Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(2), P. 273 - 273
Published: Jan. 24, 2022
Diabetes
mellitus
is
a
chronic
disease
with
high
mortality
rate
and
many
complications.
A
non-healing
diabetic
foot
ulcer
(DFU)
one
the
most
serious
complications,
leading
to
lower-extremity
amputation
in
15%
of
patients.
Nanofibers
are
emerging
as
versatile
wound
dressing
due
their
unique
healing
properties,
such
surface
area
volume
ratio,
porosity,
ability
maintain
moist
environment
capable
delivering
sustained
drug
release
oxygen
supply
wound.
The
present
study
was
aimed
prepare
evaluate
polyvinyl
alcohol
(PVA)-sodium
alginate
(SA)-silk
fibroin
(SF)-based
multifunctional
nanofibrous
scaffold
loaded
asiaticoside
(AT)
rats.
SEM
findings
showed
that
fibers'
diameters
ranged
from
100-200
nm,
tensile
strengths
12.41-16.80
MPa.
crosslinked
nanofibers
were
AT
over
an
extended
period.
MTT
scratch
assay
on
HaCat
cells
confirmed
low
cytotoxicity
significant
cell
migration,
respectively.
Antimicrobial
tests
revealed
excellent
anti-microbial
efficacy
against
P.
aeruginosa
S.
aureus
bacteria.
In-vivo
demonstrated
better
In
addition,
histopathological
studies
its
restore
normal
structure
skin.
concluded
developed
have
great
potential
for
applications.
Journal of Controlled Release,
Journal Year:
2021,
Volume and Issue:
334, P. 463 - 484
Published: March 27, 2021
Drug
delivery
devices
are
promising
tools
in
the
pharmaceutical
field,
as
they
able
to
maximize
therapeutic
effects
of
delivered
drug
while
minimizing
undesired
side
effects.
In
past
years,
electrospun
nanofibers
attracted
rising
attention
due
their
unique
features,
like
biocompatibility
and
broad
flexibility.
Incorporation
active
principles
nanofibrous
meshes
proved
be
an
efficient
method
for
situ
a
wide
range
drugs,
expanding
possibility
applicability
those
devices.
this
review,
principle
electrospinning
different
fields
applications
treated
give
overview
recent
literature,
underlining
easy
tuning
endless
combination
technique,
that
future
could
new
frontier
personalized
medicine.
Journal of Nanobiotechnology,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: Jan. 4, 2021
Abstract
Skin
is
the
body’s
first
barrier
against
external
pathogens
that
maintains
homeostasis
of
body.
Any
serious
damage
to
skin
could
have
an
impact
on
human
health
and
quality
life.
Tissue
engineering
aims
improve
damaged
tissue
regeneration.
One
most
effective
treatments
for
regeneration
angiogenesis
during
healing
period.
Over
last
decade,
there
has
been
impressive
growth
new
potential
applications
nanobiomaterials
in
engineering.
Various
approaches
developed
rate
process
using
angiogenic
nanomaterials.
In
this
review,
we
focused
molecular
mechanisms
key
factors
angiogenesis,
role
scaffold-based
accelerated
wound
based
improved
angiogenesis.
Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(12), P. 1309 - 1309
Published: Dec. 21, 2020
Recently,
increasing
public
concern
about
hygiene
has
been
driving
many
studies
to
investigate
antimicrobial
and
antiviral
agents.
However,
the
use
of
any
agents
must
be
limited
due
their
possible
toxic
or
harmful
effects.
In
recent
years,
previous
antibiotics'
lesser
side
effects,
herbal
materials
instead
synthetic
chemical
drugs
is
increasing.
Herbal
are
found
in
medicines.
Herbs
can
used
form
plant
extracts
as
active
components.
Furthermore,
most
world's
populations
strong
properties
primary
healthcare
benefits.
For
example,
herbs
an
excellent
material
replace
nanosilver
antibiotic
agent.
The
involves
ROS-mediated
mechanism
that
might
lead
oxidative
stress-related
cancer,
cytotoxicity,
heart
diseases.
Oxidative
stress
further
leads
increased
ROS
production
also
delays
cellular
processes
involved
wound
healing.
Therefore,
existing
replaced
with
biomaterials
such
medicine
high
antimicrobial,
antiviral,
antioxidant
activity.
This
review
paper
highlights
antibacterial,
radical
scavenger
(antioxidant)
materials.
Antimicrobial
activity,
ability,
potential
for
anticancer
agents,
efficacy
eliminating
bacteria
viruses
scavenging
free
radicals
discussed
this
review.
presented
include
clove,
portulaca,
tribulus,
eryngium,
cinnamon,
turmeric,
ginger,
thyme,
pennyroyal,
mint,
fennel,
chamomile,
burdock,
eucalyptus,
primrose,
lemon
balm,
mallow,
garlic,
which
all
summarized.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
17(3), P. 353 - 384
Published: Jan. 24, 2022
Bacterial
infection
and
the
ever-increasing
bacterial
resistance
have
imposed
severe
threat
to
human
health.
And
contamination
could
significantly
menace
wound
healing
process.
Considering
sophisticated
process,
novel
strategies
for
skin
tissue
engineering
are
focused
on
integration
of
bioactive
ingredients,
antibacterial
agents
included,
into
biomaterials
with
different
morphologies
improve
cell
behaviors
promote
healing.
However,
a
comprehensive
review
anti-bacterial
dressing
enhance
has
not
been
reported.
In
this
review,
various
as
dressings
will
be
discussed.
Different
kinds
agents,
including
antibiotics,
nanoparticles
(metal
metallic
oxides,
light-induced
agents),
cationic
organic
others,
their
recent
advances
summarized.
Biomaterial
selection
fabrication
structures
forms,
films,
hydrogel,
electrospun
nanofibers,
sponge,
foam
three-dimension
(3D)
printed
scaffold
regeneration,
elaborated
Current
challenges
future
perspectives
presented
in
multidisciplinary
field.
We
envision
that
provide
general
insight
elegant
design
further
refinement
dressing.
Membranes,
Journal Year:
2021,
Volume and Issue:
11(10), P. 770 - 770
Published: Oct. 9, 2021
With
the
increasing
demand
for
wound
care
and
treatment
worldwide,
traditional
dressings
have
been
unable
to
meet
needs
of
existing
market
due
their
limited
antibacterial
properties
other
defects.
Electrospinning
technology
has
attracted
more
researchers’
attention
as
a
simple
versatile
manufacturing
method.
The
electrospun
nanofiber
membrane
unique
structure
biological
function
similar
extracellular
matrix
(ECM),
is
considered
an
advanced
dressing.
They
significant
potential
in
encapsulating
delivering
active
substances
that
promote
healing.
This
article
first
discusses
common
types
dressing,
then
summarizes
development
fiber
preparation
technology.
Finally,
polymers
biologically
used
electrospinning
are
summarized,
portable
equipment
also
discussed.
Additionally,
future
research
put
forward.
Journal of Functional Biomaterials,
Journal Year:
2020,
Volume and Issue:
11(3), P. 67 - 67
Published: Sept. 22, 2020
Being
designated
to
protect
other
tissues,
skin
is
the
first
and
largest
human
body
organ
be
injured
for
this
reason,
it
accredited
with
a
high
capacity
self-repairing.
However,
in
case
of
profound
lesions
or
large
surface
loss,
natural
wound
healing
process
may
ineffective
insufficient,
leading
detrimental
painful
conditions
that
require
repair
adjuvants
tissue
substitutes.
In
addition
conventional
care
options,
biodegradable
polymers,
both
synthetic
biologic
origin,
are
gaining
increased
importance
their
biocompatibility,
biodegradation,
bioactive
properties,
such
as
antimicrobial,
immunomodulatory,
cell
proliferative,
angiogenic.
To
create
microenvironment
suitable
process,
key
property
ability
polymer
spun
into
submicrometric
fibers
(e.g.,
via
electrospinning),
since
they
mimic
fibrous
extracellular
matrix
can
support
neo-
growth.
A
number
polymers
used
biomedical
sector
comply
definition
bio-based
(known
also
biopolymers),
which
recently
being
industrial
sectors
reducing
material
energy
impact
on
environment,
derived
from
renewable
biological
resources.
review,
after
description
fundamental
concepts
healing,
emphasis
advanced
dressings,
recent
developments
electrospun
structures
efficient
applications
highlighted
discussed.
This
review
aims
improve
awareness
use
medical
devices.
Materials,
Journal Year:
2020,
Volume and Issue:
13(9), P. 2153 - 2153
Published: May 6, 2020
Pharmaceutical
nano-fibers
have
attracted
widespread
attention
from
researchers
for
reasons
such
as
adaptability
of
the
electro-spinning
process
and
ease
production.
As
a
flexible
method
fabricating
nano-fibers,
is
extensively
used.
An
unit
composed
pump
or
syringe,
high
voltage
current
supplier,
metal
plate
collector
spinneret.
Optimization
attained
undertaken
through
manipulation
variables
formulation,
including
concentration,
viscosity,
molecular
mass,
physical
phenomenon,
well
environmental
parameters
temperature
humidity.
The
achieved
by
can
be
utilized
drug
loading.
mixing
two
more
medicines
performed
via
electro-spinning.
Facilitation
inhibition
burst
release
use
approach.
This
potential
anticipated
to
facilitate
progression
in
applications
modification
tissue
engineering
(TE).
present
review
aims
focus
on
electro-spinning,
optimization
parameters,
pharmacological
applications,
biological
characteristics,
vivo
analyses
electro-spun
nano-fibers.
Furthermore,
developments
upcoming
investigation
directions
are
outlined
advancement
TE.
Moreover,
possible
complications
future
these
summarized
detail.
