Review of Distribution, Extraction Methods, and Health Benefits of Bound Phenolics in Food Plants

Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 68(11), P. 3330 - 3343

Published: Feb. 24, 2020

Phenolic compounds are important functional bioactive substances distributed in various food plants. They have gained wide interest from researchers due to their multiple health benefits. There two forms of phenolic compounds: free form and bound form. The latter is also called phenolics (BPs), which found mainly the cell wall tissues/organs plant body. can either chemically bind macromolecules matrixes or be physically entrapped intact cells. Various isolation methods, including chemical, biological, physical been employed extract BPs shown strong biological activities, antioxidant, probiotic, anticancer, anti-inflammation, antiobesity, antidiabetic effects as well beneficial on central nervous system diseases. This review summarizes research findings these topics help better understanding provide comprehensive information effects.

Language: Английский

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The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(12), P. 3056 - 3056

Published: June 22, 2019

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent development progression. Regardless of underlying cause disorder, age is strongest risk factor for developing these maladies, suggesting changes occur aging brain put it at increased neurodegenerative development. Moreover, since a number different brain, unlikely targeting single change going to be effective treatment. Thus, compounds have multiple biological activities can impact various age-associated contribute progression needed. The plant-derived flavonoids wide range could make them particularly blocking toxicity pathways associated with diseases. In this review, evidence beneficial effects models AD, PD, HD, ALS presented common mechanisms action identified. Overall, preclinical data strongly support further investigation specific treatment

Language: Английский

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Advancement in the modelling and therapeutics of Parkinson’s disease

Journal of Chemical Neuroanatomy, Journal Year: 2020, Volume and Issue: 104, P. 101752 - 101752

Published: Jan. 26, 2020

Language: Английский

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Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 89(5), P. 451 - 462

Published: Oct. 10, 2020

Autism spectrum disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal dysfunction, altered gut microbiome compositions.We sought to better understand nonbehavioral features of ASD by determining molecular signatures in peripheral tissues through mass spectrometry methods (ultrahigh performance liquid chromatography-tandem spectrometry) broad panels identified metabolites. Herein, we compared the global metabolome 231 plasma 97 fecal samples from large cohort children typically developing control children.Differences amino acid, lipid, xenobiotic metabolism distinguished samples. Our results implicated oxidative stress mitochondrial hormone level elevations, lipid profile changes, levels phenolic microbial We also revealed correlations between specific metabolite profiles clinical behavior scores. Furthermore, summary metabolites modestly associated dysfunction provided, pilot study that can be transferred via transplant into mice identified.These findings support connection metabolism, physiology, complex traits may advance discovery development biomarkers for ASD.

Language: Английский

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Blood–Brain Barrier Permeable Photoacoustic Probe for High-Resolution Imaging of Nitric Oxide in the Living Mouse Brain

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(14), P. 7952 - 7961

Published: March 31, 2023

Alternations in the brain nitric oxide (NO) homeostasis are associated with a variety of neurodegeneration diseases; therefore, high-resolution imaging NO is essential for understanding pathophysiological processes. However, currently available probes unsuitable this purpose due to their poor ability cross blood–brain barrier (BBB) or image deep tissues spatial resolution. Herein, we developed photoacoustic (PA) probe BBB crossing overcome obstacle. The shows highly selective ratiometric response toward NO, which enables micron resolution whole living mice. Using three-dimensional PA imaging, demonstrated that could be used visualize detailed distribution varying depth cross-sections (0–8 mm) Parkinson's disease (PD) mouse brain. We also investigated therapeutic properties natural polyphenols PD using as an agent and suggested potential screening agents. This study provides promising high anticipate these findings may open up new possibilities biological functions development agents diagnosis treatment diseases.

Language: Английский

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Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson’s disease: an overview and update on new developments

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(6), P. 5455 - 5464

Published: May 8, 2023

Language: Английский

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Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 21(1), P. 202 - 202

Published: Dec. 27, 2019

Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute wide range pomegranate's health benefits. While lot experimental studies have been devoted Alzheimer disease and hypoxic-ischemic brain injury, our knowledge effects against Parkinson's (PD) very limited. It suggested that its neuroprotective are mediated by ETs-derived metabolites-urolithins. In this study, we examined the capability pomegranate for protection PD in rat model parkinsonism induced rotenone. To evaluate efficiency, assessment postural instability, visualization neurodegeneration, determination oxidative damage lipids α-synuclein level, as well markers antioxidant defense status, inflammation, apoptosis, were performed midbrain. We also check presence plausible active metabolite, urolithin A, plasma brain. Our results indicated treatment provided neuroprotection evidenced stability improvement, enhancement neuronal survival, aggregation, increase mitochondrial aldehyde dehydrogenase activity, maintenance antiapoptotic Bcl-xL protein at control level. addition, evidence distribution A

Language: Английский

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Diet in Parkinson's Disease: Critical Role for the Microbiome

Frontiers in Neurology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 10, 2019

Background. Parkinson's disease (PD) is the most common movement disorder affecting up to 1% of population above age 60 and 4–5% those 85. Little progress has been made on efforts prevent development or halt progression. Diet emerged as a potential factor that may slow progression PD. In this review, we discuss evidence for role intestinal microbiome in PD how diet-associated changes be viable approach modify Methods. We reviewed studies demonstrating dietary components/foods were related risk dysregulated patients including abnormal shifts microbiota composition (i.e., dysbiosis) characterized by loss short chain fatty acid (SCFA) bacteria increased lipopolysaccharide (LPS) bacteria. also examined several candidate mechanisms which can influence NLRP3 inflammasome, insulin resistance, mitochondrial function, vagal nerve signaling. Results. The PD-associated associated with decreased production SCFA LPS it believed these contribute exacerbation robustly impacts Western diet whereas Mediterranean (including high intake fiber) decreases risk. Mechanistically consequence relative abundance SCFA-producing LPS-containing effects barrier endotoxemia systemic LPS), inflammasome activation, dysfunction, factors such glucagon like peptide 1 (GLP-1) brain derived neurotrophic (BDNF) well gluconeogenesis. Conclusions. This review summarizes model microbiota-gut-brain-axis regulation neuroinflammation new mechanisms. conclude need clinical trials test beneficial based fiber diets.

Language: Английский

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Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies

Antioxidants, Journal Year: 2020, Volume and Issue: 9(11), P. 1128 - 1128

Published: Nov. 13, 2020

Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability morbidity elderly, imposing a significant economic social burden. As components central nervous system, lipids play important roles neural health pathology. Disturbed lipid metabolism, particularly peroxidation (LPO), is associated with development many NDDs, including Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), all which show elevated levels LPO products LPO-modified proteins. Thus, inhibition oxidation might slow progression reduce severity NDD; natural antioxidants, such as polyphenols antioxidant vitamins, seem to be most promising agents. Here, we summarize current literature data that were derived from human studies on effect vitamins A, C, E supplementation patients AD, PD, ALS. Although these compounds may NDD, research gaps remain antioxidants ALS patients, indicates further applying different forms NDDs urgently needed.

Language: Английский

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Nutritional Risk Factors, Microbiota and Parkinson’s Disease: What Is the Current Evidence?

Nutrients, Journal Year: 2019, Volume and Issue: 11(8), P. 1896 - 1896

Published: Aug. 14, 2019

Parkinson's disease (PD) is a frequent neurodegenerative among elderly people. Genetic and underlying environmental factors seem to be involved in the pathogenesis of PD related degeneration dopaminergic neurons striatum. In previous experimental researches oxidative stress, mitochondrial dysfunction, homocysteine, neuroinflammation have been reported as potential mechanisms. Among factors, nutrition one most investigated areas it potentially modifiable factor. The purpose this review provide current knowledge regarding relation between diet risk. We performed comprehensive including relevant studies from year 2000 onwards prospective studies, nested case-control meta-analysis. dietary we focused on specific nutrients food groups, alcoholic beverages, uric acid, patterns. Furthermore, included microbiota recent findings shown possible impact neurodegeneration. As conclusion, there are still many controversies relationship which, beside methodological differences may due genetic gender-specific factors. However, some evidence exists protective effect poly-unsaturated fatty acids, coffee, tea but mainly men, whereas dairy products, particularly milk, might increase risk through contaminant mediated effect.

Language: Английский

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