Natural Polyphenol Recovery from Apple-, Cereal-, and Tomato-Processing By-Products and Related Health-Promoting Properties DOI Creative Commons
Katalin Szabo, Laura Mitrea, Lavinia Florina Călinoiu

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 7977 - 7977

Published: Nov. 17, 2022

Polyphenols of plant origin are a broad family secondary metabolites that range from basic phenolic acids to more complex compounds such as stilbenes, flavonoids, and tannins, all which have several phenol units in their structure. Considerable health benefits, having prebiotic potential cardio-protective weight control effects, been linked diets based on polyphenol-enriched foods plant-based products, indicating the role these substances prevention or treatment numerous pathologies. The most representative apple pomace phloridzin, chlorogenic acid, epicatechin, with major implications diabetes, cancer, cardiovascular neurocognitive diseases. cereal byproducts rich flavonoids (cyanidin 3-glucoside) (ferulic acid), significant results reducing incidence noncommunicable Quercetin, naringenin, rutin predominant molecules tomato by-products, important antioxidant antimicrobial activities. present understanding functionality polyphenols outcomes, specifically, illnesses, is summarized this review, focusing applicability evidence three extensive agrifood industries (apple, cereal, processing). Moreover, reintegration by-products into food chain via functional products personalized nutrition (e.g., 3D printing) detailed, supporting novel direction be explored within circular economy concept.

Language: Английский

Prebiotics and the Human Gut Microbiota: From Breakdown Mechanisms to the Impact on Metabolic Health DOI Open Access
Cassandre Bedu-Ferrari, Paul Biscarrat, Philippe Langella

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2096 - 2096

Published: May 17, 2022

The colon harbours a dynamic and complex community of microorganisms, collectively known as the gut microbiota, which constitutes densest microbial ecosystem in human body. These commensal microbes play key role health diseases, revealing strong potential fine-tuning microbiota to confer benefits. In this context, dietary strategies targeting modulate composition metabolic function communities are increasing interest. One such strategy is use prebiotics, defined substrates that selectively utilised by host microorganisms benefit. A better understanding pathways involved breakdown prebiotics essential improve these nutritional strategies. review, we will present concept focus on main sources nature components, mainly non-digestible polysaccharides. We review mechanisms carbohydrates intestinal short-chain fatty acids (SCFAs) molecules mediating dialogue between host. Finally, studies exploring personalised responses prebiotic ingestion. conclusion, hope be interest identify mechanistic factors for optimization prebiotic-based

Language: Английский

Citations

71
Mediterranean Diet on Sleep: A Health Alliance DOI Open Access
Egeria Scoditti, Maria Rosaria Tumolo, Sergio Garbarino

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2998 - 2998

Published: July 21, 2022

The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so it considered one the healthiest patterns. Clinical trials mechanistic studies have demonstrated its peculiar foods nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, tumorigenesis, thus preventing age-associated chronic improving wellbeing health. Nocturnal sleep an essential physiological function, whose alteration health outcomes diseases. Scientific evidence suggests are related in bidirectional relationship, understanding this association important given their role disease prevention. In review, we surveyed literature concerning current state from epidemiological on impact nighttime quantity quality. available indicate greater adherence to adequate duration several indicators better Potential mechanisms mediating effect described, gap-in-knowledge new research agenda corroborate findings discussed.

Language: Английский

Citations

71
The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota DOI Creative Commons
Aurelia Scarano, Barbara Laddomada, Federica Blando

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 630 - 630

Published: March 3, 2023

In the past decades, many studies have widely examined effects of dietary polyphenols on human health. Polyphenols are well known for their antioxidant properties and chelating abilities, by which they can be potentially employed in cases pathological conditions, such as iron overload. this review, we highlighted abilities polyphenols, due to structural specific sites, differences each class polyphenols. We also explored how iron-binding important inflammatory/immunomodulatory responses, with a special focus involvement macrophages dendritic cells, might contribute reshape gut microbiota into healthy profile. This review provides evidence that axes “polyphenol–iron metabolism–inflammatory responses” availability–gut microbiota” not been very so far, need further investigation exploit potential prevent or counteract conditions.

Language: Английский

Citations

50
Rosmarinic Acid Restores Colonic Mucus Secretion in Colitis Mice by Regulating Gut Microbiota-Derived Metabolites and the Activation of Inflammasomes DOI
Qun Wang, Kangjie Xu, Xu Cai

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(11), P. 4571 - 4585

Published: March 8, 2023

Maintaining a steady state of mucus barrier is an important potential target for polyphenol to exert its anticolitis activity. This study elucidates the pivotal role rosmaric acid (RA) in regulating function and alleviating inflammation by identifying gut microbiota-derived metabolites evaluating inhibitory effect on inflammasomes colitis mice. Results demonstrated that RA treatment promoted proliferation goblet cells restored level secretion, especially Muc2. reshaped microbiota mice, particularly boost core probiotics, such as p. Bacteroidaceae, f. Muribaculaceae, g. Alistipes, Clostridia_UCG-014. Nontargeted metabonomics targeted confirmed significant increase bile acids their (7-sulfocholic acid, stercobilin, chenodeoxycholic 3-sulfate, sulfate, ursodeoxycholic 3-sulfate), indole ((R)-2,3-dihydro-3,5-dihydroxy-2-oxo-3-indoleacetic frovatriptan, 3-formyl-6-hydroxyindole, brassicanal A), short-chain fatty (SCFAs) (acetic butyric isobutyric isovaleric valeric acid) contributed strengthened function. In addition, being absorbed mainly lower digestive tract, inhibited overexpression (especially NLRP6) occurred mice promote secretion cells. These data RA, promising candidate enhance health, colonic mediating production inflammasomes. The presented provides scientific evidence explaining apparent paradox low bioavailability high bioactivity polyphenols.

Language: Английский

Citations

48
Grape Pomace—Advances in Its Bioactivity, Health Benefits, and Food Applications DOI Creative Commons

Angélica Almanza-Oliveros,

Israel Bautista-Hernández, Cecilia Castro-López

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 580 - 580

Published: Feb. 14, 2024

From a circular economy perspective, the appropriate management and valorization of winery wastes by-products are crucial for sustainable development. Nowadays, grape pomace (GP) has attracted increasing interest within food field due to its valuable content, comprising nutritional bioactive compounds (e.g., polyphenols, organic fatty acids, vitamins, etc.). Particularly, GP polyphenols have been recognized as exhibiting technological health-promoting effects in different biological systems. Hence, is step toward offering new functional foods contributing solving waste problems wine industry. On this basis, use additive/ingredient development novel products with advantages recently proposed. In review, we summarize current knowledge on bioactivity polyphenolic-rich extracts from samples. Advances incorporation into formulations (enhancement physicochemical, sensory, quality) information supporting intellectual property related potential applications industry also discussed.

Language: Английский

Citations

34
Molecular crosstalk between polyphenols and gut microbiota in cancer prevention DOI
Falak Zeb, Huma Naqeeb, Tareq M. Osaili

et al.

Nutrition Research, Journal Year: 2024, Volume and Issue: 124, P. 21 - 42

Published: Jan. 27, 2024

Language: Английский

Citations

19
Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective DOI
Yuzhu Zhang, Jing Zhang,

Jingwen Yan

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 148, P. 104410 - 104410

Published: April 7, 2024

Language: Английский

Citations

19
Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health DOI
Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

10
A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

8
Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis DOI Open Access
Ștefan Horia Roșian,

Ioana Boarescu,

Paul-Mihai Boarescu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1379 - 1379

Published: Feb. 6, 2025

Atherosclerosis, a chronic inflammatory disease characterized by the accumulation of lipids and immune cells within arterial walls, remains leading cause cardiovascular morbidity mortality worldwide. Oxidative stress inflammation are central to its pathogenesis, driving endothelial dysfunction, foam cell formation, plaque instability. Emerging evidence highlights potential bioactive compounds with antioxidant anti-inflammatory properties mitigate these processes promote vascular health. This review explores mechanisms through which compounds-such as polyphenols, carotenoids, flavonoids, omega-3 fatty acids, coenzyme Q10, other natural compounds-modulate oxidative in atherosclerosis. It examines their effects on key molecular pathways, including inhibition reactive oxygen species (ROS) production, suppression nuclear factor-κB (NF-κB), modulation cytokines. By integrating current knowledge, this underscores therapeutic dietary supplemental complementary strategies for managing atherosclerosis, paving way future research clinical applications.

Language: Английский

Citations

6