PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(2), P. e0319386 - e0319386
Published: Feb. 25, 2025
Hearing
loss
poses
a
significant
threat
to
human
health,
with
its
prevalence
increasing
annually.
Niacin
(vitamin
B3)
is
an
essential
B
vitamin
that
plays
crucial
role
in
energy
metabolism
and
cellular
repair
the
body.
Additionally,
it
exerts
protective
influence
on
cells
of
inner
ear.
A
correlation
between
dietary
niacin
hearing
has
been
reported;
however,
results
remain
controversial,
requiring
further
investigation.
This
study
aimed
examine
potential
association
intake
United
States
(U.S.)
adults,
providing
reference
for
preventive
management
loss.
In
this
cross-sectional
study,
data
derived
from
National
Health
Nutrition
Survey
U.S.
adults
aged
20
69
years,
spanning
2011–2012
2015–2016
cycles,
were
used.
Logistic
regression,
restricted
cubic
spline
models,
subgroup
analyses,
sensitivity
analyses
used
assess
stability
results.
total
7675
participants
included,
whom
772
(10.1%)
exhibited
low-frequency
(LFHL),
1165
(15.2%)
had
speech-frequency
(SFHL),
2816
(36.7%)
high-frequency
(HFHL).
final
model,
adjusted
odds
ratios
LFHL,
SFHL,
HFHL
Q2
(16.97–23.40
mg/day)
compared
those
Q1
(≤16.96
0.73
(0.57–0.92),
0.76
(0.61–0.94),
0.80
(0.67–0.96),
respectively.
The
relationship
(HL)
was
illustrated
via
L-shaped
curve
inflection
point
approximately
23.26
mg/day.
HL
individuals
less
than
mg/day
as
follows:
0.950
(0.917–0.984)
0.951
(0.921–0.982)
0.965
(0.939–0.992)
HFHL.
To
summarize,
“L”-shaped
occurrence
estimated
at
revealed
present
study.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 18, 2025
Hyperlipidemia,
a
major
risk
factor
for
cardiovascular
diseases,
can
potentially
be
alleviated
by
dietary
antioxidants.
This
study
explored
the
relationship
between
hyperlipidemia
and
Composite
Dietary
Antioxidant
Index
(CDAI),
which
measures
antioxidant
intake
from
carotenoids,
selenium,
zinc,
vitamins
A,
C,
E.
Analyzing
data
27,493
participants
aged
20
older
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2001
2018,
we
used
weighted
regression
models
to
assess
this
association
while
adjusting
multiple
covariates.
Restricted
cubic
splines
were
also
applied
check
any
non-linear
relationships.
Findings
revealed
that
higher
CDAI
scores
significantly
correlated
with
lower
prevalence.
Specifically,
each
unit
increase
in
log-transformed
was
linked
14%
decrease
(OR
=
0.86,
95%
CI:
0.77-0.95).
Participants
top
quartile
had
15%
prevalence
compared
those
bottom
0.85,
No
significant
observed
(p
0.822).
In
conclusion,
increased
intake,
as
measured
CDAI,
is
associated
reduced
hyperlipidemia,
underscoring
role
of
antioxidants
its
management.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(1), P. e0296190 - e0296190
Published: Jan. 12, 2024
Endometriosis
is
a
multifactorial
disease
associated
with
inflammation.
Vitamin
D
has
anti-inflammatory,
antiproliferative,
anti-oxidative,
and
immunomodulatory
effects.
Whether
vitamin
levels
are
correlated
endometriosis
subject
of
ongoing
debate.
This
study
aimed
to
examine
the
association
between
serum
levels.
From
National
Health
Nutrition
Examination
Survey,
this
examined
cross-sectional
data
American
women
aged
20-54
years
from
2001
2006.
After
adjusting
for
covariates,
multivariable
logistic
regression
analysis
was
used
assess
correlations.
A
total
3,232
were
included
in
study.
The
multiple
linear
model
demonstrated
negative
correlation
25-hydroxyvitamin
D3
(cholecalciferol)
concentration
risk
after
controlling
all
confounding
variables.
odds
ratio
0.73
95%
confidence
interval
0.54-0.97
adequate
level
group
compared
insufficient
group.
Our
results
showed
that
inversely
Further
research
needed
establish
causal
relationship
determine
potential
benefits
maintaining
sufficient
prevention.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(6), P. e27426 - e27426
Published: March 1, 2024
PurposeThe
pathophysiological
mechanisms
underlying
migraine
remain
elusive,
with
oxidative
stress
hypothesized
as
a
potential
etiological
factor.
The
Oxidative
Balance
Score
(OBS)
is
comprehensive
tool
for
assessing
the
impact
of
diet
and
lifestyle
on
stress,
thereby
gauging
an
individual's
overall
antioxidant
capacity.
In
this
cross-sectional
study,
we
explored
correlation
between
OBS
prevalence
among
cohort
US
adults.MethodsWe
analyzed
data
from
6195
participants
aged
20
years
above,
drawn
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
1999
2004.
We
employed
multiple
logistic
regression,
coupled
sensitivity
analyses,
to
investigate
relationship
migraine.
Subsequent
subgroup
analyses
interaction
tests
were
performed
assess
consistency
association
across
population.ResultsMultiple
regression
revealed
inverse
likelihood
experiencing
migraines.
Specifically,
individuals
in
highest
quartile
exhibited
significantly
reduced
risk
compared
those
lowest
(OR
=
0.98,
95%
Confidence
Interval
(CI):
0.97–0.99,
P
0.0001).
Furthermore,
restricted
cubic
spline
curves
indicated
non-linear
dietary
incidence
(non-linear
0.0258).DiscussionOur
findings
suggest
that
adherence
antioxidant-rich
may
be
effective
strategy
mitigating
migraine,
potentially
by
influencing
balance.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 2, 2023
Background
The
visceral
adiposity
index
(VAI)
is
a
marker
of
abdominal
fat
distribution
and
adipose
tissue
function.
However,
the
association
between
VAI
femur
bone
mineral
density
(BMD)
osteoporosis
unclear
among
U.S.
older
adults.
Methods
Cross-sectional
data
for
adults
aged
60
years
from
2007–2020
National
Health
Nutrition
Examination
Survey
(NHANES)
were
included.
Multivariable
linear
logistic
regression
used
to
evaluate
BMD
osteoporosis.
We
smooth
curve
fitting
address
nonlinearity.
Moreover,
two-piecewise
model
was
explain
nonlinearity
further.
Results
findings
multivariable
models
showed
that
as
value
increased
by
one
unit,
prevalence
decreased
1.2%
after
adjusting
covariates
associated
with
demonstrated
positively
correlated
BMD.
Further
analysis
revealed
an
inverted
L-shaped
U-shaped
relationship
at
different
sites.
Conclusions
Our
indicated
independently
linked
higher
reveals
once
reaches
certain
threshold,
no
longer
increases
may
even
decrease.
This
suggests
moderate
accumulation
be
beneficial
health,
while
excessive
could
potentially
have
detrimental
effects.
Obesity Facts,
Journal Year:
2024,
Volume and Issue:
17(5), P. 445 - 458
Published: May 2, 2024
Obesity
has
previously
been
correlated
with
an
elevated
risk
of
reproductive
system
diseases
in
women.
The
waist-hip
ratio
(WHR)
shown
to
be
visceral
fat,
making
it
one
the
most
commonly
used
indicators
abdominal
obesity.
However,
little
is
known
about
relationship
between
WHR
and
infertility.
Therefore,
aim
this
study
was
evaluate
effect
on
infertility
women
childbearing
age.
BMC Geriatrics,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 19, 2024
Abstract
Background
Research
on
the
effects
of
body
mass
index
(BMI)
severe
headache
or
migraine
is
limited
and
controversial.
The
aim
this
study
was
to
explore
association
between
BMI
prevalence
migraine,
with
particular
interest
in
diabetes
status
difference.
Methods
present
used
analyzed
data
from
people
who
participated
National
Health
Nutrition
Examination
Survey
(NHANES)
1999
2004.
Logistic
regression
models
restricted
cubic
spline
(RCS)
were
applied
investigate
relationship
migraine.
Results
A
total
10,074
adults
aged
20
years
older
included
study.
Body
positively
related
corresponding
odds
ratio
(OR;
95%
CI)
1.02
(1.01,
1.03;
p
<
0.001).
And
compared
participants
lowest
group
(<
25
kg/m
2
),
adjusted
ORs
for
medium
(25-29.9
highest
(≥
30
)
1.14
(95%
CI:
0.98–1.32,
=
0.09)
1.30
1.11–1.52,
0.0022),
respectively.
exhibited
a
linear
overall
RCS.
Our
findings
also
suggested
an
interaction
diabetes.
non-linear.
OR
developing
1.10–1.54)
individuals
≥
29.71
Conclusion
higher
significantly
associated
increased
can
modify
them.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 15, 2025
The
triglyceride-glucose
(TyG)
index
is
not
only
a
reliable
marker
for
insulin
resistance,
but
also
has
broad
applications
in
assessing
the
risk
of
various
diseases,
including
cardiovascular
disease,
stroke,
depression,
and
Alzheimer's
disease.
study
aims
to
investigate
relationship
between
domain-specific
moderate-
or
vigorous-intensity
physical
activity
(MVPA)
TyG
among
US
adults.
participants
from
National
Health
Nutrition
Examination
Survey
(NHANES)
(2007–2018)
were
included.
Different
PA
domains,
occupation-related
MVPA
(O-MVPA),
transportation-related
(T-MVPA),
leisure-time
(LT-MVPA),
assessed
by
Global
Physical
Activity
Questionnaire.
Weighted
multivariable
linear
regression
propensity
score
matching
(PSM)
method
used
determine
index.
Furthermore,
stratified
mediation
analyses
employed
assess
potential
effect
modifications
mediators
on
association.
A
total
12,069
had
weighted
mean
age
47.43
±
16.91
years
8.58
0.67.
showed
that
whether
at
any
amount
achieving
guidelines,
was
negatively
associated
with
(β
=
-0.10,
95%CI:
-0.13-
-0.07,
P
<
0.001,
β
-0.13,
-0.17-
respectively).
O-MVPA
T-MVPA
correlated
index,
even
recommended
0.01,
-0.02–0.03,
0.59
O-MVPA,
-0.02,
-0.07–0.02,
0.32
T-MVPA).
After
PSM,
results
still
robust.
analysis
found
correlation
LT-MVPA
stronger
females,
those
higher
family
incomes,
non-smokers.
Finally,
indicated
significant
joint
BMI
relationships
(≥
150
min/week)
accounting
31.48%
effect.
decreased
adults,
while
no
such
association
observed
T-MVPA.
Specific
recommendations
categories
should
be
provided,
especially
populations
diseases
linked
high
resistance.
The
relationship
between
body
mass
index
(BMI)
and
sepsis
prognosis
remains
highly
controversial
uncertain.
This
study
investigated
the
association
BMI
in
patients
with
sepsis.
retrospective
observational
cohort
included
adult
admitted
to
intensive
care
unit
(ICU)
from
Medical
Information
Mart
for
Intensive
Care-IV
version
2.2
(MIMIC-IV
V2.2)
eICU
Collaborative
Research
Database
(eICU-CRD).
cut-off
value
of
was
identified
by
restricted
cubic
spline
(RCS)
curve
were
categorized
into
two
groups:
low
group
(<
28
kg/m2)
high
(≥
kg/m2).
primary
outcome
ICU
mortality,
secondary
outcomes
in-hospital
28-day
mortality.
We
performed
log-rank
test
detect
whether
there
is
a
difference
among
different
groups
cohorts.
Multiple
distinct
models
used
validate
robustness
results.
There
18,385
38,713
MIMIC-IV
eICU-CRD
cohorts,
respectively.
An
L-shaped
observed
mortality
analysis
2.2.
Similar
relationships
found
eICU-CRD.
When
less
than
cut-point,
risk
increased
rapidly
decreasing
BMI.
greater
levelled
off
as
increased.
Sepsis
higher
values
exhibited
decreased
all-cause
rates
cohort:
HR:
0.81,
95%
CI
0.75–0.88,
p
<
0.001;
0.75,
0.71–0.80,
0.001).
Consistent
trends
both
rates.
results
remained
robust
multiple
subgroup
analyses.
septic
patients,
indicating
that
lower
are
significantly
linked
Targeted
nutritional
interventions
close
monitoring
could
potentially
enhance
their
prognosis.
Therefore,
can
also
be
utilized
categorize
levels
effectively
predict