Cells,
Journal Year:
2024,
Volume and Issue:
13(6), P. 477 - 477
Published: March 8, 2024
The
gut
mucosal
epithelium
is
one
of
the
largest
organs
in
body
and
plays
a
critical
role
regulating
crosstalk
between
resident
microbiome
host.
To
this
effect,
tight
control
what
permitted
through
barrier
high
importance.
There
should
be
restricted
passage
harmful
microorganisms
antigens
while
at
same
time
allowing
absorption
nutrients
water.
An
increased
permeability,
or
“leaky
gut”,
has
been
associated
with
variety
diseases
ranging
from
infections,
metabolic
diseases,
inflammatory
autoimmune
to
neurological
conditions.
Several
factors
can
affect
including
cytokines,
dietary
components,
microbiome.
Here,
we
discuss
how
impacts
permeability
epithelial
harnessed
for
therapeutic
purposes.
Annual Review of Nutrition,
Journal Year:
2022,
Volume and Issue:
42(1), P. 45 - 66
Published: Aug. 22, 2022
The
consumption
of
fructose
as
sugar
and
high-fructose
corn
syrup
has
markedly
increased
during
the
past
several
decades.
This
trend
coincides
with
exponential
rise
metabolic
diseases,
including
obesity,
nonalcoholic
fatty
liver
disease,
cardiovascular
diabetes.
While
biochemical
pathways
metabolism
were
elucidated
in
early
1990s,
organismal-level
its
whole-body
pathophysiological
impacts
have
been
only
recently
investigated.
In
this
review,
we
discuss
history
consumption,
molecular
involved
different
organs
gut
microbiota,
role
pathogenesis
remaining
questions
to
treat
such
diseases.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1393 - 1393
Published: March 14, 2023
Trehalose
is
a
naturally
occurring,
non-reducing
disaccharide
comprising
two
covalently-linked
glucose
molecules.
It
possesses
unique
physiochemical
properties,
which
account
for
multiple
biological
roles
in
variety
of
prokaryotic
and
eukaryotic
organisms.
In
the
past
few
decades,
intensive
research
on
trehalose
has
uncovered
its
functions,
extended
uses
as
sweetener
stabilizer
food,
medical,
pharmaceutical,
cosmetic
industries.
Further,
increased
dietary
consumption
sparked
how
affects
gut
microbiome.
addition
to
role
sugar,
gained
attention
ability
modulate
homeostasis,
potentially
therapeutic
agent
diabetes.
This
review
discusses
bioactive
effects
trehalose,
highlighting
promise
future
industrial
scientific
contributions.
Cells,
Journal Year:
2024,
Volume and Issue:
13(6), P. 477 - 477
Published: March 8, 2024
The
gut
mucosal
epithelium
is
one
of
the
largest
organs
in
body
and
plays
a
critical
role
regulating
crosstalk
between
resident
microbiome
host.
To
this
effect,
tight
control
what
permitted
through
barrier
high
importance.
There
should
be
restricted
passage
harmful
microorganisms
antigens
while
at
same
time
allowing
absorption
nutrients
water.
An
increased
permeability,
or
“leaky
gut”,
has
been
associated
with
variety
diseases
ranging
from
infections,
metabolic
diseases,
inflammatory
autoimmune
to
neurological
conditions.
Several
factors
can
affect
including
cytokines,
dietary
components,
microbiome.
Here,
we
discuss
how
impacts
permeability
epithelial
harnessed
for
therapeutic
purposes.
