Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101641 - 101641
Published: March 8, 2025
In
recent
years,
hydrogel
microspheres
have
garnered
significant
attention
due
to
their
unique
structure
and
functionality,
demonstrating
substantial
potential
in
articular
cartilage
injury
repair.
This
paper
provides
a
comprehensive
overview
of
current
strategies
for
repair
summarizes
the
materials
preparation
methods
microspheres.
Furthermore,
it
highlights
multiple
roles
repair,
including
inflammation
control,
regulation
chondrocyte
metabolism,
drug
cell
delivery,
lubrication
improvement,
recruitment
endogenous
stem
cells.
Finally,
discusses
application
prospects
microspheres,
identifies
limitations
challenges,
offers
insights
guide
future
research
practical
applications
Subcellular
mitochondria
serve
as
sensors
for
energy
metabolism
and
redox
balance,
the
dynamic
regulation
of
functional
dysfunctional
plays
a
crucial
role
in
determining
cells'
fate.
Selective
removal
at
subcellular
level
can
provide
chondrocytes
with
to
prevent
degeneration,
thereby
treating
osteoarthritis.
Herein,
achieve
an
ideal
therapy,
cartilage
affinity
peptide
(WYRGRL)-decorated
liposomes
loaded
mitophagy
activator
(urolithin
A)
were
integrated
into
hyaluronic
acid
methacrylate
hydrogel
microspheres
through
microfluidic
technology,
named
HM@WY-Lip/UA,
that
could
efficiently
target
selectively
remove
mitochondria.
As
result,
this
system
demonstrated
advantage
function
restoration,
reactive
oxygen
species
scavenging,
cell
survival
rescue,
chondrocyte
homeostasis
maintenance
increasing
mitophagy.
In
rat
post-traumatic
osteoarthritis
model,
intra-articular
injection
HM@WY-Lip/UA
ameliorated
matrix
degradation,
osteophyte
formation,
subchondral
bone
sclerosis
8
weeks.
Overall,
study
indicated
provided
protective
effect
on
degeneration
efficacious
clinically
relevant
manner,
mitochondrial-oriented
strategy
has
great
potential
therapy
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 21, 2024
The
repair
and
regeneration
of
cartilage
has
always
been
a
hot
topic
in
medical
research.
Cartilage
organoids
(CORGs)
are
special
tissue
created
using
engineering
techniques
outside
the
body.
These
engineered
tissues
provide
models
that
simulate
complex
biological
functions
cartilage,
opening
new
possibilities
for
regenerative
medicine
treatment
strategies.
However,
it
is
crucial
to
establish
suitable
matrix
scaffolds
cultivation
CORGs.
In
recent
years,
utilizing
hydrogel
culture
stem
cells
induce
their
differentiation
into
chondrocytes
emerged
as
promising
method
vitro
construction
this
review,
methods
establishing
CORGs
summarized
an
overview
advantages
limitations
matrigel
such
provided.
Furthermore,
importance
ECM
alternative
substitutes
Matrigel,
alginate,
peptides,
silk
fibroin,
DNA
derivatives
discussed,
pros
cons
these
hydrogels
outlined.
Finally,
challenges
future
directions
research
discussed.
It
hoped
article
provides
valuable
references
design
development
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 923 - 923
Published: April 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(30)
Published: May 1, 2024
Abstract
Osteoarthritis
(OA),
a
prevalent
joint
disease
affecting
many
people
globally,
presents
significant
challenge
in
current
treatments,
which
often
only
manage
symptoms
without
halting
progression.
This
review
illuminates
novel
approaches
OA
therapy,
focusing
mainly
on
intra‐articular
injection
of
nanomaterials.
The
innovative
materials,
designed
to
either
mimic
or
augment
natural
lubrication,
show
promise
restoring
biomechanics
and
alleviating
pain.
delves
into
an
array
biomimetic
lubricants,
including
polymer
brush,
nanocomposite
hydrogel,
nanoparticles,
underscoring
their
roles
anti‐inflammation,
targeting,
cartilage
repair,
drug
delivery.
Furthermore,
the
potential
mesenchymal
stem
cells
differentiate
chondrocytes,
coupled
with
delivery
these
exosomes
via
nanomaterials,
has
promoted
cell
therapy
avenues
for
OA.
also
highlights
function
non‐coding
RNAs
such
as
miRNA,
siRNA,
circRNA,
lncRNA,
antisense
oligonucleotides
impeding
progression,
nanomaterials
facilitating
delivery,
thus
advanced
therapeutic
possibilities
immune
evasion
bone
proliferation.
Overall,
this
encapsulates
evolution
treatment
from
material
cell,
ultimately
gene
forecasting
future
where
evolve
toward
integrated,
personalized
diagnostics
therapeutics
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(11)
Published: Feb. 24, 2024
Abstract
Hydrogels,
key
in
biomedical
research
for
their
hydrophilicity
and
versatility,
have
evolved
with
hydrogel
microspheres
(HMs)
of
micron‐scale
dimensions,
enhancing
role
minimally
invasive
therapeutic
delivery,
tissue
repair,
regeneration.
The
recent
emergence
nanomaterials
has
ushered
a
revolutionary
transformation
the
field,
which
demonstrates
tremendous
potential
targeted
therapies,
biological
imaging,
disease
diagnostics.
Consequently,
integration
advanced
nanotechnology
promises
to
trigger
new
revolution
realm
hydrogels.
HMs
loaded
combine
advantages
both
hydrogels
nanomaterials,
enables
multifaceted
functionalities
such
as
efficient
drug
sustained
release,
therapy,
lubrication,
biochemical
detection,
medical
biosensing
monitoring,
micro‐robotics.
Here,
this
review
comprehensively
expounds
upon
commonly
used
classifications.
Then,
it
provides
comprehensive
insights
into
raw
materials
preparation
methods
HMs.
Besides,
common
strategies
employed
achieve
nano‐micron
combinations
are
summarized,
latest
applications
these
combined
field
elucidated.
Finally,
valuable
future
design
development
provided.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(11)
Published: Jan. 16, 2024
Targeting
macrophages
can
facilitate
the
site-specific
repair
of
critical
bone
defects.
Herein,
a
composite
hydrogel,
gelatin-Bletilla
striata
polysaccharide-mesoporous
bioactive
glass
hydrogel
(GBMgel),
is
constructed
via
self-assembly
mesoporous
on
polysaccharide
structures,
through
Schiff
base
reaction.
GBMgel
efficiently
capture
and
drive
recruitment
seed
stem
cells
vascular
budding
required
for
regeneration
in
early
stages
injury,
observed
sustained
release
inorganic
silicon
ions
further
enhances
matrix
deposition,
mineralization,
maturation.
Moreover,
use
macrophage-depleted
rat
calvarial
defect
models
confirms
that
GBMgel,
with
ligand-selective
macrophage
targeting,
increases
area
proportion
mature
bone.
Mechanistic
studies
reveal
upregulates
TLR4/NF-κB
MAPK
pathways
JAK/STAT3
pathway
later
stages;
thus
initiating
polarization
at
different
time
points.
In
conclusion,
this
study
based
endogenous
self-healing
properties
macrophages,
which
cell
homing,
provides
research
theoretical
basis
upon
tissue
be
reshaped
regenerated
using
body's
immune
power,
providing
new
strategy
treatment
