Published: Jan. 1, 2024
Language: Английский
Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13
Published: July 12, 2022
The growing incidence of neurodegenerative disorders in our populations is leading the research to identify potential biomarkers and targets for facilitating their early management treatments. Biomarkers represent crucial indicators both physiological pathological processes. Specific changes molecular cellular mechanisms processes result biochemical alterations at systemic level, which can give us comprehensive information regarding nature any disease. In addition, disease biomarker should be specific reliable, able consent distinguishing condition a tissue, organ, or system from disease, diverse among various diseases, subgroups phenotypes them. Accordingly, predict chances facilitate diagnosis, set guidelines development new therapies treating diseases disease-making process. Here, we focus attention on brain neurotrophic factor (BDNF)–tropomyosin receptor kinase (Trk) pathway, describing its multiple roles maintenance central nervous (CNS) health, as well implication pathogenesis sclerosis (MS). also evidence features such make it MS therapeutic target.
Language: Английский
Citations
43
Autophagy, Journal Year: 2023, Volume and Issue: 20(2), P. 259 - 274
Published: Sept. 15, 2023
Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS) due to an increase abnormal peripherally auto-reactive T lymphocytes which elicit autoimmunity. The main pathophysiology MS myelin sheath damage by immune cells and defect in generation oligodendrocytes. Macroautophagy/autophagy critical degradation process that eliminates dysfunctional or superfluous cellular components. Autophagy has property double-edged sword it may have both beneficial detrimental effects on neuropathology. Therefore, this review illustrates protective harmful autophagy with regard disease. prevents progression reducing oxidative stress inflammatory disorders. In contrast, over-activated associated neuropathology case use inhibitors alleviate pathogenesis MS. Furthermore, provokes activation different supporting play intricate role functions modulation regulating cell proliferation related demyelination remyelination. enhances remyelination increasing activity oligodendrocytes, astrocytes. However, induces activating microglia cells. conclusion, specific autophagic activators astrocytes, dendritic (DCs), induce against
Language: Английский
Citations
37
Autoimmunity Reviews, Journal Year: 2022, Volume and Issue: 21(12), P. 103210 - 103210
Published: Oct. 21, 2022
Language: Английский
Citations
36
Cells, Journal Year: 2022, Volume and Issue: 11(18), P. 2771 - 2771
Published: Sept. 6, 2022
Multiple sclerosis (MS) is a chronic neurodegenerative disease marked by oligodendrocyte loss, which results in central neuronal demyelination. AC/cAMP/CREB signaling dysregulation involved the progression of MS, including mitochondrial dysfunctions, reduction nerve growth factors, inflammation, apoptosis, and white matter degeneration. Our previous research has shown that Forskolin (FSK), naturally occurring direct adenylyl cyclase (AC)/cAMP/CREB activator, neuroprotective potential to alleviate pathogenic factors linked with numerous neurological abnormalities. The current study intends explore FSK at doses 40 mg/kg 60 alone, as well combination conventional medicines, such Fingolimod (FNG), Donepezil (DON), Memantine (MEM), Simvastatin (SIM) EB-induced demyelinated experimental MS rats. Adult Wistar rats were divided into nine groups, EB was infused stereotaxically rat brain’s intracerebropeduncle (ICP) area. Chronic gliotoxin treatment demyelination motor cognitive dysfunctions. FSK, combined standard medications, improves behavioral neuromuscular deficits memory Following pharmacological treatments improved remyelination enhancing myelin basic protein increasing AC, cAMP, CREB levels brain homogenates. Furthermore, therapy restored mitochondrial-ETC complex enzymes neurotransmitter while decreasing inflammatory cytokines oxidative stress markers. Luxol fast blue (LFB) stain further indicate FSK’s preventing death. Therefore, these studies contribute better understanding possible role natural phytochemicals could have neuron diseases, multiple sclerosis.
Language: Английский
Citations
17
Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4284 - 4284
Published: Nov. 27, 2021
Physical activity could play a key role in improving the quality of life, particularly patients with nervous system diseases such as multiple sclerosis (MS). Through lactacid anaerobic training, this study aims to investigate effects at bio-psycho-physical level counteract chronic fatigue associated pathology, and improve mental health psychological neurotrophic level. Eight subjects (age: 34.88 ± 4.45 years) affected by were involved. A lactate threshold training program was administered biweekly for 12 weeks beginning (T0), end (T1) 9 months after (T2), physical, hematochemicals parameters, dietary habits being tested. The results obtained confirmed that exercise can influence brain-derived factor (BDNF) levels well dehydroepiandrosterone sulfate (DHEAS) levels. In addition, baseline lactate, which be best used an energy substrate, showed decrease protocol training. Self-efficacy regarding worries concerns management significantly increased from T0 T1. eating attitudes test (EAT-26) did not highlight any disease normal diet enrolled our study. also greatly influenced psychologically emotionally, increasing their self-esteem. Lactate together habits, appears exert synergic positive on inflammation, neural plasticity neuroprotection, producing preventive MS symptoms progression.
Language: Английский
Citations
17
Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105439 - 105439
Published: Jan. 9, 2024
Language: Английский
Citations
2
Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105467 - 105467
Published: Jan. 26, 2024
Language: Английский
Citations
2
Neurology International, Journal Year: 2023, Volume and Issue: 15(1), P. 392 - 404
Published: March 10, 2023
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fluctuating weakness of the skeletal muscles. Although antibodies against junction components are recognized, MG pathogenesis remains unclear, even if with a well-known multifactorial character. However, perturbations human microbiota have been recently suggested to contribute and clinical course. Accordingly, some products derived from commensal flora demonstrated anti-inflammatory effects, while other shown possess pro-inflammatory properties. In addition, patients when compared age-matched controls showed distinctive composition in oral gut microbiota, typical increase Streptococcus Bacteroides reduction Clostridia as well short-chain fatty acid reduction. Moreover, restoring perturbation has evidenced after administration probiotics followed improvement symptoms cases. To highlight role course, here, current evidence summarized reviewed.
Language: Английский
Citations
6
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(6), P. 825 - 825
Published: May 31, 2023
Endothelial dysfunction is characterized by disturbances in nitric oxide (NO) bioavailability and increased circulating asymmetric dimethylarginine (ADMA) due to the enormous release of free radicals. Increased ADMA may cause endothelial a variety clinical disorders, such as liver kidney disease. Young male Sprague-Dawley rats at postnatal day 17 ± 1 received continuous infusion via an intraperitoneal pump induce dysfunction. Four groups (n = 10 per group) were allocated: control, control resveratrol, infusion, resveratrol groups. Spatial memory, NLR family pyrin-domain-containing 3 (NLRP3) inflammasome, cytokine expression, tight junction proteins ileum dorsal hippocampus, microbiota composition examined. We found cognitive deficits; NLRP3 inflammasome plasma, ileum, hippocampus; decreased hippocampal activation proteins; alterations ADMA-infusion young rats. Resveratrol had beneficial effects this context. In conclusion, we observed peripheral central dysbiosis with ADMA, that effects. Our work adds mounting evidence inhibiting systemic inflammation promising therapeutic avenue for cognition impairment, probably gut-brain axis.
Language: Английский
Citations
6
Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1927 - 1927
Published: May 4, 2022
Diet plays a major role in the aetiopathogenesis of many neurological diseases and may exacerbate their symptoms by inducing occurrence metabolic disorders. The results research on diet course multiple sclerosis (MS) are ambiguous, there is still no consensus concerning dietary recommendations for patients with MS. aim this study was to analyse patterns (DPs) MS assess relationships between these DPs participants were comprised 330 aged 41.9 ± 10.8 years. A survey questionnaire used collect data related diet, lifestyle health. identified using principal component analysis (PCA). Three identified: Traditional Polish, Prudent Fast Food & Convenience Food. An odds ratios adjusted age, gender, smoking education showed that patient's adherence Polish increased likelihood abdominal obesity low HDL-cholesterol concentration. Conversely, DP not significantly associated any disorder. confirmed an unhealthy connected presence some risk factors. There also urgent need educate healthy eating, because appropriate modifications improve profile clinical outcomes.
Language: Английский
Citations
8