Future Foods,
Journal Year:
2024,
Volume and Issue:
10, P. 100405 - 100405
Published: June 21, 2024
Over
the
last
decades,
consumer
has
evolved
becoming
increasingly
responsible,
showing
a
preference
for
those
foods
having
positive
impact
on
health,
society
and
environment.
In
particular,
consumers
are
an
increasing
interest
in
food
innovation
towards
capable
to
produce
health
benefits,
such
as
enriched
foods,
which
can
be
considered
functional
foods.
As
acceptance
is
crucial
success
of
innovation,
this
study
aims
investigate
consumers'
two
innovative
foods:
extra
virgin
olive
oil
with
longchain
Omega-3
fatty
acids
(EPA
DHA),
lutein-enriched
durum
wheat
pasta.
To
achieve
study's
aim,
choice
experiment
been
realized,
also
detect
WTP.
The
analysis
involved
445
Italian
consumers.
Results
show
that
price
represents
attribute
most
all
able
affect
utility,
followed
by
presence
element.
Furthermore,
shows
WTP
premium
attribute,
both
products
study.
Such
results
highlight
useful
insights
practitioners
outlines
new
perspectives
future
research.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(7), P. 3472 - 3472
Published: March 23, 2022
Although
the
human
lifespan
has
increased
in
past
century
owing
to
advances
medicine
and
lifestyle,
healthspan
not
kept
up
same
pace,
especially
brain
aging.
Consequently,
role
of
preventive
health
interventions
become
a
crucial
strategy,
particular,
identification
nutritional
compounds
that
could
alleviate
deleterious
effects
Among
nutrients
cope
with
aging
special
cognitive
decline,
long-chain
omega-3
polyunsaturated
fatty
acids
(ω-3
LCPUFAs)
docosahexaenoic
acid
(DHA)
eicosapentaenoic
(EPA),
have
emerged
as
very
promising
ones.
Due
their
neuroinflammatory
resolving
effects,
an
status
DHA
EPA
elderly
been
linked
better
function
lower
risk
dementia.
However,
results
from
clinical
studies
do
show
consistent
evidence
intake
recommendations
for
old
adults
are
lacking.
Recently,
supplementation
structured
forms
DHA,
which
can
be
derived
natural
or
targeted
structures,
proven
enhanced
bioavailability
powerful
benefits.
This
review
summarizes
present
future
perspectives
new
structures
ω-3
LCPUFAs
"omic"
technologies
combined
use
high-throughput
vivo
models
shed
light
on
relationships
underlying
mechanisms
between
healthy
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(21), P. 4566 - 4566
Published: Oct. 30, 2022
Sarcopenia
is
a
complex
process
characterized
by
progressive
decrease
in
muscle
mass
and
strength.
Various
nutrients
have
been
shown
to
be
effective
supporting
muscular
performance.
This
randomized
clinical
trial
aimed
evaluate
the
effectiveness
of
2-month
administration
food
for
special
medical
purposes
composed
omega-3
fatty
acids
(500
mg),
leucine
(2.5
g),
probiotic
Lactobacillus
paracasei
PS23
(LPPS23),
on
appendicular
lean
(ALM),
performance,
inflammatory
status,
amino
acid
profile
sarcopenic
patients.
A
total
60
participants
(aged
79.7
±
4.8
years
body
index
22.2
2.1
kg/m2)
were
enrolled
randomly
assigned
either
intervention
(n
=
22)
or
placebo
group
28).
Comparing
differences
effects
between
groups
(intervention
minus
effects),
ALM
increased
significantly
(p
<
0.05),
with
no
discernible
change
group.
Similarly,
significant
also
observed
Tinetti
scale
(+2.39
points,
p
SPPB
score
(+2.22
handgrip
strength
(4.09
kg,
0.05).
Visceral
adipose
tissue
decreased
compared
at
days
−0.69
g
(95%
CI:
−1.09,
0.29)
vs.
0.27
−0.11,
0.65),
difference
−0.96
−1.52,
0.39,
0.001).
statistically
increase
levels
valine,
leucine,
isoleucine,
profiles
was
When
taken
together,
these
beneficial
may
attributed
innovative
composition
this
medical-purpose
which
could
considered
treatment
sarcopenia
elderly.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1300 - 1300
Published: March 6, 2023
A
prospective,
randomized,
single-center
preliminary
study
was
performed
in
patients
with
keratoconus
stages
I–III
(Amsler–Krumeich),
who
received
a
high
rich
docosahexaenoic
acid
(DHA)
(1000
mg/day)
supplement
for
3
months
versus
untreated
patients.
One
eye
per
patient
evaluated.
Thirty-four
were
recruited
(75%
men,
mean
age
31
years),
15
randomized
to
the
control
group
and
19
DHA-treated
group.
Corneal
topography
variables
plasma
biomarkers
of
oxidative
stress
inflammatory
status
panel
fatty
acids
blood
samples
also
assessed.
There
significant
between-group
differences
astigmatism
axis,
asphericity
coefficient,
intraocular
pressure
favor
DHA
Additionally,
total
antioxidant
capacity
(TAC),
malondialdehyde
(MDA),
free
glutathione
(GSH)
GSH/GSSG
ratio,
as
well
reduced
values
markers,
including
interleukin
(IL)-4,
IL-6,
vascular
endothelial
growth
factor
(VEGF-A)
found.
These
findings
support
usefulness
anti-inflammatory
effects
supplementation
targeting
underlying
pathophysiological
mechanisms
keratoconus.
Prolonged
duration
may
be
needed
detect
more
noticeable
clinical
changes
corneal
topography.
Translational Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 29, 2024
Abstract
Omega-3
fatty
acids
have
been
implicated
in
the
aetiology
of
depressive
disorders,
though
trials
supplementing
omega-3
to
prevent
major
disorder
(MDD)
so
far
unsuccessful.
Whether
this
association
is
causal
remains
unclear.
We
used
two
sample
Mendelian
randomization
(MR)
investigate
causality.
Genetic
variants
associated
with
circulating
and
omega-6
UK
Biobank
(UKBB,
n
=
115,078)
were
selected
as
exposures.
The
Psychiatric
Genomics
Consortium
(PGC)
genome-wide
studies
(GWAS)
MDD
(
430,775;
cases
116,209;
controls
314,566)
recurrent
depression
(rMDD,
80,933;
17,451;
62,482),
outcomes.
Multivariable
MR
(MVMR)
models
account
for
biologically
correlated
lipids,
such
high-
low-density
cholesterol
triglycerides,
explore
relative
importance
longer-chain
eicosapentaenoic
acid
(EPA)
docosahexaenoic
(DHA)
using
data
from
Cohorts
Heart
Aging
Research
Genomic
Epidemiology
(CHARGE,
8866).
colocalization
analyses
presence
a
shared
underlying
variant
between
traits.
Genetically
predicted
total
reduced
odds
(OR
IVW
0.96
per
standard
deviation
(SD,
i.e.
0.22
mmol/l)
(95%
CIs
0.93–0.98,
p
0.003)).
largest
point
estimates
observed
(EPA),
long-chain
EPA
0.92;
95%
CI
0.88–0.96;
0.0002).
effect
was
robust
MVMR
accounting
lipids.
‘Leave-one-out’
highlighted
FADS
gene
cluster
key
driver
effect.
Colocalization
suggested
primary
outcome
sample,
but
genomic
confounding
could
not
be
fully
excluded.
This
study
supports
role
acids,
particularly
EPA,
depression,
although
pleiotropic
mechanisms
cannot
ruled
out.
findings
support
guidelines
highlighting
dose
ratio
question
whether
targeted
interventions
may
superior
universal
prevention
trials,
modest
sizes
will
limit
statistical
power.
Future Foods,
Journal Year:
2024,
Volume and Issue:
10, P. 100405 - 100405
Published: June 21, 2024
Over
the
last
decades,
consumer
has
evolved
becoming
increasingly
responsible,
showing
a
preference
for
those
foods
having
positive
impact
on
health,
society
and
environment.
In
particular,
consumers
are
an
increasing
interest
in
food
innovation
towards
capable
to
produce
health
benefits,
such
as
enriched
foods,
which
can
be
considered
functional
foods.
As
acceptance
is
crucial
success
of
innovation,
this
study
aims
investigate
consumers'
two
innovative
foods:
extra
virgin
olive
oil
with
longchain
Omega-3
fatty
acids
(EPA
DHA),
lutein-enriched
durum
wheat
pasta.
To
achieve
study's
aim,
choice
experiment
been
realized,
also
detect
WTP.
The
analysis
involved
445
Italian
consumers.
Results
show
that
price
represents
attribute
most
all
able
affect
utility,
followed
by
presence
element.
Furthermore,
shows
WTP
premium
attribute,
both
products
study.
Such
results
highlight
useful
insights
practitioners
outlines
new
perspectives
future
research.
