Diet, microbiome, and probiotics establish a crucial link in vaccine efficacy DOI Creative Commons
Soumam Dutta, Niloy Chatterjee, Nicholas L. F. Gallina

et al.

Critical Reviews in Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 20, 2025

Vaccination plays a critical role in public health by reducing the incidence and prevalence of infectious diseases. The efficacy vaccine has numerous determinants, which include age, sex, genetics, environment, geographic location, nutritional status, maternal antibodies, prior exposure to pathogens. However, little is known about gut microbiome how it can be targeted through dietary interventions improve immunological responses. Unveiling this link imperative, particularly post-pandemic world, considering impaired COVID-19 response observed dysbiotic individuals. Therefore, article aims comprehensively review diet probiotics modulate composition, linked efficacy. Dietary fiber polyphenolic compounds derived from plant-based foods microbial diversity promoting growth short-chain fatty acids-producing microbes. On other hand, animal-based have mixed effects – whey protein fish oil promote eubiosis In contrast, lard red meat adverse effects. Studies further indicate that probiotic supplements exert varied effects, mostly strain dosage-specific. Interlinking diet, microbiome, probiotics, vaccines will reveal opportunities for newer research on diet-induced microbiome-manipulated precision vaccination strategies against

Language: Английский

Dietary Phenolic Compounds—Wellbeing and Perspective Applications DOI Open Access
Dasha Mihaylova, Maria Dimitrova-Dimova, Aneta Popova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4769 - 4769

Published: April 27, 2024

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits plant-based nutrition are undeniable and research on topic rising. Modern man now aware possibilities that plant can provide seeking ways benefit from it. Dietary phenolic compounds among easily accessible beneficial substances exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well cardio-and neuroprotective activities. Several industries exploring incorporate biologically active their produce. This review concentrated presenting current information about dietary contribution maintaining good health. Additionally, this content will demonstrate importance prosperity natural for fields, i.e., food industry, cosmetology, biotechnology, others.

Language: Английский

Citations

13
A review on the composition, extraction and applications of phenolic compounds DOI
Great Iruoghene Edo, Susan Chinedu Nwachukwu,

Ali B.M. Ali

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

12
Phytochemical analysis and enhanced production of alkaloids in non-dormant corm-derived callus of Gloriosa superba (L.) using plant growth regulators and abiotic elicitors DOI
Dexter Achu Mosoh, Ashok Kumar Khandel, Sandeep Kumar Verma

et al.

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2024, Volume and Issue: 156(3)

Published: Feb. 28, 2024

Language: Английский

Citations

9
Antimicrobial Activity of Probiotic Bacteria Isolated from Plants: A Review DOI Creative Commons
Anshul Sharma, Hae‐Jeung Lee

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 495 - 495

Published: Feb. 4, 2025

Lactic acid bacteria (LAB) constitute a heterogeneous group of isolated from fermented foods, animals, plants, and mammalian guts, with many health-promoting properties. Probiotics antagonistic properties against human pathogens foodborne have garnered significant attention the scientific fraternity. A dedicated review focusing on plant-derived probiotic their has not been comprehensively reviewed. Thus, this aimed at providing an overview LAB isolates derived several unconventional sources such as fruits, seeds, fruit pulp, leaves, roots, vegetables, grasses, flowers antibacterial, antifungal, antiviral This paper reviewed antimicrobial different genera, Lactobacillus, Leuconostoc, Weissella, Enterococcus, Pediococcus, Bacillus, Fructobacillus, postbiotics, paraprobiotics. Several important mechanisms, including secretion bacteriocins, bacteriocin-like substances, reuterin, organic acids (lactic acetic), peptides, exopolysaccharides, hydrogen peroxide, attributed to actions pathogens. However, precise mode action is poorly understood; hence, further research should be conducted reveal detailed mechanisms. Finally, discusses summary future implications. Given significance, compounds can potentially exploited in food preservation safety or for medicinal applications after evaluating safety.

Language: Английский

Citations

1
Investigation of the nutritional quality of raw and processed Canadian faba bean (Vicia faba L.) flours in comparison to pea and soy using a human in vitro gastrointestinal digestion model DOI
Delphine Martineau-Côté, Allaoua Achouri, Mélanie Pitre

et al.

Food Research International, Journal Year: 2023, Volume and Issue: 173, P. 113264 - 113264

Published: July 11, 2023

Language: Английский

Citations

18
Dietary (Poly)phenols and Cognitive Decline: A Systematic Review and Meta‐Analysis of Observational Studies DOI Creative Commons
Justyna Godos, Agnieszka Micek, Pedro Mena

et al.

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 68(1)

Published: Oct. 27, 2023

Scope This study aims to systematically review observational studies investigating the relation between dietary (poly)phenol consumption and various cognitive outcomes. Methods results Embase PubMed databases are searched from inception April 2023 for intake For quantitative analyses, random effects models, subgroup dose–response analyses performed. A total of 37 included in systematic review. Among (poly)phenols, a higher flavonoids is associated with better function lower odds decline (although some exceptions). meta‐analysis shows an overall inverse association impairment reduced incidence dementia or related disorders (relative risk (RR) = 0.83, 95% confidence interval (CI): 0.76, 0.89), anthocyanins (RR 0.73, CI: 0.60, flavones 0.77, 0.63, 0.94), flavan‐3‐ols 0.86, 0.82, 0.91), flavonols 0.88, 0.80, 0.96). Data on other (poly)phenolic compounds (i.e., phenolic acids) promising but too preliminary. Conclusion Habitual inclusion diet may play preventive role against disorders.

Language: Английский

Citations

16
Exploring the bioaccessibility of polyphenols and glucosinolates from Brassicaceae microgreens by combining metabolomics profiling and computational chemometrics DOI
Pascual García-Pérez, Merve Tomaş, Araceli Rivera-Pérez

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 452, P. 139565 - 139565

Published: May 6, 2024

Language: Английский

Citations

6
Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats DOI Creative Commons
Azzurra Stefanucci,

Lorenza Marinaccio,

Eulogio J. Llorent‐Martínez

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 57, P. 103539 - 103539

Published: Dec. 26, 2023

Benign prostatic hyperplasia (BPH) and cancer are aging-associated urological conditions in men. While significant advances have been made relation to treatment, poor response, treatment resistance adverse side-effects limit currently available therapies. The possible antiproliferative and/or ameliorative potentials of Juglans regia reported, however, there is a dearth scientific information on its effect BPH or cancer. In this study, in-vivo in-vitro studies were used assess the benefits fresh walnut fruits extract prostate High-performance liquid chromatography coupled with electro spray ionization quadrupole-time-of-flight mass spectrometry (HPLC-ESI-Q-TOF) was chemical profile plant extract. anti-proliferative activity tested against normal cancerous human cell line by using iCELLigence real-time label-free analysis system. potential assessed administering at 50 100 mg/kg body weight rats testosterone induced BPH. Analysis phytochemicals revealed high concentration phenolic acids flavonoids, also showing time- dose-dependent cells, reversed biochemical histomorphological changes testosterone-induced

Language: Английский

Citations

13
The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports DOI Open Access
Ana C. Gonçalves, S. Sofia M. Rodrigues,

Rafael Rodrigues

et al.

Published: April 8, 2024

Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental compo-nents. Globally, in 2019, 18 million people had RA. RA characterised by persistent inflammation of the synovial membrane that lines joints, cartilage loss, bone erosion. Phenolic molecules are most prevalent secondary metabolites plants, diverse spectrum biological ac-tions benefit functional meals nutraceuticals. These compounds have received lot at-tention recently because they antioxidant, anti-inflammatory, immunomodulatory, anti-rheumatoid activity modulating tumour necrosis factor, mitogen-activated protein kinase, nu-clear factor kappa-light-chain-enhancer activated B cells, c-Jun N-terminal kinases, as well other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, innovative delivery technologies for treatment RA, focus on possible activities. Nonetheless, commercialization polyphenols may be achievable only after confirming safety profile completing successful clinical trials.

Language: Английский

Citations

5
Biochemical and Molecular Insights into Variation in Sesame Seed Antioxidant Capability as Revealed by Metabolomics and Transcriptomics Analysis DOI Creative Commons
Senouwa Segla Koffi Dossou,

Zishu Luo,

Qianchun Deng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 514 - 514

Published: April 25, 2024

Sesame seeds are important resources for relieving oxidation stress-related diseases. Although a significant variation in seeds’ antioxidant capability is observed, the underlying biochemical and molecular basis remains elusive. Thus, this study aimed to reveal major seed components key mechanisms that drive variability of activity (AOA) using panel 400 sesame accessions. The AOA, total flavonoid, phenolic contents varied from 2.03 78.5%, 0.072 3.104 mg CAE/g, 2.717 21.98 GAE/g, respectively. Analyses revealed flavonoids acids main contributors AOA variation, irrespective coat color. LC-MS-based polyphenol profiling high (HA) low (LA) uncovered 320 differentially accumulated compounds (DAPs), including 311 up-regulated HA seeds. Tricin, persicoside, 5,7,4′,5′-tetrahydro-3′,6-dimethoxyflavone, 8-methoxyapigenin, 6,7,8-tetrahydroxy-5-methoxyflavone were top five HA. Comparative transcriptome analysis at three developmental stages identified 627~2357 DEGs unveiled differential regulation flavonoid biosynthesis, phenylpropanoid stilbene biosynthesis capacity variation. Major regulated structural genes transcription factors identified. SINPZ0000571 (MYB), SINPZ0401118 (NAC), SINPZ0500871 (C3H) most highly induced TFs Our findings may enhance quality breeding.

Language: Английский

Citations

5