Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1845 - 1845

Published: Feb. 15, 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical medicinal sections to promote human health prevent cure different diseases. The most common found nature anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, other sub-classes. impacts of plant phenolics on promoting diseases curing preventing antioxidant effects, antibacterial impacts, cardioprotective anticancer immune system promoting, anti-inflammatory skin protective effects from UV radiation. This work aims provide an overview phenolic as important sources medical application according recently published studies, well some interesting directions future research. keyword searches flavonoids, phenolics, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, secoiridoids were performed by using Web Science, Scopus, Google scholar, PubMed. acids contain a carboxylic acid group addition the basic structure mainly divided into hydroxybenzoic hydroxycinnamic acids. Hydroxybenzoic based C6-C1 skeleton often bound small organic acids, glycosyl moieties, or cell structural components. Common include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, salicylic Hydroxycinnamic C6-C3 also molecules such quinic glucose. main caffeic, p-coumaric, ferulic, sinapic

Language: Английский

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Drug repurposing for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 18, 2024

Abstract Cancer, a complex and multifactorial disease, presents significant challenge to global health. Despite advances in surgical, radiotherapeutic immunological approaches, which have improved cancer treatment outcomes, drug therapy continues serve as key therapeutic strategy. However, the clinical efficacy of is often constrained by resistance severe toxic side effects, thus there remains critical need develop novel therapeutics. One promising strategy that has received widespread attention recent years repurposing: identification new applications for existing, clinically approved drugs. Drug repurposing possesses several inherent advantages context since repurposed drugs are typically cost-effective, proven be safe, can significantly expedite development process due their already established safety profiles. In light this, present review offers comprehensive overview various methods employed repurposing, specifically focusing on treat cancer. We describe antitumor properties candidate drugs, discuss detail how they target both hallmarks tumor cells surrounding microenvironment. addition, we examine innovative integrating with nanotechnology enhance topical delivery. also emphasize role play when used part combination regimen. To conclude, outline challenges associated consider future prospects these transitioning into application.

Language: Английский

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The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 95 - 95

Published: Dec. 21, 2022

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation the immune system. This involves imbalance between pro-inflammatory versus anti-inflammatory mediators. These mediators include various cytokines and chemokines; defined subsets T helper/T regulatory cells, M1/M2 macrophages, activating/tolerogenic dendritic antibody-producing/regulatory B cells. Despite availability many anti-inflammatory/immunomodulatory drugs, severe adverse reactions associated with their long-term use often high costs impediments in effectively controlling disease process. Accordingly, suitable alternatives being sought for these conventional drugs. Natural products offer promising adjuncts/alternatives this regard. The specific compounds isolated from dietary/medicinal plant extracts have permitted rigorous studies on disease-modulating activities mechanisms involved therein. Here, we describe basic characteristics, action, preventive/therapeutic applications 5 well-characterized natural product (Resveratrol, Curcumin, Boswellic acids, Epigallocatechin-3-gallate, Triptolide). been tested extensively animal models autoimmunity as well limited clinical trials patients having corresponding diseases. We focused our description predominantly cell-mediated such rheumatoid arthritis, multiple sclerosis, Type 1 diabetes, ulcerative colitis, psoriasis.

Language: Английский

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Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 229 - 229

Published: Jan. 10, 2023

Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve solubility bioavailability potentialize its health effects. This review investigated different CUR-based nanomedicines inflammatory immunomodulated diseases. PUBMED, EMBASE, COCHRANE, GOOGLE SCHOLAR databases were searched, Scale for Assessment Narrative Review Articles (SANRA) was used quality assessment PRISMA guidelines. Overall, 66 studies included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, COVID-19. The available scientific show there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, liposomes. These formulations CUR effectively adjuvants several immune-mediated atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, COVID-19, anti-fibrotic fibrotic disease.

Language: Английский

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Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges

Cancer Letters, Journal Year: 2023, Volume and Issue: 570, P. 216332 - 216332

Published: Aug. 1, 2023

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 21

Published: July 4, 2022

Cardiovascular diseases (CVDs) are the world's leading killers, accounting for 30% deaths. According to WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 deaths from CVD in 2030. The death rates rise as get older. Regarding gender, rate of women by (51%) is higher than that men (42%). To decrease prevent CVD, most rely on traditional medicine originating plant (phytochemicals) addition or preference commercially available drugs recover their illness. therapy efficacy 92 plants, including 15 terrestrial examined. Some medicinal plants well known treat are,

Language: Английский

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Curcumin and Weight Loss: Does It Work?

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 639 - 639

Published: Jan. 7, 2022

Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there tendency to use natural compounds for the management of obesity. There considerable body knowledge, supported by rigorous experimental data, that polyphenols, including curcumin, can be an effective safer alternative managing Curcumin important compound present in Curcuma longa L. rhizome. It lipophilic molecule rapidly permeates cell membrane. has been used as pharmacological traditional medicinal agent Ayurvedic medicine ∼6000 years. This plant metabolite doubtless effectiveness reported through increasingly detailed vitro, vivo clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing even treatment attributes have remarkably highlighted. review documents status research on mechanisms evaluates curcumin summarizes different action, associated with enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota anti-inflammatory potential curcumin. However, still need systematic targeted studies before mainstream therapy

Language: Английский

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Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 18, 2023

Due to oral nano-delivery systems for the treatment of inflammatory bowel disease (IBD) are often failed accumulated colonic site and could not achieve controlled drug release, it's urgent develop a microenvironment responsive delivery improve therapy efficacy. Inflammation at IBD is mainly mediated by macrophages, which key effector cells. Excessive inflammation leads oxidative stress intestinal mucosal damage. The use curcumin (CUR) emodin (EMO) together promising due their respective anti-inflammatory repair effects. In view pH gradient environment gastrointestinal tract, here we prepared pH-responsive sodium alginate (SA) hydrogel-coated nanoemulsions co-deliver CUR EMO (CUR/EMO NE@SA) release specifically target macrophages colon.In this study, CUR/EMO NE@SA was successfully developed, in NE loaded chitosan further crosslinked with alginate. had property colon. preparation significantly alleviate colon decreasing TNF-α IL-6 expression, increasing IL-10 scavenging reactive oxygen species ameliorating restoration tight junction protein expression. Furthermore, revealed molecular mechanism treatment, might synergic inhibition NF-κB pro-inflammatory microenvironment. Our study provides new strategy via synergically inhibiting inflammatory, repairing clearing ROS pH-sensitive hydrogel-encapsulated nanoemulsion system, be developed other chronic treatment.It's suggested that nanoemulsion-based codelivery combinatorial platform IBD.

Language: Английский

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