Causal relationship between gut microbiome and sex hormone‐binding globulin: A bidirectional two‐sample Mendelian randomization study DOI
Ziqiao Yan, Zheng Zheng,

Tiantian Xia

et al.

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 91(2)

Published: Feb. 1, 2024

Abstract Problem Currently, there is a variety of evidence linking the gut microbiota to changes in sex hormones. In contrast, causal relationship between SHBG, carrier hormones, and unclear. Method Study Bidirectional two‐sample Mendelian randomization (MR) analysis was used detect effect SHBG microbiome. Summary statistics genome‐wide association studies (GWASs) for microbiome were obtained from public datasets. Inverse‐variance weighting (IVW), weighted median, mode, MR‐Egger simple mode methods operate MR analysis. F ‐statistics sensitivity analyses performed evaluate bias reliability. Results When we set as exposure outcome, identified nine relationships. males, Coprobacter (PIVW = 2.01 × 10 −6 ), Ruminococcus 2 3.40 −5 Barnesiella 2.79 −2 Actinobacteria 3.25 ) Eubacterium fissicatena groups 3.64 associated with lower levels; Alphaproteobacteria 1.61 higher levels. females, Lachnoclostridium 9.75 −3 Defluviitaleaceae UCG011 3.67 Victivallaceae 2.23 According results reverse analysis, three significant found on microbiota. Dorea 4.17 Clostridiales 4.36 7.44 −4 higherr No signifcant heterogeneity instrumental variables or horizontal pleiotropy bidirectional Conclusions This study may provide new insights into hormone‐binding protein levels, well treatment prevention strategies diseases such abnormal

Language: Английский

Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview DOI Creative Commons
Paweł Rasmus, Elżbieta Kozłowska

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 676 - 676

Published: March 9, 2023

Depression has a multifactorial etiology comprising family history and unemployment. This review aims to summarize the evidence available for antioxidant anti-inflammatory effects of carotenoids in mood disorders. article’s methodologies were based on search PubMed database all linked published papers. Epidemiological studies indicate that diet rich vegetables, fruits, nuts, fish, olive oil may prevent development depression. Antioxidant supplementation been found combat various stress-induced psychiatric disorders, including depression anxiety. A growing body indicates have both anti-inflammatory. Studies also suggest poor dietary intake, particularly low intakes fruit vegetables high fast food other convenience foods, increase risk developing Thus, interventions potential help mitigate mental health decline general population those with Considering effects, it is expected they might exert promising antidepressant effect. Nevertheless, further (including interventional mechanistic studies) assessing effect preventing alleviating symptoms are needed.

Language: Английский

Citations

57
Balancing the Mind: Toward a Complete Picture of the Interplay between Gut Microbiota, Inflammation and Major Depressive Disorder DOI Creative Commons

Nour Dabboussi,

Espérance Debs,

Marc Bouji

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 216, P. 111056 - 111056

Published: Aug. 24, 2024

The intricate interplay existing between gut microbiota and homeostasis extends to the realm of brain, where emerging research underscores significant impact on mood regulation overall neurological well-being vice-versa, with inflammation playing a pivotal role in mediating these complex interactions. This comprehensive review explores inflammation, alterations microbiota, their major depressive disorder (MDD). It provides cohesive framework for puzzle pieces this triad, emphasizing recent advancements understanding inflammatory states' contribution features. Two directions communication brain depression are discussed, serving as potential modulator. Therapeutic implications were discussed well, drawing insights from interventional studies effects probiotics bacterial composition symptoms. Ultimately, will attempt provide complete valuable future therapeutic interventions MDD.

Language: Английский

Citations

25
Association of the newly proposed dietary index for gut microbiota and depression: the mediation effect of phenotypic age and body mass index DOI
Xuan Zhang,

Qinglong Yang,

Jingtao Huang

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Language: Английский

Citations

17
Causal effects of gut microbiota on the risk of periodontitis: a two-sample Mendelian randomization study DOI Creative Commons

Shulu Luo,

Weiran Li,

Qianqian Li

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 25, 2023

Introduction The oral cavity and the gut tract are interconnected, both contain abundant natural microbiota. Gut microbiota may interact with flora participate in development of periodontitis. However, specific role certain taxa for periodontitis has not been investigated. Mendelian Randomization is an ideal method to explore causal relationships avoiding reverse causality potential confounding factors. Thus, we conducted a two-sample study comprehensively reveal genetic effect on Methods SNPs strongly associated 196 (18,340 individuals) were selected as instrument variables, (17,353 cases 28,210 controls) was used outcome. analyzed via random inverse variance-weighted, weighted median, MR-Egger. sensitivity analyses using Cochran’s Q tests, funnel plots, leave-one-out analyses, MR-Egger intercept tests. Results Nine ( Prevotella 7, Lachnospiraceae UCG-008, Enterobacteriales , Pasteurellales Enterobacteriaceae Pasteurellaceae Bacteroidales S24.7 group, Alistipes Eisenbergiella ) predicted play enhancing risk p < 0.05). Besides, two Butyricicoccus Ruminiclostridium 6) have potentially inhibitive effects No significant estimation heterogeneity or pleiotropy detected. Conclusion Our demonstrates provides guidance clinical intervention

Language: Английский

Citations

37
The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study DOI Creative Commons

Xiaofeng Lv,

Bojun Xu,

Xiurong Tang

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: April 14, 2023

Previous epidemiological and other studies have shown an association between major depressive disorder (MDD) migraine. However, the causal relationship them remains unclear. Therefore, this study aimed to investigate MDD migraine using a bidirectional, two-sample Mendelian randomization (MR) approach.

Language: Английский

Citations

23
Potential causal association between gut microbiome and posttraumatic stress disorder DOI Creative Commons
Qiang He, Wenjing Wang, Dingkang Xu

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 31, 2024

Abstract Background The causal effects of gut microbiome and the development posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential association using mendelian randomization (MR). Methods summary-level statistics for were retrieved from a genome-wide (GWAS) MiBioGen consortium. As PTSD, Freeze 2 datasets originated Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), replicated obtained FinnGen Single nucleotide polymorphisms meeting MR assumptions selected as instrumental variables. inverse variance weighting (IVW) method was employed main approach, supplemented by sensitivity analyses evaluate pleiotropy heterogeneity ensure robustness results. We also performed reverse explore PTSD’s on relative abundances specific features microbiome. Results In PGC-PTSD, eight bacterial traits revealed between PTSD (IVW, all P < 0.05). addition, Genus.Dorea genus.Sellimonas in datasets, which occurrence PTSD. further supported IVW findings, providing additional evidence reliability. Conclusion Our provides impact microbiomes shedding new light understanding dysfunctional gut-brain axis this disorder. findings present novel call investigations confirm links, well illuminate underlying mechanisms.

Language: Английский

Citations

9
The bidirectional interaction between antidepressants and the gut microbiota: are there implications for treatment response? DOI

Gianluca Borgiani,

Chiara Possidente, Chiara Fabbri

et al.

International Clinical Psychopharmacology, Journal Year: 2024, Volume and Issue: 40(1), P. 3 - 26

Published: Feb. 6, 2024

This review synthesizes the evidence on associations between antidepressant use and gut microbiota composition function, exploring microbiota's possible role in modulating treatment outcomes. Antidepressants exert an influence measures of microbial diversity. The most consistently reported differences were β-diversity those exposed to antidepressants not exposed, with longitudinal studies supporting a potential causal association. Compositional alterations users include increase Bacteroidetes phylum, Christensenellaceae family, Bacteroides Clostridium genera, while decrease was found Firmicutes Ruminococcaceae Ruminococcus genus. In addition, attenuate depressed healthy individuals, modulate serotonin transport, metabolic functions. These lyxose degradation, peptidoglycan maturation, membrane methylerythritol phosphate pathways, alongside gamma-aminobutyric acid metabolism. Importantly, baseline increased α-diversity abundance Roseburia Faecalibacterium are associated response, emerging as promising biomarkers. highlights for predictor response emphasizes need further research elucidate mechanisms underlying antidepressant-microbiota interactions. More homogeneous standardized techniques required confirm these initial findings.

Language: Английский

Citations

9
Metabolites and Coronary heart disease: A Two Sample Mendelian Randomization DOI Creative Commons

Sheng Yang,

Feng Gao, Zhenyu Zhu

et al.

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: unknown, P. 200365 - 200365

Published: Jan. 1, 2025

Language: Английский

Citations

1
A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument DOI Creative Commons
Nele Taba, Krista Fischer,

Estonian Biobank Research Team

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 23, 2025

Assessing causality is undoubtedly one of the key questions in microbiome studies for upcoming years. Since randomized trials human subjects are often unethical or difficult to pursue, analytical methods derive causal effects from observational data deserve attention. As simple covariate adjustment not likely account all potential confounders, idea instrumental variable (IV) analysis worth exploiting. Here we propose a novel framework antibiotic regression (AB-IVR) estimating relationships between and various diseases. We rely on recent showing that treatment has cumulative long-term effect microbiome, resulting individuals with higher usage have more perturbed microbiome. apply AB-IVR method Estonian Biobank show role numerous diseases including migraine, depression irritable bowel syndrome. plethora sensitivity analyses identified robust ways further methodological developments.

Language: Английский

Citations

1
Causal associations between human gut microbiota and cholelithiasis: a mendelian randomization study DOI Creative Commons
Wei Li, Ao Ren,

Qiong Qin

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 25, 2023

There was some evidence that gut microbiota closely related to cholelithiasis, but the causal relationship between them remained unclear. In this study, we try use Two-sample Mendelian randomization (MR) clarify potential and cholelithiasis.Summary Genome-Wide Association Studies (GWAS) statistical data for obtained from MiBioGen, of cholelithiasis UK Biobank (UKB). MR analyses were performed assess causalities mainly using inverse-variance weighted (IVW) method. Sensitivity used determine robustness results. Reverse examine reverse association.Our research results, based primarily on IVW method, support existence a nine microbial taxa cholelithiasis. We observed positive association Genus Butyrivibrio (p=0.032), Lachnospiraceae_UCG_001 (p=0.015), Ruminococcaceae_NK4A214_group (p=0.003), Ruminococcaceae_UCG_011 (p=0.010) while Order Rhodospirillales (p=0.031), Actinomyces (p=0.010), Phascolarctobacterium (p=0.036), Rikenellaceae_RC9_gutgroup (p=0.023), Ruminococcaceae_UCG_013 (p=0.022) may be associated with reduced risk did not find 9 specific taxa.This is first mendelian study explore which provide new ideas theoretical basis prevention treatment in future.

Language: Английский

Citations

21