Microbiota Dysbiosis in Parkinson Disease—In Search of a Biomarker DOI Creative Commons
Julia Maya Nowak, Mateusz Henryk Kopczyński,

Andrzej Friedman

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(9), P. 2057 - 2057

Published: Aug. 23, 2022

Numerous studies have highlighted the role of gastrointestinal system in Parkinson disease pathogenesis. It is likely triggered by proinflammatory markers produced specific gut bacteria. This review's aim to identify bacterial biomarkers disease. A comprehensive search for original research papers on microbiota composition was conducted using PubMed, Embase, and Scopus databases. Research intestinal permeability, nasal oral microbiomes, interventional were excluded. The yielded results categorized into four groups: vs. healthy controls; severity; non-motor symptoms; clinical phenotypes. review accordance with PRISMA 2020 statement. total 51 met eligibility criteria. In controls group, 22 bacteria deemed potentially important. severity category, two distinguished. symptoms phenotypes categories, no distinct pathogen identified. this report varying taxonomic levels, which prevents authors from reaching a clear conclusion. Future should follow unified methodology order potential

Language: Английский

Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases DOI Open Access
Tanja Patricia Eicher, M. Hasan Mohajeri

Nutrients, Journal Year: 2022, Volume and Issue: 14(13), P. 2661 - 2661

Published: June 27, 2022

The involvement of the gut microbiota and metabolites colon-residing bacteria in brain disease pathogenesis has been covered a growing number studies, but comparative literature is scarce. To fill this gap, we explored contribution microbiota-gut-brain axis to pathophysiology seven brain-related diseases (attention deficit hyperactivity disorder, autism spectrum schizophrenia, Alzheimer's disease, Parkinson's major depressive bipolar disorder). In article, discussed changes bacterial abundance metabolic implications these on development progression. Our central findings indicate that, mechanistically, all are associated with leaky gut, neuroinflammation, over-activated microglial cells, which gut-residing their important contributors. Patients show pro-inflammatory shift colon microbiota, harbouring more Gram-negative containing immune-triggering lipopolysaccharides (LPS) cell walls. addition, properties (

Language: Английский

Citations

85
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence DOI Creative Commons
Yaning Zang, Xigui Lai, Conghui Li

et al.

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 16

Published: Feb. 8, 2023

Background and Object. There is a growing body of evidence highlighting the significant role gut microbiota in various neurological psychiatric disorders. We performed an mapping to review association between different these disorders assessed strength for associations. Methods. searched PubMed, Cochrane Library, Epistemonikos identify systematic reviews meta-analysis (SRs). diseases disorders, including Alzheimer’s disease (AD), attention deficit hyperactivity disorder (ADHD), amyotrophic lateral sclerosis (ALS), autism spectrum (ASD), anorexia nervosa (AN), bipolar (BD), eating (ED), generalized anxiety (GAD), major depressive (MDD), multiple (MS), obsessive compulsive (OCD), Parkinson’s (PD), posttraumatic stress (PTSD), spinal cord injury (SCI), schizophrenia, stroke. used A Measurement Tool Assess Systematic Reviews (AMSTAR-2) evaluate quality included SRs. also created map showing certainty evidence. Results. In total, 42 studies were this mapping. Most findings obtained from observational studies. According AMSTAR-2 assessment, 21 SRs scored “critically low” terms methodological quality, 16 SR “low,” 5 “moderate.” total 15 have been investigated potential microbiome alpha diversity disease, with Shannon index Simpson being most widely studied. 12 link beta disease. At phylum level, Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Verrucomicrobia more researched. genus Prevotella, Coprococcus, Parabacteroides, Phascolarctobacterium, Escherichia Shigella, Alistipes, Sutteralla, Veillonella, Odoribacter, Faecalibacterium, Bacteroides, Bifidobacterium, Dialister, Blautia Some found specific flora changes, some common intestinal microbiological changes. Conclusion. varied levels associations diseases; increased risk diseases, whereas others showed benefit that might be promising therapeutic targets such diseases.

Language: Английский

Citations

45
Gut microbiota and major depressive disorder: A bidirectional Mendelian randomization DOI
Min Chen,

Chao-Rong Xie,

Yunzhou Shi

et al.

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 316, P. 187 - 193

Published: Aug. 10, 2022

Language: Английский

Citations

64
Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis DOI Creative Commons
Chaoren Tan, Qiqi Yan, Yue Ma

et al.

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying pathophysiology of depression remain elusive. Recently, cumulate research suggests that disturbance microbiota-gut-brain axis may play vital role in etiology while correcting this could alleviate symptoms. The vagus nerve, linking brain gut through its afferent efferent branches, critical route bidirectional communication axis. Directly or indirectly, fibers can sense relay microbiota signals to induce disorders including depression. Also, changes response stress result hyperpermeability inflammation mediating by vagal efferents, which be detrimental Notably, nerve stimulation owns an anti-inflammatory effect was proved for treatment. Nevertheless, accompanied low tone, derive from contribute pathogenesis In review, we aim explore perspective axis, highlighting relationship among hyperpermeability, inflammation,

Language: Английский

Citations

55
Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity DOI Creative Commons

Fernanda-Marie Tette,

Samuel K. Kwofie,

Michael D. Wilson

et al.

Current Issues in Molecular Biology, Journal Year: 2022, Volume and Issue: 44(4), P. 1434 - 1451

Published: March 22, 2022

The role of the microbiota-gut-brain (MGB) axis in mood regulation and depression treatment has gained attention recent years, as evidenced by growing number animal human studies that have reported anti-depressive associated gamma-aminobutyric acid-ergic (GABAergic) effects probiotics developed from Lactobacillus rhamnosus bacterial strains gut microbiome. depressive states attenuated these patients suffering clinical also characterize severe relapse-inducing withdrawal phase addiction cycle, which been found to arise intoxication-enabled hyperregulation hypothalamic-pituitary-adrenal (HPA) axis, body's major stress response system, a corresponding attenuation its main inhibitory acid (GABA) signaling system. Therefore, use general cases provides hope for novel therapeutic approach remediation. This review discusses potential avenues probiotic application can be used restore central GABAergic activity responsible attenuating depression-inducing HPA hyperactivity withdrawal. Also, information is provided on brain other known GABA-producing microbiota.

Language: Английский

Citations

50
Is depression the missing link between inflammatory mediators and cancer? DOI
Barbara Polityńska,

Olga Pokorska,

Anna M. Wojtukiewicz

et al.

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 240, P. 108293 - 108293

Published: Oct. 8, 2022

Language: Английский

Citations

44
An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders DOI Creative Commons
Alejandro Borrego-Ruiz, Juan J. Borrego

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 128, P. 110861 - 110861

Published: Sept. 9, 2023

There is a lot of evidence establishing that nervous system development related to the composition and functions gut microbiome. In addition, central (CNS) controls imbalance intestinal microbiota, constituting bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine neural circuits via vagal pathway. Several empirical data associated microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism Parkinson's other psychological disorders, like anxiety depression. Fecal transplantation (FMT) therapy has shown can transfer behavioral features recipient animals, which provides strong establish causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, demonstrated an important influence neurological disorders by synthesis neuroactive compounds interact regulation inflammatory processes. Further research needed demonstrate dysbiosis psychiatric how microbiota-based interventions may be used potential therapeutic tools.

Language: Английский

Citations

39
Toxic vascular effects of polystyrene microplastic exposure DOI
Jianlong Yan, Yanbin Pan,

Junbo He

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167215 - 167215

Published: Sept. 19, 2023

Language: Английский

Citations

28
The current state of research for psychobiotics use in the management of psychiatric disorders–A systematic literature review DOI Creative Commons
Octavian Vasiliu

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 23, 2023

The need to find new therapeutic interventions in patients diagnosed with psychiatric disorders is supported by the data suggesting high rates of relapse, chronic evolution, resistance, or lack adherence and disability. use pre-, pro-, synbiotics as add-ons management has been explored a way augment efficacy psychotropics improve chances for these reach response remission. This systematic literature review focused on tolerability psychobiotics main categories it conducted through most important electronic databases clinical trial registers, using PRISMA 2020 guidelines. quality primary secondary reports was assessed criteria identified Academy Nutrition Diabetics. Forty-three sources, mostly moderate quality, were reviewed detail, regarding assessed. Studies exploring effects mood disorders, anxiety schizophrenia spectrum substance eating attention deficit hyperactivity disorder (ADHD), neurocognitive autism (ASD) included. overall good, but evidence support their specific mixed. There have favor probiotics ADHD, ASD, also association selenium disorders. In several domains, research still an early phase development, e.g., (only three preclinical studies being found) (one identified). Although no well-defined recommendation could yet be formulated product there encouraging further research, especially if identification sub-populations that may benefit from this intervention. Several limitations field should addressed, i.e., majority finalized trials are short duration, inherent heterogeneity diversity Philae prevents generalizability results studies.

Language: Английский

Citations

23
Potential effects of the most prescribed drugs on the microbiota-gut-brain-axis: A review DOI Creative Commons

Kirti Garg,

M. Hasan Mohajeri

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 207, P. 110883 - 110883

Published: Jan. 18, 2024

The link between drug-induced dysbiosis and its influence on brain diseases through gut-residing bacteria their metabolites, named the microbiota-gut-brain axis (MGBA), remains largely unexplored. This review investigates effects of commonly prescribed drugs (metformin, statins, proton-pump-inhibitors, NSAIDs, anti-depressants) gut microbiota, comparing findings with altered bacterial populations in major (depression, multiple sclerosis, Parkinson's Alzheimer's). report aims to explore whether can development progression via MGBA. Central indicate that all explored induce dysbiosis. These patterns were associated disorders. varied across different taxa, possibly mediated by direct or metabolites. Each drug induced both positive negative changes abundance bacteria, indicating a counterbalancing effect. Moreover, above-mentioned exhibited similar effects, suggesting they may counteract enhance each other's when taken together comorbid patients. In conclusion, interplay species abundances have greater impact than individual strains. Future research is needed better understand implications for disease pathogenesis, potential develop more effective therapeutic options patients brain-related diseases.

Language: Английский

Citations

11