Clinical Diabetes and Endocrinology, Journal Year: 2024, Volume and Issue: 10(1)
Published: Dec. 2, 2024
Language: Английский
Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 63 - 63
Published: Feb. 1, 2025
In this work, the hypolipidemic and antioxidative capacity of FSGLR (S7) GIEWA (S10) from miiuy croaker swim bladders was explored systematically in an oleic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model HepG2 cells. Moreover, activity S7 S10 their abilities were preliminarily investigated combination with molecular docking technology. The results indicated that could decrease amount lipid accumulation content triglycerides (TG) total cholesterol (TC) OA-induced NAFLD cell a dose-dependent manner. addition, exhibited better bile salt binding, pancreatic lipase (PL) inhibition, esterase (CE) inhibition capacities. mechanisms connected downregulation mRNA expression levels adipogenic factors, including sterol-regulatory element-binding protein-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), protein (SREBP)-2, hydroxymethylglutaryl-CoA reductase (HMGR), synthase (FAS) (p < 0.01), upregulation β-oxidation-related carnitine palmitoyltransferase 1 (CPT-1), acyl-CoA oxidase (ACOX-1), peroxisome proliferator-activated receptor α (PPARα). significantly protect cells against oxidative damage, antioxidant related to increased intracellular proteases (superoxide dismutase, SOD; glutathione peroxidase, GSH-PX; catalase, CAT) remove excess reactive oxygen species (ROS) production malondialdehyde (MDA). presented findings indicate functions make them potential candidates for treatment NAFLD.
Language: Английский
Citations
1
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: Feb. 12, 2025
Background Nonalcoholic fatty liver disease (NAFLD) is a chronic and its prevalence has risen sharply. However, whether nutrition, dietary strategies, exercise, lifestyle environment have preventive value for NAFLD remains unclear.
Language: Английский
Citations
1
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15
Published: May 11, 2022
Nonalcoholic fatty liver disease (NAFLD) defines fat accumulation in the liver, and it is commonly associated with metabolic syndromes like diabetes obesity. Progressive NAFLD leads to nonalcoholic steatohepatitis (NASH) ultimately causes cirrhosis hepatocellular carcinoma, NASH currently a frequent cause of transplantation. Oxidative stress often contributed progression NAFLD, hence, antioxidants such as silymarin, silybin, or silibinin, pentoxifylline, resveratrol, vitamins A, C, E are used clinical trials against NAFLD. Silymarin induces peroxisome proliferator-activated receptor α (PPARα), acid sensor, which promotes transcription genes that required for enzymes involved lipid oxidation hepatocytes. Silybin inhibits sterol regulatory element-binding protein 1 carbohydrate response downregulate expression responsible de novo lipogenesis by activating AMP-activated kinase phosphorylation. Pentoxifylline TNF-α endoplasmic reticulum stress-mediated inflammatory nuclear factor kappa B (NF-κB) activation. Thus, prevents progression. Resveratrol methylation at Nrf-2 promoters NF-κB activity via SIRT1 activation conditions. However, clinically, resveratrol has not shown promising beneficial effects. Vitamin C patients. effectively regressing hepatic fibrosis. Hence, its combination antifibrotic agents an adjuvant produce synergistic effect. date, none these have been definite therapeutic agent Further, should be studied patients larger populations multiple endpoints future.
Language: Английский
Citations
36
Cells, Journal Year: 2022, Volume and Issue: 11(21), P. 3390 - 3390
Published: Oct. 27, 2022
Nonalcoholic steatohepatitis (NASH) increases with fructose consumption and metabolic syndrome has been recently linked endogenous ethanol production, notably by high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn). Candida yeasts are the main causes of auto-brewery syndromes but have neglected in NASH. Here, fecal microbial content 10 cases controls were compared. Ethanol was measured gas chromatography-mass spectrometry. Species identification performed MALDI-TOF MS, triglyceride production assessed a colorimetric enzymatic assay. The concentration four times higher patients NASH (median [interquartile range]: 0.13 [0.05-1.43] vs. 0.034 [0.008-0.57], p = 0.037). Yeasts isolated from almost all not (9/10 0/10, 0.0001). Pichia kudriavzevii most frequent (four patients), while glabrata, albicans, Galactomyces geotrichum identified two each. produced than that bacteria (median, 3.36 [0.49-5.60] 0.32 [0.009-0.43], 0.0029). Using 10% D-fructose restricted medium, we showed NASH-associated transformed ethanol. Unexpectedly, substantial amount triglycerides. strains maximal levels vitro. Our preliminary human descriptive vitro experimental results suggest neglected. In addition to K. pneumoniae, gut could be pathophysiology species- strain-specific manner through fructose-dependent alcohol production.
Language: Английский
Citations
34
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4583 - 4583
Published: Feb. 26, 2023
Nonalcoholic fatty liver disease (NAFLD), a chronic condition associated with metabolic dysfunction and obesity, has reached epidemic proportions worldwide. Although early NAFLD can be treated lifestyle changes, the treatment of advanced pathology, such as nonalcoholic steatohepatitis (NASH), remains challenge. There are currently no FDA-approved drugs for NAFLD. Fibroblast growth factors (FGFs) play essential roles in lipid carbohydrate metabolism have recently emerged promising therapeutic agents diseases. Among them, endocrine members (FGF19 FGF21) classical (FGF1 FGF4) key regulators energy metabolism. FGF-based therapies shown benefits patients NAFLD, substantial progress been made clinical trials. These FGF analogs effective alleviating steatosis, inflammation, fibrosis. In this review, we describe biology four metabolism-related FGFs (FGF19, FGF21, FGF1, their basic action mechanisms, then summarize recent advances biopharmaceutical development
Language: Английский
Citations
21
JHEP Reports, Journal Year: 2023, Volume and Issue: 6(1), P. 100964 - 100964
Published: Nov. 17, 2023
High ultra-processed food (UPF) consumption is associated with the development of various diet-related non-communicable diseases, especially obesity and type 2 diabetes. The present study aimed to systematically review association between UPF non-alcoholic fatty liver disease (NAFLD) its leading risk factors; metabolic syndrome (MetS) insulin resistance (IR).
Language: Английский
Citations
19
Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(24), P. 9370 - 9380
Published: June 8, 2023
Non-alcoholic steatohepatitis (NASH) has become the most important reason of liver disease around world and is predisposed to further progression cirrhosis hepatocellular carcinoma. Ginsenoside Rk3 been reported have a plenty biological activities, including anti-apoptotic, anti-anemia, protective effects against acute kidney injury. However, whether ginsenoside can improve NASH not yet. Therefore, purpose this study investigate effect its mechanism action. C57BL/6 mice were treated with different dosages after being established as model. Our results showed that administration significantly improved inflammation, lipid deposition, fibrosis caused by high-fat-high-cholesterol (HFHC) diet CCl4 injection in mice. Notably, was discovered inhibit PI3K/AKT signaling pathway. Additionally, treatment remarkably amended abundance short-chain fatty acids. These changes associated beneficial variations variety composition intestinal microbiota. In conclusion, ameliorates hepatic non-alcoholic inflammation triggers flora, helping reveal host-microbe interactions. The outcomes indicate promising drug candidate for NASH.
Language: Английский
Citations
18
Hepatology Communications, Journal Year: 2023, Volume and Issue: 7(10)
Published: Sept. 27, 2023
NAFLD is the most common chronic liver disease worldwide, characterized by lipid accumulation in liver, and usually evolves from steatohepatitis to fibrosis, cirrhosis, or even HCC. Its incidence rapidly rising parallel with increasing prevalence of obesity metabolic syndrome. Current therapies are limited lifestyle changes including dietary intervention exercise, which modification exerts an important part losing weight preventing NAFLD. In this review, we briefly discuss roles mechanisms components fructose, non-nutritive sweeteners, fat, proteins, vitamins progression prevention We also summarize several popular patterns such as calorie-restricted diets, intermittent fasting, ketogenic Mediterranean approach stop hypertension diets compare effects low-fat low-carbohydrate development Moreover, potential drugs targeting metabolic-related targets
Language: Английский
Citations
17
Annals of Hepatology, Journal Year: 2024, Volume and Issue: 29(3), P. 101491 - 101491
Published: Feb. 25, 2024
Our objective was to measure and compare the intake of macro micronutrients in a cohort individuals with Metabolic Syndrome Associated Steatotic Liver Disease (MASLD) compared matched controls identify areas further research this area; we identified nutrition-associated associations MASLD United States general population.
Language: Английский
Citations
8
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215864 - 215864
Published: May 7, 2024
Language: Английский
Citations
8