The effect of fatigue on postural control in individuals with multiple sclerosis: A systematic review DOI Creative Commons
Parisa Sedaghati, Mohammad Alghosi, F Hosseini

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 31, 2023

Abstract Background: Fatigue is the most disabling ‎symptom for individuals with multiple ‎sclerosis which can significantly affect postural control by impairing ability of central nervous system to modulate sensory inputs and coordinate motor responses. This systematic review aimed accumulate existing evidence. investigate effect ‎fatigue on in ‎sclerosis.‎ Methods: was performed compliance Preferred Reporting Items Systematic Reviews Meta-analyses (PRISMA) statement registered PROSPERO ID CRD42022376262‎. Web Science, PubMed, Scopus, Google Scholar systematically searched until January 2023, a manual search using reference lists included studies. Two authors independently selected studies, extracted data, evaluated their ‎methodological quality Downs Black checklist. The process later discussed ‎with third author.‎ Results: Five studies were this review, consistent evidence investigating direct ‎relationship between fatigue ‎postural ‎sclerosis. All reported negative effects control. Four ‎studies executed walking tests as protocols, one study used strength testing protocol both legs, served fatigue-inducing activity‎. Conclusions: available suggests that may experience deficits due fatigue. However, present body literature exhibits limitations terms its methodology. Gender differences, balance, task, muscle function are important factors need be taken into account when relationship MS. Further high-quality research necessary comprehend complex interplay MS-related after physical activity.

Language: Английский

Fatigue in early multiple sclerosis; MRI metrics of neuroinflammation, relapse and neurodegeneration DOI Creative Commons
Rozanna Meijboom, Peter Foley, Niall MacDougall

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(5)

Published: Jan. 1, 2024

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain spinal cord. Fatigue common disabling symptom from MS onset, however mechanisms by which underlying processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments MS-related fatigue. MRI provides insights into

Language: Английский

Citations

1
Improvement of the thalamocortical white matter network in people with stable treated relapsing–remitting multiple sclerosis over time DOI Creative Commons
Abdulaziz Alshehri, Nikitas Koussis, Oun Al‐iedani

et al.

NMR in Biomedicine, Journal Year: 2024, Volume and Issue: 37(6)

Published: Feb. 21, 2024

Abstract Advanced imaging techniques (tractography) enable the mapping of white matter (WM) pathways and understanding brain connectivity patterns. We combined tractography with a network‐based approach to examine WM microstructure on network level in people relapsing–remitting multiple sclerosis (pw‐RRMS) healthy controls (HCs) over 2 years. Seventy‐six pw‐RRMS matched 43 HCs underwent clinical assessments 3T MRI scans at baseline (BL) 2‐year follow‐up (2‐YFU). Probabilistic was performed, accounting for effect lesions, producing connectomes 25 million streamlines. Network differences fibre density across BL 2‐YFU were quantified using statistics (NBS). Longitudinal NBS pw‐RRMS, tested correlations disability, cognition fatigue scores. Widespread reductions found compared cortical regions, more detected 2‐YFU. Pw‐RRMS had reduced thalamocortical This appeared after correction age, robust different thresholds, did not correlate lesion volume or disease duration. demonstrated long‐distance improvement network, regardless burden, duration therapy, suggesting potential locus neuroplasticity MS. network's role disease's lifespan its implications prognosis treatment warrants further investigation.

Language: Английский

Citations

1
EDSS and infratentorial white matter lesion volume are considered predictors of fatigue severity in RRMS DOI Creative Commons
M. Ezzeldin, Doaa M. Mahmoud,

Shady M. Safwat

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 14, 2023

Fatigue is a common disabling symptom of relapsing remitting multiple sclerosis (RRMS). Many studies have linked grey matter atrophy to fatigue, but white lesion load (WM-LL) has received less attention. Here we assess the relation between fatigue and regional WM-LL volumetric measures. 63 patients with RRMS participated in this study; mean age was 31.9 ± 8.1 years. Each patient provided demographic details scored on expanded disability status scale (EDSS) severity (FSS). VolBrain, fully automated, operator-independent tool used whole brain volume. The were classified into three groups: no (FSS < 4), low moderate ≥ 4 ≤ 5) high > 5). 33.3% had significant 25.4% mild-to-moderate 41.3% fatigue. Age, disease duration, relapses, EDSS positively correlated (P = 0.034, 0.002, 0.009 0.001 respectively). Whole volume, total (juxtacortical, periventricular, infratentorial) also severity. Ordinal regression analysis for showed infratentorial volume best predictors. In conclusion, (cerebellar brainstem) are predictors

Language: Английский

Citations

3
Cognitive fatigue-related sensory gating deficits in people with multiple sclerosis DOI Creative Commons
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle

et al.

Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 176, P. 105950 - 105950

Published: Dec. 6, 2022

Cognitive fatigue is highly prevalent in people with multiple sclerosis (pwMS) and significantly limits their quality of life. Fatigue can be subdivided into a subjective feeling constant (trait) or current (state) exhaustion, as well an objective performance decline, also known fatigability. However, the diagnosis pwMS purely subjective, leaving fatigability mostly unattended. Sensorimotor sensory gating deficits have recently been described possible markers for healthy subjects. Thus, this study aimed to investigate potential prepulse inhibition (PPI) ratios P50 suppression surrogate cognitive pwMS.PPI were assessed before after 30-min fatigability-inducing AX- continuous task. Subjective trait was operationalized via self-report questionnaires, state visual analog scales (VAS), change both ratios. The data analyzed using Linear Mixed Models Pearson correlations.We included 18 20 controls (HC) final analyses. task-induced more pronounced pwMS. While initial PPI similar groups, disrupted induction PPI, on other hand, decreased groups. Moreover, negatively associated pwMS, indicating that higher gating. Finally, fatigability-related changes VAS ratings, but only HC.This demonstrated promising parameter. Importantly, correlated ratings. Our results extend broaden understanding pathophysiological neuronal mechanisms MS-related fatigue. This first present fatigue-related disruption

Language: Английский

Citations

3
Associations of depression and perceived physical fatigability with white matter integrity in older adults DOI
Chemin Lin, Fang‐Cheng Yeh, Nancy W. Glynn

et al.

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 340, P. 111793 - 111793

Published: Feb. 10, 2024

Language: Английский

Citations

0
Behavioral disorders in multiple sclerosis: a comprehensive review DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

0
Alterations in functional connectivity of interoceptive and Cortico-Subcortical areas in Multiple Sclerosis-Related fatigue DOI
Carla Silva‐Batista,

Ishu Arpan,

Mariana Penteado Nucci

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0
Structural and functional brain correlates of the neutrophil- and monocyte-to-lymphocyte ratio in neuropsychiatric syndromes DOI Creative Commons
Roger C. McIntosh

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100940 - 100940

Published: Dec. 26, 2024

Language: Английский

Citations

0
The interaction between metaplastic neuromodulation and fatigue in multiple sclerosis DOI

Claire H. Xian,

Chiara Barbi, Mitchell R. Goldsworthy

et al.

Journal of the Neurological Sciences, Journal Year: 2022, Volume and Issue: 444, P. 120521 - 120521

Published: Dec. 11, 2022

Language: Английский

Citations

2
Fatigability-related oscillatory brain activity changes in people with MS DOI Creative Commons
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2022, Volume and Issue: 69, P. 104457 - 104457

Published: Dec. 6, 2022

Fatigue, a multidimensional and challenging symptom associated with various underlying conditions, can manifest as subjective feeling performance fatigability. The latter is often defined an objectively measurable decline time on task. Both syndromes are highly prevalent in people multiple sclerosis (pwMS) resistant to medical therapy. In the absence of valid reliable objective parameters, current cognitive fatigue diagnosis remains purely subjective. Assessing brain wave activity changes has repeatedly been viable strategy for monitoring healthy subjects. this study, we aimed investigate oscillatory their associations pwMS. We enrolled 21 pwMS controls (HC) study. Subjects performed sustained attention task divided into six blocks over course 30 minutes, underwent resting state EEGs before after During task, subjects were asked rate levels mental fitness, exhaustion, mind wandering. Using Linear Mixed Models, explored fatigability-related by focusing reaction variability, ratings fatigability, well frontomedial theta, occipital alpha power. further investigated initial fatigability-induced differences between HC at rest. Finally, Pearson correlations used examine relationship fatigability parameters. Our results revealed systematically stronger development that was measurable. PwMS reported lower fitness demonstrated greater variability times Occipital power significantly increased during Especially upper power, increase more prominent compared HC. However, time-on-task-induced our study not ratings. expand understanding neural mechanisms underlining may complement therapy quantitative methods.

Language: Английский

Citations

1