Chronic diseases are first associated with the degradation and artificialization of food matrices rather than with food composition: calorie quality matters more than calorie quantity

European Journal of Nutrition, Journal Year: 2022, Volume and Issue: 61(5), P. 2239 - 2253

Published: Jan. 24, 2022

Language: Английский

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The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1496 - 1496

Published: March 20, 2023

There is growing interest in the role that intestinal microbiota and related autoimmune processes may have genesis presentation of some psychiatric diseases. An alteration communication microbiota-gut-brain axis, which constitutes a communicative model between central nervous system (CNS) gastro-enteric tract, has been identified as one possible causes The purpose this narrative review to describe evidence supporting gut diseases impact diet on mental health. Change composition could determine an increase permeability barrier, leading cytokine storm. This trigger systemic inflammatory activation immune response: series events repercussions release neurotransmitters, altering activity hypothalamic-pituitary-adrenal reducing presence trophic brain factors. Although disorders seem be connected, more effort needed understand potential causative mechanisms underlying interactions these systems.

Language: Английский

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Understanding Immune Responses to Viruses—Do Underlying Th1/Th2 Cell Biases Predict Outcome?

Viruses, Journal Year: 2022, Volume and Issue: 14(7), P. 1493 - 1493

Published: July 8, 2022

Emerging and re-emerging viral diseases have increased in number geographical extent during the last decades. Examples include current COVID-19 pandemic recent epidemics of Chikungunya, Ebola, Zika viruses. Immune responses to viruses been well-characterised within innate adaptive immunity pathways with outcome following infection predominantly attributed properties virus circumstances infection. Perhaps belief that immune system is often considered as a reactive component host defence, springing into action when threat detected, has contributed poorer understanding inherent differences an individual’s absence any pathology. In this review, we focus on how these factors (age, ethnicity, underlying pathologies) may skew T helper cell response, thereby influencing but also whether can use biases predict patients at risk deviant response apply strategies avoid or overcome them.

Language: Английский

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Mediterranean diet and mitochondria: New findings

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 176, P. 112165 - 112165

Published: April 5, 2023

Mitochondria are subcellular organelles known for their central role in several energetic processes. Accumulating evidence supports a key mitochondria the physiological response to both acute and chronic stress exposure, and, ultimately, biological embedding of adversity health psychological functioning that increases interest these medical conditions typical older people. At same time, Mediterranean diet (MedDiet) seems affect function further justifying this lowering risk negative outcomes. In review, we have elucidated human diseases including fundamental stress, aging, neuropsychiatric metabolic disorders. Overall, MedDiet can limit production free radicals, being rich polyphenols. Moreover, reduced mitochondrial reactive oxygen species (mtROS) ameliorated damage apoptosis. Similarly, whole grains maintain respiration membrane potential, finally improving function. Other components anti-inflammatory effects, again modulating For example, delphinidin (a flavonoid present red wine berries) restored elevated level respiration, mtDNA content, complex IV activity; similarly, resveratrol lycopene, grapefruits tomatoes, exerted an effect enzymes. Altogether, findings support notion positive effects be mediated by modulation indicating necessity studies beings confirming findings.

Language: Английский

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Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4236 - 4236

Published: Sept. 30, 2023

Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention in recent years due to its potential health benefits. Found various foods and often used energy drinks supplements, taurine been studied extensively understand impact on human physiology. Determining exact functional roles represents complex multifaceted topic. We provide an overview of the scientific literature present analysis effects aspects health, focusing aging cardiovascular pathophysiology, but also including athletic performance, metabolic regulation, neurological function. Additionally, our report summarizes current recommendations for intake addresses safety concerns. Evidence from both animal studies indicates that may have beneficial effects, blood pressure improved cardiac fitness, enhanced vascular health. Its mechanisms action antioxidant properties make it intriguing candidate anti-aging strategies.

Language: Английский

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