Published: July 22, 2022
se "reinventar" para atender ao novo cenário.
ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.
Language: Английский
Citations
29
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 17
Published: March 12, 2022
Psoriasis is defined as chronic, immune-mediated disease. Regardless of the development new therapeutic approaches, precise etiology psoriasis remains unknown and speculative. The aim this review was to systematize results previous research on role oxidative stress aberrant immune response in pathogenesis psoriasis, well impact certain modalities status patients with psoriasis. Complex pathways both innate adaptive systems appear be major pathomechanisms Oxidative represents another important contributor pathophysiology disease, redox imbalance has been reported skin cells and, systemically, plasma blood cells, more recently, also saliva. Current model begins activation system susceptible person by some environmental factor loss tolerance autoantigens. Increased production IL-17 appears most prominent pathogenesis, while IL-23 recognized master regulator having a specific cross bridging acquired immunity. Other proinflammatory cytokines, including IFN-γ, TNF-α, IL-1β, IL-6, IL-22, IL-26, IL-29, or IL-36, have play roles can promote inflammation through several signaling pathways. noticeable powerful antioxidative effects exert various biologics compared convenient modalities, such methotrexate phototherapy. complex interaction redox, immune, inflammatory should focused further researches tackling supplementation could solution refractory cases
Language: Английский
Citations
52
Journal of Functional Foods, Journal Year: 2022, Volume and Issue: 98, P. 105276 - 105276
Published: Oct. 7, 2022
Grape pomace is the main solid residue of wine industry, mainly composed seeds, skins and stalks, all containing high amounts valuable phytochemicals. Considering its potential, in this review, an outlook on different resources products, which can be obtained by recovery grape provided. Special attention has been devoted to analysis chemical, physical biotechnological processes applied also value compounds such as supplements, nutraceuticals cosmeceuticals, that manufactured. In particular, first part update composition provided along with traditional fate. second part, more modern green approaches tested sustainable management are reported discussed.
Language: Английский
Citations
45
Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 591 - 591
Published: Jan. 18, 2022
Psoriasis is a common, chronic systemic inflammatory disease affecting 125 million people worldwide. It associated with several important conditions, including psoriatic arthritis, cardiometabolic syndrome, and depression, leading to significant reduction in patients’ quality of life. Current treatments only reduce symptoms, not cure. This review discusses the mechanisms involved initiation development disease, role oxidative stress this autoimmune as well potential therapeutic options substances natural origin. The main aim study intended offer literature present plants phytochemicals that can represent remedies fight against psoriasis. We identified many vitro, vivo, clinical trials studies evaluated relationship between chosen immune system response course sought find articles about efficacy natural-derived drugs controlling symptoms their ability maintain long-term inactivity without side effects, result our work review, which highlights effectiveness plant-derived burden on patients by decreasing conditions.
Language: Английский
Citations
39
Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(2), P. 997 - 1014
Published: Jan. 11, 2023
Psoriasis is an autoimmune skin disease that generally affects 1%-3% of the total population globally. Effective treatment psoriasis limited because numerous factors, such as ineffective drug delivery and efficacy following conventional pharmaceutical treatments. Nanofibers are widely being used nanocarriers for effective their multifunctional distinctive properties, including a greater surface area, higher volume ratio, increased elasticity improved stiffness resistance to traction, favorable biodegradability, high permeability, sufficient oxygen supply, which help maintain moisture content improve bioavailability drugs. Similar extracellular matrix, nanofibers have regeneration capacity, promoting cell growth, adhesion, proliferation, also more controlled release pattern compared with other therapies at psoriatic site. To ensure targeting better antipsoriatic efficacy, this study formulated evaluated tazarotene (TZT)-calcipotriol (CPT)-loaded nanofiber carbopol-based hydrogel film. The was prepared using electrospinning polyvinyl alcohol/polyvinylpyrrolidone (PVA/PVP) K-90 polymeric blend later incorporated into carbopol base form films. were biochemically
Language: Английский
Citations
33
Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 840 - 840
Published: Feb. 7, 2023
Psoriasis is an inflammatory disease with strong genetic links and numerous features of autoimmunity that are also influenced by environment lifestyle, including nutritional factors physical activity (PA), regards to the condition patients. Recent reports in field nutrigenomics indicate a significant impact nutrients modulating microRNAs. However, few studies have evaluated effect systems PA on treating psoriasis. This narrative review updates information regarding current dietary recommendations for individuals psoriasis discusses role diet prevention treatment. Application nutrigenetics therapy discussed. The PubMed Google Scholar databases were searched using MeSH terms “nutrigenomics”, “dietetics”, “diet therapy”, “diet”, “physical activity”, “exercise” conjunction “psoriasis” “dermatology”. Evidence has shown patients should personalized anti-inflammatory diet. less physically active; most performed exercises low-to-moderate intensity likely undertake regular exercise. Identifying nutrigenomic discoveries lifestyle interventions associated can help physicians therapists develop educational programs manage protect against disease.
Language: Английский
Citations
27
Nutrients, Journal Year: 2021, Volume and Issue: 14(1), P. 119 - 119
Published: Dec. 28, 2021
Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities persons with A change eating habits can improve quality life patients by relieving lesions reducing risk other diseases. low-energy diet recommended for excess body weight. Persons suffering from psoriasis should limit intake saturated fatty acids replace them polyunsaturated omega-3 family, which have an anti-inflammatory effect. In therapy psoriasis, introduction antioxidants such as vitamin A, C, E, carotenoids, flavonoids, selenium extremely important. Vitamin D supplementation also recommended. Some authors suggest that alternative diets positive effect on course These include: gluten-free vegetarian Mediterranean diet. Diet be tailored to pharmacological treatment. For instance, folic acid introduced taking methotrexate. The purpose this paper discuss detail nutritional recommendations
Language: Английский
Citations
43
Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 337 - 337
Published: Feb. 18, 2024
. Psoriasis is a chronic inflammatory skin disease and the result of interaction between numerous external internal factors. presents wide range manifestations encompassing individual lesions varying from pinpoint to large plaques that can evolve into generalised forms. The mirror pathophysiological mechanisms involved in psoriasis pathogenesis, such as inflammation, dysregulation immune response, uncontrolled proliferation keratinocytes angiogenesis. In this article, we present latest advances achieved regarding markers correlate with severity.
Language: Английский
Citations
6
Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3972 - 3972
Published: Nov. 7, 2021
The physiological markers of autoimmune diabetes include functional disorders the antioxidative system as well progressing inflammation and presence autoantibodies. Even though people with type 1 show genetic predispositions facilitating onset disease, it is believed that dietary factors can stimulate initiation progression disease. This paper analyses possibility using tea an element diet therapy in treatment diabetes. Based on information available literature covering last 10 years, impact regular consumption or supplements containing polyphenols oxidative status inflammatory response organism was analyzed. Studies conducted laboratory animals, human patients, vitro revealed positive effects isolated therefrom diabetic body. Few reports pertain to organisms affected by most (over 85%) have focused cases 2 It has been concluded introducing into diet, possible alleviate some consequences stress inflammation, thus limiting their destructive patients’ organisms, consequently improving quality life, regardless Furthermore, elimination should reduce incidence immune response. One consider more widespread promotion individuals genetically predisposed diabetes, especially considering drink’s low price, easy availability, overall benefits health, above all, fact be safely used over extended periods time, patient’s age.
Language: Английский
Citations
32
Clinical Nutrition, Journal Year: 2025, Volume and Issue: 47, P. 68 - 82
Published: Feb. 15, 2025
Language: Английский
Citations
0