wave,
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(8), P. e29297 - e29297
Published: April 1, 2024
Abstract
In
radiotherapy,
metallic
nanoparticles
are
of
high
interest
in
the
fight
against
cancer
for
their
radiosensitizing
effects.
This
study
aimed
to
evaluate
ability
core-shell
Fe3O4@Au
potentiate
irradiation
effects
on
redox-,
pro-inflammatory
markers,
and
cell
death
A549
human
pulmonary
cells.
The
hybrid
were
synthesized
using
green
chemistry
principles
by
sonochemistry
method.
Their
characterization
transmission
electron
microscopy
demonstrated
an
average
size
8
nm
a
homogeneous
distribution
gold.
decreased
hydrodynamic
these
compared
magnetite
(Fe3O4)
showed
that
gold
coating
significantly
reduced
aggregation
Fe3O4
particles.
internalization
accumulation
within
cells
Prussian
Blue
staining.
reactive
oxygen
species
(ROS)
levels
measured
fluorescent
probe
DCFH-DA
up-regulated,
as
well
mRNA
expression
SOD,
catalase,
GPx
antioxidant
enzymes,
redox-dependent
transcription
factor
Nrf2,
ROS-producing
enzymes
(Nox2
Nox4),
quantified
RT-qPCR.
Furthermore,
coupled
with
increased
canonical
cytokines
chemokines
(TNF-α,
IL-1β,
IL-6,
CXCL8,
CCL5)
assessed
RT-qPCR
ELISA.
Hybrid
did
not
DNA
damage
detected
immunofluorescence
following
irradiation.
Nevertheless,
caused
cellular
damage,
leading
apoptosis
through
activation
caspase
3/7,
secondary
necrosis
LDH
release,
growth
arrest
evaluated
clonogenic-like
assay.
potential
radiosensitivity
cancerous
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10712 - 10712
Published: Oct. 5, 2024
Within
the
field
of
nanomedicine,
which
is
revolutionizing
cancer
treatment,
solid
lipid
nanoparticles
(SLNs)
have
shown
advantages
over
conventional
chemotherapy
when
tested
on
cells
in
preclinical
studies.
SLNs
proven
to
be
an
innovative
strategy
for
treatment
triple-negative
breast
cells,
providing
greater
efficiency
than
existing
treatments
various
The
encapsulation
antineoplastic
drugs
has
facilitated
a
sustained,
controlled,
and
targeted
release,
enhances
therapeutic
reduces
adverse
effects.
Moreover,
surface
can
modified
increase
efficiency.
For
instance,
coating
these
particles
with
polyethylene
glycol
(PEG)
decreases
their
opsonization,
resulting
longer
life
circulatory
system.
creation
positively
charged
cationic
(cSLNs),
achieved
by
utilization
surfactants
or
ionic
lipids
structural
groups,
increases
affinity
cell
membranes
plasma
proteins.
Hyaluronic
acid
been
added
so
that
distinct
pH
tumor
would
stimulate
release
drug
and/or
genetic
material.
current
review
summarizes
recent
research
SLNs,
focusing
transport
agents
cytotoxic
effect
cancer.
