Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9577 - 9577

Published: May 31, 2023

The human gut microbiome contains the largest number of bacteria in body and has potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, diverse overall health. When becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, ageing, this profound effect on our health linked many diseases, including metabolic inflammatory neurological diseases. While humans largely association dysbiosis with disease, animal models, causative can be demonstrated. brain particularly important maintaining health, strong neurodegenerative neurodevelopmental This suggests that microbiota composition used make early diagnosis diseases modifying microbiome-gut-brain axis might present therapeutic target for have proved intractable, aim altering trajectory such as Alzheimer's Parkinson's multiple sclerosis, autism spectrum disorder, attention-deficit hyperactivity among others. other potentially reversible migraine, post-operative cognitive dysfunction, long COVID, which considered models therapy disease. role traditional methods microbiome, well newer, more novel treatments faecal transplants photobiomodulation, are discussed.

Language: Английский

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Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 331 - 331

Published: March 8, 2024

Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, lipid-lowering effects, in addition thermogenic capacity. While intake dietary sources such as curry may be sufficient affect intestinal microbiome thus act indirectly, intact curcumin body too low (<1 microM) not signaling gene expression, observed vitro with cultured cells (10–20 microM). Several strategies can envisioned increase levels body, decreasing metabolism or absorption through formation nanoparticles. However, since high could also lead undesired regulatory effects on cellular studies need carefully monitored. Here, we review bioavailability what extent using nanoformulations bioactivity metabolites. This enhancement potentially amplify disease-preventing curcumin, often by leveraging robust antioxidant properties.

Language: Английский

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Curcumin in Metabolic Health and Disease

Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4440 - 4440

Published: Dec. 11, 2021

In recent years, epidemiological studies have suggested that metabolic disorders are nutritionally dependent. A healthy diet is rich in polyphenols may be beneficial the treatment of diseases such as polycystic ovary syndrome, non-alcoholic fatty liver disease, cardiovascular and, particular, atherosclerosis. Curcumin a polyphenol found turmeric and has been reported to antioxidant, anti-inflammatory, hepatoprotective, anti-atherosclerotic, antidiabetic properties, among others. This review summarizes influence supplementation with curcumin on parameters selected disorders.

Language: Английский

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Curcumin and Weight Loss: Does It Work?

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 639 - 639

Published: Jan. 7, 2022

Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there tendency to use natural compounds for the management of obesity. There considerable body knowledge, supported by rigorous experimental data, that polyphenols, including curcumin, can be an effective safer alternative managing Curcumin important compound present in Curcuma longa L. rhizome. It lipophilic molecule rapidly permeates cell membrane. has been used as pharmacological traditional medicinal agent Ayurvedic medicine ∼6000 years. This plant metabolite doubtless effectiveness reported through increasingly detailed vitro, vivo clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing even treatment attributes have remarkably highlighted. review documents status research on mechanisms evaluates curcumin summarizes different action, associated with enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota anti-inflammatory potential curcumin. However, still need systematic targeted studies before mainstream therapy

Language: Английский

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Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

Biocell, Journal Year: 2023, Volume and Issue: 47(11), P. 2547 - 2566

Published: Jan. 1, 2023

Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with multitude of factors linked to Inflammatory Bowel Disease (IBD). These encompass cytokines, oxidative stress-associated enzymes, modulation the intestinal microbiota. Notably, curcumin demonstrated therapeutic potential colitis, wherein it exerts negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, β-catenin. Moreover, inhibits expression pro-inflammatory enzymes co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating characteristic neutrophil infiltration observed IBD. Another facet curcumin's action involves its microbiota itself contributes beneficial biotrans formations curcumin, enhancing effectiveness IBD treatment. On front, ability induce and/or endoscopic remission without any reported toxic effects. Hence, warrants consideration an adjunctive therapy management. Subsequent investigations should concentrate meticulously evaluating impact these precise targets.

Language: Английский

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Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 934 - 934

Published: March 23, 2024

Herbal medicines are used by patients with IBD despite limited evidence. We present a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating treatment herbal in active ulcerative colitis (UC). A search query designed library informationist was to identify potential articles for inclusion. Articles were screened data extracted at least two investigators. Outcomes interest included clinical response, remission, endoscopic safety. identified 28 RCTs 18 herbs. In pooled analyses, when compared placebo, response rates significantly higher Indigo naturalis (IN) (RR 3.70, 95% CI 1.97–6.95), but not Curcuma longa (CL) 1.60, 0.99–2.58) or Andrographis paniculata (AP) 0.95, 0.71–1.26). There rate remission CL 2.58, 1.18–5.63), AP 1.31, 0.86–2.01). Higher 1.56, 1.08–2.26) 19.37, 2.71–138.42) significant CL. has evidence supporting its use as an adjuvant therapy UC. Research larger scale well-designed RCTs, manufacturing regulations, education needed.

Language: Английский

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Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 211, P. 368 - 379

Published: May 14, 2022

Language: Английский

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Development of curcumin incorporated composite films based on chitin and glucan complexes extracted from Agaricus bisporus for active packaging of chicken breast meat

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 221, P. 536 - 546

Published: Sept. 8, 2022

Language: Английский

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Chondroitin sulfate functionalized palmitic acid and cysteine cografted-quaternized chitosan for CD44 and gut microbiota dual-targeted delivery of curcumin

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100617 - 100617

Published: March 25, 2023

Curcumin (CUR) has a regulatory effect on the gut microbiota (GM), and its significant anti-inflammatory properties make it research hotspot for inflammatory bowel disease (IBD) treatment. However, low bioavailability poor pharmacokinetic of CUR limit practical application. Herein, CD44 GM dual-targeted nanoparticles (NPs) loaded with (CUR@Chs-PNC NPs) were derived from quaternized chitosan surface functionalization chondroitin sulfate (Chs). The generated CUR@Chs-PNC NPs had an ideal average particle size (238.9 ​nm), uniform distribution, positive charge (+41.93 ​mV). Strikingly, good sustained-release in simulated gastrointestinal environment exhibited full drug release when colon environment. Moreover, Chs endowed notable CD44-targeted delivery ability thereby enhanced content plasma SD rats. biodistribution vivo indicated that could prolong intestinal residence time, promoting interaction between GM. Most importantly, DSS-induced colitis mouse model, decreased activity index, improved oxidative stress inflammation condition, promoted production short-chain fatty acids (SCFAs), regulated immune cells, maintained microbiome homeostasis. This study demonstrates NPs, which exhibit excellent biocompatibility biodegradability, on-demand property, capacities, have potential further application treatment colitis.

Language: Английский

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Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154986 - 154986

Published: July 21, 2023

Language: Английский

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