Designing Nutrition for Health—Incorporating Dietary By-Products into Poultry Feeds to Create Functional Foods with Insights into Health Benefits, Risks, Bioactive Compounds, Food Component Functionality and Safety Regulations

Foods, Journal Year: 2023, Volume and Issue: 12(21), P. 4001 - 4001

Published: Nov. 1, 2023

This review delves into the concept of nutrition by design, exploring relationship between poultry production, utilization dietary by-products to create functional foods, and their impact on human health. Functional foods are defined as products that extend beyond basic nutritional value, offering potential benefits in disease prevention management. Various methods, including extraction, fermentation, enrichment, biotechnology, nanotechnology, employed obtain bioactive compounds for these foods. also examines innovative approach enhancing livestock diets through animal-based methods. Bioactive found such essential fatty acids, antioxidants, carotenoids, minerals, vitamins, peptides, highlighted promoting well-being mitigating chronic diseases. Additionally, explores functionality food components within products, emphasizing critical roles bioaccessibility, bioactivity, bioavailability The importance considering key aspects design enhanced production is thoroughly reviewed. safety establishment regulations guidelines was It concluded integration principles empowers individuals make informed choices can prioritize health well-being. By incorporating rich compounds, consumers proactively take steps prevent manage issues, ultimately contributing a healthier society lifestyle.

Language: Английский

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Dietary Intake, Mediterranean and Nordic Diet Adherence in Alzheimer’s Disease and Dementia: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 336 - 336

Published: Jan. 17, 2025

Background/Objectives: Dementia is not a single disease but an umbrella term that encompasses range of symptoms, such as memory loss and cognitive impairments, which are severe enough to disrupt daily life. One the most common forms dementia Alzheimer’s Disease (AD), complex neurodegenerative condition influenced by both genetic environmental factors. Recent research has highlighted diet potential modifiable risk factor for AD. Decades have explored role dietary patterns, including Mediterranean Diet (MD) its components, in neuroprotection health. Systematic review examines studies investigating impact Diet, Mediterranean-like diets, Nordic (ND), intake specific components extra virgin olive oil rapeseed on function, onset, progression AD dementia. Methods: A comprehensive search PubMed, Directory Open Access Journals, Social Science Research Network was conducted independently two reviewers using predefined terms. The period included from 2006 2024. Eligible meeting inclusion criteria were systematically reviewed, yielding 88 studies: 85 focused MD relationship dementia, while only 3 investigated ND. Results: findings suggest adherence diets generally associated with improved function delayed decline these can improve function. Some identified higher legume consumption decreased incidence, fruits vegetables, carbohydrates, eggs lowered prevalence. Most demonstrated high or ND better lower poor cognition comparison individuals adherence. However, some reported no significant benefits outcomes, indicated red meat linked Conclusion: Despite promising trends, evidence remains varying across studies, underscoring need further establish definitive associations between These highlight essential interventions prevention management AD, therefore offering critical insights into underlying mechanisms may brain

Language: Английский

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Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 29, 2023

Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, currently approved only provide symptomatic benefits. Emerging epidemiological clinical studies suggest that lifestyle changes, including diet physical activity, offer alternative therapeutic route slowing preventing cognitive decline dementia. Age single most common risk factor dementia, it associated cellular bioenergetics metabolic processes. Therefore, nutrient-rich critical optimal brain health. Furthermore, type 2 diabetes (T2D) AD, diets reduce T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, DASH diets, fruits, leafy green vegetables, fish, nuts, olive oil, prevent or slow decline. The mechanisms by which these nutrients promote health, however, are not yet completely understood. Other dietary approaches eating regimes, ketogenic intermittent fasting, also emerging as beneficial This review summarizes pathophysiology, factors, pathways activated several regimes shown promising results promoting

Language: Английский

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Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s Disease

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(4), P. 819 - 839

Published: April 17, 2023

Alzheimer's disease (AD) is a neurodegenerative characterized by progressive cognitive impairment and neuroinflammation. Recent research has revealed the crucial role of gut microbiota microbial metabolites in modulating AD. However, mechanisms which microbiome affect brain function remain poorly understood. Here, we review literature on changes diversity composition patients with AD animal models We also discuss latest progress understanding pathways from host or diet regulate By effects dietary components function, composition, metabolites, examine potential for manipulation through intervention to delay progression Although it challenging translate our microbiome-based approaches guidelines clinical therapies, these findings provide an attractive target promoting function.

Language: Английский

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Alzheimer’s disease: a mini-review for the clinician

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: June 22, 2023

Alzheimer's disease (AD), the most common form of dementia, is a striking example connection between neurophysiological abnormalities and higher-order cognitive deficiencies. Since its initial description in 1906, research into pathophysiology etiology AD has led to illumination an incredibly complex set genetic molecular mechanisms for disease's progression, characterized by much more than neuropathological hallmarks beta-amyloid (Aβ) plaques neurofibrillary tangles (NFTs). In this review, findings relating neurodegeneration present clinical presentation treatment are summarized, with emphasis on interconnectedness pathophysiology. Further, diagnostic guidelines provided based National Institute Aging-Alzheimer's Association (NIA-AA) workgroup's recommendations. Through dissemination detailed but digestible open access resources such as one, we can move towards increase equity accessibility education modern clinician.

Language: Английский

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Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Antioxidants, Journal Year: 2023, Volume and Issue: 12(1), P. 180 - 180

Published: Jan. 12, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS

Language: Английский

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Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 16, 2024

Abstract Background This study aims to investigate the relationship between vitamin B1 intake and cognitive function in older adults. Methods cross-sectional observational utilized data from National Health Nutrition Examination Survey (NHANES) 2011–2014. A total of 2422 participants were included analysis, with dietary being determined by averaging two 24-h recalls. Cognitive was assessed using three tests: Digit Symbol Substitution Test (DSST) for processing speed, Animal Fluency (AFT) executive function, a Consortium Establish Registry Alzheimer's disease (CERAD) subtest memory. Test-specific global cognition z score created. Multivariate linear regression models used explore association function. Results participants, aged 60 years older, NHANES across survey cycles (2011–2014). Higher associated higher DSST, AFT scores (P < 0.001) as well = 0.008). In fully adjusted model, compared lowest quartile (Q1), highest (Q4) related DSST (β 2.23, 95% CI 0.79 ~ 3.67) sore 0.09, 0.02 0.16). The US adults is linear. There no detected significant statistical interaction these variables. Conclusions Increased better individuals over 60.

Language: Английский

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Gut microbiota and its metabolites in Alzheimer’s disease: from pathogenesis to treatment

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17061 - e17061

Published: March 13, 2024

Introduction An increasing number of studies have demonstrated that altered microbial diversity and function (such as metabolites), or ecological disorders, regulate bowel–brain axis involvement in the pathophysiologic processes Alzheimer’s disease (AD). The dysregulation microbes their metabolites can be a double-edged sword AD, presenting possibility microbiome-based treatment options. This review describes link between imbalances interactions AD modalities microbiota, potential interventions such prebiotics, probiotics, synbiotics, fecal microbiota transplantation, dietary complementary therapeutic strategies targeting pathogenesis progression. Survey methodology Articles from PubMed china.com on intestinal flora were summarized to analyze data conclusions carefully ensure comprehensiveness, completeness, accuracy this review. Conclusions Regulating gut balance upregulates neurotrophic factor expression, regulates microbiota-gut-brain (MGB) axis, suppresses inflammatory responses. Based emerging research, explored novel directions for future research clinical interventions, injecting new vitality into development.

Language: Английский

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The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 18, 2025

Alzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues mortality among older individuals. This condition involves progressive deterioration in cognitive function onset dementia. Recent advancements suggest that development AD more intricate than its underlying brain abnormalities alone. In addition, disease, metabolic syndrome, oxidative stress are all intricately linked one another. Increased concentrations circulating lipids disturbances glucose homeostasis contribute intensification lipid oxidation, leading gradual depletion body’s antioxidant defenses. heightened metabolism adversely impacts cell integrity, resulting neuronal damage. Pathways commonly acknowledged as contributors pathogenesis include alterations synaptic plasticity, disorganization neurons, death. Abnormal some membrane proteins thought creation amyloid (Aβ) oligomers, which extremely hazardous neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers these neurotransmitter systems induce cellular dysfunction, an imbalance signaling, and, ultimately, manifestation neurological symptoms. Antioxidants have impact on human since they may improve aging process by combating free radicals. Neurodegenerative diseases currently incurable; however, be effectively managed. An appealing alternative utilization natural antioxidants, such polyphenols, through diet or dietary supplements, offer numerous advantages. Within this framework, we extensively examined importance advancement well potential influence antioxidants mitigating effects.

Language: Английский

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Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2091 - 2091

Published: Dec. 8, 2023

Metabolic syndrome (MS) is a growing disorder affecting thousands of people worldwide, especially in industrialised countries, increasing mortality. Oxidative stress, hyperglycaemia, insulin resistance, inflammation, dysbiosis, abdominal obesity, atherogenic dyslipidaemia and hypertension are important factors linked to MS clusters different pathologies, such as diabesity, cardiovascular diseases neurological disorders. All biochemical changes observed MS, dysregulation the glucose lipid metabolism, immune response, endothelial cell function intestinal microbiota, promote pathological bridges between metabolic syndrome, diabesity neurodegenerative This review aims summarise syndrome's involvement highlight link diseases. A better understanding could novel strategic approach reduce comorbidities.

Language: Английский

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