Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Bulletin of Experimental Biology and Medicine, Journal Year: 2021, Volume and Issue: 171(2), P. 179 - 189

Published: May 1, 2021

Language: Английский

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Dietary polyphenols as antidiabetic agents: Advances and opportunities

Food Frontiers, Journal Year: 2020, Volume and Issue: 1(1), P. 18 - 44

Published: March 1, 2020

Abstract Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web Science) on “polyphenols diabetes” significantly increased since 2010. This review highlights the advances opportunities dietary agents. prevent manage Type 2 diabetes mellitus via insulin‐dependent approaches, for instance, protection pancreatic islet β‐cell, reduction β‐cell apoptosis, promotion proliferation, attenuation oxidative stress, activation insulin signaling, stimulation pancreas to secrete insulin, well insulin‐independent approaches including inhibition glucose absorption, digestive enzymes, regulation intestinal microbiota, modification inflammation response, formation advanced glycation end products. Moreover, ameliorate diabetic complications, such vascular dysfunction, nephropathy, retinopathy, neuropathy, cardiomyopathy, coronary diseases, renal failure, so on. structure–activity relationship is still not clear. individual flavonoid or isoflavone has no therapeutic effect patients, although data are very limited. Resveratrol, curcumin, anthocyanins showed activity study. How hyperglycemia influences bioavailability bioactivity understood. An understanding how alters will lead an improvement their benefits outcomes.

Language: Английский

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Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 24, 2022

Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony peoples’ normal life worldwide. Despite availability insulin preparations several synthetic oral antidiabetic drugs, there is crucial need for discovery development novel drugs because resistance side effects those in long-term use. On contrary, plants or herbal sources are getting popular day by to scientists, researchers, pharmaceutical companies all over world search potential bioactive compound(s) targeted that may control diabetes with least unwanted conventional drugs. In this review, we have presented prospective candidates comprised either isolated phytochemical(s) and/or extract(s) containing phytoconstituents which been reported vitro , vivo clinical studies possessing noteworthy potential. The mode actions, attributed activities phytochemicals plant extracts also described focus on phytosources further therapeutics.

Language: Английский

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Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(8), P. 806 - 806

Published: Aug. 17, 2021

Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by chronic hyperglycaemia, insulin resistance, and inefficient secretion action. Primary care in T2DM pharmacological, using drugs several groups that include sensitisers (e.g., biguanides, thiazolidinediones), secretagogues sulphonylureas, meglinides), alpha-glucosidase inhibitors, newest incretin-based therapies sodium-glucose co-transporter inhibitors. However, their long-term application can cause many harmful side effects, emphasising importance natural therapeutic products. Natural health substances including non-flavonoid polyphenols resveratrol, curcumin, tannins, lignans), flavonoids anthocyanins, epigallocatechin gallate, quercetin, naringin, rutin, kaempferol), plant fruits, vegetables other products garlic, green tea, blackcurrant, rowanberry, bilberry, strawberry, cornelian cherry, olive oil, sesame carrot) may be a safer alternative to primary pharmacological therapy. They are recommended as food supplements prevent and/or ameliorate T2DM-related complications. In advanced stage T2DM, combination therapy synthetic agents compounds with synergistic interactions makes treatment more efficient. this review, both pharmaceutical selected products, well therapies, characterized. Mechanisms action possible negative effects also provided.

Language: Английский

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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111888 - 111888

Published: July 5, 2021

Curcumin, isolated from Curcuma longa L., is a fat-soluble natural compound that can be obtained ginger plant tuber roots, which accumulative evidences have demonstrated it resist viral and microbial infection has anti-tumor, reduction of blood lipid glucose, antioxidant removal free radicals, active against numerous disorders various chronic diseases including cardiovascular, pulmonary, neurological autoimmune diseases. In this article highlighted the recent evidence curcuminoids applied in sevral aspects medical problem particular COVID-19 pandemics. We searched several literature databases MEDLINE (PubMed), EMBASE, Web Science, Cochrane Library, Google Scholar, ClinicalTrials.gov website via using curcumin medicinal properties as keyword. All studies published time when database was established to May 2021 retrieved. This review summarizes growing confirmation for mechanisms related curcumin's physiological pharmacological effects with target proteins interaction molecular docking. The purpose provide deeper insight understandings value discovery development new drugs. Curcumin could used prevention or therapy cardiovascular disease, respiratory diseases, cancer, neurodegeneration, infection, inflammation based on cellular biochemical, regulation, suppression immunomodulation.

Language: Английский

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The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: May 3, 2021

Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology's multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there growing evidence about the effectiveness using herbal supplements in preventing controlling DM. Curcumin a bioactive component found Curcuma longa, which exhibits several physiological pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, anti-diabetic activities. For these reasons, our objective to systematically review effects longa or curcumin on Databases PUBMED EMBASE were searched, final selection included sixteen studies fulfilled inclusion criteria. The results showed curcumin's activity might be due its capacity suppress oxidative stress inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, body mass index. Nanocurcumin also associated with significant reduction triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, plasma malonaldehyde. Therefore, can considered therapeutic approach patients

Language: Английский

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Exudate Absorbing and Antimicrobial Hydrogel Integrated with Multifunctional Curcumin-Loaded Magnesium Polyphenol Network for Facilitating Burn Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22355 - 22370

Published: Nov. 6, 2023

Burns are among the most common causes of trauma worldwide. Reducing healing time deep burn wounds has always been a major challenge. Traditional dressings not only require lengthy medical procedure but also cause unbearable pain and secondary damage to patients. In this study, we developed an exudate-absorbing antimicrobial hydrogel with curcumin-loaded magnesium polyphenol network (Cur-Mg@PP) promote wound healing. That was composed ε-poly-l-lysine (ε-PLL)/polymer poly(γ-glutamic acid) (γ-PGA) (PP) (Cur-Mg). Because strong water absorption property ε-PLL γ-PGA, Cur-Mg@PP powder can quickly absorb exudate transform into moist viscous hydrogel, thus releasing payloads such as ion (Mg2+) curcumin (Cur). The released Mg2+ Cur demonstrated good therapeutic efficacy on analgesic, antioxidant, anti-inflammation, angiogenesis, tissue regeneration. Our findings provide strategy for accelerating

Language: Английский

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Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Cytokine, Journal Year: 2023, Volume and Issue: 164, P. 156144 - 156144

Published: Feb. 15, 2023

Language: Английский

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Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives

Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1227 - 1227

Published: Sept. 2, 2022

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with increased prevalence and incidence. In addition to its macrovascular damage, through microvascular complications, such as Diabetic Kidney Disease (DKD), DM further compounds quality life these patients. Considering DKD main cause end-stage renal disease (ESRD) in developed countries, extensive research currently investigating matrix pathophysiology. Hyperglycemia, inflammation oxidative stress (OS) are mechanisms behind this disease. By generating pro-inflammatory factors (e.g., IL-1,6,18, TNF-α, TGF-β, NF-κB, MCP-1, VCAM-1, ICAM-1) activation diverse pathways PKC, ROCK, AGE/RAGE, JAK-STAT), they promote a pro-oxidant state impairment antioxidant system (NRF2/KEAP1/ARE pathway) and, finally, alterations filtration unit. Hitherto, wide spectrum pre-clinical clinical studies shows beneficial use NRF2-inducing strategies, NRF2 activators Bardoxolone methyl, Curcumin, Sulforaphane their analogues), other natural properties treatment. However, limitations regarding lack larger trials, solubility or delivery hamper implementation for use. Therefore, review, we will discuss mechanisms, especially NRF2/KEAP1/ARE involvement, while highlighting potential therapeutic approaches that target via OS.

Language: Английский

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Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms

Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 3996 - 3996

Published: May 10, 2023

Type II diabetes mellitus and its related complications are growing public health problems. Many natural products present in our diet, including polyphenols, can be used treating managing type different diseases, owing to their numerous biological properties. Anthocyanins, flavonols, stilbenes, curcuminoids, hesperidin, hesperetin, naringenin, phenolic acids common polyphenols found blueberries, chokeberries, sea-buckthorn, mulberries, turmeric, citrus fruits, cereals. These compounds exhibit antidiabetic effects through pathways. Accordingly, this review presents an overview of the most recent developments using food for mellitus, along with various mechanisms. In addition, work summarizes literature about anti-diabetic effect evaluates potential as complementary or alternative medicines treat mellitus. Results obtained from survey show that anthocyanins, manage by protecting pancreatic β-cells against glucose toxicity, promoting β-cell proliferation, reducing apoptosis, inhibiting α-glucosidases α-amylase. these antioxidant anti-inflammatory activities, modulate carbohydrate lipid metabolism, optimize oxidative stress, reduce insulin resistance, stimulate pancreas secrete insulin. They also activate signaling inhibit digestive enzymes, regulate intestinal microbiota, improve adipose tissue absorption, formation advanced glycation end products. However, insufficient data available on effective mechanisms necessary diabetes.

Language: Английский

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