Estrogenic flavonoids and their molecular mechanisms of action DOI Creative Commons
Ryoiti Kiyama

The Journal of Nutritional Biochemistry, Journal Year: 2022, Volume and Issue: 114, P. 109250 - 109250

Published: Dec. 9, 2022

Flavonoids are a major group of phytoestrogens associated with physiological effects, and ecological social impacts. Although the estrogenic activity flavonoids was reported by researchers in fields medical, environmental food studies, their molecular mechanisms action have not been comprehensively reviewed. The respective classes flavonoids, anthocyanidins/anthocyanins, 2-arylbenzofurans/3-arylcoumarins/α-methyldeoxybenzoins, aurones/chalcones/dihydrochalcones, coumaronochromones, coumestans, flavans/flavan-3-ols/flavan-4-ols, flavanones/dihydroflavonols, flavones/flavonols, homoisoflavonoids, isoflavans, isoflavanones, isoflavenes, isoflavones, neoflavonoids, oligoflavonoids, pterocarpans/pterocarpenes, rotenone/rotenoids, summarized through comprehensive literature search, structure-activity relationship, biological activities, signaling pathways, applications were discussed. contained at least one chemical mimicking estrogen, varied, such as those estrogenic, anti-estrogenic, non-estrogenic, biphasic additional activities crosstalk/bypassing, which exert cell pathways. Such mechanistic variations estrogen limited to observed among other broad categories chemicals, thus this chemicals can be termed "estrogenome". This review article focuses on connection mainly between outer inner environments, represent activities/signaling respectively, form basis understand applications. will markedly progress due emerging technologies, artificial intelligence for precision medicine, is also true study estrogenome including flavonoids.

Language: Английский

Dietary Phenolic Compounds: Their Health Benefits and Association with the Gut Microbiota DOI Creative Commons

Yoko Matsumura,

Masahiro Kitabatake,

Shin-ichi Kayano

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 880 - 880

Published: April 4, 2023

Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while antioxidants in foods may prevent a number of diseases delay aging by exerting their effects vivo. Phenolic compounds are phytochemicals flavonoids which consist flavonols, flavones, flavanonols, flavanones, anthocyanidins, isoflavones, lignans, stilbenoids, curcuminoids, phenolic acids, tannins. They have hydroxyl groups molecular structures. These present most plants, abundant nature, contribute to the bitterness color foods. Dietary compounds, quercetin onions sesamin sesame, exhibit antioxidant activity help cell diseases. In addition, other kinds tannins, larger weights, many unexplained aspects still exist. The activities be beneficial for human health. On hand, metabolism intestinal bacteria changes structures these with properties, resulting metabolites exert recent years, it has become possible analyze composition microbiota. augmentation microbiota intake been implicated disease prevention symptom recovery. Furthermore, "brain-gut axis", is communication system between gut microbiome brain, attracting increasing attention, research revealed that dietary affect brain homeostasis. this review, we discuss usefulness against some biotransformation microbiota, microflora, on brain-gut axis.

Language: Английский

Citations

62
Lachnospiraceae are emerging industrial biocatalysts and biotherapeutics DOI Creative Commons
Tom Zaplana, Solange Miele, Andrew C. Tolonen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 4, 2024

The

Language: Английский

Citations

29
From Gut to Hormones: Unraveling the Role of Gut Microbiota in (Phyto)Estrogen Modulation in Health and Disease DOI

Nikki Kumari,

Rashmi Kumari,

Ankita Dua

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(6)

Published: Feb. 11, 2024

Abstract The human gut microbiota regulates estrogen metabolism through the “estrobolome,” collection of bacterial genes that encode enzymes like β‐glucuronidases and β‐glucosidases. These deconjugate reactivate estrogen, influencing circulating levels. estrobolome mediates enterohepatic circulation bioavailability estrogen. Alterations in composition function have been associated with estrogen‐related diseases breast cancer, enometrial polycystic ovarian syndrome (PCOS). This is likely due to dysregulated signaling partly contributed by microbial impacts on metabolism. Dietary phytoestrogens also undergo into active metabolites equol, which binds receptors exhibits higher estrogenic potency than its precursor daidzein. However, ability produce equol varies across populations, depending presence specific microbes. Characterizing equol‐producing populations can provide microbiome‐based biomarkers. Further research needed investigate components estrobolome, phytoestrogen‐microbiota interactions, mechanisms linking dysbiosis pathology. current evidence suggests an integral regulator status clinical relevance women's health hormonal disorders.

Language: Английский

Citations

21
Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum DOI Creative Commons
Miaomiao Li, Xue Han, Lijun Sun

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 25, 2024

Background Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence IBD driven complex interactions multiple factors. objective this study was to evaluate therapeutic effects IAA in colitis.

Language: Английский

Citations

17
Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals DOI Creative Commons
Laura M. Beaver, Paige Jamieson, Carmen P. Wong

et al.

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100376 - 100376

Published: Jan. 1, 2025

Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.

Language: Английский

Citations

3
Phytochemicals as modifiers of gut microbial communities DOI
Giulia Dingeo, Alex Brito, Hanen Samouda

et al.

Food & Function, Journal Year: 2020, Volume and Issue: 11(10), P. 8444 - 8471

Published: Jan. 1, 2020

Phytochemicals effect micribiota via prebiotic effects, antimicrobial properties, tight junction influences, quorum-communication-quenching, among others, influencing host health.

Language: Английский

Citations

121
A Guide to Diet-Microbiome Study Design DOI Creative Commons
Abigail Johnson,

Jack Jingyuan Zheng,

Jea Woo Kang

et al.

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: June 12, 2020

Intense recent interest in understanding how the human gut microbiome influences health has kindled a concomitant linking dietary choices to variation. Diet is known be driver of variation, and yet precise mechanisms by which certain components modulate microbiome, produces byproducts secondary metabolites from components, are not well understood. Interestingly, despite strong influence diet on majority studies published date contain little or no analysis intake. Although an increasing number now collecting some form data even performing interventions, there clear standards field for collect design diet-microbiome study. In this paper, we review current practices study make several recommendations best provoke broader discussion field. Based literature, recommend that include multiple consecutive samples per timepoint phase days history prior each sample whenever feasible. We find evidence direct effects likely observable within days, while length intervention required observing microbiome-mediated host phenotype biomarkers, depending outcome, may much longer, order weeks months. Finally, demonstrating interactions personalized suggest should either longitudinal sampling individuals identify responses, adequate participants spanning range types generalized responses.

Language: Английский

Citations

115
Gut microbes and health DOI Creative Commons

Julia Álvarez,

José Manuel Fernández‐Real, Francisco Guarner

et al.

Gastroenterología y Hepatología (English Edition), Journal Year: 2021, Volume and Issue: 44(7), P. 519 - 535

Published: May 26, 2021

The human body is populated by myriads of microorganisms throughout its surface and in the cavities connected to outside. microbial colonisers intestine (microbiota) are a functional non-expendable part organism: they provide genes (microbiome) additional functions resources our species participate multiple physiological processes (somatic development, nutrition, immunity, etc.). Some chronic non-communicable diseases developed society (atopias, metabolic syndrome, inflammatory diseases, cancer some behaviour disorders) associated with dysbiosis: loss richness intestinal microbiota deviation from ancestral environment. Changes vertical transmission microbiome, use antiseptics antibiotics, dietary habits industrialised appear be at origin dysbiosis. Generating maintaining diversity new clinical target for health promotion disease prevention. El cuerpo humano está poblado por miríadas de microorganismos en toda su superficie y las cavidades conectadas con el exterior. Los colonizadores microbianos del intestino son parte funcional no prescindible organismo humano: aportan (microbioma) funciones adicionales los recursos nuestra especie participan múltiples procesos fisiológicos (desarrollo somático, nutrición, inmunidad, Algunas enfermedades crónicas transmisibles la sociedad desarrollada síndrome metabólico, inflamatorias, cáncer algunos trastornos conducta) se asocian disbiosis: pérdida riqueza especies desviación entorno microbiano ancestral. cambios transmisión microbioma, uso antisépticos antibióticos, hábitos dietéticos industrializada parecen estar origen disbiosis. Generar mantener diversidad es un nuevo objetivo clínico para promoción salud prevención enfermedades.

Citations

83
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos DOI Creative Commons
Hiroshi Tsugawa, Amit Rai, Kazuki Saito

et al.

Natural Product Reports, Journal Year: 2021, Volume and Issue: 38(10), P. 1729 - 1759

Published: Jan. 1, 2021

Plants and their associated microbial communities are known to produce millions of metabolites, a majority which still not characterized will be illuminated by the advance metabolomics informatics techniques.

Language: Английский

Citations

78
Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes? DOI Creative Commons
Carlos E. Iglesias‐Aguirre, Adrián Cortés‐Martín, María Ángeles Ávila‐Gálvez

et al.

Food & Function, Journal Year: 2021, Volume and Issue: 12(21), P. 10324 - 10355

Published: Jan. 1, 2021

The final drivers for the health effects of (poly)phenol consumption have not been fully identified. Specific associations between and circulating-excreted metabolites and(or) gut microbial ecologies do prove a causal role.

Language: Английский

Citations

76