Review: Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19

International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 193, P. 948 - 955

Published: Oct. 18, 2021

Language: Английский

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Zinc Deficiency Associated With an Increase in Mortality in COVID-19 Patients: A Meta-Analysis

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The exact role of zinc in COVID-19-infected patients is not well understood. We examined the effects and outcomes deficiency on patients. focused patient outcomes: severity, symptomatology, mortality. meta-analysis was performed to examine whether individuals suffered greater symptomology Secondary explored included severity hospital length stay. For mortality, we found that with had a risk mortality than without (risk ratio (RR)=5.77; 95% confidence interval (CI): 3.48, 9.54; p=0.004). symptomology, symptomatology (RR=1.39; CI: 1.13, 1.70; p=0.020). Zinc-deficient are at for symptomatology. Our findings further reinforce importance supplementation as prophylactic agent against viral infections such COVID-19.

Language: Английский

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Weight loss, malnutrition, and cachexia in COVID‐19: facts and numbers

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2020, Volume and Issue: 12(1), P. 9 - 13

Published: Dec. 31, 2020

Abstract Patients with COVID‐19 disease are prone to develop significant weight loss and clinical cachexia. Three reports altogether 589 patients that reported on cachexia in were identified. Disease severity of the timing assessment during course these variable—65 (11%) intensive care treated at time assessment, 183 (31%) cared for sub‐intensive or intermediate structures. The frequency ≥5% (that defines cachexia) was 37% (range 29–52%). Correlates occurrence be raised C‐reactive protein levels, impaired renal function status, longer duration disease. Underweight status by WHO criteria (BMI < 18.5 kg/m 2 ) only observed 4% analysing data from seven studies 6661 patients. Cachexia needs loss. associated is understood affect muscle fat tissue as also seen many other chronic illness‐associated forms There factors can contribute body wasting COVID‐19, they include appetite taste, fever inflammation, immobilization, well general malnutrition, catabolic–anabolic imbalance, endocrine dysfunction, organ‐specific complications such cardiac dysfunction. Treatment should a focus nutritional support rehabilitative exercise whenever possible. Specific anti‐cachectic therapies do not exist, but constitute high medical need prevent long‐term disability due acute

Language: Английский

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Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2021, Volume and Issue: 23(2), P. 299 - 308

Published: April 13, 2021

COVID-19 extra-pulmonary features include several endocrine manifestations and these are becoming strongly clinically relevant in patients affected influencing disease severity outcomes.At the beginning of pandemic no population data on calcium levels were available April 2020 a first case severe acute hypocalcemia an Italian patient with SARS-CoV-2 infection was reported. Subsequently, studies reported as highly prevalent biochemical abnormality marked negative influence severity, inflammation thrombotic markers, mortality. Also high prevalence vertebral fractures worse respiratory impairment widespread vitamin D deficiency have been frequently observed, suggesting emerging "Osteo-Metabolic Phenotype" COVID-19.To date, potential pathophysiological factors hypothesized to play role determining including dependent viral mechanisms action, hypovitaminosis general population, chronic malnutrition during critical illness unbound unsaturated fatty acids inflammatory responses.Since is frequent finding hospitalized possibly predicting outcomes leading cardiovascular neurological complications if severe, it reasonable assess, monitor and, indicated, replace at hospital evaluation hospitalization.

Language: Английский

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The Impact of Nutrition on the COVID-19 Pandemic and the Impact of the COVID-19 Pandemic on Nutrition

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1752 - 1752

Published: May 21, 2021

The coronavirus disease 2019 (COVID-19) pandemic has had significant morbidity, mortality, social and financial implications for the global population. Despite this knowledge, we still know very little about how COVID-19 infection affects quality of life resulting from changes in nutritional behaviour and, conversely, nutrition could modulate epidemiology COVID-19. In addition, isolation most have experienced due to regulations imposed by governments during may also effects on our behaviour. It is possible that interventions incidence mortality rates. purpose review evaluate current status research topic as it relates pandemic.

Language: Английский

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COVID-19 is associated with oropharyngeal dysphagia and malnutrition in hospitalized patients during the spring 2020 wave of the pandemic

Clinical Nutrition, Journal Year: 2021, Volume and Issue: 41(12), P. 2996 - 3006

Published: June 15, 2021

Prevalence and complications of oropharyngeal dysphagia (OD) malnutrition (MN) in COVID-19 patients is unknown. Our aim was to assess the prevalence, risk factors clinical outcomes OD MN a general hospital during first wave pandemic.

Language: Английский

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The validity of the global leadership initiative on malnutrition criteria for diagnosing malnutrition in critically ill patients with COVID-19: A prospective cohort study

Clinical Nutrition ESPEN, Journal Year: 2021, Volume and Issue: 43, P. 377 - 382

Published: April 2, 2021

Language: Английский

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Approaches to Nutritional Screening in Patients with Coronavirus Disease 2019 (COVID-19)

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(5), P. 2772 - 2772

Published: March 9, 2021

Malnutrition is common among severe patients with coronavirus disease 2019 (COVID-19), mainly elderly adults and comorbidities. It also associated atypical presentation of the disease. Despite possible contribution malnutrition to acquisition severity COVID-19, it not clear which nutritional screening measures may best diagnose in these at early stages. This crucial importance given urgency rapid progression vulnerable groups. Accordingly, this review examines available literature for different approaches implemented COVID-19 patients, a special focus on adults. After search, we selected scrutinized 14 studies assessing patients. The Nutrition Risk Screening 2002 (NRS-2002) has demonstrated superior sensitivity other traditional measures. controlling status (CONUT) score, comprises serum albumin level, cholesterol lymphocytes count, as well combined CONUT-lactate dehydrogenase-C-reactive protein score expressed predictive capacity even that NRS-2002 (0.81% 0.92% vs. 0.79%) midlife elder Therefore, simple based routinely conducted laboratory investigations such CONUT be timely, cheap, valuable alternatives identifying high risk. Mini Nutritional Assessment (MNA) was only measure used detect residual risk remitting patients—MNA scores correlated hypoalbuminemia, hypercytokinemia, weight loss. Older males inflammation, gastrointestinal symptoms, pre-existing comorbidities (diabetes, obesity, or hypertension) are more prone subsequently poor prognosis both during acute phase convalescence. Thus, they need frequent monitoring support while detecting treating general public might necessary increase resilience against COVID-19.

Language: Английский

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Malnutrition Increases Hospital Length of Stay and Mortality among Adult Inpatients with COVID-19

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1310 - 1310

Published: March 21, 2022

Background: Malnutrition has been linked to adverse health economic outcomes. There is a paucity of data on malnutrition in patients admitted with COVID-19. Methods: This retrospective cohort study consisting 4311 COVID-19 adult (18 years and older) inpatients at 5 Johns Hopkins-affiliated hospitals between 1 March 3 December 2020. Malnourishment was identified using the universal screening tool (MUST), then confirmed by registered dietitians. Statistics were conducted SAS v9.4 (Cary, NC, USA) software examine effect mortality hospital length stay among inpatient encounters, while accounting for possible covariates regression analysis predicting or log-transformed stay. Results: who older, male, had lower BMIs higher likelihood mortality. Patients 76% more likely have (p < 0.001) 105% longer 0.001). Overall, 12.9% (555/4311) diagnosed associated an 87.9% increase Conclusions: In inpatients, increased

Language: Английский

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Global patterns of change in the burden of malnutrition in older adults from 1990 to 2021 and the forecast for the next 25 years

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 20, 2025

Malnutrition poses a significant public health challenge, particularly as the global population ages. However, there is notable lack of comprehensive literature analyzing burden malnutrition among elderly. Data on nutritional deficiencies indicators-prevalence, incidence, and disability-adjusted life years (DALYs)-for individuals aged 70 older were extracted from Global Burden Diseases, Injuries, Risk Factors Study (GBD) database 1990 to 2021. The estimated annual percentage change (EAPC) was used assess trends in burden. Predictions for new cases over next 25 also made. In 2021, 97.60 million elderly reported globally, 1.2-fold increase 44.36 1990. prevalence rate has decreased with an EAPC -0.32%. Women experienced more than men but had lower rate. Furthermore, high socio-demographic index (SDI) regions, both DALYs rates increased EAPCs 0.33% 1.34%, respectively. negatively correlated SDI. 2022 2046 approximately 29.64 by 2046, despite declining incidence Despite decline since 1990, remains high, SDI regions where have increased. With projected rise cases, effective prevention management strategies are urgently needed support adults.

Language: Английский

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