Benefits of Vitamin D in Health and Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2419 - 2419

Published: May 23, 2023

This Special Issue of Nutrients, titled "Benefits Vitamin D in health and diseases", includes a total twenty-five publications that consider different aspects vitamin D, both at the cellular/preclinical clinical levels, neonates or children, pregnant women, adults elderly subjects [...].

Language: Английский

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Particularities regarding Clinical-biological and Evolutive Parameters of Immune-mediated Rheumatic Diseases in Patients with COVID-19 – systematic literature review

Balneo and PRM Research Journal, Journal Year: 2023, Volume and Issue: 14(Vol.14, no.2), P. 562 - 562

Published: June 23, 2023

Background: Since its outbreak in 2019, Coronavirus disease 2019 (COVID-19)/Severe Acu-te Respiratory Syndrome 2 (SARS-CoV-2) was a serious medical threat and declared Global Pandemic, triggering fear, panic uncertainty for people around the Globe. Among those individuals, there is specific category of patients – ones with immune-mediated rheumatic diseases (IMIDs) whose mantra from diagnosis to avoid infections at all costs because additional negative impact on immune sys-tem overall reactivity. Objective: Considering aforementioned, our objective understand in-depth relation system IMIDs set-ting Severe Acute (SARS-CoV-2), real bur-den vaccination against COVID-19. Materials Methods: In this res-pect, we have conducted thoroughly systematic literature review according “Prefer-red Reporting Items Systematic Reviews Meta-Analyses (PRISMA)” concept. Following five-steps algorithm, first selected 745 articles that were published re-putable international databases, ISI-indexed, period 1 January, 2021–31 December, 2022. After consequent elimination duplicates, not En-glish-written “open access” then applying PEDro classification/scoring-inspired, only 58 full qualitative reading. last stage,20 arti-cles “excluded reasons”, they didn’t offer significant information. The-refore, review, 38 included.Results: data gathered described molecular pathways activation triggered by COVID-19, significance clinical paraclinical aspects IMID infected new Coronavirus. Patients are higher risk hospitalization if diagnosed SARS-CoV2 more prone severe outcomes death. Risk factors associated death are: age, comorbidities, un-derlying activity, therapies used (“the good” being anti-tumor necrosis factor α, “the bad” Methotrexate, Sulfasalazine, Azathioprine ugly” anti CD20 mono-clonal antibodies). There several reports flares new-onset after CO-VID-19 disease, but larger studies registri-es do confirm incidence flare-ups or IMIDs. Regarding vaccination, mounting importance timing between immunomodulatory immunosuppres-sive agents administration vaccine. And least, discussed about Long COVID role artificial intelligence pandemic related-drug development. Discussion Conclusion: The consistent expertise practice. This article part doctoral study centralized same topics, current deepe-ning knowledge intersection COVID-19/SARS-CoV2 future objective: compare information synthetized here database almost 170 Romanian COVID-19/SARS-CoV2. next extend multicenter control one. Keywords: SARS-CoV2, Immune Mediated Rheumatic Diseases, Rheumatoid Arthri-tis, Systemic Lupus Erythematosus, COVID-19 Vaccine,

Language: Английский

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Vitamin D deficiency is an indicator of high mortality

Sanitarnyj vrač (Sanitary Doctor), Journal Year: 2024, Volume and Issue: 2, P. 125 - 141

Published: Jan. 29, 2024

Studies in recent years indicate that vitamin D deficiency has a great impact on the overall health and life expectancy of person, preparations can be successfully used to prevent treat wide range diseases adults children. At same time, Russian Federation, prevalence reaches 84 %. In this regard, statistical studies mortality population Europe (including Russia), USA Canada, depending deficiency, have been conducted. The results showed these countries is associated with statistically significant directly proportional relationships (p = 0.002‑0.03) total from non-communicable diseases, coronary heart disease, stroke, chronic obstructive pulmonary diabetes COVID-19. it seems absolutely necessary radically change attitude population, authorities, medical workers public problem D-vitamin Federation. It prepare implement federal regional programs for D-vitaminization including large-scale information campaign benefits D, monitoring level most vulnerable categories their treatment supplements, which will improve status reduce premature

Language: Английский

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Increased Early Postoperative Complication Rate after Osteoporotic Hip Fracture in Patients with Low 25 (OH) Vitamin D Levels

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1917 - 1917

Published: June 18, 2024

This study investigated the association of preoperative 25-hydroxy (25 (OH)) vitamin D levels with postoperative complications in osteoporotic hip fracture patients following surgery. We hypothesized that low concentrations 25 (OH) might have an increased risk developing adverse outcomes. Between January 2019 and December 2020, a retrospective observational was conducted, including low-energy fragility fractures at proximal femur. Regarding levels, were divided into two groups (<30 ng/mL ≥30 ng/mL). Early late assessed graded according to Clavien–Dindo classification system. Logistic regression analysis performed demonstrate between ng/mL, ng/mL) after adjusting for age sex. Of 314 patients, 222 (70.7%) had level <30 ng/mL. The mean serum 22.6 (SD 13.2). In 116 (36.9%), observed, most occurring short term (95 30.2%). Late present 21 (6.7%), as Clavien I (57.1%). identified independent factor early (OR 2.06, 95% CI 1.14–3.73, p = 0.016), while no significant correlation found 1.08, 0.40–2.95, 0.879). conclusion, be predictor complications. However, future studies are warranted determine factors long-term establish appropriate intervention strategies.

Language: Английский

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An Epidemiological Perspective on New Pediatric Cases of Type 1 Diabetes and Vitamin D Deficiency in South-East Romania: A Retrospective Study

Children, Journal Year: 2024, Volume and Issue: 11(10), P. 1162 - 1162

Published: Sept. 25, 2024

The aim of this study is to analyze the epidemiological characteristics and biological profile children from southeast Romania who have been newly diagnosed with type 1 diabetes (T1DM) investigate potential relationships between vitamin D deficiency onset disease, especially in context COVID-19 pandemic.

Language: Английский

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The Synergic Immunomodulatory Effect of Vitamin D and Chickpea Protein Hydrolysate in THP-1 Cells: An In Vitro Approach

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12628 - 12628

Published: Nov. 25, 2024

Vitamin D (VD), a crucial micronutrient, regulates bone health and immune responses. Recent studies suggest that VD may confer protective effects against chronic inflammatory diseases. Additionally, plant-based peptides can show biological activities. Furthermore, the supplementation of protein hydrolysates with could potentially enhance bioactivity peptides, leading to synergistic effects. In this study, THP-1 cells were exposed low concentrations Lipopolysaccharide (LPS) induce inflammation, followed by treatment vitamin at different (10, 25, or 50 nM) chickpea hydrolysate ("H30BIO") supplemented VD. The cytotoxicity was evaluated using viability assay confirm its safety. cytokine secretion TNF-α, IL-1β, IL6 assessed in cell supernatant, gene expression

Language: Английский

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Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4072 - 4072

Published: Nov. 27, 2024

Latent autoimmune diabetes of adults (LADA) is the most prevalent form (AI-D) in adulthood; however, its accurate diagnosis and optimal treatment remain challenging. Vitamin D deficiency (VDD) commonly observed LADA patients, while increased vitamin exposure through supplementation dietary intake associated with a reduced incidence LADA. Although limited, case reports, case-control studies, randomized clinical trials have examined effects supplementation—alone or combined dipeptidyl peptidase-4 inhibitors (DPP4-is)—on glucose regulation, residual β-cell function, glutamic acid decarboxylase antibody (GADA65) levels. Findings, preliminary, indicate that may enhance glycemic control, preserve reduce activity. Given accessibility, affordability, relative safety, presents an attractive adjunct option for patients. This narrative review discusses current evidence on potential therapeutic benefits patients AI-D, including LADA, who are also deficient. Beginning exploration epidemiological patterns, presentation, diagnostic framework essential understanding identifying this then examines proposed mechanisms which influence modulation pancreatic β-cells, integrating recent data pertinent to pathology. By distilling consolidating existing research, we aim provide platform advancing targeted investigations within distinct patient population.

Language: Английский

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The Relationship between Selected Inflammation and Oxidative Stress Biomarkers and Carotid Intima-Media Thickness (IMT) Value in Youth with Type 1 Diabetes Co-Existing with Early Microvascular Complications

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(16), P. 4732 - 4732

Published: Aug. 13, 2022

Recent years have confirmed the importance of oxidative stress and biomarkers inflammation in estimating risk cardiovascular disease (CVD) explaining not fully understood pathogenesis diabetic macroangiopathy. We aimed to analyze relation between intima-media thickness (IMT) common carotid arteries occurrence classical factors, together with newly proposed CVD (high-sensitivity C-reactive protein (hsCRP), myeloperoxidase (MPO), adiponectin, N-terminal-pro B-type natriuretic peptide (NT-proBNP) vitamin D) youth type 1 diabetes (T1D) recognized screening tests present early stages microvascular complications (VC). The study group consisted 50 adolescents young adults T1D, mean age 17.1 (10-26 range), including 20 patients VC (+) 30 (-). control (Control) 22 healthy volunteers, 16.5 (11-26 range). In patients, we found a significantly higher concentration HbA1c, lipid levels, hsCRP NT-proBNP. BMI blood pressure values were highest group. Higher levels MPO lower D both groups vs. Control. IMT was correlated positively hsCRP, NT-pro-BNP negatively levels. conclusion, T1D many abnormalities new biomarkers. seem be most important markers for NT-proBNP may possible marker myocardial injury this population.

Language: Английский

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Effects on Serum Inflammatory Cytokines of Cholecalciferol Supplementation in Healthy Subjects with Vitamin D Deficiency

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4823 - 4823

Published: Nov. 14, 2022

The effects of different cholecalciferol supplementation regimens on serum inflammatory cytokines in healthy subjects with vitamin D deficiency are still lacking. This is a single-center, open-label, randomized, parallel group study involving deficient (baseline 25OHD < 20 ng/mL) receiving oral three dosing regimens: Group A: 10,000 IU/day for 8 weeks followed by 1000 4 weeks; B: 50,000 IU/week 12 and C: 100,000 IU every other week weeks. IL-17A, IL-6, IL-8, IL-10, IL-23 TNFα were measured at baseline 4, 8, 12, 16. 75 enrolled (58.7% female), an average age 34.1 ± 10.2 years. No statistical differences observed among groups either IL-23, IL-8 or IL-10 any time point; was indetectable. Concerning the whole sample, trend analysis showed statistically significant linear decreasing values over treatment period IL-6 (p = 0.016) IL-17A 0.006), while no trends teste cytokines. found concentrations tested between In young individuals D, administration decrease concentrations, without marked using regimens.

Language: Английский

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The effect of vitamin D deficiency on the morbidity and mortality of the Russian Federation northern territories population

Sanitarnyj vrač (Sanitary Doctor), Journal Year: 2023, Volume and Issue: 4, P. 242 - 256

Published: March 29, 2023

The prevalence of vitamin D deficiency among the population northern territories increases due to fact that level and duration ultraviolet radiation UVB — a necessary condition for production prohormone, decreases extinction values as it rises high latitudes, which inevitably leads an increase in deficiency. In this regard, statistical studies have been conducted on relationship between morbidity mortality breadth territory residence life. results showed directly proportional, statistically significant (p = 0.0001–0.04) latitude female male (especially) from all causes working age, well age categories 0–14, 15–17 older than 18 years: respiratory organs; musculoskeletal system connective tissue; nervous system; Neoplasms. analysis large body scientific literature studies, our opinion, allow us identify factor affecting premature higher territories. we emphasize need radical change attitude problem. Vitamin by practitioners officials responsible health status Russian Federation at levels government federal, regional, municipal.Reducing will help improve life expectancy fellow citizens.

Language: Английский

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