Mediation Role of Telomere Length in the Relationship between Physical Activity and PhenoAge: A Population-based Study DOI Creative Commons
Yanwei You,

Dizhi Wang,

Hao Ding

et al.

Journal of Exercise Science & Fitness, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research. study encompassed cohort 6200 participants aged 20 years above, sourced from the National Health Nutrition Examination Survey (NHANES). Physical (PA) levels were assessed employing Global Activity Questionnaire, while DNA samples collected to determine measured base pairs. PhenoAge, an emerging index relying on nine distinct chemical biomarkers, was computed. Incorporating fully adjusted model, our analysis showed significant correlations PA engagement PhenoAge [Low PA, β (95 % CI): 0.039(-0.071,-0.008), p = 0.021; Moderate 0.058(-0.082,-0.034), < 0.001; High 0.069(-0.096,-0.042), 0.001]. Furthermore, positive link emerged elevated with CI) 0.011(0.001, 0.022), 0.034. A mediation performed, demonstrating that length mediated connection proportion calculated at 3.57 %. Our findings suggest may play key role mitigating processes by preserving highlighting potential as target for interventions aimed promoting healthy longevity.

Language: Английский

Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study DOI Creative Commons
Yanwei You, Yuquan Chen, Ruidong Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 15, 2024

Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting healthy aging. This study aims to (i) identify the sleep duration trend US adults; (ii) investigate relationship between and phenotypic age; (iii) explore role of exercise this relationship. Phenotypic age as novel index was calculated according biomarkers collected from adults based on National Health Nutrition Examination Survey (NHANES). information self-reported by participants discerned through individual interviews. The principal analytical method employed weighted multivariable linear regression modeling, which accommodated for complex multi-stage sampling design. potential non-linear explored using restricted cubic spline (RCS) model. Furthermore, subgroup analyses evaluated effects sociodemographic lifestyle factors primary outcomes. A total 13,569 were finally included in, thereby resulting population 78,880,615. An examination temporal trends revealed declining proportion individuals with insufficient markedly deficient time since 2015-2016 cycle. Taken normal group reference, extreme short [β (95% CI) 0.582 (0.018, 1.146), p = 0.044] long 0.694 (0.186, 1.203), 0.010] both positively associated fully adjusted According dose-response age, benefit regular activity, whereas more tended have higher age. There an inverted U-shaped durations represents important step forward our understanding By shedding light topic providing practical recommendations habits, researchers help live longer, healthier, fulfilling lives.

Language: Английский

Citations

48
Accelerometer-measured physical activity and sedentary behaviour are associated with C-reactive protein in US adults who get insufficient sleep: A threshold and isotemporal substitution effect analysis DOI
Yanwei You

Journal of Sports Sciences, Journal Year: 2024, Volume and Issue: 42(6), P. 527 - 536

Published: March 18, 2024

This study aimed to investigate the association between physical activity, sedentary behaviour and chronic inflammation in short sleep adults. The included 2,113 NHANES participants with self-reported insufficient sleep. C-reactive protein (CRP) was used as inflammatory biomarker. Physical activity were objectively measured by accelerometers. Weighted regression model, two – piecewise linear restricted cubic splines applied evaluate associations mentioned above. An isotemporal substitution model assess modelled effects of replacing time (ST) moderate-to-vigorous levels (MVPA) or light (LPA). After adjusting for potential confounding factors, higher ST lower LPA MVPA associated CRP levels. Isotemporal analysis indicated that 30 minutes a significant decrease Saturation suggested may plateau at over 20 per day. Findings this provides insight into benefits MVPA. also suggests increasing beyond certain point not provide additional anti-inflammatory population.

Language: Английский

Citations

44
Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies DOI Creative Commons
Yanwei You, Jinwei Li, Yang Zhang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Aims The molecular mechanism of short‐sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011–2014) explore cellular mechanisms mice. Methods Systemic immune‐inflammation index (SII) was calculated using blood‐cell based biomarkers. Further, we employed integrated bioinformatics single‐cell transcriptomics (GSE137665) examine how sleep exposure influenced pathways associated with inflammation brain. To signaling biological processes deprivation, carried out enrichment analyses utilizing GO KEGG databases. Results Population results showed that, compared normal group, severe lower ability all four tests. Moreover, a higher SII level correlated scores In mice study, elevated activation pathway observed cell subgroups neurons within deprivation recovery cohorts. Additionally, heightened expression oxidative stress response noted GABAergic during deprivation. Conclusion study contributed understanding influence its mechanisms.

Language: Английский

Citations

36
Saturation effects of the relationship between physical exercise and systemic immune inflammation index in the short-sleep population: a cross-sectional study DOI Creative Commons
Yanwei You, Alimjan Ablitip, Yuquan Chen

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 17, 2024

Abstract Background Short sleep can lead to an increase in inflammation and regular exercise has been shown have a mitigation effect. However, the association between physical (PE) short population is unknown intriguing issue. Methods NHANES dataset spanning years 2007 2018 were analyzed. To investigate relationship mentioned above, we carried out multivariate linear regression models controlling for sociodemographic lifestyles factors. The systemic immune index (SII) served as reflection of inflammatory potential, calculated product platelet count, neutrophil divided by lymphocyte count. Self-reported questionnaires used collect information. Results A total 14,664 participants included final analysis. Across three models, PE showed significant negative associations with SII continuous variable [Crude Model, β (95% CI): -1.261(-1.600, -0.922), p < 0.001; Model 1, -1.005(-1.344, -0.666), 2, -0.470(-0.827, -0.112), = 0.011]. consistent nature findings persisted when investigating categorized variable. By two-piecewise model, saturation effect inflection point 2400 MET-minutes/week. Conclusion This study suggested that performing no more than MET-minutes/week was associated lower levels population, while might not bring additional benefits.

Language: Английский

Citations

28
Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions DOI Creative Commons
Ioulia Barakou, Bregje L. Seves, Ulric S. Abonie

et al.

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 28, 2025

Language: Английский

Citations

2
Associations of lifestyle characteristics with circulating immune markers in the general population based on NHANES 1999 to 2014 DOI Creative Commons

Linfen Guo,

Yating Huang,

Jing He

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 11, 2024

Abstract Lifestyles maybe associated with the immune and inflammatory state of human body. We aimed to comprehensively explore relationship between lifestyles circulating immune-inflammatory markers in general population. Data from NHANES 1999–2014 was used. Lifestyle factors included leisure-time physical activity (LTPA), diet quality (Healthy Eating Index-2015, HEI-2015), alcohol consumption, cigarettes smoking, sleep hour sedentary time. Immune makers C-reactive protein (CRP), neutrophil–lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet–lymphocyte (PLR) monocyte–lymphocyte (MLR). Generalized linear regression models were used adjust confounders. Regressions restricted cubic splines utilized evaluate potentially non-linear relationships exposures outcomes. As results, HEI negatively CRP (P < 0.001), SII NLR 0.001). Cigarettes per day positively = 0.008). Alcohol consumption but PLR 0.012) MLR Physical 0.005), 0.002), 0.010). Participants higher healthy lifestyle score had significantly lower CRP, (all P values 0.05). Most sensitivity analyses found similar results. In conclusion, we significant associations population, which may reflect a response unhealthy lifestyles.

Language: Английский

Citations

6
The association of physical activity and sedentary behavior with depression in US adults: NHANES 2007–2018 DOI Creative Commons

Y. B. Dato' Chua Jui Meng,

Nan Ma,

Yixin Shi

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: June 21, 2024

Depression is largely preventable, and strategies that can effectively suppress its development are imperative. We aimed to examine whether physical activity sedentary behavior were associated with depression explore the possible mediatory role of complete blood count in this association.

Language: Английский

Citations

6
Exploration of physical activity, sedentary behavior and insulin level among short sleepers DOI Creative Commons
Yuquan Chen, Yanwei You,

Mengxian Wei

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

Sufficient physical activity and sleep duration are essential for overall health. While one-third of the US population reports short (<7 h), which is proven to link with negative health status. Current evidence on relationship between activity, sedentary behavior, serum insulin level in groups limited.

Language: Английский

Citations

6
The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007–2018 DOI Open Access

Shuli An,

Jian G. Qin, Xuan Gong

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4164 - 4164

Published: Nov. 30, 2024

The dietary index for gut microbiota (DI-GM) is a newly proposed metric assessing diet quality, and its relationship with biological age unclear. We hypothesize that consuming foods conducive to healthy environment may decelerate aging.

Language: Английский

Citations

6
Age difference in the connection between systemic inflammatory response and metabolic syndrome DOI Creative Commons

Haishan Wei,

Dan Xu, Jiying Chen

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Background This research aims to investigate the connection between systemic inflammatory response and metabolic syndrome (MetS) across different age groups, with aim of proposing more targeted recommendations. Methods study enrolled 15 959 adults from 2001-2018 National Health Nutrition Examination Survey whom 6739 were diagnosed MetS. After dividing immune-inflammation index (SII) into 4 quartiles, Kruskal–Wallis test weighted chi-square employed assess statistical differences. Weighted multivariable logistic regression analysis, subgroup sensitivity restricted cubic spline examine relationship SII Results Our revealed that exhibits a quantitative association MetS [odds ratio (OR) = 1.56; 95% confidence interval (CI): 1.37-1.79; P &lt; .001]. Elevated is an independent risk factor for 5 components Different groups alcohol consumption status could modify was statistically significant in 18 65 group but not elderly (OR 1.08; CI, .95-1.23; .248). Multiple imputation confirmed robustness our results. Moreover, inverted U-shaped curve. Conclusion highlights predictive significance forecasting incidence young middle-aged populations. The differences mechanisms various necessitate further exploration.

Language: Английский

Citations

5