Mutual Two-Way Interactions of Curcumin and Gut Microbiota

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 1055 - 1055

Published: Feb. 5, 2020

Curcumin, an herbal naturally occurring polyphenol, has recently been proposed for the treatment of neurodegenerative, neurological and cancer diseases due to its pleiotropic effect. Recent studies indicated that dysbiosis is associated with abovementioned other diseases, gut microflora may be a new potential therapeutic target. The working hypothesis could explain curative role curcumin, despite limited availability, curcumin acts indirectly on brain, affecting “gut–brain–microflora axis”, complex two-way system in which microbiome composition, are factors preserve determine brain health. It therefore suspected metabolites have direct regulatory effect vice versa, paradox between curcumin’s poor bioavailability commonly reported effects. Curcumin can health benefits by eliminating intestinal dysbiosis. In addition, undergoes enzymatic modifications bacteria, forming pharmacologically more active than their parent, curcumin. this review, we summarize number highlight interaction microbiota consider possibility microbiome-targeted therapies using particularly disease entities currently without causal treatment.

Language: Английский

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Curcumin nanoformulations to combat aging-related diseases

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 69, P. 101364 - 101364

Published: May 14, 2021

Language: Английский

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Curcumin and Its Potential Impact on Microbiota

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 2004 - 2004

Published: June 10, 2021

Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which led doubts about its effectiveness. antioxidant anti-inflammatory effects, demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities curcumin are limited by solubility, bioavailability, pharmacokinetic profile. The bidirectional interactions between gut microbiota play key roles understanding ambiguity biological activity curcumin, including wider impact.

Language: Английский

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Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: updating the status of clinical evidence

Food & Function, Journal Year: 2021, Volume and Issue: 12(24), P. 12235 - 12249

Published: Jan. 1, 2021

The mechanism of action curcumin targets diverse markers both oxidative stress and inflammation to mitigate metabolic syndromes such as obesity, T2D, NAFLD, or even dyslipidemia. Arrow pointing up: Increase; down: decrease.

Language: Английский

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Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 164, P. 113091 - 113091

Published: May 6, 2022

Language: Английский

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