Magnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis DOI Creative Commons
Wang Liao,

Jiana Wei,

Chongxu Liu

et al.

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(10), P. 2281 - 2289

Published: Dec. 21, 2023

JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to development of Alzheimer’s disease. Magnesium-L-threonate has recently been found have protective effects on learning and memory aged disease model mice. However, magnesium-L-threonate gut microbiota remain unknown. Previously, we reported that treatment improved cognition reduced oxidative stress inflammation a double-transgenic line mice expressing amyloid-β precursor protein mutant human presenilin 1 (APP/PS1). Here, performed 16S rRNA amplicon sequencing liquid chromatography-mass spectrometry analyze changes microbiome serum metabolome following exposure similar mouse model. modulated abundance three genera microbiota, decreasing Allobaculum increasing Bifidobacterium Turicibacter . We also differential metabolites magnesium-L-threonate-regulated were enriched various pathways associated with neurodegenerative diseases. The western blotting detection intestinal tight junction proteins (zona occludens 1, occludin, claudin-5) showed repaired barrier dysfunction APP/PS1 These findings suggest reduce clinical manifestations through mice, providing an experimental basis for

Language: Английский

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions DOI Creative Commons
Kenji Hashimoto

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(9), P. 3625 - 3637

Published: Sept. 1, 2023

Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.

Language: Английский

Citations

56
Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review DOI Open Access
Paulina Iwaniak,

Maja Owe-Larsson,

Ewa M. Urbańska

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2915 - 2915

Published: March 2, 2024

In the era of a steadily increasing lifespan, neurodegenerative diseases among elderly present significant therapeutic and socio-economic challenge. A properly balanced diet microbiome diversity have been receiving attention as targets for interventions in neurodegeneration. Microbiota may affect cognitive function, neuronal survival death, gut dysbiosis was identified Parkinson’s disease (PD). Tryptophan (Trp), an essential amino acid, is degraded by microbiota hosts numerous compounds with immune- neuromodulating properties. This broad narrative review presents data supporting concept that microbiota, Trp-kynurenine (KYN) pathway aryl hydrocarbon receptors (AhRs) form triad involved PD. disturbed gut–brain axis allows bidirectional spread pro-inflammatory molecules α-synuclein, which contribute to development/progression disease. We suggest peripheral levels kynurenines AhR ligands are strongly linked Trp metabolism should be studied together composition microbiota. Such approach can clearly delineate sub-populations PD patients manifesting microbiota–Trp-KYN–brain triad, who would benefit from modifications metabolism. Analyses microbiome, Trp-KYN metabolites signaling shed light on mechanisms intestinal distress identify new diagnosis treatment early-stage Therapeutic based combination well-defined food regimen, probiotics seem potential require further experimental clinical research.

Language: Английский

Citations

13
Gut–Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson’s Disease DOI Open Access

Elizabeth Riegelman,

Kathy S. Xue, Jia-Sheng Wang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2041 - 2041

Published: June 27, 2024

With the recognition of importance gut-brain axis in Parkinson's disease (PD) etiology, there is increased interest developing therapeutic strategies that target α-synuclein, hallmark abhorrent protein PD pathogenesis, which may originate gut. Research has demonstrated inhibiting aggregation, oligomerization, and fibrillation α-synuclein are key for modification. Polyphenols, rich fruits vegetables, drawing attention their potential role this context. In paper, we reviewed how polyphenols influence composition functional capabilities gut microbiota resulting microbial metabolites potentially enhance modulation aggregation. Understanding interaction between identifying specific microbes efficacy crucial precision nutrition based on microbiome.

Language: Английский

Citations

9
Gut microbiota dysbiosis contributes to α-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson's disease DOI Creative Commons

Xiaoli Fang,

Sha Liu, Bilal Muhammad

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 19(9), P. 2081 - 2088

Published: Jan. 12, 2024

JOURNAL/nrgr/04.03/01300535-202409000-00042/figure1/v/2024-01-30T062302Z/r/image-tiff Parkinson's disease is a neurodegenerative characterized by motor and gastrointestinal dysfunction. Gastrointestinal dysfunction can precede the onset of symptoms several years. Gut microbiota dysbiosis involved in pathogenesis disease, whether it plays causal role dysfunction, mechanism underlying this potential effect, remain unknown. CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP) signaling, activated bacterial endotoxin, promote α-synuclein transcription, thereby contributing to pathology. In study, we aimed investigate gut C/EBPβ/AEP α-synuclein-related pathology, using rotenone-induced mouse model combined with antibiotic-induced microbiome depletion fecal transplantation. We found that rotenone administration resulted perturbation intestinal barrier, as well activation C/EBP/AEP pathway, aggregation, tyrosine hydroxylase-positive neuron loss substantia nigra mice deficits. However, treatment did not have any these adverse effects whose was depleted pretreatment antibiotics. Importantly, transplanting derived from treated induced deficits, inflammation, endotoxemia. Transplantation healthy control alleviated endotoxemia, barrier impairment. These results highlight vital inducing signaling activation, pathology disease. Additionally, our findings suggest supplementing may be safe effective could help ameliorate progression deficits patients

Language: Английский

Citations

8
Endoplasmic reticulum stress: A possible connection between intestinal inflammation and neurodegenerative disorders DOI Creative Commons
Giorgio Vivacqua, Romina Mancinelli, Stefano Leone

et al.

Neurogastroenterology & Motility, Journal Year: 2024, Volume and Issue: 36(5)

Published: March 10, 2024

Abstract Background Different studies have shown the key role of endoplasmic reticulum (ER) stress in autoimmune and chronic inflammatory disorders, as well neurodegenerative diseases. ER leads to formation misfolded proteins which affect secretion different cell types that are crucial for intestinal homeostasis. Purpose In this review, we discuss its involvement development bowel diseases, conditions can cause severe damage gastrointestinal tract, focusing on alteration Paneth cells goblet (the principal secretory phenotypes epithelial cells). is also discussed context protein misfolding represents signature mechanism. consequent accumulation might represent a bridge between inflammation neurodegeneration along gut‐to‐brain axis, affecting homeostasis equilibrium commensal microbiota. Targeting could foster future designing new biomarkers therapeutic approaches disorders.

Language: Английский

Citations

7
Antipsychotic drug-induced behavioral abnormalities in common carp: The potential involvement of the gut microbiota-brain axis DOI

Xulu Chang,

Yihao Shen,

Mingqi Yang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134444 - 134444

Published: April 30, 2024

Language: Английский

Citations

7
Adolescent alcohol drinking interaction with the gut microbiome: implications for adult alcohol use disorder DOI Creative Commons
Bruk Getachew, Sheketha R. Hauser, Samia Bennani

et al.

Advances in Drug and Alcohol Research, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 15, 2024

Reciprocal communication between the gut microbiota and brain, commonly referred to as “gut-brain-axis” is crucial in maintaining overall physiological homeostasis. Gut development brain maturation (neuronal connectivity plasticity) appear be synchronized follow same timeline during childhood (immature), adolescence (expansion) adulthood (completion). It important note that mesolimbic reward circuitry develops early on, whereas of inhibitory frontal cortical neurons delayed. This imbalance can lead increased acquirement reward-seeking risk-taking behaviors adolescence, consequently eventuate heightened risk for substance abuse. Thus, there high initiation alcohol drinking significantly increases use disorder (AUD) adulthood. The underlying causes AUD are not well understood. suggested alcohol-associated impairment plays a key role neurodevelopment Furthermore, alcohol-induced dysregulation microglia, either directly or indirectly through interaction with microbiota, may critical neuroinflammatory pathway leading neurodevelopmental impairments AUD. In this review article, we highlight influence adolescent on gut-brain axis eventual manifestation novel therapeutic interventions via manipulations discussed briefly.

Language: Английский

Citations

6
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review DOI Creative Commons

Alexandra K. Mitchell,

Rebecca R. Bliss,

Frank Church

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1241 - 1241

Published: Sept. 30, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative in which treatment often includes an exercise regimen. Exercise neuroprotective animal models of PD, and, more recently, human clinical studies have verified exercise's disease-modifying effect. Aerobic and resistance training improve many PD's motor non-motor symptoms, while neuromotor therapy stretching/flexibility exercises positively contribute to the quality life people with PD. Therefore, understanding role managing this complex disorder crucial. Exerkines are bioactive substances that synthesized released during been implicated several positive health outcomes, including neuroprotection. protect neuronal cells vitro rodent PD vivo. both increase exerkine levels blood, suggesting for exerkines theory. Many demonstrate potential protecting brain against pathological missteps caused by Every person (people) (PwP) needs comprehensive plan tailored their unique abilities. Here, we provide template help PwP understand importance treating describe barriers confronting attempt exercise, suggestions overcoming these barriers, explore In conclusion, together create powerful system should slowing chronic progression

Language: Английский

Citations

6
The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease DOI Creative Commons

Shengyang Zhou,

Ting Li,

Wei Zhang

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(8), P. 2361 - 2372

Published: June 3, 2024

JOURNAL/nrgr/04.03/01300535-202508000-00026/figure1/v/2024-09-30T120553Z/r/image-tiff Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon 7-mediated signaling contributes to Parkinson’s disease remains unknown. Here we report that is markedly up-regulated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced mouse model of and co-localizes with microglial cells. Both selective cyclic guanosine monophosphate adenosine synthase inhibitor RU.521 stimulator genes H151 effectively suppressed activation BV2 microglia exposed 1-methyl-4-phenylpyridinium inhibited transformation into neurotoxic M1 phenotype. In addition, siRNA-mediated knockdown expression reduced inducible nitric oxide synthase, tumor necrosis α, CD16, CD32, CD86 increased anti-inflammatory markers ARG1 YM1. Taken together, our findings indicate synthase–stimulator genes–interferon pathway pathogenesis

Language: Английский

Citations

6
The molecular interplay between human and bacterial amyloids: Implications in neurodegenerative diseases DOI
Neha Jain

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Journal Year: 2024, Volume and Issue: 1872(4), P. 141018 - 141018

Published: April 17, 2024

Language: Английский

Citations

5