BMC Pharmacology and Toxicology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Dec. 18, 2024
Abstract
This
study
explores
an
eco-friendly
approach
to
mitigate
risks
associated
with
organophosphorus
insecticides,
particularly
Chlorpyrifos,
by
synthesizing
silver
nanoparticles
(AgNPs)
using
Psidium
guajava
leaf
extract
and
preparing
a
nanocomposite
(AgNPs/S18)
Chlorpyrifos
pesticide.
The
green-synthesized
AgNPs
AgNPs/S18
were
characterized
various
analytical
techniques,
confirming
the
successful
synthesis
of
average
size
37
nm
forming
stable
nanocomposite.
Antibacterial
assays
demonstrated
significant
activity
against
Staphylococcus
aureus,
showing
87.8%
reduction
achieving
72%
in
bacterial
population.
Cytotoxicity
evaluations
on
normal
liver
cancer
cell
lines
revealed
enhanced
cytotoxicity
compared
alone,
suggesting
potential
applications
targeted
therapies.
In
vivo
studies
rats
protective
effects
Chlorpyrifos-induced
toxicity
kidney
tissues.
Histopathological
ultrastructural
analyses
showed
both
treatments,
nanocomposite,
significantly
mitigated
cellular
damage
caused
exposure.
These
findings
suggest
that
their
offer
promising
reducing
pesticide
hazards
while
maintaining
efficacy.
research
contributes
developing
safer
alternatives
pest
management,
addressing
need
for
more
environmentally
friendly
agricultural
practices
protecting
human
health
ecosystems.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1184 - 1184
Published: March 6, 2025
Flavonoids
represent
a
class
of
natural
plant
secondary
metabolites
with
multiple
activities
including
antioxidant,
antitumor,
anti-inflammatory,
and
antimicrobial
properties.
However,
due
to
their
structural
characteristics,
they
often
exhibit
low
bioavailability
in
vivo.
In
this
review,
we
focus
on
the
vivo
study
flavonoids,
particularly
effects
gut
microbiome
common
modifications
such
as
methylation,
acetylation,
dehydroxylation,
etc.
These
aim
change
characteristics
original
substances
enhance
absorption
bioavailability.
order
improve
discuss
two
feasible
methods,
namely
dosage
form
modification
chemical
modification,
hope
that
these
approaches
will
offer
new
insights
into
application
flavonoids
for
human
health.
article,
also
introduce
types,
sources,
efficacy
flavonoids.
conclusion,
is
comprehensive
review
how
Nano LIFE,
Journal Year:
2024,
Volume and Issue:
15(03)
Published: Aug. 27, 2024
Dental
adhesive
materials
play
a
crucial
role
in
modern
dentistry,
enabling
the
bonding
of
restorative
to
tooth
structures.
However,
concerns
about
conventional
agents’
potential
toxicities
and
adverse
effects
have
been
raised.
This
has
sparked
interest
exploring
alternative
environmentally
friendly
for
dental
applications.
Hemidesmus
indicus
commonly
known
as
Indian
sarsaparilla,
used
historically
Ayurvedic
medicine,
gained
attention
nanotechnology
functionalizing
nanoparticles.
The
primary
objective
this
study
is
develop
biogenic
titanium
oxide
nanoparticles
(H-TiO
2
NPs)
using
natural
reducing
agent
further
coated
with
curcumin,
specifically
material
were
prepared
green
synthesis
method
characterized
by
various
techniques.
biocompatibility
bioactivity
assessed
multiple
assays.
synthesized
root
extract
capped
curcumin
showed
maximum
absorbance
at
302
nm
498
UV
spectra.
presence
characteristic
peaks
fingerprint
region
FTIR
spectra
reveals
capping
on
TiO
NPs.
monoclinic
structure
was
displayed
XRD
pattern.
SEM
micrograph
uncoated
NPs
exhibits
spherical
morphology
size
range
around
100-140
nm.
Further,
EDAX
HCTN
elemental
composition
43.7%
oxygen,
33.4%
carbon
22.8%
Titanium.
studies
towards
peripheral
blood
mononuclear
cells
(PBMCs)
erythrocytes
proved
its
nontoxic
properties.
In
vitro,bioactivity
revealed
that
exhibited
significant
antibacterial
anti-inflammatory
activity,
evidenced
inhibition
protein
denaturation.
demonstrated
bioactivities
make
them
candidates
results
highlighted
promising
materials,
offering
antimicrobial
contributes
eco-friendly
biocompatible
use
dentistry.
in-depth
analysis
necessary
fully
understand
their
efficacy,
safety
long-term
performance
