Preventing and Controlling Zinc Deficiency Across the Life Course: A Call to Action DOI Creative Commons
Nicola M. Lowe, Andrew G Hall, Martin R. Broadley

et al.

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(3), P. 100181 - 100181

Published: Jan. 26, 2024

Through diverse roles, zinc determines a greater number of critical life functions than any other single micronutrient. Beyond the well-recognized importance for child growth and resistance to infections, has numerous specific roles covering regulation glucose metabolism, growing evidence links deficiency with increased risk diabetes cardiometabolic disorders. Zinc nutriture is thus vitally important health across course. also one most common forms micronutrient malnutrition globally. A clearer estimate burden disparity attributable in adulthood later emerges when accounting its contribution global elevated fasting blood related non-communicable diseases (NCDs). Yet progress attenuating prevalence been limited due, part, lack sensitive methods assess human status. This narrative review covers recent developments our understanding zinc's role health; impact changing climate context on intake; novel functional biomarkers showing promise monitoring population-level interventions; solutions improving population intake. It aims spur implementation evidence-based interventions preventing controlling Increasing intake combatting requires context-specific strategies combination complementary, including supplementation, food fortification, agricultural such as biofortification, alongside efforts improve bioavailability. Enhancing dietary content bioavailability through biofortification an inclusive nutrition solution that can benefit vulnerable individuals populations affected by inadequate diets greatest extent.

Language: Английский

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection DOI Open Access
Adrian F. Gombart,

Adeline Pierre,

Silvia Maggini

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(1), P. 236 - 236

Published: Jan. 16, 2020

Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, B12, folate, zinc, iron, copper, selenium, which play vital, often synergistic roles at every stage of response. Adequate amounts are essential to ensure proper function physical barriers cells; however, daily micronutrient intakes necessary may be higher than current recommended dietary allowances. Certain populations have inadequate intakes, situations with increased requirements (e.g., infection, stress, pollution) further decrease stores within body. Several deficient, even marginal impair immunity. Although contradictory data exist, available evidence indicates immune-supporting modulate reduce risk infection. Micronutrients strongest for D zinc. Better design human clinical studies addressing dosage combinations different required substantiate benefits against

Language: Английский

Citations

1127
Wound dressings: Current advances and future directions DOI Open Access
Erfan Rezvani Ghomi, Shahla Khalili, Saied Nouri Khorasani

et al.

Journal of Applied Polymer Science, Journal Year: 2019, Volume and Issue: 136(27)

Published: March 18, 2019

ABSTRACT Wound healing is a complicated and continuous process affected by several factors, which needs an appropriate surrounding to achieve accelerated healing. recruits three different phases: inflammation, proliferation, maturation. Due the types of wounds, as well advancement in medical technology, various products have been developed repair skin lesions. Our objective investigate wound dressings from traditional current methods treatment. The article presents characteristics ideal dressing, requirements for selection detailed classification dressings. Animal origin, herbal synthetic are firstly introduced reviewed. Then, nonmedicated including alginate, hydrogel, hydrocolloid dressings, medicated discussed. Finally, developmental prospectives new generations future researches presented. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. , 136 47738.

Language: Английский

Citations

696
Recent aspects of the effects of zinc on human health DOI
Christos T. Chasapis,

Panagoula-Stamatina A. Ntoupa,

Chara Spiliopoulou

et al.

Archives of Toxicology, Journal Year: 2020, Volume and Issue: 94(5), P. 1443 - 1460

Published: May 1, 2020

Language: Английский

Citations

513
The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis DOI Creative Commons
Inga Weßels, Benjamin Rolles, Lothar Rink

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: July 10, 2020

During the current corona pandemic, new therapeutic options against this viral disease are urgently desired. Due to rapid spread and immense number of affected individuals worldwide, cost-effective, globally available, safe with minimal side effects simple application extremely warranted. This review will therefore discuss potential zinc as preventive agent alone or in combination other strategies, meets all above described criteria. While a variety data on association individual status respiratory tract infections study evidence regarding COVID-19 is so far missing but can be assumed was indicated by others detailed perspective, focusing re-balancing immune response supplementation. Especially, role viral-induced vascular complications has barely been discussed, far. Interestingly, most risk groups for at same time that were associated deficiency. As essential preserve natural tissue barriers such epithelium, preventing pathogen entry, balanced function system redox system, deficiency probably added factors predisposing infection detrimental progression COVID-19. Finally, due its direct antiviral properties, it administration beneficial population, especially those suboptimal status.

Language: Английский

Citations

322
Bioactive Compounds for Skin Health: A Review DOI Open Access
Monika Michalak, Monika Pierzak, Beata Kręcisz

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 203 - 203

Published: Jan. 12, 2021

Human skin is continually changing. The condition of the largely depends on individual’s overall state health. A balanced diet plays an important role in proper functioning human body, including skin. present study draws attention to bioactive substances, i.e., vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus their effects aim was review literature substances parameters such as elasticity, firmness, wrinkles, senile dryness, hydration color, define process ageing.

Language: Английский

Citations

242
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes DOI

Daiyong Chao,

Qingfeng Dong,

Zhixuan Yu

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(51), P. 23438 - 23447

Published: Dec. 13, 2022

Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in the primary difference between normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) healing of rats through integrating metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species modulate oxidative stress microenvironment wounds, leads natural transition from proliferation phase. Impressively, efficacy one-time-applied was comparable that human epidermal growth factor Gel, widely used drug various treatments. Such effective, safe, convenient meet complex demands.

Language: Английский

Citations

172
Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing DOI
Tina Mehrabi, Abdorreza S. Mesgar, Zahra Mohammadi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2020, Volume and Issue: 6(10), P. 5399 - 5430

Published: Aug. 25, 2020

The morbidity, mortality, and burden of burn victims patients with severe diabetic wounds are still high, which leads to an extensively growing demand for novel treatments high clinical efficacy. Biomaterial-based wound treatment approaches have progressed over time from simple cotton wool dressings advanced skin substitutes containing cells growth factors; however, no care approach is yet completely satisfying. Bioactive glasses materials potential in many areas that exhibit unique features biomedical applications. Today, bioactive not only amorphous solid structures can be used as a substitute hard tissue but also promising soft regeneration healing Biologically active elements such Ag, B, Ca, Ce, Co, Cu, Ga, Mg, Se, Sr, Zn incorporated glass networks; hence, the superiority these multifunctional current results their ability release multiple therapeutic ions environment, target different stages process. dissolution products potency inducing angiogenesis exerting several biological impacts on cell functions, involved some other valuable applications, namely hemostatic antibacterial properties. In this review, we focus structure, dynamic process injured skin, existing approaches. basic concepts reviewed better understand relationship between structure its We illustrate role repair regeneration. Finally, research studies applications summarized future trends field elaborated.

Language: Английский

Citations

161
Silver nanoparticles: Advanced and promising technology in diabetic wound therapy DOI
Hira Choudhury, Manisha Pandey,

Yan Qing Lim

et al.

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 112, P. 110925 - 110925

Published: April 11, 2020

Language: Английский

Citations

155
Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management DOI

Zhina Hadisi,

Mehdi Farokhi, Hamid Reza Bakhsheshi‐Rad

et al.

Macromolecular Bioscience, Journal Year: 2020, Volume and Issue: 20(4)

Published: Feb. 19, 2020

Abstract Burn injuries represent a major life‐threatening event that impacts the quality of life patients, and places enormous demands on global healthcare systems. This study introduces fabrication characterization novel wound dressing made core–shell hyaluronic acid–silk fibroin/zinc oxide (ZO) nanofibers for treatment burn injuries. The configuration enables loading ZO—an antibacterial agent—in core nanofibers, which in return improves sustained release drug maintains its bioactivity. Successful formation zinc are confirmed by transmission electron microscopy, Fourier‐transform infrared spectroscopy, energy dispersive X‐ray. activity dressings examined against Escherichia coli Staphylococcus aureus it is shown addition ZO property dose‐dependent fashion. However, vitro cytotoxicity studies show high concentration (>3 wt%) toxic to cells. In vivo indicate loaded with (3 substantially healing procedure significantly reduces inflammatory response at site. Overall, introduced herein holds great promise management

Language: Английский

Citations

149
Exploration of the antibacterial and wound healing potential of a PLGA/silk fibroin based electrospun membrane loaded with zinc oxide nanoparticles DOI
Atta ur Rehman Khan, Kai Huang, Jinzhong Zhao

et al.

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(5), P. 1452 - 1465

Published: Jan. 1, 2021

Zinc oxide nanoparticles (ZnO NPs) are known for their antibacterial, antioxidant, and anti-inflammatory activities. Moreover, ZnO NPs can stimulate cell migration, re-epithelialization, angiogenesis. All these attributes highly relevant to wound healing. Local administration of the be achieved through electrospun nanofibers. We hypothesized that use poly(lactide-co-glycolic acid) (PLGA)/silk fibroin (SF) nanofiber-based delivery would maintain bioavailability on area synchronization with unique structural features nanofibers, could closure, collagen deposition, cellular In this study, we fabricated PLGA/SF (PS) nanofibrous (NF) membranes without extensively characterized them various physicochemical biological attributes. Scanning electron microscopy (SEM) revealed smooth fibers concentration-dependent increase in fiber diameter. Transmission (TEM) also confirmed encapsulation polymer matrix. The successful loading was further by X-ray diffraction. Furthermore, mechanical testing a tensile strength. biocompatibility evaluated vitro culture. A mild anti-oxidant activity noted mainly due presence silk fibroin. antibacterial tests PLGA/SF/3% (PSZ3) remained completely active against E. coli S. aureus. More importantly, NF were vivo healing potential. PSZ3 membrane not only facilitated early closure but remarkably enhanced quality histopathological analysis. Re-epithelialization, granulation tissue formation, angiogenesis some key parameters significantly boosted loaded composite membranes. Based extensive characterization evaluation, has turned out potential candidate applications.

Language: Английский

Citations

149