Journal of Functional Morphology and Kinesiology,
Journal Year:
2024,
Volume and Issue:
9(3), P. 124 - 124
Published: July 17, 2024
Prolonged
exposure
to
high
dosages
of
dexamethasone,
which
is
a
synthetic
glucocorticoid
and
well-known
anti-inflammatory
drug,
may
lead
an
increase
in
reactive
oxygen
species
production,
contributing
muscle
wasting.
The
prevention
atrophy
by
ingestion
functional
foods
attractive
issue.
In
the
last
decade,
natural
antioxidant
compounds
have
been
increasingly
investigated
as
promising
molecules
able
counteract
oxidative-stress-induced
atrophy.
Recently,
we
demonstrated
properties
two
main
olive
oil
polyphenols
also
known
for
their
anticancer
activities
different
cell
models.
Here,
preventive
effect
tyrosol
on
dexamethasone-induced
has
means
morpho-functional
approaches
C2C12
myotubes.
Dexamethasone-treated
cells
showed
reduced
fiber
size
when
compared
control
ones.
While
long
confluent
myotubes
could
be
observed
samples,
those
exposed
dexamethasone
appeared
immature
syncytia.
Dysfunctional
mitochondria
accumulation
autophagic
vacuoles
contributed
myotube
degeneration
death.
Tyrosol
administration
before
treatment
prevented
wasting
rescued
mitochondrial
lysosomal
functionality.
These
findings
demonstrate
that
attenuates
damage,
encourage
use
this
molecule
preclinical
clinical
studies
synergy
with
other
or
physical
activity
aim
prevent
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2325 - 2325
Published: July 19, 2024
Background:
Chronic
kidney
disease
(CKD)
will
become
the
fifth
leading
cause
of
death
in
world
by
2040.
It
is
fundamental
to
prevent
and
treat
this
pathology
reduce
its
impact
on
national
health
costs.
This
trial’s
aim
evaluate
effects
induced
a
combination
consumed
functional
foods
(FFs)
with
adapted
physical
activity
(APA)
progression
CKD-related
comorbidities.
Methods:
The
study
lasted
12
weeks.
We
divided
40
CKD
patients
into
four
groups:
mixed
(FF
+
APA),
APA,
FF
control
group
(usual
care).
FFs
were
characterized
their
total
antioxidant
capacity
antiradical
activity.
APA
was
performed
though
an
online
training
protocol,
three
times
per
week,
1
h
each
session.
Results:
At
end
study,
we
observed,
group,
decrease
azotemia
(p
=
0.0272),
diastolic
blood
pressure
0.0169),
C-reactive
protein
0.0313),
increases
FORD
test
0.0203)
fat
free
mass
0.0258).
showed
reduction
cholesterol
0.0039).
Conclusions:
can
help
counteract
several
comorbidities,
such
as
arterial
hypertension,
dyslipidemia
uremic
sarcopenia,
improve
patients’
quality
life.
Integrative Cancer Therapies,
Journal Year:
2023,
Volume and Issue:
22
Published: Jan. 1, 2023
Along
with
high
calorie
and
protein
diet,
a
new
comprehensive
dietary
approach
is
needed
to
control
cachexia
caused
by
cancer
its
related
outcomes.
This
study
was
done
evaluate
the
effect
of
Mediterranean
diet
on
body
composition,
nutritional
status,
inflammatory
markers
among
patients.In
this
randomized
clinical
trial,
46
patients
colorectal
cancer-induced
were
included.
After
randomization,
23
allocated
intervention
group
(Mediterranean
diet)
(nutritional
counseling
for
weight
gain
prevention
loss
in
patients).
The
primary
outcome
including
muscle
health,
along
secondary
outcomes
such
as
quality
life,
serum
proteins
evaluated
at
start
eighth
week
study.
Statistical
analysis
performed
according
intention-to-treat
concept.
To
compare
changes
dependent
variables
between
2
groups,
covariance
(ANCOVA)
performed.After
adjustment
baseline
values,
age,
sex,
supplements
use,
mean
(P
<
.001),
lean
mass
=
fat
.002),
strength
.001)
significantly
increased
compared
group.
Regarding
markers,
level
tumor
necrosis
factor-alpha
(TNF-α)
sensitive-C-reactive
(hs-CRP)
.01)
Interleukin
6
(IL-6)
improved
Moreover,
group,
score
global
health
status
.02)
physical
performance
increased.It
appears
that
implementation
might
be
strategy
improve
composition
cachexia.Iranian
Registry
Clinical
Trials
(www.irct.ir);
ID:
IRCT20211027052884N1.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(23), P. 4914 - 4914
Published: Nov. 24, 2023
Sarcopenia
has
recently
been
recognized
as
a
complication
of
diabetes.
However,
there
are
few
results
about
the
prevalence
sarcopenia
and
dynapenia
related
clinical
outcomes
in
type
1
diabetes
mellitus
(T1DM).
Our
objectives
were
to
evaluate
determine
whether
any
associations
with
disease-related
factors
people
T1DM.
A
cross-sectional
study
was
conducted
We
assessed
appendicular
skeletal
mass
index
(ASMI)
using
bioimpedance
50
Hz
(Nutrilab
Akern).
Muscle
function
through
handgrip
strength
(HGS)
Jamar
dynamometer.
defined
low
HGS
ASMI,
whereas
normal
ASMI.
used
data
from
Spanish
population
percentile
table
cut-off
point
at
p5
dynapenia.
The
association
clinical,
metabolic,
lifestyle
variables
studied.
This
included
62
T1DM
patients
(66%
females,
mean
age
38
±
14
years,
body
(BMI)
24.9
4.7
kg/m2).
8%
23%,
respectively.
In
our
sample,
more
men
sarcopenic
dynapenic
groups.
group
showed
significantly
higher
HbA1c
value.
Lower
duration,
PREDIMED
score,
BMI,
muscle
measures
(fat-free
(FFMI),
cell
(BCMI))
associated
sarcopenia.
Decreased
phase
angle
(PhA),
values
significant
high
study.
Specifically,
proportion
quite
high.
ASMI
practical
tools
for
assessment
health
status
T1DM,
poor
glycemic
control,
underweight,
adherence
Mediterranean
diet.
Thus,
may
predict
accelerated
aging
Healthcare,
Journal Year:
2023,
Volume and Issue:
11(13), P. 1928 - 1928
Published: July 3, 2023
The
main
objective
of
this
study
was
to
assess
the
relationship
between
Mediterranean
diet
(MD)
adherence
and
health-related
quality
life
(HRQOL)
according
anthropometric
measurements
teaching
research
staff
(TRS)
at
University
Granada
(UGR),
Spain.
This
diagnostic,
non-experimental,
cross-sectional,
observational
performed
on
university
lecturers
(65
women
62
men)
using
a
correlational
descriptive
methodology.
lecturers'
were
taken,
while
MD
determined
PREvention
with
MEDiterranean
(PREDIMED)
questionnaire.
Short
Form
Health
Survey
(SF-36)
used
for
measuring
HRQOL.
Better
results
body
composition
associated
improvements
in
physical
mental
dimensions
adherence.
Statistically
significant
differences
found
sexes,
men
showing
higher
values
weight,
height,
waist
circumference,
BMI,
waist/hip
ratio
(WHR),
muscle
mass,
systolic
diastolic
pressure
than
women.
Similarly,
positively
correlated
vitality
(r
=
0.233;
p
0.009),
social
functioning
0.229;
0.008),
component
summary
0.205;
0.021).
regression
model
that
(β
0.239,
0.041),
(PD)
-0.473,
<
0.000),
fat
percentage
(FP)
-0.241,
0.004),
age
-0.231,
0.022)
significantly
predicted
obtained
suggest
healthy
dietary
patterns
such
as
an
optimum
contribute
improved
Contemporary Clinical Trials Communications,
Journal Year:
2023,
Volume and Issue:
33, P. 101125 - 101125
Published: April 1, 2023
Decreased
walking
speed
in
older
patients
admitted
to
convalescent
rehabilitation
wards
(CRWs)
is
one
of
the
factors
that
inhibit
home
discharge.
Therefore,
interventions
improve
gait
CRWs
are
important,
and
rhythmic
auditory
stimulation
(RAS)
may
be
an
effective
intervention
strategy.
However,
effect
RAS
on
not
well
known.
this
study
protocol
aims
determine
feasibility
RAS-based
practice
for
CRW.The
designed
as
a
single-center,
open-label,
pilot,
randomized,
parallel-group
study.
Participants
will
30
aged
≥65
years
CRW
randomly
assigned
experimental
group
(RAS-based
practice;
n
=
15)
or
control
(normal
15).
In
both
groups,
conducted
min
per
session,
5
times
week
3
weeks.
The
primary
outcome
change
10-m
walk
test
weeks
after
baseline
assessment.
Secondary
score
Medical
Outcome
Study
8-Item
Short-Form
Health
Survey
Japanese
version
modified
Gait
Efficacy
Scale
from
assessment
later.This
exploratory
RCT
was
developed
using
strict
scientific
standards
based
defined
protocols.
Thus,
used
assess
viability
larger
investigation
into
practice.
If
our
theory
accurate,
could
serve
foundation
establishing
common
strategy.This
registered
University
Hospital
Information
Network
(UMIN)
clinical
trials
registry
Japan
(UMIN000049089).
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3085 - 3085
Published: July 9, 2023
Knee
osteoarthritis
(KOA)
is
one
of
the
most
common
joint
diseases,
especially
in
individuals
with
obesity.
Another
condition
within
this
population,
and
which
presents
frequently,
sarcopenic
obesity
(SO),
defined
as
an
increase
body
fat
a
decrease
muscle
mass
strength.
The
current
paper
aims
to
describe
recent
nutritional
strategies
can
generally
improve
KOA
clinical
severity
and,
at
same
time,
ameliorate
SO
indices.
Searches
were
carried
out
PubMed
Science
Direct
databases
data
summarized
using
narrative
approach.
Certain
key
findings
have
been
revealed.
Firstly,
screening
identification
patients
important,
end,
simple
physical
performance
tests
anthropometric
measures
are
available
literature.
Secondly,
adherence
Mediterranean
diet
achievement
significant
weight
loss
by
means
low-calorie
diets
(LCDs)
remain
cornerstone
treatment
population.
Thirdly,
supplementation
certain
micronutrients
such
vitamin
D,
essential
non-essential
amino
acids,
well
whey
protein,
also
appear
be
beneficial.
In
conclusion,
review,
we
presented
detailed
flowchart
three
different
tracks
that
adopted
both
based
on
disease
severity.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(18), P. 4017 - 4017
Published: Sept. 16, 2023
Skeletal
muscles
are
an
indispensable
actor
for
daily
activities,
playing
essential
role
in
locomotion
through
both
the
control
of
posture
and
position
by
joint
stabilization
[...]
International Journal of Food Sciences and Nutrition,
Journal Year:
2023,
Volume and Issue:
75(1), P. 45 - 57
Published: Oct. 16, 2023
AbstractOlive
oil,
essential
ingredient
of
the
Mediterranean
diet,
is
attracting
a
growing
interest
due
to
increasing
evidence
on
its
beneficial
effects
human
health.
This
study
investigated
whether
extra
virgin
olive
oil
(EVOO)
possess
prebiotic
properties.
Twenty
different
monovarietal
EVOO
samples
from
5
Marche
region
cultivars
(Italy)
were
studied.
The
activity
EVOOs
was
assessed
monitoring
selective
stimulation
gut
bacterial
species
and
short
chain
fatty
acids
(SCFAs)
production,
using
an
in
vitro
fermentation
system.
All
selectively
stimulated
Lactobacillus
spp.,
with
stronger
than
that
observed
inulin
(positive
control).
Also,
bifidobacteria
population
increased;
this
bifidogenic
Raggia
cultivar.
SCFAs
appeared
significantly
higher
after
24
h
all
fermentations
control.
Acetic
propionic
production
particularly
stimulated.
Overall,
most
had
potential
activity,
similar
or
inulin.Keywords:
Extra
oilsprebioticslactobacillus
spp.bifidobacterium
spp.short-chain
AcknowledgmentsThe
authors
would
like
thank
Prof.
Ewen
MacDonald
for
critical
review
manuscript.Disclosure
statementNo
conflict
reported
by
author(s).Additional
informationFundingThis
supported
UNICAM
_Call
FAR
2014-2015.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1302 - 1302
Published: April 26, 2024
Oleocanthal
(OC)
is
a
monophenol
of
extra-virgin
olive
oil
(EVOO)
endowed
with
antibiotic,
cardioprotective
and
anticancer
effects,
among
others,
mainly
in
view
its
antioxidant
anti-inflammatory
properties.
OC
has
been
largely
investigated
terms
activity,
Alzheimer
disease
collagen-induced
arthritis;
however,
the
possibility
that
it
can
also
affect
muscle
biology
totally
overlooked
so
far.
This
study
first
to
describe
modulates
alterations
induced
C2C12
myotubes
by
stimuli
known
induce
wasting
vivo,
namely
TNF-α,
or
medium
conditioned
C26
cachexia-inducing
tumor
(CM-C26).
were
exposed
CM-C26
TNF-α
presence
absence
for
24
48
h
analyzed
immunofluorescence
Western
blotting.
In
combination
CM-C26,
was
revealed
be
able
restore
both
myotube’s
original
size
morphology
normal
levels
atrogin-1
MuRF1.
seems
unable
impinge
on
autophagic–lysosomal
proteolytic
system
protein
synthesis.
Modulations
towards
expression
molecules
involved
myogenesis,
such
as
Pax7,
myogenin
MyHC,
observed
myotube
cultures
CM-C26.
conclusion,
data
presented
here
show
exerts
protective
action
mechanisms
likely
involving
downregulation
ubiquitin–proteasome-dependent
proteolysis
partial
relief
myogenic
differentiation
impairment.
Journal of Functional Morphology and Kinesiology,
Journal Year:
2024,
Volume and Issue:
9(3), P. 124 - 124
Published: July 17, 2024
Prolonged
exposure
to
high
dosages
of
dexamethasone,
which
is
a
synthetic
glucocorticoid
and
well-known
anti-inflammatory
drug,
may
lead
an
increase
in
reactive
oxygen
species
production,
contributing
muscle
wasting.
The
prevention
atrophy
by
ingestion
functional
foods
attractive
issue.
In
the
last
decade,
natural
antioxidant
compounds
have
been
increasingly
investigated
as
promising
molecules
able
counteract
oxidative-stress-induced
atrophy.
Recently,
we
demonstrated
properties
two
main
olive
oil
polyphenols
also
known
for
their
anticancer
activities
different
cell
models.
Here,
preventive
effect
tyrosol
on
dexamethasone-induced
has
means
morpho-functional
approaches
C2C12
myotubes.
Dexamethasone-treated
cells
showed
reduced
fiber
size
when
compared
control
ones.
While
long
confluent
myotubes
could
be
observed
samples,
those
exposed
dexamethasone
appeared
immature
syncytia.
Dysfunctional
mitochondria
accumulation
autophagic
vacuoles
contributed
myotube
degeneration
death.
Tyrosol
administration
before
treatment
prevented
wasting
rescued
mitochondrial
lysosomal
functionality.
These
findings
demonstrate
that
attenuates
damage,
encourage
use
this
molecule
preclinical
clinical
studies
synergy
with
other
or
physical
activity
aim
prevent
