Omega-9 fatty acids: potential roles in inflammation and cancer management

Journal of Genetic Engineering and Biotechnology, Journal Year: 2022, Volume and Issue: 20(1), P. 48 - 48

Published: March 16, 2022

Omega-9 fatty acids represent one of the main mono-unsaturated (MUFA) found in plant and animal sources. They are synthesized endogenously humans, though not fully compensating all body requirements. Consequently, they considered as partially essential acids. MUFA a healthier alternative to saturated fats have several health benefits, including anti-inflammatory anti-cancer characters. This review capitalizes on major omega-9 pharmacological activities context inflammation management for its different natural forms dietary The observed effects reported oleic acid (OA), mead acid, erucic were directed attenuate physiological pathological conditions such wound healing eye by altering production inflammatory mediators, modulating neutrophils infiltration, VEGF effector pathway. OA action mechanisms anti-tumor agent cancer types compiled first time based anti- pro-carcinogenic actions.We conclude that pathways likely explain anti-proliferative activity suppression migration proliferation breast cells, well stimulation tumor suppressor genes. Such warrant further supportive clinical epidemiological studies confirm beneficial outcomes consumption especially over long-term intervention.

Language: Английский

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Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 120, P. 140 - 153

Published: Jan. 4, 2022

Over the last three decades, consumption of total and saturated fat has steadily declined in Western diets as a proportion calories intake. At same time, omega (ω)-6 fatty acid intake risen at expense ω-3 acids, resulting an ω-6/ω-3 ratio 20:1 or higher. The observed changes acids coincide with significantly increased prevalence coronary heart disease, hypertension, cancer, diabetes, obesity, rheumatoid arthritis, autoimmune neurodegenerative disorders. low may be attributed to their absence from diet lack awareness about suitable dietary sources. A sustainable cost-effective way reaching large population essential is fortification staple foods. variety food items enriched have entered market recent years, including beef, fish, dairy products, cereals, cereal bars, infant formula. present review discusses role ω-6 well ratio, on human health. Additionally, it focuses latest developments regarding sources, innovative technologies, challenges acids.

Language: Английский

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Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

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Uses of rosemary (Salvia rosmarinus) extract as natural preservative in peanut oil, African walnut oil and their 60:40 and 50:50 blends during accelerated storage

Food and Humanity, Journal Year: 2025, Volume and Issue: unknown, P. 100507 - 100507

Published: Jan. 1, 2025

Language: Английский

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Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial

BMJ, Journal Year: 2025, Volume and Issue: unknown, P. e080795 - e080795

Published: Feb. 11, 2025

Abstract Objective To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity. Design Multicentre, randomised, parallel group trial. Setting Three tertiary hospitals Shanghai, China. Participants 1000 adult obesity (body mass index ≥28) who were scheduled for endoscopy. Interventions randomly allocated to receive regular or HFNC a procedure propofol and low dose sufentanil. Main outcome measures The primary was (75%≤SpO 2 <90% <60 s) procedure. Secondary outcomes included incidences subclinical respiratory depression (90%≤SpO <95% any duration) severe (SpO <75% duration 75%≤SPO >60 Results From 6 May 2021 26 2023, 984 (mean age 49.2 years; 36.9% (n=363) female) completed study analysed. Compared oxygenation, reduced from 21.2% (103/487) 2.0% (10/497) (difference −19.14, 95% confidence interval −23.09 −15.36; P<0.001), 36.3% (177/487) 5.6% (28/497) −30.71, −35.40 −25.92; 4.1% (20/487) 0% (0/497) −4.11%, −6.26 −2.48; P<0.001). Other sedation related adverse events did not differ between two groups. Conclusions In obesity, via significantly hypoxia, depression, without increasing other events. Trial registration ClinicalTrials.gov NCT04500392 .

Language: Английский

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Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Antioxidants, Journal Year: 2021, Volume and Issue: 10(4), P. 507 - 507

Published: March 24, 2021

Aging and, particularly, the onset of age-related diseases are associated with tissue dysfunction and macromolecular damage, some which can be attributed to accumulation oxidative damage. Recently, growing interest has emerged on beneficial effects plant-based diets for prevention chronic including obesity, diabetes, cardiovascular disease. Several studies collectively suggests that intake polyphenols their major food sources may exert improving insulin resistance related diabetes risk factors, such as inflammation stress. They most abundant antioxidants in diet, been a reduced aging humans. Polyphenolic shown effective at ameliorating several phenotypes, stress, inflammation, impaired proteostasis, cellular senescence, both vitro vivo. In this paper, these phytochemicals (either pure forms or polyphenolic-food) reviewed summarized according affected signaling pathways. Finally, effectiveness anti-aging preventive action nutritional interventions based rich polyphenolic food, Blue zones, discussed.

Language: Английский

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Traditional Fermented Foods and Beverages from around the World and Their Health Benefits

Microorganisms, Journal Year: 2022, Volume and Issue: 10(6), P. 1151 - 1151

Published: June 2, 2022

Traditional fermented foods and beverages play an important role in a range of human diets, several experimental studies have shown their potential positive effects on health. Studies from different continents revealed strong associations between the microorganisms present certain (e.g., agave fructans, kefir, yeats, kombucha, chungkookjang, cheeses vegetables, among others) weight maintenance, reductions risk cardiovascular disease, antidiabetic constipation benefits, improvement glucose lipids levels, stimulation immunological system, anticarcinogenic and, most importantly, reduced mortality. Accordingly, aim this review is to corroborate information reported that comprised interventions involving consumption traditional or association with This work focuses used food 2014 present. In conclusion, could be promotion Further are needed understand mechanisms involved inflammatory, immune, chronic gastrointestinal diseases roles terms preventing managing those diseases.

Language: Английский

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Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4471 - 4471

Published: July 13, 2022

The essential fatty acid alpha-linolenic (ALA) is present in high amounts oils such as flaxseed, soy, hemp, rapeseed, chia, and perilla, while stearidonic abundant echium oil. ALA metabolized to eicosapentaenoic (EPA) docosahexaenoic (DHA) by desaturases elongases humans. conversion of EPA DHA limited, these long-chain n−3 polyunsaturated acids (PUFAs) are mainly provided from dietary sources (fish seafood). This review provides an overview studies that explored the effects supplementation with obesity related diseases. obesity-associated changes desaturase elongase activities summarized, they could influence metabolic ALA. Generally, or ALA-rich leads increase levels has no effect on omega-3 index. According literature data, enhance PUFA obesity. Recent confirm intake should be considered a primary treatment strategy for improving index

Language: Английский

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Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA

Foods, Journal Year: 2022, Volume and Issue: 11(13), P. 1883 - 1883

Published: June 25, 2022

Today's consumers are increasingly aware of the beneficial effects n-3 PUFA in preventing, delaying, and intervening various diseases, such as coronary artery disease, hypertension, diabetes, inflammatory autoimmune disorders, neurodegenerative depression, many other ailments. The role on aging cognitive function is also one hot topics basic research, product development, clinical applications. For decades, PUFA, especially EPA DHA, have been supplied by fish oil seafood. With continuous increase global population, awareness about health benefits socioeconomic improvement worldwide, supply chain facing increasing challenges insufficient production. In this regard, microalgae well considered promising sources to mitigate shortages. use produce PUFA-rich oils has explored for over two decades some species already used commercially particular EPA- and/or DHA-rich oils. addition biomass contains high value biomolecules, which can be food, dietary supplement, pharmaceutical ingredient, feedstock. present review covers EPA, with attention given approaches attempted nutritional interventions using DHA alone or combined nutrients bioactive compounds towards improved conditions people mild impairment Alzheimer's disease. It applications food supplement sectors economic environmental sustainability a platform

Language: Английский

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Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 20

Published: March 27, 2022

The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity complex metabolic disease with multiple pathophysiological clinical conditions comorbidities are associated such diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, inflammation-based conditions. In obese individuals, adipocyte cells increased the expression leptin, angiotensin, adipocytokines, plasminogen activators, C-reactive protein. Currently, options for treatment lifestyle behaviors interventions limited, keeping healthy challenging. Various types phytochemicals have been investigated antiobesity potential. Here, we discuss pathophysiology signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients natural products, therapeutic application obesity.

Language: Английский

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