Molecules,
Journal Year:
2021,
Volume and Issue:
26(23), P. 7084 - 7084
Published: Nov. 23, 2021
Selenium
(Se),
a
microelement
essential
for
life,
is
critical
homeostasis
of
several
functions,
such
as
those
related
to
immune–endocrine
function
and
signaling
transduction
pathways.
In
particular,
Se
the
thyroid,
it
particularly
abundant
in
this
gland.
Unfortunately,
deficiency
very
common
condition
worldwide.
Supplementation
possible,
but
has
narrow
safety
level,
toxic
levels
are
close
normally
required
correct
need.
Thus,
whether
obtaining
optimal
selenium
concentration
desirable,
risk
dangerous
concentrations
must
be
equally
excluded.
This
review
addressed
contribution
by
environment
food
intake
on
circulating
(e.g.,
geographical
factors,
soil
climate,
different
quantities
food,
nuts,
cereals,
eggs,
meat
fish)
effects
its
or
excess,
together
with
role
selenoproteins
thyroid
pathophysiology
Hashimoto’s
thyroiditis
Graves’
disease).
Nutrients,
Journal Year:
2020,
Volume and Issue:
12(8), P. 2358 - 2358
Published: Aug. 7, 2020
The
novel
coronavirus
infection
(COVID-19)
conveys
a
serious
threat
globally
to
health
and
economy
because
of
lack
vaccines
specific
treatments.
A
common
factor
for
conditions
that
predispose
progress
is
low-grade
inflammation,
e.g.,
as
seen
in
metabolic
syndrome,
diabetes,
heart
failure,
which
micronutrient
deficiencies
may
contribute.
aim
the
present
article
was
explore
usefulness
early
intervention,
with
focus
on
zinc,
selenium,
vitamin
D,
relieve
escalation
COVID-19.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(22), P. 5346 - 5346
Published: Nov. 16, 2020
Low
levels
of
micronutrients
have
been
associated
with
adverse
clinical
outcomes
during
viral
infections.
Therefore,
to
maximize
the
nutritional
defense
against
infections,
a
daily
allowance
vitamins
and
trace
elements
for
malnourished
patients
at
risk
or
diagnosed
coronavirus
disease
2019
(COVID-19)
may
be
beneficial.
Recent
studies
on
COVID-19
shown
that
vitamin
D
selenium
deficiencies
are
evident
in
acute
respiratory
tract
Vitamin
improves
physical
barrier
viruses
stimulates
production
antimicrobial
peptides.
It
prevent
cytokine
storms
by
decreasing
inflammatory
cytokines.
Selenium
enhances
function
cytotoxic
effector
cells.
Furthermore,
is
important
maintaining
T
cell
maturation
functions,
as
well
cell-dependent
antibody
production.
C
considered
an
antiviral
agent
it
increases
immunity.
Administration
increased
survival
rate
attenuating
excessive
activation
immune
response.
cytokines
free
radical
formation,
yield.
also
attenuates
responses
hyperactivation
In
this
mini-review,
roles
C,
D,
system
discussed
relation
COVID-19.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(2), P. 251 - 251
Published: Jan. 27, 2022
Selenium
is
an
essential
microelement
required
for
a
number
of
biological
functions.
Selenium-and
more
specifically
the
amino
acid
selenocysteine-is
present
in
at
least
25
human
selenoproteins
involved
wide
variety
functions,
ranging
from
regulation
reactive
oxygen
species
(ROS)
concentration
to
biosynthesis
hormones.
These
processes
also
play
central
role
preventing
and
modulating
clinical
outcome
several
diseases,
including
cancer,
diabetes,
Alzheimer's
disease,
mental
disorders,
cardiovascular
fertility
impairments,
inflammation,
infections
(including
SARS-CoV-2).
Over
past
years,
studies
focusing
on
relationship
between
selenium
such
pathologies
have
been
reported.
Generally,
adequate
nutritional
state-and
some
cases
supplementation-have
related
improved
prognostic
reduced
risk
developing
diseases.
On
other
hand,
supra-nutritional
levels
might
adverse
effects.
The
results
recent
these
topics
are
summarized
discussed
this
review,
with
particular
emphasis
advances
achieved
last
decade.
Nutrients,
Journal Year:
2020,
Volume and Issue:
13(1), P. 54 - 54
Published: Dec. 27, 2020
The
use
of
dietary
supplements
(DSs)
has
been
steadily
increasing
all
over
the
world
and
additionally,
sales
DSs
have
dynamical
increased
in
wake
coronavirus
disease
2019
(COVID-19)
most
countries.
We
investigated
phenomenon
2020
through
(1)
exploration
Google
searches
worldwide
Poland
(with
Trends
(GT)
tool),
(2)
analyses
results
PLifeCOVID-19
Online
Studies
conducted
during
first
second
wave
pandemic.
GT
analysis
cross-sectional
studies
revealed
that
COVID-19
outbreak
March
2020,
interest
immune-related
compounds
foods
like
vitamins
C
D,
zinc,
omega-3,
garlic,
ginger,
or
turmeric,
as
well
their
consumption
increased.
Improving
immunity
was
main
reason
behind
supplementation
changes
pro-healthy
foods.
shown
these
interests
were
positively
correlated
with
COVID-19,
but
adversely
cumulative
cases
deaths.
Respondents
tended
to
start
rather
than
one.
Except
for
role
D
C,
selenium
patients
deficiencies
those
nutrients,
there
are
no
clear
convincing
support
prevention
treatment
healthy,
well-nourished
individuals.
Moreover,
risk
elevated
intake
some
nutrients
due
popularity
exists,
effective
education
consumers
rationale
health-protecting
behaviors
against
should
be
developed.
Redox Biology,
Journal Year:
2020,
Volume and Issue:
37, P. 101715 - 101715
Published: Sept. 10, 2020
Selenium
is
a
trace
element
essential
to
human
health
largely
because
of
its
incorporation
into
selenoproteins
that
have
wide
range
protective
functions.
has
an
ongoing
history
reducing
the
incidence
and
severity
various
viral
infections;
for
example,
German
study
found
selenium
status
be
significantly
higher
in
serum
samples
from
surviving
than
non-surviving
COVID-19
patients.
Furthermore,
significant,
positive,
linear
association
was
between
cure
rate
Chinese
patients
with
regional
status.
Moreover,
continued
rise
beyond
intake
required
optimise
selenoproteins,
suggesting
are
probably
not
whole
story.
Nonetheless,
reduced
expression
number
including
those
involved
controlling
ER
stress,
along
increased
IL-6
SARS-CoV-2
infected
cells
culture
suggests
potential
link
selenoprotein
COVID-19-associated
inflammation.
In
this
comprehensive
review,
we
describe
infections
then
go
on
assess
benefits
adequate
even
supra-nutritional
We
discuss
indispensable
function
coordinating
successful
immune
response
follow
by
reviewing
cytokine
excess,
key
mediator
morbidity
mortality
COVID-19,
relationship
comment
fact
synthetic
redox-active
compound,
ebselen,
been
experimentally
strong
inhibitor
main
protease
enables
maturation
within
host.
That
finding
species
formed
at
high
might
hypothetically
inhibit
proteases.
consider
tactics
could
employ
evade
host
interfering
system.
Recognition
myriad
mechanisms
which
potentially
benefit
provides
rationale
randomised,
controlled
trials
supplementation
infection.
Redox Biology,
Journal Year:
2020,
Volume and Issue:
38, P. 101764 - 101764
Published: Oct. 20, 2020
SARS-CoV-2
infections
cause
the
current
coronavirus
disease
(COVID-19)
pandemic
and
challenge
immune
system
with
ongoing
inflammation.
Several
redox-relevant
micronutrients
are
known
to
contribute
an
adequate
response,
including
essential
trace
elements
zinc
(Zn)
selenium
(Se).
In
this
study,
we
tested
hypothesis
that
COVID-19
patients
characterised
by
Zn
deficiency
status
provides
prognostic
information.
Serum
was
determined
in
serum
samples
(n
=
171)
collected
consecutively
from
surviving
29)
or
non-survivors
6).
Data
European
Prospective
Investigation
into
Cancer
Nutrition
(EPIC)
study
were
used
for
comparison.
concentrations
patient
low
as
compared
healthy
subjects
(mean
±
SD;
717.4
246.2
vs
975.7
294.0
μg/L,
P
<
0.0001).
The
majority
of
at
different
time
points
(25/34,
i.e.,
73.5%)
almost
half
survivors
(56/137,
40.9%)
below
threshold
deficiency,
638.7
μg/L
(the
2.5th
percentile
EPIC
cohort).
view
Se
biomarker
transporter
selenoprotein
(SELENOP)
is
also
particularly
COVID-19,
prevalence
a
combined
deficit,
SELENOP
2.56
mg/L.
This
deficit
observed
0.15%
cohort
subjects,
19.7%
50.0%
non-survivors.
Accordingly,
composite
(SELENOP
age)
proved
reliable
indicator
survival
receiver
operating
characteristic
(ROC)
curve
analysis,
yielding
area
under
(AUC)
94.42%.
We
conclude
within
reference
ranges
indicate
high
odds
assume
correcting
diagnostically
proven
and/or
personalised
supplementation
may
support
convalescence.
