Nutrients,
Journal Year:
2023,
Volume and Issue:
15(8), P. 1853 - 1853
Published: April 12, 2023
Declines
in
physical
performance
and
cognition
are
commonly
observed
older
adults.
The
geroscience
paradigm
posits
that
a
set
of
processes
pathways
shared
among
age-associated
conditions
may
also
serve
as
molecular
explanation
for
the
complex
pathophysiology
frailty,
sarcopenia,
cognitive
decline.
Mitochondrial
dysfunction,
inflammation,
metabolic
alterations,
declines
cellular
stemness,
altered
intracellular
signaling
have
been
muscle
aging.
Neurological
factors
included
determinants
sarcopenia.
Neuromuscular
junctions
(NMJs)
synapses
bridging
nervous
skeletal
systems
with
relevant
role
age-related
musculoskeletal
derangement.
Patterns
circulating
neurotrophic
associated
frailty
These
mostly
related
to
disarrangements
protein-to-energy
conversion
well
reduced
calorie
protein
intake
sustain
mass.
A
link
between
sarcopenia
decline
adults
has
described
possible
muscle-derived
mediators
(i.e.,
myokines)
mediating
muscle–brain
crosstalk.
Herein,
we
discuss
main
mechanisms
involved
axis
their
implication
An
overview
current
behavioral
strategies
allegedly
act
on
is
provided.
Seminars in Immunology,
Journal Year:
2023,
Volume and Issue:
69, P. 101802 - 101802
Published: July 7, 2023
The
multifaceted
microbiota
characterizing
our
gut
plays
a
crucial
role
in
maintaining
immune,
metabolic
and
tissue
homeostasis
of
the
intestine
as
well
distal
organs,
including
central
nervous
system.
Microbial
dysbiosis
is
reported
several
inflammatory
intestinal
diseases
characterized
by
impairment
epithelial
vascular
barriers,
defined
leaky
gut,
it
potential
danger
condition
associated
with
development
metabolic,
neurodegenerative
diseases.
Recently,
we
pointed
out
strict
connection
between
brain
via
novel
axis.
Here
want
to
deepen
knowledge
on
gut-brain
axis,
particular
emphasis
microbial
dysbiosis,
cerebral
firm
association
axis
will
be
summarized
context
protection,
amelioration
or
boosting
Alzheimer,
Parkinson,
Major
depressive
Anxiety
disorders.
Understanding
relationship
disease
pathophysiology,
mucosal
barrier
function
host-microbe
interaction
foster
use
microbiome
biomarker
for
health
target
therapeutic
nutritional
advances.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(15), P. 8417 - 8417
Published: July 29, 2022
Brain-derived
neurotrophic
factor
(BDNF)
is
the
most
abundant
neurotrophin
in
adult
brain
and
functions
as
both
a
primary
signal
neuromodulator.
It
serves
essential
roles
neuronal
development,
maintenance,
transmission,
plasticity,
thereby
influencing
aging,
cognition,
behavior.
Accumulating
evidence
associates
reduced
central
peripheral
BDNF
levels
with
various
neuropsychiatric
disorders,
supporting
its
potential
utilization
biomarker
of
pathologies.
Subsequently,
extensive
research
has
been
conducted
to
evaluate
restoring,
or
otherwise
augmenting,
transmission
therapeutic
approach.
Promising
results
were
indeed
observed
for
genetic
upregulation
exogenous
administration
using
multitude
murine
models
neurological
psychiatric
diseases.
However,
varying
mechanisms
have
proposed
underlie
effects,
many
findings
indicate
engagement
disease-specific
other
non-specific
mechanisms.
This
because
essentially
affects
all
aspects
cellular
function
through
tropomyosin
receptor
kinase
B
(TrkB)
signaling,
disruptions
which
vary
between
regions
across
different
pathologies
leading
diversified
consequences
on
cognition
Herein,
we
review
neurophysiology
signaling
classify
converging
diverging
molecular
underlying
potentials
disorders.
These
include
neuroprotection,
synaptic
immunomodulation,
plasticity
facilitation,
secondary
neuromodulation,
preservation
neurovascular
unit
integrity
viability.
Lastly,
discuss
several
suggesting
common
mediator
actions
centrally
acting
pharmacological
agents
used
treatment
illness.
Inflammopharmacology,
Journal Year:
2023,
Volume and Issue:
32(2), P. 1421 - 1437
Published: Aug. 4, 2023
Abstract
Parkinson’s
disease
(PD)
is
the
second
most
common
progressive
age-related
neurodegenerative
disorder.
Paramount
evidence
shed
light
on
role
of
PI3K/AKT
signaling
activation
in
treatment
disorders.
can
be
activated
via
cAMP-dependent
pathways
achieved
by
phosphodiesterase
4
(PDE4)
inhibition.
Roflumilast
a
well-known
PDE4
inhibitor
that
currently
used
chronic
obstructive
pulmonary
disease.
Furthermore,
roflumilast
has
been
proposed
as
favorable
candidate
for
neurological
The
current
study
aimed
to
unravel
neuroprotective
rotenone
model
PD
rats.
Ninety
male
rats
were
allocated
into
six
groups
follows:
control,
(1.5
mg/kg/48
h,
s.c.),
L-dopa
(22.5
mg/kg,
p.o),
and
(0.2,
0.4
or
0.8
p.o).
All
treatments
administrated
21
days
1
h
after
injection.
Rats
treated
with
showed
an
improvement
motor
activity
coordination
well
preservation
dopaminergic
neurons
striatum.
Moreover,
increased
cAMP
level
axis
stimulation
CREB/BDNF/TrkB
SIRT1/PTP1B/IGF1
cascades.
also
caused
upsurge
mTOR
Nrf2,
halted
GSK-3β
NF-ĸB,
suppressed
FoxO1
caspase-3.
Our
revealed
exerted
effects
rotenone-induced
neurotoxicity
These
mediated
crosstalk
between
which
activates
trajectory.
Therefore,
inhibition
likely
offer
reliable
persuasive
avenue
curing
activation.
Graphical
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5123 - 5123
Published: May 8, 2024
Adult
neurogenesis
in
the
dentate
gyrus
(DG)
is
impaired
during
Alzheimer's
disease
(AD)
progression.
Curcumin
has
been
reported
to
reduce
cell
apoptosis
and
stimulate
neurogenesis.
This
study
aimed
investigate
influence
of
curcumin
on
adult
AD
mice
its
potential
mechanism.
Two-month-old
male
C57BL/6J
were
injected
with
soluble
β-amyloid
(Aβ1-42)
using
lateral
ventricle
stereolocalization
establish
models.
An
immunofluorescence
assay,
including
bromodeoxyuridine
(BrdU),
doublecortin
(DCX),
neuron-specific
nuclear
antigen
(NeuN),
was
used
detect
hippocampal
Western
blot
an
enzyme-linked
immunosorbent
assay
(ELISA)
test
expression
related
proteins
secretion
brain-derived
neurotrophic
factor
(BDNF).
A
Morris
water
maze
cognitive
function
mice.
Our
results
showed
that
administration
(100
mg/kg)
rescued
Aβ1-42
mice,
shown
as
enhanced
BrdU+/DCX+
BrdU+/NeuN+
cells
DG.
In
addition,
regulated
phosphatidylinositol
3
kinase
(PI3K)/protein
B
(Akt)
-mediated
glycogen
synthase
kinase-3β
(GSK3β)
/Wingless/Integrated
(Wnt)/β-catenin
pathway
cyclic
adenosine
monophosphate
response
element-binding
protein
(CREB)/BDNF
Inhibiting
Wnt/β-catenin
depriving
BDNF
could
reverse
both
upregulated
curcumin-treated
conclusion,
our
indicates
curcumin,
through
targeting
PI3K/Akt,
regulates
GSK3β/Wnt/β-catenin
CREB/BDNF
pathways,
improving
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 7, 2025
Following
prolonged
exposure
to
hypoxic
conditions,
for
example,
due
ascent
high
altitude,
aging
or
stroke,
cognitive
deficits
can
develop.
The
exact
nature
and
genesis
of
hypoxia-induced
remain
unresolved.
Curcumin
has
been
reported
stimulate
neurogenesis
reduce
neuronal
degeneration.
This
study
aimed
investigate
the
effect
curcumin
on
in
hypoxic-brain
injury
mice
its
potential
mechanism.
Eight-week-old
male
C57BL/6J
were
normobaric-hypoxia
(13%O2)
14
days
establish
models.
Morris
water
maze
novel
object
recognition
used
detect
function
each
mouse.
Immunofluorescence
assays,
including
Fluoro-Jade
C
(FJC)
bromodeoxyuridine
(BrdU),
degeneration
neurogenesis.
Thy1-YFP
transgenic
synapse
plasticity.
Our
results
showed
that
administration
rescued
impaired
cognition
mice,
shown
as
enhanced
BrdU+
dendritic
spine
hippocampus.
At
molecular
level,
was
found
promote
expression
brain-derived
neurotrophic
factor
(BDNF)
postsynaptic
density
protein
95
(PSD95).
primary
hippocampal
neuron
detection
could
growth.
In
conclusion,
our
indicates
curcumin,
increased
BDNF
PSD95
contacted
with
interneurons,
salvaged
interneurons
may
normalize
ambient
neuroplasticity,
resulting
preservation
processes
well
contributing
improve
performance.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 12, 2022
Low
back
pain
is
a
major
cause
of
disability
worldwide
that
declines
the
quality
life;
it
poses
substantial
economic
burden
for
patient
and
society.
Intervertebral
disc
(IVD)
degeneration
(IDD)
main
low
pain,
also
pathological
basis
several
spinal
degenerative
diseases,
such
as
intervertebral
herniation
stenosis.
The
current
clinical
drug
treatment
IDD
focuses
on
symptoms
not
their
pathogenesis,
which
results
in
frequent
recurrence
gradual
aggravation.
Moreover,
side
effects
associated
with
long-term
use
these
drugs
further
limit
use.
mechanism
complex,
oxidative
stress
inflammation
play
an
important
role
promoting
IDD.
They
induce
destruction
extracellular
matrix
IVD
reduce
number
living
cells
functional
cells,
thereby
destroying
function
occurrence
development
Phytochemicals
from
fruits,
vegetables,
grains,
other
herbs
protective
they
have
anti-inflammatory
antioxidant
properties.
This
article
reviews
phytochemicals
regulatory
different
molecular
pathways
related
to
pathogenesis
therapeutic
limitations
future
prospects
been
reviewed.
are
promising
candidates
research
treatment.
