Genetic and epigenetic correlation between diabetic retinopathy and polycystic ovarian syndrome: in-silico analyses-experimental research

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(3), P. 1295 - 1300

Published: Feb. 5, 2025

Introduction: Metabolic disorders, such as diabetes, can give rise to complications like diabetic retinopathy and polycystic ovarian syndrome, which have emerged a primary concern among healthcare systems. This study aims explore the genetic epigenetic associations between syndrome. Methods: Gene expression data were retrieved from Expression Omnibus database. Common genes identified using Venn diagrams, while Enrichment Analysis Resource database pinpointed shared signaling pathways. Additionally, microRNAs circular RNAs MiRmap Circaintractome databases investigate potential links two conditions. Results: of datasets Series Accession 53 257 54 248 revealed eight genes. These are involved in pathways related glycine, serine, threonine metabolism, tRNA biosynthesis, DNA repair. Furthermore, associated with miRNA (6 cases) (12 identified. molecular factors play key roles critical biological processes insulin secretion, adiponectin regulation, electron transport respiratory chain. Conclusion: highlights genetic, epigenetic, metabolic demonstrating that disruptions these may exacerbate complications. Identifying common provides avenues for clinical management treatment disorders.

Language: Английский

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Prevalence of metabolic syndrome and its association with selected factors among people with psychiatric conditions in Ethiopia: a systematic review and meta-analysis

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

Metabolic syndrome is a cluster of metabolic risk factors, including glucose intolerance, dyslipidemia, central obesity, high triglyceride levels, and low levels high-density lipoprotein. It the commonest type co-morbidity among people with psychiatric conditions particularly in middle-income countries due to poor health care systems financial burden. may be prolonged use medications, diminished quality life, personal behavioral-related factors. Except for single studies fluctuating reports, there no nationwide study conducted on prevalence Ethiopia. Thus, this review aims estimate pooled its association selected factors We thorough search PubMed, Scopus, Wiley online library, African journals online, Google Scholar. For analysis, STATA version 14 software was used. A funnel plot Egger's regression test statistic were used find potential reporting bias. fixed effect model contrast summary effects, odds ratios, 95% confidence intervals all over research findings. The Newcastle–Ottawa Scale (NOS) evaluate each included study. Eight articles final after retrieving 9,714 through electronic database searching. By using national cholesterol education adult treatment panel criteria, Ethiopia found 37.33% (95%CI: 24.52–50.14). Being female AOR = 2.66; CI: 0.89, 7.92), urban residency (AOR 2.84; 0.56, 14.45), physical inactivity 3.80; 1.61, 8.98), alcohol consumption 4.53; 1.62, 12.71) body mass index higher than normal range 4.66; 1.22, 17.85) significantly associated conditions. According review, schizophrenic-form disorder, delusional major depressive schizophrenia, bipolar schizoaffective disorder frequently reported This systematic meta-analysis revealed that magnitude gender, inactivity, consumption, determined occurrence syndrome. policymakers, clinicians, other concerned stakeholders must reinforce effective strategies control, timely screening, prevention, management PROSPERO CRD42023405293.

Language: Английский

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A decade review on phytochemistry and pharmacological activities of Cynomorium songaricum Rupr.: Insights into metabolic syndrome

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156602 - 156602

Published: March 2, 2025

Language: Английский

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The Effect of Tai Chi on Cardiometabolic Risk Factors: Systematic Review and Meta-Analysis

Journal of Integrative and Complementary Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Background and Aim: Cardiovascular diseases (CVDs), the leading cause of sudden death, are primarily driven by metabolic dysfunction, a core mechanism underlying their onset progression. Emerging research suggests that Tai Chi, an ancient martial art, positively impacts health. Accordingly, we sought to conduct systematic review examine clinical evidence regarding effectiveness safety Chi in managing cardiometabolic risk factors (CRFs). Methods Results: A comprehensive literature search eight electronic databases identified randomized controlled trials (RCTs) met predefined inclusion criteria, focusing on adults with CRFs such as obesity, hyperlipidemia, hypertension, glycemic dysregulation. Interventions involving were compared nonexercise controls or other exercise modalities. Outcomes included lipid profiles, blood pressure, glucose, body composition, adverse events. Thirteen RCTs 1746 participants included. significantly reduced triglycerides (TG) (mean difference [MD] = -0.20, p < 0.0001), fasting glucose (MD -0.36, 0.025), DBP -4.49, 0.010), waist circumference -3.34, while increasing high-density lipoprotein cholesterol 0.09, 0.0001) interventions. Compared exercises, total -0.33, 0.007) TG -0.14, 0.0056). The Grading Recommendations, Assessment, Development, Evaluations (GRADE) assessment indicated overall quality supporting these findings was moderate. No serious events reported. Conclusion: is effective safe intervention for CRFs, especially populations unable engage high-intensity exercise. While demonstrates modest efficacy its accessibility make it valuable option practice. Further high-quality studies needed confirm long-term effects optimize strategies.

Language: Английский

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The neutrophil to lymphocyte ratio (NLR) positively correlates with the presence and severity of metabolic syndrome in obese adults, but not in obese children/adolescents

BMC Endocrine Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 26, 2023

Metabolic syndrome (MetS) associated with obesity is a pathological condition increasing worldwide. Recent studies have demonstrated that the neutrophil to lymphocyte ratio (NLR) can be successfully used stage MetS in obese adults. The aim of study was evaluate NLR values 552 children/adolescents (M 219, F 333; 14.8 [12.9-16.3] years) and 231 adults 88, 143; 52.3 [36.4-63.3] morbid obesity, subdivided into subgroups according presence or absence MetS. Adult patients showed higher prevalence compared pediatric population (71% vs 26%), greater number subjects 3 4-5 altered components for (P-value = 0.041) those without. also positively correlated severity grade 0.032). By contrast, MetS, were comparable recorded without 0.861), no correlation being found 0.441). Our confirms importance as an inflammatory indicator adult severe while it excludes similar role children/adolescents.

Language: Английский

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C-Reactive Protein as a Marker of Inflammation in Children and Adolescents with Metabolic Syndrome: A Systematic Review and Meta-Analysis

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2961 - 2961

Published: Nov. 2, 2023

Metabolic syndrome (MetS) in the pediatric population has been reported many studies to be associated with an inflammatory response. However, our knowledge, there is no definitive conclusion form of a meta-analysis. The issue we aimed address whether C-reactive protein (CRP) trustworthy marker detecting inflammation children and adolescents MetS. We systematically searched PubMed, MEDLINE, Cochrane Central Register Controlled Trials, ISI Web Science, SCOPUS until 31 June 2023 for involving MetS where hsCRP or CRP were measured. After screening process, identified 24 full-text articles that compared 930 patients either healthy (n = 3782) obese 1658) controls. risk bias included was assessed using Begg’s rank correlation test Egger’s regression test. Statistical analysis carried out based on pooled mean differences (MDs) 95% CI. Data showed higher levels than those controls (MD 1.28, CI: (0.49–2.08), p 0.002) 0.88, (0.38–1.39), 0.0006). conventional methods found more accurate differentiating between obesity MetS, 0.60, (−0.08–1.28), 0.08). No assessed. In conclusion, reliable from ones. On other hand, it did not prove very distinguishing who had obese. There should research performed this field.

Language: Английский

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The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(9), P. 3859 - 3866

Published: June 21, 2023

Abstract The electiveness of Capsicum annuum supplementation in controlling dyslipidemia adults has been unclear. Therefore, this meta‐analysis focuses on the relationship between C. and lipid profile with metabolic syndrome (MetS) related disorders. PubMed, Scopus, ISI Web Science, Cochrane Library were searched up to March 2021. Only randomized controlled trials (RCTs) studying administration compared control markers MetS disorders examined. Pooled effect sizes reported as weighted mean differences (WMDs) 95% confidence intervals (CIs). results four eligible RCTs showed that could significantly reduce total cholesterol (TC) (WMD: −4.98 mg/dL, CI: −7.08 −2.88, p ≤ 0.001) levels, but did not regulate triglyceride, high‐density lipoprotein cholesterol, low‐density concentrations. In summary, present findings suggest beneficial effects reduction plasma levels TC. However, draw a firm link profile, more adequate sample sizes, specifically subjects are warranted.

Language: Английский

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Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans

Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3231 - 3231

Published: Sept. 16, 2021

The atherogenic index of plasma (AIP), composed triglycerides and high-density lipoprotein cholesterol, is a novel critical marker for assessing the risk atherogenicity cardiometabolic health. We aimed to prospectively study association between AIP incident ischemic heart disease (IHD) in large cohort non-diabetic Korean adults. Data were assessed from 17,944 participants without diabetes Health Risk Assessment Study (HERAS) Korea Insurance Review (HIRA) data. divided into four groups according quartiles, calculated as log (triglyceride/high-density cholesterol). hazard ratios (HRs) with 95% confidence intervals (CIs) IHD using multivariate Cox proportional-hazard regression models over 50-month period that followed baseline survey. During follow-up period, 332 (1.9%) developed IHD. HRs quartiles 2-4 1.58 (95% CI, 1.03-2.43), 1.82 1.20-2.78), 2.11 1.37-3.24) after adjusting age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, fasting glucose, high-sensitivity C-reactive protein level, hypertension medication. Higher levels may precede predict development

Language: Английский

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Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance

The Egyptian Heart Journal, Journal Year: 2023, Volume and Issue: 75(1)

Published: April 4, 2023

In normal circumstances, AT secretes anti-inflammatory adipokines (AAKs) which regulates lipid metabolism, insulin sensitivity, vascular hemostasis, and angiogenesis. However, during obesity dysfunction occurs leads to microvascular imbalance several pro-inflammatory (PAKs), thereby favoring atherogenic dyslipidemia resistance. Literature suggests decreased levels of circulating AAKs increased PAKs in obesity-linked disorders. Importantly, have been reported play a vital role metabolic disorders mainly resistance, type-2 diabetes mellitus coronary heart diseases. Interestingly, counteract the exert cardioprotection via signaling pathways such as PI3-AKT/PKB pathway. Although literature reviews presented number investigations detailing specific involved disorders, concerning remains sketchy. view above, present contribution an effort has made provide insight on modulating atherogenesis resistance."Obesity-linked resistance", "obesity-linked cardiometabolic disease", "anti-inflammatory adipokines", "pro-inflammatory "adipose tissue dysfunction" are keywords used for searching article. Google scholar, Google, Pubmed Scopus were search engines articles.This review offers overview pathophysiology obesity, management areas need attention novel therapeutic their possible future perspectives agents.

Language: Английский

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Advances in Gut Microbiota-Targeted Therapeutics for Metabolic Syndrome

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 851 - 851

Published: April 24, 2024

Previous investigations have illuminated the significant association between gut microbiome and a broad spectrum of health conditions, including obesity, diabetes, cardiovascular diseases, psychiatric disorders. Evidence from certain studies suggests that dysbiosis microbiota may play role in etiology obesity diabetes. Moreover, it is acknowledged dietary habits, pharmacological interventions, psychological stress, other exogenous factors can substantially influence microbial composition. For instance, diet rich fiber has been demonstrated to increase population beneficial bacteria, whereas consumption antibiotics reduce these advantageous communities. In light established correlation various pathologies, strategically altering profile represents an emerging therapeutic approach. This be accomplished through administration probiotics or prebiotics, which aim refine and, consequently, mitigate manifestations associated diseases. The present manuscript evaluates recent literature on relationship metabolic syndrome published over past three years anticipates future directions this evolving field.

Language: Английский

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