Impact of interventions on the quality of life of cancer patients: a systematic review and meta-analysis of longitudinal research

Health and Quality of Life Outcomes, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 11, 2023

Abstract The impact of cancer interventions has been conducted in several research due to the significant burden this non-communicable disease. that played an important role improvement patient’s quality life (QoL) and health-related (HRQL) can be classified into two main groups: pharmaceutical non-pharmacological methods. However, studies so far often analyze a specific group for types cancer. Thus, systematic review meta-analysis, we synthesized overall on patients’ cancers. In research, followed Preferred Reporting Items Systematic Review Meta-Analysis Protocols (PRISMA-P) search longitudinal original Web Science (WOS) database. After that, Newcastle-Ottawa Scale (NOS) Jadad were used assess non-randomized control trials randomized trials, respectively. Then, characteristics included described six fields table random effect model with robust estimation was applied health utility patients. From database, 122 meta-regression, most them having high or fair quality. European Organization treatment scale (EORTC-QLQ) measurement at 65.15%. adjusted models, Visual Analogue (VAS) had statistics all models when compared it EQ-5D ( p < 0.05) such as breast, lung, prostate comparing hematological 0.01). Moreover, radiotherapy, screening, combination chemotherapy best supportive care also 0.01) radiotherapy only. Our suggest vital both improve some common

Language: Английский

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Exploratory Research: Patient‐Reported Factors Contributing to Decreased Oral Intake During Radiotherapy in Head and Neck Cancer

Head & Neck, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

ABSTRACT Background Radiotherapy (RT) in head and neck cancer (HNC) can cause multiple side effects such as nausea, pain, taste loss, fatigue, oral mucositis, xerostomia, acute radiation‐associated dysphagia (RAD). These factors threaten patients' intake (OI) during this RT. Reduced OI weight dehydration, malnutrition, various comorbidities. On top, reduced significantly affects quality of life may contribute to RAD through the disuse swallowing muscles. With aim maximizing retention a patient's OI, it is important gain an insight into that have greatest impact. Therefore, study aims identify impact contributing on decreased Methods During their treatment, 55 HNC patients completed questionnaire at 5 different time points: weeks 1, 2, 3, 4 end RT (week 7). First, rated compared pre‐RT 100 mm visual analogue scale (VAS). Subsequently, reported separate VAS degree which loss taste, smell, interest food, hunger contributed decrease (0: no contribution; 100: complete contribution). SPSS version 27 was used analyze results. Results over RT, with lowest first all pointed out strongest OI. The most patient‐reported impacting factor taste. At importance pain nausea still increases, while contribution other drops slightly. Conclusion This cohort shows several prospective analysis self‐reported demonstrate has followed by hunger, pain.

Language: Английский

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Dysphagia, nutritional status, and quality of life in patients with head and neck cancer undergoing radiotherapy alone or combined with chemotherapy: an observational study

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Radiotherapy (RT) is the most common nonsurgical treatment for head and neck cancer (HNC) may or not be combined with chemotherapy (CT). Dysphagia, characterized by impaired swallowing function, one of side effects RT, occurring during after persist long treatment. To compare evolution dysphagia, nutritional status, quality life (QoL) in periods immediately before RT HNC individuals who received only RT/CT. Prospective longitudinal observational study performed a hospital Brazilian public health system. The were allocated into two groups: RG (n = 20), consisting patients HNC, RCG 27), plus CT. evaluated to identify classify dysphagia (PARD protocol), anthropometric variables (BMI, triceps skinfold thickness, arm calf circumferences, manual dynamometry), QoL (QLC-30 H&N-35 questionnaires). groups homogeneous demographic characteristics tumor stage. showed higher proportion worsening severity (p < 0.01) assessment 0.05). A negative correlation was observed between initial–final change BMI total sample (rho=-0.379, p worsened domains evaluated, but additional global nausea vomiting leads early development which can adversely affect status QoL. Including CT regimen more accentuated parameters.

Language: Английский

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Adipose tissue characteristics as a new prognosis marker of patients with locally advanced head and neck cancer

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 14, 2025

Patients with head and neck cancer (HNC) are at increased risk of malnutrition due to the presence tumor treatments. Body composition is a prognostic factor in these patients. However, relationship between adipose tissue characteristics survival HNC still unclear. To evaluate associations adiposity, radiodensity muscularity prognosis patients locally advanced undergoing chemoradiotherapy. This retrospective study included 132 diagnosed HNC. assessment was performed using computed tomography (CT) images level third cervical vertebra (C3). The total (TATR), index (TATI) skeletal muscle (SMI) were evaluated. primary outcome overall (OS). highest TATI tertile had lower mortality when compared those lowest tertile, HR: 0.56, 95% confidence Interval (CI): 0.32-0.96; p = 0.039. TATR not associated death. greater adiposity higher median medium (p 0.0193). Individuals energy intake than 0.03). Additionally, low worse OS multivariable analysis (HR: 1.77, CI: 1.01-3.07; 0.044). In HNC, our findings underscore significance elevated beyond maintained muscularity, as independent protective factors for survival. Our highlights critical importance assessing body initiating early nutritional interventions improve

Language: Английский

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Prähabilitation und „enhanced recovery after surgery“ bei onkologischen Operationen im Kopf-Hals-Bereich

HNO, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

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Exercise therapy: an effective approach to mitigate the risk of cancer metastasis

World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 16, 2025

Cancer metastasis is a primary contributor to cancer-related mortality, and mitigating the risk of has emerged as central concern in oncology research. In recent years, exercise therapy, non-pharmacological intervention, received considerable attention for its ability enhance patients' quality life prognosis. Exercise significantly inhibits cancer spread, diminishes risk, improves therapy outcomes. Nonetheless, exact mechanisms via which dissemination cells are not fully elucidated. This review seeks examine prospective research avenues treatment metastasis. Moreover, it methodically examines pertinent clinical scientific data, along with efficacy therapies real-world applications. The evaluation moreover suggests future avenues, including more profound exploration mechanisms, augmentation trials, advancement personalized precision enhanced multidisciplinary collaboration. shows significant potential metastasis, incorporation into holistic frameworks advised improve general health prognostic results.

Language: Английский

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Pre‐rehabilitation interventions for patients with head and neck cancers: A systematic review and meta‐analysis

Head & Neck, Journal Year: 2023, Volume and Issue: 46(1), P. 86 - 117

Published: Oct. 28, 2023

Abstract Objective To investigate the effect of pre‐rehabilitation interventions such as nutrition and exercise for patients with head neck cancer (HNC). Methods Web Science, PubMed, Scopus, Google Scholar, Cochrane databases were searched up to December 2022. Quality life, length hospital stay, postoperative complications, change in body mass index or muscle mass, functional assessments primary outcomes. PRISMA guidelines adhered to, study was registered on PROSPERO. The Collaboration tool Newcastle Ottawa scale assessed quality included studies. Pooled data are presented odds ratios (OR) 95% confidence intervals (CI). Analysis conducted using RevMan5.4. Results A total 31 articles quantitative analysis 15 qualitative synthesis. Nutrition alone resulted significant weight retention (2.60; 2.32, 2.88, p < 0.00001), stay (−4.00; −6.87, −1.13), = 0.0006) complications (0.64; 0.49, 0.83, 0.0009). psychoeducation a reduction mortality rate (0.70; 1.00, 0.05 0.60; 0.48, 0.74, dysphagia (0.55; 0.35, 0.87, 0.01). Exercise improvements loss, dysphagia. Randomized controlled trials (RCTs) had moderate risk bias cohort studies fair good quality. Conclusion Prehabilitation programs based exercise, nutrition, demonstrated improved post‐interventional outcomes HNC, morbidity. Studies longer follow‐ups larger sample sizes, investigations comparing nutritional supplements needed.

Language: Английский

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Pretreatment fat‐free mass index correlates with early death in patients with head and neck squamous cell carcinoma

Head & Neck, Journal Year: 2024, Volume and Issue: 46(4), P. 808 - 818

Published: Jan. 9, 2024

Abstract Background A significant proportion of patients with head and neck squamous cell carcinoma (HNSCC) are malnourished at diagnosis. In this study, we investigated how pretreatment body mass index (BMI) fat‐free (FFMI) correlate early death, whether these measurements useful markers prognosis for risk stratification cancer patients. Methods Patients ( n = 404) newly diagnosed, curable HNSCC WHO performance status 0–2 were prospectively included met a study representative before treatment initiation, as well up to four follow‐up visits. All provided an estimate weight 6 months prior Bioelectrical impedance analysis (BIA) was performed all initiation. Results Most had oropharyngeal (46%), oral cavity (28%), or laryngeal (12%). Forty‐five (11%) the standardized criteria malnutrition according Global Leadership Initiative on Malnutrition (GLIM) FFMI diagnosis lower in who died within 12 after start than survived time points p 0.035 0.005, respectively). Conclusions independent prognostic factor death HNSCC. Pretreatment BMI not termination. Thus, may be cancer.

Language: Английский

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Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Journal of Clinical Nursing, Journal Year: 2024, Volume and Issue: 33(6), P. 2030 - 2049

Published: March 7, 2024

Abstract Aims and Objectives To assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head neck cancer. Background Radiation‐induced is highly prevalent Current medications are limited susceptible to side effects, while there an increasing adoption interventions, optimal one remains unclear. Design Systematic review network meta‐analysis based on PRISMA‐NMA guidelines. Methods Six databases were searched. Two authors independently performed literature screening, data extraction methodological quality assessment included studies. Traditional pairwise was by R Studio. A then conducted effects interventions Results Fifty‐two studies involving seven types enrolled. The indicated that natural plant‐based therapies might be most effective, health education second honey third effective reducing incidence mucositis. For mucositis‐related pain, showed only effective. Conclusions Nonpharmacological management among Relevance clinical practice a category safe adjunctive should encouraged practice. Trial registration details CRD42023400745.

Language: Английский

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Effectiveness of mHealth diet interventions in cancer survivors: A systematic review and meta-analysis of randomized controlled trials

Asia-Pacific Journal of Oncology Nursing, Journal Year: 2023, Volume and Issue: 10(3), P. 100196 - 100196

Published: Feb. 14, 2023

To evaluate the effects of mobile health (mHealth) diet interventions on cancer survivors' intake, weight change, waist circumference, hip and quality life (QoL). The PubMed, Embase, Web Science, Cochrane Library, Scopus, ProQuest, China National Knowledge Infrastructure, Wanfang, SinoMed databases were searched from their inception to September 25, 2022. Randomized controlled trials (RCTs) mHealth in survivors identified. Two researchers independently selected included studies appraised quality. methodological was assessed using Revised risk-of-bias tool for RCTs (RoB2). A total 15 involving 2363 included. MHealth significantly improved fruit vegetable intake (standardized mean difference [SMD] ​= ​0.19, 95% confidence interval [CI] [0.05, 0.33], P ​< ​0.01), QoL (SMD ​0.13, CI [0.01, 0.26], ​0.04) reduced fat ​-0.22, [-0.34, -0.11], ​-0.35, [-0.48, -0.22], circumference (MD ​-1.43, [-2.33, -0.53], ​-3.54, [-4.88, -2.19], < 0.01) survivors. No significant differences observed energy (P ​0.46) or whole grain ​0.14). may be an effective strategy Large-scale with rigorous study designs are needed examine effect intervention delivered via mHealth.

Language: Английский

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