Fermented foods: Harnessing their potential to modulate the microbiota-gut-brain axis for mental health

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105562 - 105562

Published: Jan. 25, 2024

Over the past two decades, whole food supplementation strategies have been leveraged to target mental health. In addition, there has increasing attention on ability of gut microbes, so called psychobiotics, positively impact behaviour though microbiota-gut-brain axis. Fermented foods offer themselves as a combined microbiota modulating intervention. Indeed, they contain potentially beneficial microbial metabolites and other bioactives, which are being harnessed axis for positive benefits. This review highlights diverse nature fermented in terms raw materials used type fermentation employed, summarises their potential shape composition microbiota, brain communication pathways including immune system and, ultimately, modulate Throughout, we identify knowledge gaps challenges faced designing human studies investigating health-promoting individual or components thereof. Importantly, also suggest solutions that can advance understanding therapeutic merit

Language: Английский

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Is There More to Olive Oil than Healthy Lipids?

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3625 - 3625

Published: Aug. 18, 2023

The Mediterranean diet is a healthy dietary pattern whose main characteristic olive oil consumption. potential health benefits of have been extensively investigated and the present review provides more recent clinical evidence supporting positive impact intake on human health. PubMed (n = 227) Scopus 308) databases were searched for published studies in English over past six years (October 2016 to December 2022), following key word searches "olive oil" "health". Major findings associated with antioxidant anti-inflammatory effects, improvement endothelial function lipid profile, prevention obesity, diabetes, cardiovascular neurodegenerative diseases, modulation gut microbiota. These are attributed nutritional composition oil, which has high content monounsaturated fatty acids (MUFA) (oleic acid particular) minor compounds such as polyphenols (oleuropein hydroxytyrosol). Although additional research continues be required, recently generated supports contribute beneficially management variety non-communicable consequence synergism between its components' complexity.

Language: Английский

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Effect of Extra Virgin Olive Oil on Anthropometric Indices, Inflammatory and Cardiometabolic Markers: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 154(1), P. 95 - 120

Published: Nov. 15, 2023

Language: Английский

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Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction and metabolic syndrome

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103311 - 103311

Published: Aug. 14, 2024

Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst identification responsible constituents for beneficial effects is still pending. We sought to assess and compare cardioprotective potential oleuropein (OL), hydroxytyrosol (HT), oleocanthal (OC) oleanolic Acid (OA), regarding Ischemia/Reperfusion Injury (IRI) CVD risk factors alleviation. The scope study was design a potent safe combinatorial therapy high-cardiovascular-risk patients on bench-to-bedside approach. evaluated IRI-limiting 6-weeks treatment with OL, HT, OC or OA at nutritional doses, healthy metabolic syndrome (MS)-burdened mice. Three regimens were designed mixture preponderant benefits (OL-HT-OC, Combo 2), including infarct sparing antiglycemic potency, compared isolated compounds, further investigated its anti-atherosclerotic effects. In vivo experiments revealed that combination regimen 2 presented most favorable limiting size hyperglycemia, which selected be clinical setting Chronic Coronary Artery Syndrome (CCAS) patients. Cardiac function, inflammation markers oxidative stress assessed baseline after 4 weeks OL-HT-OC supplement study. found significantly reduced Controls. OL exhibited antihyperglycemic properties attenuated hypercholesterolemia. OL-HT-OA, OL-HT-OC-OA cardioprotective, whereas only mitigated hyperglycemia. cardioprotection attributed apoptosis suppression, enhanced antioxidant upregulation enzymes. Additionally, it atherosclerotic plaque extent vivo. ameliorated cardiac, vascular endothelial function small-scale Conclusively, exerts vivo, remarkable clinically translatable high-risk

Language: Английский

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Associations of Systematic Inflammatory Markers with Diet Quality, Blood Pressure, and Obesity in the AIRWAVE Health Monitoring Study

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3129 - 3141

Published: May 1, 2024

Introduction: Chronic low-grade inflammation is a characteristic feature of obesity, and elevated levels are associated with pathophysiologic consequences constellation metabolic disturbances, such as hypertension. The relationships diet, hypertension complex, hence, this study aimed to assess cross-sectional between inflammatory scores, diet quality, high blood pressure (BP), in the Airwave Health Monitoring Study cohort, large cohort police officers staff United Kingdom. Methods: Data from 5198 men 3347 women who completed health screening measurements dietary assessment 2007 2012 were included (n=8545 adults). Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), systemic immune-inflammation index (SII) calculated. Diet quality was evaluated using Nutrient-Rich Food 9.3 (NRF9.3) score. Results: Results show that 1SD higher score, waist circumference, systolic/diastolic BP significantly SII differences − 33.3 (95% confidence interval (CI): 49.0, 17.6), 8.2 CI: 0.2, 16.6), 17.9 10.1, 25.8), 18.3 10.8, 25.7) (Model 2; P< 0.0001), respectively. A BMI also PLR (P< 0.0001). odds those systolic diastolic 0.0001, P=0.0006, respectively). Conclusion: In conclusion, findings analysis add existing knowledge indicating link conditions hypertension, behavioral factors including quality. Of various scores evaluated, consistently these conditions. Keywords: markers, pressure, obesity

Language: Английский

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Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1440 - 1440

Published: July 25, 2022

Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there no specific pharmacological treatment this disease. Objective: To assess the relationship between adherence to and intrahepatic fat content (IFC), levels of oxidative stress, inflammation biomarkers after 6-month lifestyle intervention in NAFLD patients. Methods: Patients diagnosed with (n = 60 adults; 40–60 years old) living Balearic Islands, Spain, were classified into two groups, according MedDiet 6 months intervention. Anthropometry, blood pressure, IFC, maximal oxygen uptake, pro/antioxidant inflammatory measured plasma PBMCs before Results: Reductions weight, body mass index, pressure levels, circulating glucose, glycosylated hemoglobin, markers damage—aspartate aminotransferase (AST), alanine (ALT), gamma-glutamyl transferase (GGT), cytokeratin 18 (CK-18)—were observed The highest reductions group best MedDiet. significant improvement cardiorespiratory fitness was also higher adherence. activities catalase superoxide dismutase mononuclear cells increased only adherence, well gene expression cells. malondialdehyde myeloperoxidase decreased, resolvin-D1 both groups intervention, whereas interleukin-6 decreased Conclusions: greater related improvements fitness, pro-oxidative proinflammatory status patients nutritional based on

Language: Английский

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Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals

Antioxidants, Journal Year: 2022, Volume and Issue: 11(3), P. 437 - 437

Published: Feb. 22, 2022

Extra virgin olive oil (EVOO) is the typical source of fats in Mediterranean diet. While fatty acids are essential for EVOO nutraceutical properties, multiple biological activities also due to presence polyphenols. In this work, autochthonous Tuscany EVOOs were chemically characterized and selected samples extracted obtain hydroalcoholic phytocomplexes, which assayed establish their anti-inflammatory vasorelaxant properties. The polar extracts via 1H-NMR UHPLC-HRMS investigate chemical composition CaCo-2 cells exposed glucose oxidase or rat aorta rings contracted by phenylephrine. Apigenin luteolin found as representative flavones; other components pinoresinol, ligstroside, oleuropein. showed antioxidant properties modulation NF-κB Nrf2 pathways, respectively, good activity, both absence an intact endothelium. conclusion, study evaluated cv., promising effects.

Language: Английский

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Dietary EVOO Polyphenols and Gut Microbiota Interaction: Are There Any Sex/Gender Influences?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(9), P. 1744 - 1744

Published: Sept. 2, 2022

Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source fat in Mediterranean diet, is associated with beneficial health effects and a reduced risk developing chronic degenerative disorders. The EVOO can be attributed to its unique composition monounsaturated fats phenolic compounds provide important antioxidant, anti-inflammatory, immune-modulating activities. On other hand, it well known gut microbiota has several roles normal human physiology, influenced by multitude environmental lifestyle factors, among which dietary components play relevant role. In last few years, two-way interaction between polyphenols, including those EVOO, microbiota, i.e., modulation polyphenols polyphenol metabolism bioavailability attracted growing attention, being potentially explain final as profile. Furthermore, sex gender affect habits, intake, nutrient metabolism. Lastly, been recently suggested differences could involved unequal incidence metabolic diseases observed women men, due sex-dependent on shaping profiles according diet. This review summarizes most recent studies relationship taking into account possible influences modulating such an interaction.

Language: Английский

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Synergistic Beneficial Effects of Flaxseed (Linum usitatissimum L.) Oil and Olive (Olea europaea L.) Oil Against Metabolic Dysfunction Associated Fatty Liver and Its Complications

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 2, 2024

ABSTRACT Flaxseed and olive oil effectively treat numerous diseases health conditions, particularly metabolic disorders. Traditional medicine has used both oils for managing cardiovascular disease, diabetes, gastrointestinal dysfunctions, metabolic‐dysfunction‐associated fatty liver disease (MAFLD), obesity, more. This review explores the bioactive polyphenolic compounds in flaxseed that provide anti‐inflammatory, antioxidant, anti‐microbial, hepatoprotective, cardioprotective, antidiabetic, gastroprotective benefits. contains beneficial like alpha‐linolenic acid (ALA), lignans, ferulic acid, p‐coumaric phytosterols. It contributes to its therapeutic effects on other conditions. Olive phenolic compounds, including oleic hydroxytyrosol, tocopherols, which are similarly linked benefits, especially MAFLD. The purpose of this is elucidate mechanisms action these highlighting their potential various diseases.

Language: Английский

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Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

Journal of Oleo Science, Journal Year: 2022, Volume and Issue: 71(8), P. 1199 - 1206

Published: Jan. 1, 2022

Pain is a sensation humans sense as protective mechanism against physical injury. This closely related to inflammation. It ranges from mild highly obnoxious. well-known that the levels of inflammatory biomarker, C-reactive protein (CRP), increase manifold in acute inflammation and pain. Olive oil, known have many phytochemicals, has been traditionally used alleviate Amongst major phenolic compounds olive oil are oleuropein (OLE), hydroxytyrosol (HT), tyrosol, oleocanthal. Whether analgesic anti-inflammatory properties due any specific interections not known. Therefore, this study aimed elucidate possible anti-nociceptive those by using molecular docking software MOE 2015, comparing energy value binding site synthetic non-steroidal drugs (NSAIDs) phosphocholine. The experiment showed all could directly interact with CRP. Oleuropein had most potent interaction CRP (-7.7580), followed indomethacin (-6.0775), oleocanthal (-5.5734), ibuprofen (-5.3857), phosphocholine (-4.3876), HT (-4.2782), tyrosol (-4.2329). Interestingly, present found other phytochemicals can be exploited potential, safe, cost-effective lead compound(s) for activity, supported its data.

Language: Английский

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