Neurohumoral Profiles and Childhood Adversity of Patients with Multisomatoform Disorder and Pain as the Leading Bodily Symptom DOI Open Access
Johannes Achenbach,

Lilly Volkmann,

Anh-Thu Tran

et al.

Disease Markers, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 10

Published: Feb. 22, 2022

Patients suffering from chronic pain often present with multifactorial underlying conditions, sometimes without concrete pathological physical findings. Functional somatic syndromes (FSS) and somatoform disorders show a high prevalence of 8-20% are associated adverse childhood experiences (ACE) stress. As many different FSS have overlapping symptoms, the concept multisomatoform disorder (MSD) has been introduced as an encompassing concept. We hypothesize that common neurohumoral profile is in patients MSD distinct gender- age-matched controls thus provides insight into possible mechanisms.In 151 (138 females) 149 matched (131 females), we determined ACE by Childhood Trauma Questionnaire (CTQ) stress Trier Inventory for Chronic Stress (TICS). Furthermore, serum levels leptin, FSH, LH, cortisol, DHEA-S, IGF-1 assessed.There were significant differences IGF-1, cortisol between controls, mainly driven female participants. Levels leptin significantly correlated BMI patients, subgroup. This correlation was exaggerated when compared to controls. Both CTQ TICS predicted directly indirectly through leptin.There evidence healthy similar what demonstrated other states. The observed can be taken dysregulated response metabolic balance well state hypocortisolism HPA-axis dysfunction. play major role development altered profile.

Language: Английский

The endocannabinoid system in appetite regulation and treatment of obesity DOI Creative Commons
Marija Kurtov, Igor Rubinić, Robert Likić

et al.

Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(5)

Published: Sept. 18, 2024

The endocannabinoid system (ECS) is a complex cell-signaling that responsible for maintaining homeostasis by modulating various regulatory reactions in response to internal and environmental changes. influence of ECS on appetite regulation has been subject much recent research, however, the full extent its impact remains unknown. Current evidence links human obesity activation, increased levels both central peripheral tissues, along with cannabinoid receptor type 1 (CBR1) up-regulation. These findings imply potential pharmacological use treatment obesity. Here, we present pathophysiological processes involving ECS, highlighting different options activity treat However, those possibilities under investigation requires further research.

Language: Английский

Citations

11
Neural correlates of obesity across the lifespan DOI Creative Commons
Filip Morys,

Christina Tremblay,

Shady Rahayel

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: May 28, 2024

Abstract Associations between brain and obesity are bidirectional: changes in structure function underpin over-eating, while chronic adiposity leads to atrophy. Investigating brain-obesity interactions across the lifespan can help better understand these relationships. This study explores interaction cortical morphometry children, young adults, older adults. We also investigate genetic, neurochemical, cognitive correlates of associations. Our findings reveal a pattern lower thickness fronto-temporal regions associated with all age cohorts varying age-dependent patterns remaining regions. In adults neurochemical expression inflammatory mitochondrial genes. children is modifications involved emotional attentional processes. Thus, might originate from during early adolescence, leading neurodegeneration later life through mechanisms.

Language: Английский

Citations

10
Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review DOI Creative Commons
Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 22, 2021

Inflammatory bowel disease (IBD) is a general term used to describe group of chronic inflammatory conditions the gastrointestinal tract unknown etiology, including two primary forms: Crohn's (CD) and ulcerative colitis (UC). The endocannabinoid system (ECS) plays an important role in modulating many physiological processes intestinal homeostasis, modulation motility, visceral sensation, or immunomodulation inflammation IBD. It consists cannabinoid receptors (CB1 CB2), transporters for cellular uptake ligands, endogenous bioactive lipids (Anandamide 2-arachidonoylglycerol), enzymes responsible their synthesis degradation (fatty acid amide hydrolase monoacylglycerol lipase), manipulation which through agonists antagonists system, shows potential therapeutic ECS disease. This review summarizes components on inflammation, suggesting advantages cannabinoid-based therapies

Language: Английский

Citations

53
Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases DOI Creative Commons
Dan Wu, Huiying Wang, Lijun Xie

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: July 5, 2022

The rapid increase of obesity and associated diseases has become a major global health problem. Adipose tissues are critical for whole-body homeostasis. gut microbiota been recognized as significant environmental factor in the maintenance energy homeostasis host immunity. A growing body evidence suggests that regulates metabolism through close cross-talk with adipose tissues. It modulates expenditure alleviates by promoting expenditure, but it also produces specific metabolites structural components may act central factors pathogenesis inflammation, insulin resistance, obesity. Understanding relationship between provide potential intervention strategies to treat diseases. In this review, we focus on recent advances its actions highlight joint tissue each other regulation metabolism.

Language: Английский

Citations

36
Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function DOI Open Access
Kieran Shay Struebin Abbotts, Taylor Russell Ewell,

Hannah Michelle Butterklee

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2152 - 2152

Published: May 21, 2022

Cannabidiol (CBD) is widely available and marketed as having therapeutic properties. Over-the-counter CBD unregulated, many of the claims lack scientific support, controversy exists to safety CBD-liver interaction. The study aims were compare pharmacokinetics commercial metabolites following ingestion five different formulations, determine influence on food induced thermogenesis, pharmacokinetics, markers liver function. Fourteen males (body mass index ≥ 25 kg/m2) studied in a placebo-controlled, randomized, crossover design. On occasions, formulations ingested (one per visit). two additional or placebo was meal. servings standardized 30 mg. Considerable pharmacokinetic variability existed between formulations; this transferred several metabolites. did not thermogenesis but favorably modify early insulin triglyceride responses. Food appreciably altered CBD. Finally, evoke physiologically relevant changes Collectively, these data suggest that consumers should be aware appreciable differences unlikely caloric cost eating may prove some benefit initial metabolic responses, consuming with alters dynamics metabolism increases systemic availability, low-dose probably does represent risk normal

Language: Английский

Citations

35
Structure-based identification of a G protein–biased allosteric modulator of cannabinoid receptor CB1 DOI Creative Commons
Siyuan Shen, Chao Wu, Guifeng Lin

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(24)

Published: June 3, 2024

Cannabis sativa is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis, Δ9-tetrahydrocannabinol (THC), and other agonists engage the orthosteric site CB1, activating both Gi β-arrestin signaling pathways. activation diverse pathways could result on-target side effects cannabis addiction, which may hinder potential. A significant challenge pharmacology design a ligand that can modulate specific CB1. By leveraging insights from structure–function selectivity relationship (SFSR), we have identified signaling–biased agonist-allosteric modulators (ago-BAMs). Further, two cryoelectron microscopy (cryo-EM) structures reveal binding mode ago-BAM at extrahelical allosteric Combining mutagenesis pharmacological studies, elucidated detailed mechanism ago-BAM-mediated biased signaling. Notably, CB-05 demonstrated analgesic efficacy with fewer effects, minimal drug toxicity no addiction mouse models. In summary, our finding not only suggests ago-BAMs CB1 provide potential nonopioid strategy management but also sheds light on BAM identification GPCRs.

Language: Английский

Citations

6
Role of Cannabinoids in Oral Cancer DOI Open Access

Brigitte Cretu,

Maria-Alexandra Zamfir, Săndica Bucurică

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 969 - 969

Published: Jan. 12, 2024

Cannabinoids have incited scientific interest in different conditions, including malignancy, due to increased exposure cannabis. Furthermore, cannabinoids are increasingly used alleviate cancer-related symptoms. This review paper aims clarify the recent findings on relationship between and oral cancer, focusing molecular mechanisms that could link with cancer pathogenesis. In addition, we provide an overview of current future perspectives management patients using cannabinoid compounds. Epidemiological data cannabis use development conflicting. However, vitro studies assessing effects cells unveiled promising anti-cancer features, apoptosis inhibition cell proliferation. Downregulation various signaling pathways has been identified experimental models exposed cannabinoids. some countries, several synthetic or phytocannabinoids approved as medical adjuvants for undergoing chemoradiotherapy. may improve overall well-being by relieving anxiety, depression, pain, nausea. conclusion, compounds is complex, further research necessary elucidate potential risks their protective impact cancer.

Language: Английский

Citations

4
Novel Orthosteric/Allosteric Ligands of Cannabinoid Receptors: An Unexpected Pharmacological Profile DOI
Rebecca Ferrisi, Beatrice Polini,

Anna Maria Smolyakova

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The design of dualsteric/bitopic receptor ligands as compounds capable simultaneously interacting with both the orthosteric and an allosteric binding site has gained importance to achieve enhanced specificity minimize off-target effects. In this work, we reported synthesis biological evaluation a new series compounds, namely,

Language: Английский

Citations

0
The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity; modulation by linoleic acid and exercise DOI Creative Commons

Quratul Ain,

Melpomeni Malamouli,

Deanne H. Hryciw

et al.

Advanced Exercise and Health Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Weight management: functional foods for a balanced body DOI
Zahra Emam‐Djomeh,

Salma Samieitousi,

Sara Gashtasbi

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 89 - 108

Published: Jan. 1, 2025

Language: Английский

Citations

0