The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Language: Английский

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Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease

Annual Review of Nutrition, Journal Year: 2023, Volume and Issue: 43(1), P. 385 - 407

Published: Aug. 21, 2023

As dietary guidance for populations shifts from preventing deficiency disorders to chronic disease risk reduction, the biology supporting such becomes more complex due multifactorial profile of and inherent population heterogeneity in diet–disease relationship. Diet is a primary driver risk, population-based should account individual responses. Cascading effects on evidentiary standards are not straightforward. Precision remains consideration prevent through identification subgroups with unique nutritional needs. Reducing diet requires greater precision ( a) establishing essential nutrient needs throughout life cycle both health disease; b) considering nutrients other food substances metabolic, immunological, inflammatory, physiological responses healthy aging; c) eating behaviors. Herein we provide template guiding recommendations reducing diseases heterogenous populations.

Language: Английский

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Consumers’ acceptance and willingness to pay for enriched foods: Evidence from a choice experiment in Italy

Future Foods, Journal Year: 2024, Volume and Issue: 10, P. 100405 - 100405

Published: June 21, 2024

Over the last decades, consumer has evolved becoming increasingly responsible, showing a preference for those foods having positive impact on health, society and environment. In particular, consumers are an increasing interest in food innovation towards capable to produce health benefits, such as enriched foods, which can be considered functional foods. As acceptance is crucial success of innovation, this study aims investigate consumers' two innovative foods: extra virgin olive oil with longchain Omega-3 fatty acids (EPA DHA), lutein-enriched durum wheat pasta. To achieve study's aim, choice experiment been realized, also detect WTP. The analysis involved 445 Italian consumers. Results show that price represents attribute most all able affect utility, followed by presence element. Furthermore, shows WTP premium attribute, both products study. Such results highlight useful insights practitioners outlines new perspectives future research.

Language: Английский

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A Comparative Study about the Neuroprotective Effects of DHA-Enriched Phosphatidylserine and EPA-Enriched Phosphatidylserine against Oxidative Damage in Primary Hippocampal Neurons

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(7), P. 410 - 410

Published: July 19, 2023

Nerve damage caused by accumulated oxidative stress is one of the characteristics and main mechanisms Alzheimer’s disease (AD). Previous studies have shown that phosphatidylserine (PS) rich in eicosapentaenoic acid (EPA) docosahexaenoic (DHA) plays a significant role preventing mitigating progression AD. However, whether DHA-PS EPA-PS can directly protect primary hippocampal neurons against has not been studied. Here, neuroprotective functions H2O2/t-BHP-induced possible were evaluated neurons. It was found could significantly improve cell morphology promote restoration neural network structure. Further showed both them alleviated stress-mediated mitochondrial dysfunction. inhibited phosphorylation ERK, thus playing an anti-apoptotic role, increased protein expressions p-TrkB p-CREB, role. In addition, EPA-PS, rather than enhance synaptic plasticity increasing expression SYN, reduce levels p-GSK3β p-Tau. These results provide scientific basis for use DHA/EPA-enriched phospholipids treatment neurodegenerative diseases, also reference development related functional foods.

Language: Английский

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Impact of wall materials and DHA sources on the release, digestion and absorption of DHA microcapsules: Advancements, challenges and future directions

Food Research International, Journal Year: 2024, Volume and Issue: 191, P. 114646 - 114646

Published: June 18, 2024

Language: Английский

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Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 9, 2024

Abstract Background Chronic inflammation and metabolic dysfunction are key features of systemic aging, closely associated with the development progression age-related diseases. Bazi Bushen (BZBS), a traditional Chinese medicine used to alleviate frailty, delays biological aging by modulating DNA methylation levels. However, precise mechanism its anti-aging effect remains unclear. In this study, we developed Energy Expenditure Aging Index (EEAI) estimate age. By integrating EEAI transcriptome analysis, aimed explore impact BZBS on dysregulation in naturally mice. Methods We conducted indirect calorimetry analysis five groups mice different ages utilized data construct EEAI. 12 -month-old C57BL/6 J were treated or β-Nicotinamide Mononucleotide (NMN) for 8 months. Micro-CT, Oil Red O staining, calorimetry, RNA sequencing, bioinformatics qRT-PCR performed investigate regulatory effects energy metabolism, glycolipid inflammaging. Results The results revealed that treatment effectively reversed decline expenditure enhanced overall as indicated index derived from metabolism parameters across various ages. Subsequent investigations showed reduced age-induced visceral fat accumulation hepatic lipid droplet aggregation. Transcriptomic perirenal liver pathways, such PPAR signaling pathway, fatty acid oxidation, cholesterol improved glycolysis mitochondrial respiration. Additionally, there was significant improvement inhibiting inflammation-related arachidonic acid-linoleic pathway restraining IL-17 TNF inflammatory pathways activated via senescence secretory phenotype (SASP). Conclusions has potential organs aged maintain homeostasis. This study presents novel clinical therapeutic approaches prevention

Language: Английский

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Nature's Toolbox for Alzheimer's Disease: A Review on the Potential of Natural Products as Alzheimer's Disease Drugs

Neurochemistry International, Journal Year: 2024, Volume and Issue: 176, P. 105738 - 105738

Published: April 12, 2024

Language: Английский

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Functional foods and aging and antiaging: a recipe for longevity

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 161 - 173

Published: Jan. 1, 2025

Language: Английский

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The impact of formulation design on the Oral bioavailability of Omega-3 polyunsaturated fatty acids

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116171 - 116171

Published: March 13, 2025

Omega-3 polyunsaturated fatty acids (n-3 PUFA) are essential dietary supplements with widespread health benefits. However, achieving therapeutic n-3 PUFA levels in systemic circulation represents a significant dosing challenge, complicated by complex interaction between different physiological and chemical factors. Recently, efforts have been directed towards creating "bio-accessible" formulations that overcome this challenge enabling increased oral absorption across the small intestine. impact of varying physiochemical formulation properties on bioavailability remains poorly understood requires further investigation. This review explores design, including self-emulsifying systems, micro- nano-emulsions, chewable gels, microencapsulation, pharmacokinetics, considering both clinical preclinical investigations. Key challenges developing highly bioavailable quantifying their absorption, biodistribution metabolism discussed. Finally, recent progress next-generation formulations, solid lipid nanoparticles nanostructured carriers, targeting through innovative structuring approaches will be addressed. The is ultimately influenced multiple design factors related to each strategy, underscoring need for systematic approach involves comprehensive testing candidate under simulated gastrointestinal conditions.

Language: Английский

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Omega-3 Fatty Acids: Key Players in Cognitive Function and Brain Health

Journal of Education Health and Sport, Journal Year: 2025, Volume and Issue: 77, P. 56776 - 56776

Published: Jan. 3, 2025

Introduction: Omega-3 fatty acids, particularly DHA and EPA, are crucial for brain health. Modern diets, often lacking in omega-3, highlight their importance combating cognitive decline, neurodegenerative diseases, mental disorders. Purpose of research: This study explores the roles omega-3 acids health functions, including mechanisms action potential preventing alleviating diseases. Materials methods: involves a comprehensive review scientific literature on impact functions. The search was conducted using PubMed Google Scholar, focusing peer-reviewed articles, clinical trials, meta-analyses relevant to health, outcomes. Results conclusions: Research shows that EPA supplementation can significantly improve memory learning, especially older individuals those with impairments. Omega-3s also show reducing risk diseases like Alzheimer's through anti-inflammatory antioxidant properties. In omega-3s help reduce symptoms depression schizophrenia, although effectiveness depends dosage ratio. essential Their supplementation, combined cognitively stimulating activities, offers substantial benefits, aging populations. Further research is needed fully understand omega-3s' mechanisms, optimal dosing, use treating neurological

Language: Английский

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