Journal of Obstetrics and Gynaecology Research,
Journal Year:
2021,
Volume and Issue:
47(3), P. 1145 - 1152
Published: Jan. 18, 2021
Abstract
Aim
To
evaluate
the
effect
of
a
ketogenic
diet
(KD)
in
women
with
polycystic
ovary
syndrome
(PCOS)
and
liver
dysfunction
who
were
obese.
Methods
Women
PCOS
obese
enrolled
this
prospective,
open‐label,
parallel‐group,
controlled
pilot
trial,
randomly
received
KD
(KD
group)
or
conventional
pharmacological
treatment
(Essentiale
plus
Yasmin,
control
1:1
ratio
for
12
weeks.
The
primary
endpoint
was
function
markers.
Secondary
endpoints
included
menstrual
cycle,
anthropometric
characteristics,
body
composition,
hormonal
levels,
metabolic
biomarkers.
Results
Of
20
eligible
participants
enrolled,
18
completed
study.
group
reported
significant
reduction
characteristics
composition
from
baseline
to
week
(all
p
<
0.05).
In
addition,
there
reductions
plasma
estradiol,
progesterone
levels
two
groups
0.05),
but
no
between‐group
difference
observed.
significantly
reduced
markers
compared
(
signs
fatty
disappeared
six
out
seven
after
weeks
intervention,
while
only
one
10
disappeared.
Conclusions
addition
improving
had
additional
benefits
reducing
blood
glucose
weight,
function,
treating
traditional
Obesity Facts,
Journal Year:
2021,
Volume and Issue:
14(2), P. 222 - 245
Published: Jan. 1, 2021
<b><i>Background:</i></b>
The
very
low-calorie
ketogenic
diet
(VLCKD)
has
been
recently
proposed
as
an
appealing
nutritional
strategy
for
obesity
management.
VLCKD
is
characterized
by
a
low
carbohydrate
content
(<50
g/day),
1–1.5
g
of
protein/kg
ideal
body
weight,
15–30
fat/day,
and
daily
intake
about
500–800
calories.
<b><i>Objectives:</i></b>
aim
the
current
document
to
suggest
common
protocol
summarize
existing
literature
on
its
efficacy
in
weight
management
weight-related
comorbidities,
well
possible
side
effects.
<b><i>Methods:</i></b>
This
prepared
adherence
with
Preferred
Reporting
Items
Systematic
Review
Meta-Analyses
(PRISMA)
guidelines.
Literature
searches,
study
selection,
methodology
development,
quality
appraisal
were
performed
independently
2
authors
data
collated
means
meta-analysis
narrative
synthesis.
<b><i>Results:</i></b>
Of
645
articles
retrieved,
15
studies
met
inclusion
criteria
reviewed,
revealing
4
main
findings.
First,
was
shown
result
significant
loss
short,
intermediate,
long
terms
improvement
composition
parameters
glycemic
lipid
profiles.
Second,
when
compared
other
interventions
same
duration,
showed
major
effect
reduction
fat
mass,
waist
circumference,
total
cholesterol
triglyceridemia
improved
insulin
resistance.
Third,
although
also
resulted
glycemia,
HbA1c,
LDL
cholesterol,
these
changes
similar
those
obtained
interventions.
Finally,
can
be
considered
safe
approach
under
health
professional’s
supervision
since
most
effects
are
usually
clinically
mild
easily
manage
recovery
often
spontaneous.
<b><i>Conclusions:</i></b>
recommended
effective
dietary
treatment
individuals
after
considering
potential
contra-indications
keeping
mind
that
any
personalized.
<b><i>Prospero
Registry:</i></b>
assessment
composition,
overweight
obese
subjects:
(CRD42020205189).
Obesity Reviews,
Journal Year:
2020,
Volume and Issue:
21(8)
Published: March 24, 2020
Summary
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
major
cause
of
chronic
disease,
characterized
by
hepatic
fat
accumulation
and
possible
development
inflammation,
fibrosis,
cancer.
The
ketogenic
diet
(KD),
with
its
drastic
carbohydrate
reduction,
now
popular
weight
loss
intervention,
despite
safety
concerns
on
association
liver.
However,
KDs
were
also
reported
to
be
beneficial
pathology,
ketone
bodies
recently
proposed
as
effective
modulators
inflammation
fibrosis.
If
the
impact
NAFLD
established,
less
known
effect
macronutrient
distribution
such
outcome.
In
hypocaloric
regimen,
latter
seems
not
crucial,
whereas
at
higher
calorie
intake,
ratio
and,
theoretically,
ketosis,
may
become
important.
could
positively
for
their
very
low
content,
whether
ketosis
plays
an
additional
role
unknown.
Indeed,
several
mechanisms
directly
link
improvement,
elucidating
these
aspects
would
pave
way
new
therapeutic
strategies.
We
herein
aimed
providing
accurate
revision
current
literature
NAFLD,
focusing
clinical
evidence,
metabolic
pathways
involved,
strict
categorization
dietary
interventions.
Metabolic Syndrome and Related Disorders,
Journal Year:
2021,
Volume and Issue:
20(2), P. 94 - 103
Published: Dec. 17, 2021
Background:
The
objective
of
this
open-label
pilot
study
was
to
investigate
the
efficacy
a
very-low-carbohydrate
ketogenic
diet
(VLCKD),
known
as
Nic's
Ketogenic
Diet,
for
140
days
on
cardiometabolic
markers
in
healthy
adults
with
mildly
elevated
low-density
lipoprotein
cholesterol
(LDL-C).
Methods:
Study
assessments
were
conducted
at
Day
0,
28,
56,
70,
84,
112,
and
140,
weight
blood
pressure
(BP)
measured
fasting
collected
analysis
plasma
lipids.
A
DEXA
scan
performed
body
mass
index
recorded
140.
Blood
glucose,
inflammatory,
thyroid
0
Compliance
assessed
using
weekly
3-day
food
records
daily
glucose
ketone
monitoring.
Results:
results
showed
that
fat
percentage
decreased
by
2.25%
4.41%
70
respectively
(P
≤
0.012).
Significant
reductions
android,
gynoid,
android/gynoid
ratio
increases
muscle
occurred
Total
cholesterol,
LDL-C,
high-density
increased
systolic
BP
glycated
hemoglobin
(HbA1c)
<
0.05).
Following
VLCKD
found
be
safe
well
tolerated.
Conclusion:
beneficial
changes
composition
eutrophic
overweight
participants
140-day
suggesting
future
role
populations
cardiovascular
disease
risk.
Future
research
larger
sample
size
randomized
double
blind
clinical
trial
is
warranted
confirm
these
results.
Clinical
Trial
Registration
number:
NCT04195594.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(5), P. 1654 - 1654
Published: May 13, 2021
Considering
the
lack
of
a
comprehensive,
multi-faceted
overview
ketogenic
diet
(KD)
in
relation
to
health
issues,
we
compiled
evidence
related
use
its
impact
on
microbiome,
epigenome,
diabetes,
weight
loss,
cardiovascular
health,
and
cancer.
The
KD
could
potentially
increase
genetic
diversity
microbiome
ratio
Bacteroidetes
Firmicutes.
epigenome
might
be
positively
affected
by
since
it
creates
signaling
molecule
known
as
β-hydroxybutyrate
(BHB).
has
helped
patients
with
diabetes
reduce
their
HbA1c
need
for
insulin.
There
is
suggest
that
can
help
visceral
adiposity,
appetite
control.
also
suggests
eating
high-fat
improves
lipid
profiles
lowering
low-density
lipoprotein
(LDL),
increasing
high-density
(HDL),
triglycerides
(TG).
Due
Warburg
effect,
used
an
adjuvant
treatment
starve
cancer
cells,
making
them
more
vulnerable
chemotherapy
radiation.
potential
positive
impacts
each
these
areas
warrant
further
analysis,
improved
studies,
well-designed
randomized
controlled
trials
illuminate
therapeutic
possibilities
provided
this
dietary
intervention.
AJP Endocrinology and Metabolism,
Journal Year:
2022,
Volume and Issue:
324(1), P. E24 - E41
Published: Nov. 16, 2022
The
prevalence
of
obesity
has
increased
dramatically
during
the
past
decades,
which
been
a
major
health
problem.
Since
1975,
number
people
with
worldwide
nearly
tripled.
An
increasing
studies
find
as
driver
chronic
kidney
disease
(CKD)
progression,
and
mechanisms
are
complex
include
hemodynamic
changes,
inflammation,
oxidative
stress,
activation
renin-angiotensin-aldosterone
system
(RAAS).
Obesity-related
is
characterized
by
glomerulomegaly,
often
accompanied
localized
segmental
glomerulosclerosis
lesions.
In
these
patients,
early
symptoms
atypical,
microproteinuria
being
main
clinical
manifestation
nephrotic
syndrome
rare.
Weight
loss
RAAS
blockers
have
protective
effect
on
obesity-related
CKD,
but
even
so,
significant
proportion
patients
eventually
progress
to
end-stage
renal
despite
treatment.
Thus,
it
critical
comprehend
underlying
CKD
create
new
tactics
for
slowing
or
stopping
progression.
this
review,
we
summarize
current
knowledge
disease,
its
pathological
future
perspectives
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(18), P. 3809 - 3809
Published: Sept. 15, 2022
Foods
high
in
carbohydrates
are
an
important
part
of
a
healthy
diet,
since
they
provide
the
body
with
glucose
to
support
bodily
functions
and
physical
activity.
However,
abusive
consumption
refined,
simple,
low-quality
has
direct
implication
on
mental
pathophysiology.
Then,
carbohydrate
is
postulated
as
crucial
factor
development
main
Western
diseases
21st
century.
We
conducted
this
narrative
critical
review
using
MedLine
(Pubmed),
Cochrane
(Wiley),
Embase,
CinAhl
databases
MeSH-compliant
keywords:
evolution,
development,
phylogenetic,
GUT,
microbiota,
stress,
metabolic
health,
behaviors,
disease,
cardiovascular
anxiety,
depression,
cancer,
chronic
kidney
failure,
allergies,
asthma
order
analyze
impact
health.
Evidence
suggests
that
carbohydrates,
especially
fiber,
beneficial
for
well-being
growth
gut
microorganisms
consequently
host
symbiotic
relationship,
producing
microbial
alterations
negative
effect
health
different
organic
systems.
In
addition,
evidence
simple
refined
mood
categories,
including
alertness
tiredness,
reinforcing
vicious
circle.
Regarding
sugar
intake
can
affect
prognosis
uncontrolled
puts
individuals
at
risk
developing
syndrome
subsequently
disease.
Food and Agricultural Immunology,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 16, 2025
The
Very
Low-Energy
Ketogenic
Therapy
(VLEKT)
is
a
structured,
multi-phase
dietary
regimen
characterized
by
carbohydrate
intake
of
less
than
50
g/day
and
daily
caloric
fewer
800
kcal,
which
induces
ketosis
facilitates
significant
weight
loss.
Evidence
suggests
that
this
nutritional
therapy
can
improve
glycemic
control,
lipid
profiles,
blood
pressure,
making
it
promising
option
for
managing
type
2
diabetes
(T2D)
reducing
cardiovascular
risk.
These
benefits
are
achieved
through
reductions
in
triglycerides
low-density
lipoprotein
cholesterol
(LDL-c),
alongside
increases
high-density
(HDL-c).
However,
the
effects
VLEKT
on
metabolism
remain
controversial.
review
emphasizes
urgent
need
further
research
to
validate
long-term
safety
efficacy
VLEKT.
It
also
highlights
critical
role
personalized
plans,
supervised
healthcare
professionals,
optimize
health
outcomes
address
individual
patient
needs.
The Journal of Clinical Endocrinology & Metabolism,
Journal Year:
2020,
Volume and Issue:
105(9), P. 2939 - 2949
Published: June 2, 2020
Abstract
Context
We
compared
the
efficacy,
safety,
and
effect
of
45-day
isocaloric
very-low-calorie
ketogenic
diets
(VLCKDs)
incorporating
whey,
vegetable,
or
animal
protein
on
microbiota
in
patients
with
obesity
insulin
resistance
to
test
hypothesis
that
source
may
modulate
response
VLCKD
interventions.
Subjects
Methods
Forty-eight
(19
males
29
females,
homeostatic
model
assessment
(HOMA)
index
≥
2.5,
aged
56.2
±
6.1
years,
body
mass
[BMI]
35.9
4.1
kg/m2)
were
randomly
assigned
three
regimens
(≤800
kcal/day)
containing
plant,
protein.
Anthropometric
indexes;
blood
urine
chemistry,
including
parameters
kidney,
liver,
glucose,
lipid
metabolism;
composition;
muscle
strength;
taxonomic
composition
gut
microbiome
assessed.
Adverse
events
also
recorded.
Results
Body
weight,
BMI,
pressure,
waist
circumference,
HOMA
index,
insulin,
total
low-density
lipoprotein
cholesterol
decreased
all
patients.
Patients
who
consumed
whey
had
a
more
pronounced
improvement
strength.
The
markers
renal
function
worsened
slightly
group.
A
decrease
relative
abundance
Firmicutes
an
increase
Bacteroidetes
observed
after
consumption
VLCKDs.
This
pattern
was
less
consuming
Conclusions
VLCKDs
led
significant
weight
loss
striking
metabolic
over
period.
based
vegetable
have
safer
profile
result
healthier
than
those
proteins.
are
effective
maintaining
performance.
Obesity Reviews,
Journal Year:
2020,
Volume and Issue:
21(10)
Published: July 10, 2020
Summary
First
identified
as
a
feasible
treatment
for
intractable
epilepsy,
the
ketogenic
diet
(KD)
has
recently
gained
popularity
thanks
to
growing
evidence
on
applications
such
weight
loss,
most
importantly,
but
also
NAFLD,
cancer,
neurologic
conditions
and
chronic
pain.
As
with
any
treatment,
whether
pharmacologic
or
not,
KD
might
not
be
an
appropriate
intervention
every
individual,
number
of
contraindications
have
been
proposed,
now
deeply
rooted
into
clinical
practice,
excluding
de
facto
many
patients
that
could
benefit
from
its
use.
However,
these
concerns
were
expressed
due
absence
studies
conducted
fragile
populations,
assessment
lately
emerged
relative
safety
is
currently
lacking
much
needed.
We
herein
provide
critical
revision
literature
behind
each
alert,
in
order
guide
through
options
case
subjects
indication
borderline
safe
situation.
Based
available
evidence,
possible
use
this
therapeutic
should
assessed
patient‐to‐patient
basis
by
adequately
skilled
medical
doctors,
keeping
mind
current
recommendations,
reading
them
knowledge
state
art.